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World Journal of Clinical Cases 2021年第22期9卷 6329-6342页

作者： Ya-Jing Sun Ling-Zi Xu Zeng-Hui Ma Yu-Lu Yang Ting-Ni Yin xiao-yun gong Zi-Lin Gao Yan-Ling Liu Jing Liu Peking University Sixth Hospital Peking University Institute of Mental HealthNHC Key Laboratory of Mental Health(Peking University)National Clinical Research Center for Mental Disorders(Peking University Sixth Hospital)Beijing 100191China Quanzhou Children’s and Women’s Hospital Quanzhou 362000Fujian ProvinceChina Department of Mathematics Changzhi Medical CollegeChangzhi 046000Shanxi ProvinceChina

BACKGROUND Health-related risky behaviors generally refer to behaviors that have a negative impact on health and quality of ***-related risky behaviors in adolescents with high-functioning autism(HFA)have not been well understood so *** with HFA may have more health-related risky behaviors than neurotypical *** To investigate health-related risky behaviors and their risk factors with *** This is an observational *** study enrolled 110 adolescents aged 12-19-years-old meeting Diagnostic and Statistical Manual of Mental Disorders 4th edition criteria for *** were recruited from Peking University Sixth *** were also 110 age,sex and nationality matched controls enrolled who came from a public school in Beijing,*** groups completed the Adolescents Health-related Risky Behavior *** tests were carried out for comparison of the Adolescents Health-related Risky Behavior Inventory scores between the two *** recognition,the Inventory of Subjective Life Quality for Child and Adolescent,Chinese Wechsler Intelligence Scale for Children,Wechsler Intelligence Scale for Adult-Chinese Revised,Theory of Mind test and Autism Spectrum Screening Questionnaire were assessed in the autism group to explore factors associated with health-related risky *** regression analysis was conducted to explore the risk factors of health-related risky behaviors in the HFA *** The results showed that the total score of the Adolescents Health-related Risky Behavior Inventory and scores of“aggression and violence,”“suicide and selfinjury,”“health compromising behavior”and“unprotected sex”subscales in the HFA group were significantly higher than those in the control group(Z range-4.197 to-2.213,P<0.05).Among the associated factors,poor emotional experience(B=-0.268,P<0.001),depression(B=-0.321,P<0.001),low score of intelligence(B=-0.032,P=0.042),low score of Theory of Mind test

关键词： High-functioning autism Adolescents Health-related risky behaviors Associated factors Risk factors Cross-sectional study

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Novel strategies to mine alcoholism-related haplotypes and genes by combining existing knowledge framework

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Science China(Life Sciences) 2009年第2期52卷 163-172页

作者： ZHANG RuiJie1, LI Xia1,2, JIANG YongShuai1, LIU GuiYou1, LI ChuanXing1, ZHANG Fan1, xiao yun1 & gong BinSheng1 1 Department of Bioinformatics, Harbin Medical University, Harbin 150086, China 2 Biomedical Engineering Institute of CUMS, Beijing 100054, China Department of Bioinformatics Harbin Medical University Harbin China Biomedical Engineering Institute of CUMS Beijing China

High-throughout single nucleotide polymorphism detection technology and the existing knowledge provide strong support for mining the disease-related haplotypes and genes. In this study, first, we apply four kinds of haplotype identification methods (Confidence Intervals, Four Gamete Tests, Solid Spine of LD and fusing method of haplotype block) into high-throughout SNP genotype data to identify blocks, then use cluster analysis to verify the effectiveness of the four methods, and select the alco- holism-related SNP haplotypes through risk analysis. Second, we establish a mapping from haplotypes to alcoholism-related genes. Third, we inquire NCBI SNP and gene databases to locate the blocks and identify the candidate genes. In the end, we make gene function annotation by KEGG, Biocarta, and GO database. We find 159 haplotype blocks, which relate to the alcoholism most possibly on chromosome 1~22, including 227 haplotypes, of which 102 SNP haplotypes may increase the risk of alcoholism. We get 121 alcoholism-related genes and verify their reliability by the functional annotation of biology. In a word, we not only can handle the SNP data easily, but also can locate the disease-related genes pre- cisely by combining our novel strategies of mining alcoholism-related haplotypes and genes with ex- isting knowledge framework.

关键词： haplotype block alcoholism gene functional annotation gene location linkage disequilibrium

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可见-近红外光谱结合CARS优化模型预测棕榈油碘值

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分析试验室 2017年第7期36卷 790-793页

作者：秦修远翟媛媛李晓云龚? 北京服装学院材料科学与工程学院北京100029 瑞士万通中国有限公司北京100101

采用可见-近红外透射光谱结合CARS变量优选方法优化模型,对棕榈油碘值进行近红外定量分析。通过将使用不同预处理方法产生的建模效果进行比较,找到了理想的预处理方法,通过CARS变量选择方法优选出与棕榈油碘值相关的有效波点共60个,利... 详细信息

采用可见-近红外透射光谱结合CARS变量优选方法优化模型,对棕榈油碘值进行近红外定量分析。通过将使用不同预处理方法产生的建模效果进行比较,找到了理想的预处理方法,通过CARS变量选择方法优选出与棕榈油碘值相关的有效波点共60个,利用60个有效波点建立棕榈油碘值优化模型。根据优化模型的建模集相关系数(R_c=0.9814)和预测集相关系数(R_p=0.9806),得到的建模均方根误差(RM SEC=0.0398)和预测均方根误差(RM SEP=0.0406)优于采用全波段建立的模型得到的系数误差。利用可见近红外透射光谱结合CARS变量优选方法,简化了棕榈油碘值模型,并能够保证碘值预测的准确度。

关键词：棕榈油碘值近红外 CARS变量优选

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一款通用CPU的存储器内建自测试设计

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同济大学学报（自然科学版） 2002年第10期30卷 1204-1208页

作者：何蓉晖李华伟李晓维宫云战中国科学院计算技术研究所北京100080

存储器内建自测试 (memorybuilt-inself-test,MBIST)是一种有效的测试嵌入式存储器的方法 .在一款通用CPU芯片的可测性设计 (design -for-testability ,DFT)中 ,MBIST作为cache和TLB的存储器测试解决方案被采用 ,以简化对布局分散、大... 详细信息

存储器内建自测试 (memorybuilt-inself-test,MBIST)是一种有效的测试嵌入式存储器的方法 .在一款通用CPU芯片的可测性设计 (design -for-testability ,DFT)中 ,MBIST作为cache和TLB的存储器测试解决方案被采用 ,以简化对布局分散、大小不同的双端口SRAM的测试 .5个独立的BIST控制器在同一外部信号BistMode的控制下并行工作 ,测试结果由扫描链输出 ,使得测试时间和芯片引脚开销都降到最小 .所采用的march 13n算法确保了对固定型故障、跳变故障、地址译码故障和读写电路的开路故障均达到 10 0 %的故障覆盖率 .

关键词： CPU 存储器内建自测试故障模型 march算法可测性设计超大规模集成电路 IP核

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The cardiovascular effects of central Hydrogen sulphide are related to KATP channels opening mechanism

The cardiovascular effects of central Hydrogen sulphide are ...

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中国神经科学学会第四次会员代表大会暨第八届全国学术会议

作者： Yan LU~(1,*),Wen-Qing LIU~2,xiao-yun LI~1,gong-Min GAO~1 1 Department of Clinical Laboratory,San Ai Tang Hospital,Lanzhou 730030,China 2 Department of General Surgery,First Hospital of Lanzhou University,730000,LanZhou,China

objective Although hydrogen sulphide(HS),an endogenous "gasotransmitter",existing with a high concetration in the central nervous system,the central cardiovascular effects of endogenous HS are not fully *** present study was designed to comparatively investigate the central cardiovascular effects and mechanism of endogenous HS in anesthetized *** the central cardiovascular functions of endogenous HS were determined by intracerebroventricular(icv) apphcation of NaHS(0.1 mmol),the donor of HS,or CBS activator s-adenosyl-L-methionine (SAM,0.05 mmol) into lateral cerebral ventricle(LCV) in anesthetized *** inhibitor hydroxylamine(HA,10 mmol) or K blocker glibenclamide(1 g/L) were prior applied into LCV to observe the central NaHS-induced cardiovascular responses after CBS was inhibited or K channels was *** Icv injection of NaHS(0.1 mmol) produced a significant decrease in BP(from 93±11 to 67±8 mmHg,P<0.05) and HR(from 450±14 to 370±38 bpm,P<0.05) compared to *** injection of SAM(0.05μmol) also produced a significant hypotension(from 94±4 to 71±10 mmHg,P<0.05) and bradycardia(from 444±35 to 385±64 bmp,P<0.05),which was similar to those of icv injection of ***, the hypotension and bradycardia induced by icv injection of NaHS could effectively be abolished by pretreatment with glibenclamide but not with *** The present study suggests that central HS produces hypotension and bradycardia,at least partly,by the K channel opening mechanism.

关键词： rat hydrogen sulfide blood pressure heart rate

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Optical microcavity： from fundamental physics to functional photonics devices

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Science Bulletin 2016年第3期61卷 185-186页

作者： yun-Feng xiao Qihuang gong State Key Laboratory for Mesoscopic Physics and School ofPhysics Peking University Beijing 100871 China Collaborative Innovation Center of Quantum Matter Beijing 100871 China

Optical microcavities have attracted strong research interests,for their unique property of confining photons for a long time in small volumes,which significantly enhances light–matter interaction[1].In recent decades,various fabrication techniques of microcavities with higher quality factors(Q)and smaller mode volumes(V_m)have been developed,pushing forward studies from fundamental physics to functional photonics *** optomechanics provides an ideal platform for exploring the quantum nature of macroscopic objects[2]。

关键词：光学微腔光子器件物理功能量子信息处理时间性能相互作用制造技术质量因素

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Potassium and calcium channels in different nerve cells act as therapeutic targets in neurological disorders

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Neural Regeneration Research 2025年第5期20卷 1258-1276页

作者： Qing Qiu Mengting Yang Danfeng gong Haiying Liang Tingting Chen Department of Pharmacology School of PharmacyNantong UniversityNantongJiangsu ProvinceChina Jiangsu Province Key Laboratory of Inflammation and Molecular Drug Target NantongJiangsu ProvinceChina Department of Pharmacy Longyan First Affiliated Hospital of Fujian Medical UniversityLongyanFujian ProvinceChina

The central nervous system, information integration center of the body, is mainly composed of neurons and glial cells. The neuron is one of the most basic and important structural and functional units of the central nervous system, with sensory stimulation and excitation conduction functions. Astrocytes and microglia belong to the glial cell family, which is the main source of cytokines and represents the main defense system of the central nervous system. Nerve cells undergo neurotransmission or gliotransmission, which regulates neuronal activity via the ion channels, receptors, or transporters expressed on nerve cell membranes. Ion channels, composed of large transmembrane proteins, play crucial roles in maintaining nerve cell homeostasis. These channels are also important for control of the membrane potential and in the secretion of neurotransmitters. A variety of cellular functions and life activities, including functional regulation of the central nervous system, the generation and conduction of nerve excitation, the occurrence of receptor potential, heart pulsation, smooth muscle peristalsis, skeletal muscle contraction, and hormone secretion, are closely related to ion channels associated with passive transmembrane transport. Two types of ion channels in the central nervous system, potassium channels and calcium channels, are closely related to various neurological disorders, including Alzheimer's disease, Parkinson's disease, and epilepsy. Accordingly, various drugs that can affect these ion channels have been explored deeply to provide new directions for the treatment of these neurological disorders. In this review, we focus on the functions of potassium and calcium ion channels in different nerve cells and their involvement in neurological disorders such as Parkinson's disease, Alzheimer's disease, depression, epilepsy, autism, and rare disorders. We also describe several clinical drugs that target potassium or calcium channels in nerve cells and could be u

关键词： astrocytes calcium channels central nervous system extracellular ion concentration microglia neurological disorders neurons potassium channels

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A cellular scale numerical study of the effect of mechanical properties of erythrocytes on the near-wall motion of platelets

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Acta Mechanica Sinica 2014年第2期30卷 274-280页

作者： Jing Xu xiao-Long Wang yun-Qiao Liu xiao-Bo gong MOE Key Laboratory of Hydrodynamics Department of Engineering MechanicsShanghai Jiao Tong University SJTU-CU ICRC Shanghai Jiao Tong University

The effect of mechanical properties of erythrocytes on the near-wall motion of platelets was numerically studied with the immersed boundary method. Cells were modeled as viscous-fluid-filled capsules surrounded by hyper-elastic membranes with negligible thickness. The numerical results show that with the increase of hematocrit, the near-wall approaching of platelets is enhanced, with which platelets exhibit larger deformation and orientation angle of its near-wall tank-treading motion, and the lateral force pushing platelets to the wall is increased with larger fluctuation amplitude. Meanwhile the near-wall approaching is reduced by increasing the stiffness of erythrocytes.

关键词： Hemodynamics Fluid-membrane interaction Immersed boundary method Near-wall motion of platelet

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活性染料深浓色染色织物湿摩擦牢度探讨

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纺织科技进展 2011年第4期 30-32页

作者：杨晓红龚蕴玉蔡磊南通纺织职业技术学院江苏南通226007

活性染料深浓色染色织物的湿摩擦牢度是困扰提高产品质量的难题之一。以棉织物为染色对象,分析了活性染料湿摩擦牢度的影响因素,并通过实验对活性染料染色加工工艺进行探讨,找出的最佳染色条件为:70℃时上染、固色,NaCl、Na2CO3用量为15... 详细信息

活性染料深浓色染色织物的湿摩擦牢度是困扰提高产品质量的难题之一。以棉织物为染色对象,分析了活性染料湿摩擦牢度的影响因素,并通过实验对活性染料染色加工工艺进行探讨,找出的最佳染色条件为:70℃时上染、固色,NaCl、Na2CO3用量为15 g/L。

关键词：棉织物染色活性染料湿摩擦牢度深浓色

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在IVF中卵巢储备低下患者添加脱氢表雄酮(DHEA)有效性的Meta分析

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生殖与避孕 2014年第12期34卷 997-1003页

作者：田海清毛新敏巩晓芸李霞王致辉腊晓琳新疆医科大学第一附属医院乌鲁木齐830054

目的:研究添加脱氢表雄酮(dehydroepiandrosterone,DHEA)对于卵巢储备功能低下(DOR)患者的有效性。方法:数据库检索术语DHEA/dehydroepiandrosterone/diminished ovarian reserve/poor responders/premature ovarian failure(POF)/primary ovarian insufficiency(POI)/premature ovarian aging(POA)。研究至少包括下列结果中的一项:抗苗勒氏管激素(AMH)、促卵泡生成素(FSH)、获卵数、胚胎移植数、临床妊娠率。经筛选在116篇临床试验中只有3项随机对照试验(RCT)研究,1项队列研究和1项配对研究符合纳入标准。结果:使用DHEA治疗组的临床妊娠率高于未治疗使用DHEA的对照组,差异有统计学意义(OR=8.23,95%CI=1.47~46.12)。AMH、FSH、获卵数、胚胎移植数治疗组与对照组间无统计学差异(P>0.05)。结论:在大约206个IVF周期中,基于上述可用的有限数据研究分析,DHEA能提高IVF周期中DOR女性的临床妊娠率。但没有证据支持DHEA治疗后能改善患者FSH、AMH值,以及提高获卵数、可移植胚胎数。

关键词：脱氢表雄酮(DHEA) 卵巢功能低下(DOR) 体外受精(IVF)

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