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A novel photo-initiated approach for preparing aluminum diethylphosphinate under atmospheric pressure

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Chinese Chemical Letters 2011年第4期22卷 385-388页

作者： Li Yang Xin Yu Han Xue Jiao Tang Chang Xiu Han Yi xiao zhou bao Gui Zhang College of Environmental Science & Engineering Nankai University Tianjin 300071 China

A novel preparation of aluminum diethylphosphinate（AlPi） was carried out with free-radical addition reaction by means of UV-irradiation under atmospheric pressure.A solution of sodium hypophosphite was treated with ethylene and irradiated with ultraviolet light in the presence of an amount of photoinitiator effective to initiate the free-radical reaction between the hypophosphite anion and the double bond of the ethylene *** ethylene was micro-bubbled into the reaction mixture with the addition of the photoinitiator,and the gas-liquid contact surface and the photoinitiator concentration in the gas-liquid interface were increased *** yield of the final product could be improved to about 96%.The contents of P,Al in samples were detected by ICP,and the molecular structure of the samples was confirmed by ^（31）P NMR,~1H NMR and FTIR spectroscopic *** stability of the final products was investigated in detail by TG-DTA.

关键词： Photoinitiator Aluminum diethylphosphinate FTIR ^1H NMR

Major causes of fever of unknown origin at Peking Union Medical College Hospital in the past 26 years

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Chinese Medical Journal 2013年第5期126卷 808-812页

作者： SHI xiao-chun LIU xiao-qing zhou bao-tong ZHANG Li-fan MA xiao-jun DENG Guo-hua LI Tai-sheng SHENG Rui-yuan WANG Ai-xia Department of Infectious Diseases Peking Union Medical CollegeHospital Chinese Academy of Medical Sciences & Peking UnionMedical College Beijing 100730 China

Background Despite the recent advances in medicine, fever of unknown origin （FUO） remains a diagnostic and therapeutic challenge even to expert physicians. To increase the knowledge of FUO, we conducted a retrospective study to investigate the causes of FUO and the change of major causes of FUO during the past 26 years. Methods The clinical data were retrospectively analyzed from 997 patients with FUO hospitalized at the Peking Union Medical College Hospital （PUMCH） between January 2004 and October 2010. Furthermore, the results were compared to that reported in previous studies of FUO in PUMCH since 1985. Results Of the 997 FUO cases, definite diagnosis was eventually achieved in 797 （79.9%） patients. The most common cause of FUO was infectious diseases （479 cases, 48.0%）, with tuberculosis accounting for 45.3% （217/479） of the cases of infections. One hundred and sixty-eight （16.9%） patients were diagnosed with connective tissue diseases, with Still＇s disease and vasculitis accounted for 31.5% （53/168） and 24.4% （41/168） of this category, respectively. Neoplasms and miscellaneous causes were found in 7.9% （79/997） and 7.1% （71/997）, respectively. However, no definite diagnosis had been made in the remaining 200 （20.1%） cases until they were discharged from the hospital. Conclusions During different periods, infectious diseases, especially tuberculosis, were the leading etiology of FUO and the proportion of tuberculosis had no significant difference. While the frequency of neoplasms was descending, the proportion of lymphoma in neoplasm was ascending; the frequency of undiagnosed＇cases was increasing, but in most FUO cases the causes can be diagnosed eventually after careful analysis of clinical data.

关键词： fever of unknown origin differential diagnosis

Synthesis of a Novel Anion Receptor Based on Porphyrin

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Synthesis of a Novel Anion Receptor Based on Porphyrin

全反式维甲酸对原代培养卵黄囊瘤细胞系体外生长影响的观察

中国化学会第四届有机化学学术会议

作者： bao, xiao-Ping zhou, Bin WU, Lei LI, Zao-Ying (College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072)

＜正＞Porphyrin and its derivatives have been studied for many years in many fields, such as catalysts, materials and medicine, etc. However, their applications in supramolecular chemistry, especially in anion recognition, related investigations are relatively rare. Most of anion receptors reported based-on porphyrin have picket-fence geometrical

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中华肿瘤防治杂志 2011年第6期18卷 420-423页

作者：张浩川包小周陈聪德陈肖鸣温州医学院附属育英儿童医院儿外科浙江温州325027

目的:体外观察全反式维甲酸(ATRA)对卵黄囊瘤细胞系细胞体外生长的影响。方法:卵黄囊瘤细胞系细胞持续培养在含ATRA的96孔板中,采用MTT法检测ATRA的体外抗增殖效果,采用流式细胞仪检测ATRA对细胞周期的影响,用相差倒置显微镜及透射电镜... 详细信息

目的:体外观察全反式维甲酸(ATRA)对卵黄囊瘤细胞系细胞体外生长的影响。方法:卵黄囊瘤细胞系细胞持续培养在含ATRA的96孔板中,采用MTT法检测ATRA的体外抗增殖效果,采用流式细胞仪检测ATRA对细胞周期的影响,用相差倒置显微镜及透射电镜观察细胞形态变化。结果:MTT法检测发现,ATRA作用后细胞的增殖受到了抑制,随着浓度和时间的增加,其抑制作用增强,与对照组比较差异有统计学意义,P<0.05。流式细胞仪检测结果显示,经ATRA处理后的卵黄囊瘤细胞明显阻滞于G1期,S期比例减少,与对照组比较差异有统计学意义,P<0.05。光镜和透射电镜可观察到经ATRA处理后的卵黄囊瘤细胞部分发生形态学的良性分化:超微下见胞核体积缩小且形态规则,核仁减少和消失,细胞表面微绒毛及树枝状伪足消失。对照组细胞无此表现。结论:ATRA对卵黄囊瘤细胞有诱导分化作用,有效抑制了肿瘤细胞的增殖,其机制可能与引起细胞周期阻滞于G1期有关。

关键词：维甲酸卵黄囊瘤细胞周期

邻苯二甲酸二乙基己酯对成年大鼠睾丸前列腺素E_2含量及COX-2 mRNA表达的影响

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中国临床药理学与治疗学 2011年第1期16卷 38-41页

作者：张浩川陈聪德包小周陈肖鸣温州医学院附属育英儿童医院小儿外科

目的:研究邻苯二甲酸二乙基己酯(DE-HP)对成年大鼠睾丸前列腺素E2(PGE2)含量及环氧合酶-2(COX-2)mRNA表达的影响。方法:雄性SD成年大鼠40只,随机分成4组,每组10只,设3个染毒剂量组(10、100、500 ***-1.d-1DEHP溶媒为玉米油)和1个对照组... 详细信息

目的:研究邻苯二甲酸二乙基己酯(DE-HP)对成年大鼠睾丸前列腺素E2(PGE2)含量及环氧合酶-2(COX-2)mRNA表达的影响。方法:雄性SD成年大鼠40只,随机分成4组,每组10只,设3个染毒剂量组(10、100、500 ***-1.d-1DEHP溶媒为玉米油)和1个对照组(玉米油),饲养4周后处死。用ELISA测定睾丸组织PGE2含量;应用免疫组化法检测40只雄性SD成年大鼠睾丸组织中COX-2的表达及其定位情况;RT-PCR法检测各组睾丸组织COX-2 mRNA表达及其定位情况。结果:实验组睾丸组织中PGE2含量和睾丸组织的COX-2mRNA表达均低于对照组,COX-2则主要表达于精原细胞。结论:DEHP能使成年大鼠睾丸生精细胞功能损伤,使睾丸组织PGE2合成降低,其机制可能与下调COX-2 mRNA表达有关。

关键词：邻苯二甲酸二乙基己酯睾丸前列腺素E2 COX-2 mRNA

De novo synthesis of atropisomeric benzofurans via Cu/SPDO complex catalyzed asymmetric formal [3 + 2] annulation

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Science China Chemistry 2025年第01期 174-180页

作者： Fan-xiao Meng Xing-Yu Wang Ka Lu Ju-Song Yang Fu-Min Zhang Ai-Jun Ma bao Du Yong-Qiang Tu State Key Laboratory of Applied Organic Chemistry College of Chemistry and Chemical Engineering Lanzhou University School of Chemistry and Chemical Engineering Shanghai Jiao Tong University School of Biotechnology and Health Sciences Wuyi University

Herein, the de novo synthesis of atropisomeric benzofurans through the Cu/spirocyclic-pyrrolidine-oxazoline(SPDO) complex catalyze asymmetric formal [3 + 2] cycloaddition between quinones and ynamides is explored, producing a range of structurally diverse axially chiral benzofurans in satisfactory yields with good to excellent enantioselectivities. Furthermore, density functional theory calculations were applied to explain the possible reaction mechanism.

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Integrating lipidomics and gut microbiota to study the anti-hyperlipidemia effect of Sargentodoxae Caulis extract

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Traditional Medicine Research 2025年第1期10卷 1-11页

作者： xiao-xiao Zhang Li Jia Xiu-Jun Zhan Charity Ngina Qing-Rui Zhang xiao-Ge Li Qi-bao Jiang Shi Bai Miao-Miao Jiang National Key Laboratory of Chinese Medicine Modernization Tianjin University of Traditional Chinese MedicineTianjin 301617China Haihe Laboratory of Modern Chinese Medicine Tianjin 301617China School of Medicine Taizhou UniversityTaizhou 318000China.

Background:Sargentodoxae Caulis(SC)is the vine stem of Sargentodoxa Cuneata(Oliv.)Rehd.&*** in ***,and it in traditional Chinese medicine has been known for promoting blood circulation and removing blood stasis as recorded in the ancient book“Illustrated Classics of Materia Medica”.It has been used effectively to treat blood stasis too in modern clinical ***,the anti-hyperlipidemia effect of SC is not fully *** paper aims at exploring the use of SC stems to improve the balance of blood lipids in the body,and its new role in treating ***:The effects of SC extract on hyperlipidemia were explored by combining lipidomics and gut ***,we explored the potential mechanism of SC in treating hyperlipidemia by pathway ***:The results showed that the stem extract of SC could restore the physiological and biochemical indices of hyperlipidemia in mice,as well as repair the morphological and structural damage to *** to the Model group,the SC extract significantly reduced the liver index,epididymal fat index,and Lee’s *** also significantly decreased serum levels of total cholesterol,triglycerides,low-density lipoprotein cholesterol,peroxisome proliferator-activated receptor gamma(PPAR-γ),D-lactate,and free fatty acids,while significantly increasing the relative content of peroxisome proliferator-activated receptor alpha(PPAR-α).These changes were statistically ***-targeted lipidomics,based on LC-MS,were utilized to investigate the lipid metabolism characteristics in serum,liver,and epididymal fat of the *** was observed that,compared to the blank group,the Model group exhibited significant changes primarily in glycerol lipids and *** treatment group also displayed alterations in these lipids.A total of 38,81,and 27 differential lipids were identified in serum,liver,and epididymal fat samples,*** these,14 common differenti

关键词： hyperlipidemia Sargentodoxae Caulis lipidomics intestinal flora

小儿睾丸卵黄囊瘤细胞的体外培养及生物学特性研究

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中华小儿外科杂志 2011年第3期32卷 186-189页

作者：张浩川沈金辉陈聪德包小周李仲荣陈肖鸣温州医学院附属育英儿童医院小儿外科 325000

目的采用组织培养技术在体外培养取自人体的睾丸卵黄囊瘤组织，探讨小儿睾丸卵黄囊瘤组织的体外培养方法及生物学特性。方法采用组织块培养法培养1例睾丸卵黄囊瘤患儿手术的标本，从形态学、细胞生长动力学、肿瘤内分泌、染色体分析... 详细信息

目的采用组织培养技术在体外培养取自人体的睾丸卵黄囊瘤组织，探讨小儿睾丸卵黄囊瘤组织的体外培养方法及生物学特性。方法采用组织块培养法培养1例睾丸卵黄囊瘤患儿手术的标本，从形态学、细胞生长动力学、肿瘤内分泌、染色体分析、细胞DNA分析等方面初步研究了小儿睾丸卵黄囊瘤细胞的生物学特性。结果小儿睾丸卵黄囊瘤细胞无论形态学观察，还是功能学测定，均符合卵黄囊瘤细胞的特征，染色体众数39-97条，并具有体外分泌AFP功能。其特有表现为：细胞贴壁生长，呈短梭形或多角形，细胞密集时可多层重叠生长，肿瘤细胞表面有明显的微绒毛，细胞核形态怪异，细胞倍增时间较长。结论小儿睾丸卵黄囊瘤细胞在体外生长稳定，增殖活跃，肿瘤细胞的纯度较高，可以用于后续的实验研究。

关键词：卵黄囊瘤睾丸组织培养技术

信息熵在区域土地利用结构研究中的应用——以重庆市江北区为例

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西南师范大学学报（自然科学版） 2004年第6期29卷 1062-1065页

作者：刘筱非周宝同杨庆媛赵娅奇周滔西南师范大学国土资源研究所重庆400715

提出了信息熵的2个应用领域:①信息熵是土地利用系统有序程度的标志,其变化能反映系统的状态与演化趋势.②信息熵的序列变化可用来刻画土地利用结构的动态演变.分析了江北区1996年至2003年信息熵的变化,认为土地利用系统呈有序度... 详细信息

提出了信息熵的2个应用领域:①信息熵是土地利用系统有序程度的标志,其变化能反映系统的状态与演化趋势.②信息熵的序列变化可用来刻画土地利用结构的动态演变.分析了江北区1996年至2003年信息熵的变化,认为土地利用系统呈有序度降低.

关键词：江北区土地利用系统区域土地利用有序度重庆土地利用结构信息熵刻画结构研究序列