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加味少腹逐瘀汤联合米非司酮对肾虚血瘀型子宫内膜异位症痛经患者盆腔炎性“瀑布”及血液流变指数的影响

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时珍国医国药 2024年第4期35卷 913-916页

作者：黄灿灿岳斌武权生张小花申剑甘肃中医药大学甘肃兰州730000

目的探究加味少腹逐瘀汤联合米非司酮对子宫内膜异位症痛位患者的盆腔免疫炎性微环境及血液流变学影响。方法选取2022年1月至2023年3月108名子宫内膜异位症患者按照随机数字表分为两组,对照组54例给予米非司酮,观察组在对照组的基础上... 详细信息

目的探究加味少腹逐瘀汤联合米非司酮对子宫内膜异位症痛位患者的盆腔免疫炎性微环境及血液流变学影响。方法选取2022年1月至2023年3月108名子宫内膜异位症患者按照随机数字表分为两组,对照组54例给予米非司酮,观察组在对照组的基础上再予加味少腹逐瘀汤,治疗3个月经周期。治疗结束后比较两组总有效率、VAS评分、血清指标(CA-125、IL-6、IL-8、TNF-α)、辅助性T淋巴细胞17(Th17)、调节性T淋巴细胞(Treg)细胞数量、全血黏度(ηb),血浆黏度(ηp),红细胞聚集指数(AI)、流动力学(子宫动脉收缩期最大血流速度、PI、RI)的差异;比较两组的不良反应。结果两组治疗均收效,且观察组疗效总有效率高于对照组(Z=-3.621,P<0.05);经治疗,两组患者VAS评分、血清指标、血流动力学指标均有所改善(P<0.05),且观察组更为显著(P<0.05);而血液流变学指数仅观察组明显改善(P<0.05),两组不良反应发生率无统计学差异。结论加味少腹逐瘀汤联合米非司酮对子宫内膜异位症痛经疗效肯定,这可能与缓解盆腔炎症“瀑布”、改善局部微循环及血浆黏度的作用有关。

关键词：加味少腹逐瘀汤米非司酮子宫内膜异位症痛经炎性因子血流动力学

医学生生活行为方式对生理亚健康状况影响的结构方程分析

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现代预防医学 2024年第8期51卷 1479-1485页

作者：商杰森程怀志陈东权田若童高凌霄郭斌哈尔滨医科大学大庆校区

目的了解生活行为方式对医学生生理亚健康的影响及其路径，为高校开展健康管理和健康教育提供依据。方法采用分层整群随机抽样方法，选取某医科大学3 100名医学生为研究对象，使用一般情况调查表、生活方式因素调查表和亚健康评定量表... 详细信息

目的了解生活行为方式对医学生生理亚健康的影响及其路径，为高校开展健康管理和健康教育提供依据。方法采用分层整群随机抽样方法，选取某医科大学3 100名医学生为研究对象，使用一般情况调查表、生活方式因素调查表和亚健康评定量表（SHMS V1.0）进行问卷调查，应用χ2检验、探索性因子分析和结构方程模型进行统计分析和路径构建。结果医学生亚健康状态总检出率为62.2%;饮酒（χ2=12.245,P<0.001）、活动情况(锻炼频率（χ2=46.115,P<0.001）;课间活动频率（χ2=7.179,P=0.028）;休闲方式促健康情况（χ2=60.789,P<0.001）)、饮食习惯(点外卖频率（χ2=8.912,P=0.012）;饮用含糖饮料频率（χ2=23.437,P<0.001）;不良饮食习惯（χ2=82.863,P<0.001）)、手机电脑使用情况(手机电脑使用时长（χ2=12.350,P=0.002）;短视频浏览时长（χ2=9.291,P=0.026）)在不同生理健康状态的医学生中的分布差异具有统计学意义；模型显示，活动情况对医学生生理亚健康的直接效应值为0.26（95%CI:0.137～0.366）;饮食习惯对医学生生理亚健康的直接效应值为-0.171（95%CI:-0.233～-0.035）,间接效应值为-0.04（95%CI:-0.085～-0.015）;手机电脑使用情况对医学生生理亚健康的间接效应值为-0.043（95%CI:-0.087～-0.017）。结论医学生亚健康状况总检出率较高，活动情况是医学生生理亚健康重要的影响因素，并在饮食习惯和手机电脑使用情况对医学生生理亚健康的影响中具有中介作用。

关键词：医学生生活行为方式生理亚健康影响结构方程

Hexagonal arrangement of phospholipids in bilayer membranes

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Chinese Physics B 2020年第3期29卷 137-141页

作者： xiao-Wei Chen Ming-Xia Yuan Han Guo zhi Zhu Terahertz Technology Innovation Research Institute Shanghai Key Laboratory of Modern Optical SystemTerahertz Science Cooperative Innovation CenterSchool of Optical-Electrical Computer EngineeringUniversity of Shanghai for Science and TechnologyShanghai 200093China

The phospholipid membrane plays a key role in myriad biological processes and phenomena, and the arrangement structure of membrane determines its function. However, the molecular arrangement structure of phospholipids in cell membranes is difficult to detect experimentally. On the basis of molecular dynamic simulations both in a non-destructive way and at native environment, we observed and confirmed that the phospholipids self-assemble to a hexagonal arrangement structure under physiological conditions. The underlying mechanism was revealed to be that there are hexagonal arrangement regions with a lower free energy around each lipid molecule. The findings potentially advance the understanding of biological functions of phospholipid bilayers.

关键词： phospholipid bilayer bio-membrane structure molecular dynamic simulation self-assemble

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白细胞介素-13参与瘙痒的研究进展

中国现代医学杂志 2024年第11期34卷 59-65页

作者：梁小玲何爽伍师坚伍冠一广西中医药大学基础医学院广西南宁530299

瘙痒是一种使人不愉快的搔抓感觉。各种皮肤病、系统性疾病、神经性疾病、心理性疾病等,均可引发瘙痒,其发病机制复杂。白细胞介素-13(IL-13)属于2型细胞因子,在瘙痒中扮演着重要的作用。IL-13主要由辅助型T细胞2(Th2)细胞分泌,其通过... 详细信息

瘙痒是一种使人不愉快的搔抓感觉。各种皮肤病、系统性疾病、神经性疾病、心理性疾病等,均可引发瘙痒,其发病机制复杂。白细胞介素-13(IL-13)属于2型细胞因子,在瘙痒中扮演着重要的作用。IL-13主要由辅助型T细胞2(Th2)细胞分泌,其通过与白细胞介素-13受体α1(IL-13Rα1)和白细胞介素-4受体α(IL-4Rα)组成的异二聚体结合引起细胞的反应,可直接引起瘙痒或者间接促进其他瘙痒因子释放。该文综述IL-13及其受体的细胞来源、信号通路及其在瘙痒中的作用机制和靶向治疗药物的最新进展。

关键词：白细胞介素-13 瘙痒激酶抑制剂生物制剂

Vitrectomy with internal limiting membrane peeling versus its flap insertion for macular hole in high myopia: a Meta-analysis

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International Journal of Ophthalmology(English edition) 2020年第1期13卷 141-148页

作者： Ya-Jun wu Jie Rao Kang-Rui wu Na wu Yi Cheng xiao-Xuan Xu Li Yan Yi Shao Yu Tian xiao-Rong wu Department of Ophthalmology the First Affiliated Hospital of Nanchang UniversityNanchang 330006Jiangxi ProvinceChina Department of Ophthalmology the Second Xiangya HospitalCentral South UniversityChangsha 410008Hunan ProvinceChina

AIM: To compare the anatomic and functional outcomes between vitrectomy with internal limiting membrane(ILM) peeling and internal ILM flap insertion technique for high myopia macular hole(MH).METHODS: Pub Med, Cochrane Library, EMBASE, and CNKI were systematically searched, and all studies involved MH were included. The closure rate of MH and the postoperative best-corrected visual acuity(BCVA) at 6 mo after the initial surgery were the primary measures. All statistical tests were performed in Review Manager ***: Five studies that included 151 eyes of 151 patients were finally included, all of which were retrospectively comparative studies. Between the pars plana vitrectomy(PPV) with ILM peeling surgery and the ILM insertion technique, the latter had significantly better efficacy with respect to the closure rate of MH(OR=21.32, 95%CI=7.25-62.67, P<0.001);However, regarding BCVA at 6 mo after the initial surgery in MH, there was no statistical significance between the groups(OR=-0.04, 95%CI=-0.22-0.14, P=0.66). In addition, regarding the rate of retinal reattachment after the initial surgery, the two different methods were not significantly different(OR=2.22, 95%CI=0.34-14.32, P=0.4).CONCLUSION: Both ILM peeling and ILM insertion technique could significantly improve anatomic outcomes of MH in high myopia with or without retinal detachment(RD), and anatomic outcomes are more effective. However, there is no statistical significance in BCVA at 6 mo after the initial surgery in MH, or in the rate of retinal reattachment after the first surgery, between the two methods.

关键词： macular hole high myopia best-corrected visual acuity retinal attachment Meta-analysis

Interlayer interference mechanism of multi-seam drainage in a CBM well:An example from Zhucang syncline

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International Journal of Mining Science and Technology 2016年第6期26卷 1101-1108页

作者： Jiang Wei wu Caifang Wang Qiao xiao Zhenghui Liu Yang Hunan Provincial Key Laboratory of Shale Gas Resource Utilization Hunan University of Science and Technology Institute of Geology School of Civil EngineeringHunan University of Science and Technology School of Resource & Geoscience China University of Mining and Technology

Based on the characteristics of the strong volatility of physical property in vertical direction, high gas content, high resource abundance and large exploitation potentiality of coal reservoir in Bide-Santang basin of zhina coal field, we study the generation mechanism of interlayer interference, propagation rules of reservoir pressure drop and influencing factors of gas productivity in CBM multi-seam drainage in the paper. On the basis of the actual production data of X-2 well of Zhucang syncline in Bide-Santang basin,by simulating the gas production process of a CBM well under the condition of multiple seam with COMET3 numerical simulation software, we analyze the influencing factors of gas productivity during the process of multi-seam drainage, and illuminate the interlayer interference mechanism of multiseam drainage. The results show that permeability, reservoir pressure gradient, critical desorption pressure and fluid supply capacity of stratum have great influence on gas productivity of multi-seam drainage while coal thickness has little influence on it. Permeability, reservoir pressure gradient and fluid supply capacity of stratum affect the propagation velocity of reservoir pressure drop and thereby affect the final gas productivity. Moreover, the influence of critical desorption pressure on gas productivity of multiseam drainage is reflected in the gas breakthrough time and effective desorption area.

关键词： Zhucang syncline CBM Multi-seam drainage Interlayer interference Influencing factors

无金属酸性条件下催化合成β-溴代烯基硫醚的工艺优化研究

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现代化工 2024年第8期44卷 146-151页

作者：冯雨薇粟晖栾天黄晓程梁月清姚志湘广西科技大学生物与化学工程学院广西柳州545006 广西糖资源绿色加工重点实验室广西柳州545006

在氢溴酸与硝酸的混酸催化体系下,以二苯基乙炔和对甲苯二硫醚为原料合成β-溴代烯基硫醚。利用拉曼光谱结合空间角转换法建立了反应体系中β-溴代烯基硫醚含量的无损快速分析方法。通过设计响应面优化实验,考察混酸摩尔比、原料摩尔比... 详细信息

在氢溴酸与硝酸的混酸催化体系下,以二苯基乙炔和对甲苯二硫醚为原料合成β-溴代烯基硫醚。利用拉曼光谱结合空间角转换法建立了反应体系中β-溴代烯基硫醚含量的无损快速分析方法。通过设计响应面优化实验,考察混酸摩尔比、原料摩尔比、反应温度对β-溴代烯基硫醚产率的影响。结果表明,β-溴代烯基硫醚合成的优化工艺条件为:n(氢溴酸)∶n(硝酸)=10∶0.5、n(二苯基乙炔)∶n(对甲苯二硫醚)=2∶1.1、反应温度为40℃、反应时间为4 h,此时β-溴代烯基硫醚产率为90.52%。

关键词： β-溴代烯基硫醚酸性催化剂拉曼光谱角度转换

In situ synthesis of polycrystalline cubic boron nitride in cBN-Al-Ti system with different Gd_(2)O_(3) additions

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Rare Metals 2021年第5期40卷 1267-1274页

作者： Sheng-Lin Zhong zhi-Kai Li Chao Chen Chuan Chen Peng Wang Yi wu College of Materials Science and Engineering Guilin University of TechnologyGuilin 541004China

Polycrystalline cubic boron nitride was sintered under high temperature(1400℃)and high pressure(5.5 GPa)using an in situ synthesis *** composition,microstructure,relative density and mechanical properties of the polycrystalline cubic boron nitride(PcBN)with different contents of Gd_(2)O_(3) were studied by means of X-ray diffraction(XRD),scanning electron microscopy(SEM)and energy-dispersive spectroscopy(EDS).The results show that the phases of TiB_(2),TiN,AIN,AlTi_(2)N and GdB_(6) are formed through in situ synthesis of cBN-Al-Ti-Gd_(2)O_(3) *** the Gd_(2)O_(3) content increasing,the relative density increases and mechanical properties of PcBN begin to increase and then *** amount of Gd_(2)O_(3) can advance the formation of TiB_(2) and improve the aspect ratio of TiB_(2).When Gd_(2)O_(3) content is 1.0 wt%,the PcBN exhibits optimal comprehensive mechanical properties,with a microhardness of 33.35 GPa and a flexural strength of 972.37 MPa.

关键词： Polycrystalline cubic boron nitride(PcBN) TiB_(2) Rod crystal Rare earth oxides Mechanical properties

19种杀虫剂对藜麦甜菜筒喙象的室内防治试验

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湖北农业科学 2024年第4期63卷 67-72页

作者：许志萍赵晓军邢鲲赵飞山西农业大学植物保护学院山西太谷030801

选用19种杀虫剂,以硅藻土及黄绵土作为农药载体,开展了藜麦(Chenopodium quinoa)甜菜筒喙象(Lixus subtilis Boheman)的室内防治试验。结果表明,以黄绵土或硅藻土为载体时,40%毒死蜱乳油和40%辛硫磷乳油都表现出了较高的速效性和持效性,... 详细信息

选用19种杀虫剂,以硅藻土及黄绵土作为农药载体,开展了藜麦(Chenopodium quinoa)甜菜筒喙象(Lixus subtilis Boheman)的室内防治试验。结果表明,以黄绵土或硅藻土为载体时,40%毒死蜱乳油和40%辛硫磷乳油都表现出了较高的速效性和持效性,7 d后防治效果均达100%,推荐生产使用。以硅藻土为载体时,可显著提高5%啶虫脒乳油、3.2%高氯·甲维盐微乳剂、5%甲氨基阿维菌素苯甲酸盐悬浮剂和20%呋虫胺可溶粒剂的防治效果,药后7 d防治效果分别为100.0%、100.0%、73.3%和95.8%,可有效防治藜麦甜菜筒喙象,推荐在生产中采用杀虫剂与硅藻土混合施用的方式施药。

关键词：藜麦(Chenopodium quinoa) 甜菜筒喙象(Lixus subtilis Boheman) 杀虫剂室内防治防治效果