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Cognitive dysfunction in schizophrenia patients caused by downregulation of γ-aminobutyric acid receptor subunits

World Journal of Psychiatry 2024年第6期14卷 784-793页

作者： Xi Chen Ya-Nan Zhou xiao-zi lu Ren-Jiao Li Yi-Fan Xiong Xia Sheng Wei-Wei Zhu Department of Child and Adolescent Psychiatric Brain Hospital of Hunan ProvinceThe Second People’s Hospital of Hunan ProvinceChangsha 410007Hunan ProvinceChina Department of Psychiatry Qingdao Mental Health CenterQingdao 266034Shandong ProvinceChina Department of Psychiatry Brain Hospital of Hunan ProvinceThe Second People’s Hospital of Hunan ProvinceChangsha 410007Hunan ProvinceChina Department of Sleep Disorders and Neurosis Brain Hospital of Hunan ProvinceThe Second People’s Hospital of Hunan ProvinceChangsha 410007Hunan ProvinceChina

BACKGROUND The expression pattern of gamma aminobutyric acid(GABA)receptor subunits are commonly altered in patients with schizophrenia,which may lead to nerve excitation/inhibition problems,affecting cognition,emotion,and *** To explore GABA receptor expression and its relationship with schizophrenia and to provide insights into more effective *** This case-control study enrolled 126 patients with schizophrenia treated at our hospital and 126 healthy volunteers who underwent physical examinations at our hospital during the same *** expression levels of the GABA receptor subunits were detected using 1H-magnetic resonance *** recognized cognitive battery tool,the MATRICS Consensus Cognitive Battery,was used to evaluate the scores for various dimensions of cognitive *** correlation between GABA receptor subunit downregulation and schizophrenia was also *** Significant differences in GABA receptor subunit levels were found between the case and control groups(Pluding attention/alertness and learning ability(P0.05).CONCluSION Downregulation of the GABA receptor subunits is positively correlated with *** other words,when GABA receptor subunits are downregulated in patients,cognitive impairment becomes more severe.

关键词： Cognitive function Schizophrenia Downregulation Gamma-aminobutyric acid receptor subunits Correlation

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Recent Strategies and Advances in Hydrogel-Based Delivery Platforms for Bone Regeneration

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NANO-MICRO LETTERS 2025年第1期17卷 1-51页

作者： Wang, xiao Zeng, Jia Gan, Donglin Ling, Kun He, Mingfang Li, Jianshu lu, Yongping Guangyuan Cent Hosp Sci & Technol Innovat Ctr Biomed Mat & Clin Res Guangyuan Key Lab Multifunct Med Hydrogel Guangyuan 628000 Peoples R China Nanjing Normal Univ Jiangsu Collaborat Innovat Ctr Biomed Funct Mat Sch Chem & Mat Sci Jiangsu Key Lab Biofunct Mat Nanjing 210023 Peoples R China Sichuan Univ Coll Polymer Sci & Engn State Key Lab Polymer Mat Engn Chengdu 610065 Peoples R China

Recent advances in the combined delivery platform that integrate nano-/microscale carriers and with 3D hydrogel network for bone regeneration are *** strategies for bioactive molecules delivery involving nanoparticles, nanosheets, and microspheres, along with extra stimuli such as near-infrared light, temperature changes, ultrasonication, and inflammatory conditions, are *** prospects and challenges for the clinical translation and the development of nano-/microscale incorporated hydrogel-based delivery platform are discussed. Bioactive molecules have shown great promise for effectively regulating various bone formation processes, rendering them attractive therapeutics for bone regeneration. However, the widespread application of bioactive molecules is limited by their low accumulation and short half-lives in vivo. Hydrogels have emerged as ideal carriers to address these challenges, offering the potential to prolong retention times at lesion sites, extend half-lives in vivo and mitigate side effects, avoid burst release, and promote adsorption under physiological conditions. This review systematically summarizes the recent advances in the development of bioactive molecule-loaded hydrogels for bone regeneration, encompassing applications in cranial defect repair, femoral defect repair, periodontal bone regeneration, and bone regeneration with underlying diseases. Additionally, this review discusses the current strategies aimed at improving the release profiles of bioactive molecules through stimuli-responsive delivery, carrier-assisted delivery, and sequential delivery. Finally, this review elucidates the existing challenges and future directions of hydrogel encapsulated bioactive molecules in the field of bone regeneration.

关键词： Hydrogel Bone regeneration Bioactive molecules Drug delivery Nano-/microscale carriers

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Unlocking the stable interface in aqueous zinc-ion battery with multifunctional xylose-based electrolyte additives

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Journal of Energy Chemistry 2025年第1期100卷 770-778页

作者： xiaoqin Li Jian Xiang lu Qiu xiaohan Chen Yinkun Zhao Yujue Wang Qu Yue Taotao Gao Wenlong Liu Dan xiao Zhaoyu Jin Panpan Li Institute for Advanced Study Chengdu University School of Mechanical Engineering Chengdu University College of Food and Biological Engineering Chengdu University Institute of Fundamental and Frontier Sciences University of Electronic Science and Technology of China College of Materials Science and Engineering Sichuan University

The growth of dendrites and the side reactions occurring at the Zn anode pose significant challenges to the commercialization of aqueous Zn-ion batteries（AziBs）. These challenges arise from the inherent conflict between mass transfer and electrochemical kinetics. In this study, we propose the use of a multifunctional electrolyte additive based on the xylose（Xylo） molecule to address these issues by modulating the solvation structure and electrode/electrolyte interface, thereby stabilizing the Zn anode. The introduction of the additive alters the solvation structure, creating steric hindrance that impedes charge transfer and then reduces electrochemical kinetics. Furthermore, in-situ analyses demonstrate that the reconstructed electrode/electrolyte interface facilitates stable and rapid Zn2+ion migration and suppresses corrosion and hydrogen evolution reactions. As a result, symmetric cells incorporating the Xylo additive exhibit significantly enhanced reversibility during the Zn plating/stripping process, with an impressively long lifespan of up to 1986 h, compared to cells using pure ZnSO4electrolyte. When combined with a polyaniline cathode, the full cells demonstrate improved capacity and long-term cyclic stability. This work offers an effective direction for improving the stability of Zn anode via electrolyte design, as well as highperformance AziBs.

关键词： Solvation

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Clinicopathological differences between patients with schistosomal appendicitis and non schistosomal appendicitis:A retrospectively study of past ten years

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World Journal of Clinical Cases 2025年第2期13卷 24-32页

作者： xiao-Yi Wang Yao Hao zi-Jian Wang Xiu-Liang Xu Jiang-Hua Yang Department of Infectious Diseases The First Affiliated of Wannan Medical CollegeWuhu 241001Anhui ProvinceChina

BACKGROUND Chronic schistosomiasis causes multiple organ and multiple system diseases,especially the digestive *** eggs are mainly deposited in the stomach,liver and colorectal,but a few eggs are deposited in the appendix and cause *** present,there are few studies on schistosomal *** To explore the differences in epidemiological,clinical and pathological characteristics between schistosomal appendicitis and non-schistosomal appendicitis over the past decade in order to assess the impact of schistosomiasis on *** The differences of general data,clinical data and laboratory examination data of patients with appendicitis from October 2013 to October 2023 were retrospectively *** patients were divided into two groups for *** were 136 patients in schistosomal appendicitis group and 5418 patients in non-schistosomal appendicitis *** Schistosomal appendicitis accounted for 2.45%of all patients with appendicitis,and the annual proportion in the past decade was 2.2%,2.9%,1.8%,1.9%,3.4%,3.1%,1.9%,1.6%,3%,2.6%,*** prevalence of schistosomal appendicitis was middle-aged and elderly males,with an average age of 61.73±15.335 *** main population of non-schistosomal appendicitis was middle-aged men,with an average age of 35.8±24.013 years(P<0.001).The distribution of pathological types of appendicitis was different between the two groups(P<0.001).The incidence of acute suppurative appendicitis in non-schistosomal appendicitis was higher than that in schistosomal appendicitis[odds ratio(OR)=0.504;95%confidence interval(CI):0.349-0.728;P<0.001].The proportion of acute attack of chronic appendicitis in schistosomal appendicitis was higher than that in non-schistosomal appendicitis(OR=2.614;95%CI:1.815-3.763;P<0.001).The proportion of schistosomal appendicitis patients complicated with colorectal cancer was higher than that of nonschistosomal appendicitis patients(OR=5.087;95%CI:1.427-

关键词： Schistosomal appendicitis Schistosomiasis Appendix Colorectal cancer Clinicopathological characteristics

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金属极化行为影响因素的研究

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福建师范大学学报（自然科学版） 2007年第5期23卷 71-74页

作者：陈顺玉陈古榕肖子露徐玉枝福建师范大学化学与材料学院福建福州350007

通过测定铁和碳钢电极在不同的电解质溶液、碳钢电极在不同浓度和温度的(NH4)2CO3溶液中的极化曲线来研究电极材料、电解质溶液的种类、(NH4)2CO3溶液的浓度以及温度等因素对金属钝化行为的影响.

关键词：碳钢铁极化 (NH4)2CO3溶液温度

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不同类型道路密度对公共空间盗窃犯罪率的影响——基于ZG市的实证研究

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人文地理 2017年第6期32卷 32-38,46页

作者：柳林杜方叶肖露子宋广文刘凯姜超中山大学地理科学与规划学院综合地理信息研究中心广州510275 辛辛那提大学地理系辛辛那提oh452210131

道路密度对犯罪分布存在影响已得到大多数学者的证实,但忽略了不同类型道路属性的差异对犯罪的影响。不同类型道路在社会—建成环境等各种属性方面存在较大的差异,因此明确不同类型道路密度对公共空间盗窃犯罪率存在的影响有助于犯罪的... 详细信息

道路密度对犯罪分布存在影响已得到大多数学者的证实,但忽略了不同类型道路属性的差异对犯罪的影响。不同类型道路在社会—建成环境等各种属性方面存在较大的差异,因此明确不同类型道路密度对公共空间盗窃犯罪率存在的影响有助于犯罪的防控。基于此,本文以派出所为单元构建多元线性回归模型进行研究。研究发现,不同类型道路密度对公共空间盗窃犯罪率影响不同:城市次干道、城市支路和其他可通车道路密度对公共空间盗窃犯罪率有正向影响;不可通车道路密度对公共空间盗窃犯罪率有负向影响;城市主干道密度对公共空间盗窃犯罪率影响不显著。不同类型道路社会—建成环境的差异是公共空间盗窃犯罪率不同的原因。研究结果可为犯罪精准防控提供指导。

关键词：道路类型公共空间盗窃日常活动理论社会-建成环境

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Catalyst–Support Interaction in Polyaniline‑Supported Ni_(3)Fe Oxide to Boost Oxygen Evolution Activities for Rechargeable Zn‑Air Batteries

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Nano-Micro Letters 2025年第1期17卷 176-190页

作者： xiaohong Zou Qian lu Mingcong Tang Jie Wu Kouer Zhang Wenzhi Li Yunxia Hu xiaomin Xu xiao Zhang Zongping Shao Liang An Department of Mechanical Engineering The Hong Kong Polytechnic UniversityHung HomKowloonHong Kong SARPeople’s Republic of China Jiangsu Key Laboratory of Atmospheric Environment Monitoring and Pollution Control Jiangsu Collaborative Innovation Center of Atmospheric Environment and Equipment TechnologySchool of Environmental Science and TechnologyNanjing University of Information Science and TechnologyNanjing 210044People’s Republic of China Department of Chemistry The Chinese University of Hong KongMa Lin BuildingShatinHong Kong SAR 999077People’s Republic of China WA School of Mines:Minerals Energy and Chemical Engineering(WASM‑MECE)Curtin UniversityPerthWA 6102Australia Research Institute for Advanced Manufacturing The Hong Kong Polytechnic UniversityHung HomKowloonHong Kong SARPeople’s Republic of China Research Institute for Smart Energy The Hong Kong Polytechnic UniversityHung HomKowloonHong Kong SARPeople’s Republic of China

Catalyst–support interaction plays a crucial role in improving the catalytic activity of oxygen evolution reaction(OER).Here we modulate the catalyst–support interaction in polyaniline-supported Ni_(3)Fe oxide(Ni_(3)Fe oxide/PANI)with a robust hetero-interface,which significantly improves oxygen evolution activities with an overpotential of 270 mV at 10 mA cm^(-2)and specific activity of 2.08 mA cm_(ECSA)^(-2)at overpotential of 300 mV,3.84-fold that of Ni_(3)Fe *** is revealed that the catalyst–support interaction between Ni_(3)Fe oxide and PANI support enhances the Ni–O covalency via the interfacial Ni–N bond,thus promoting the charge and mass transfer on Ni_(3)Fe *** the excellent activity and stability,rechargeable Zn-air batteries with optimum Ni_(3)Fe oxide/PANI are assembled,delivering a low charge voltage of 1.95 V to cycle for 400 h at 10 mA cm^(-2).The regulation of the effect of catalyst–support interaction on catalytic activity provides new possibilities for the future design of highly efficient OER catalysts.

关键词： Catalyst-support interaction Supported catalysts Heterointerface Oxygen evolution reaction Zn-air batteries

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De novo synthesis of atropisomeric benzofurans via Cu/SPDO complex catalyzed asymmetric formal [3 + 2] annulation

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Science China Chemistry 2025年第1期 174-180页

作者： Fan-xiao Meng Xing-Yu Wang Ka lu Ju-Song Yang Fu-Min Zhang Ai-Jun Ma Bao Du Yong-Qiang Tu State Key Laboratory of Applied Organic Chemistry College of Chemistry and Chemical Engineering Lanzhou University School of Chemistry and Chemical Engineering Shanghai Jiao Tong University School of Biotechnology and Health Sciences Wuyi University

Herein, the de novo synthesis of atropisomeric benzofurans through the Cu/spirocyclic-pyrrolidine-oxazoline(SPDO) complex catalyze asymmetric formal [3 + 2] cycloaddition between quinones and ynamides is explored, producing a range of structurally diverse axially chiral benzofurans in satisfactory yields with good to excellent enantioselectivities. Furthermore, density functional theory calculations were applied to explain the possible reaction mechanism.

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增城市3维互动全景展示系统的建设与应用

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地理信息世界 2012年第5期10卷 60-64页

作者：周婷婷肖露子曹凯滨增城市测绘院广东广州511300 中山大学地理科学与规划学院广东广州510275

主要探讨增城市3维互动全景展示系统的建设方法、技术路线、关键技术及其在各个领域的应用。系统通过旅游和农业资源的整合,让大众了解增城旅游与农业资源,推动农业、旅游业和地理信息系统的产业化发展。此外,作为一个可持续发展的系统... 详细信息

主要探讨增城市3维互动全景展示系统的建设方法、技术路线、关键技术及其在各个领域的应用。系统通过旅游和农业资源的整合,让大众了解增城旅游与农业资源,推动农业、旅游业和地理信息系统的产业化发展。此外,作为一个可持续发展的系统,今后在城市规划等相关领域也将发挥一定作用。

关键词： 3维地理信息系统 3维建模虚拟现实增城市

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Simulation of BCC dissolution in Fe-Cr-Ni system by ICME

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Journal of Iron and Steel Research International 2023年第4期30卷 660-676页

作者： zi-tian Zhang Jing-jing Wang Wei Liu xiao-gang lu School of Materials Science and Engineering Shanghai UniversityShanghai 200444China Ansteel Beijing Research Institute Co. Ltd.Beijing 102211China Materials Genome Institute Shanghai UniversityShanghai 200444China

Integrated simulation on dissolution of the body-centered-cubic(bcc,α)phase in the face-centered cubic(fcc,γ)matrix in the ternary Fe–Cr–Ni system is a first step toward the study of phase transformations in steels in the framework of integrated computational materials *** accuracy of the simulation highly depends on the qualities of the thermodynamic data and atomic ***,the Fe–Cr–Ni system and its binary sub-systems were thermodynamically assessed by using the CALculation of PHAse Diagrams approach coupled with first-principles calculations,based on various types of thermodynamic data and phase diagrams from the *** the thermodynamics incorporated,the atomic mobilities and diffusivities of the fcc and bcc phases in the Fe–Cr–Ni system were then *** calculated diffusion coefficients show a satisfactory agreement with the experimental data in a wide range of composition and *** with these requisite data,the diffusion-controlled bcc dissolution was finally simulated which well agrees with the experiments for different experimental conditions.

关键词： First-principles calculation Thermodynamics Diffusion Dissolution Fe–Cr–Ni system

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