检索结果-南通市图书馆

Chinese Journal of Polymer Science 2021年第9期39卷 1093-1109页

作者： Jie Zhou xiao-yuan zhang Zhi-Qiang Su State Key Laboratory of Chemical Resource Engineering Beijing Key Laboratory of Advanced Functional Polymer CompositesBeijing University of Chemical TechnologyBeijing 100029China

Hybrids,produced by hybridization of proteins,peptides,DNA,and other new biomolecules with polymers,often have unique functional *** properties,such as biocompatibility,stability and specificity,lead to various smart *** review mainly introduces biomolecule polymer hybrid materials by reversible deactivation radical polymerization(RDRP),emphasizing reverse addition-fragmentation chain transfer(RAFT)polymerization,and nitroxide mediated polymerization(NMP).It includes the methods of RDRP to improve the biocompatibility of biomedical materials and organisms by surface *** key to the current synthesis of biomolecule polymer hybrids is to control ***,this review describes several different kinds of biomolecule polymer hybrid materials and their applications in the biomedical *** progresses provide ideas for the investigation of biodegradable and highly bioactive biomedical soft tissue *** research hotspots of nanotechnology in biomedical fields are controlled drug release materials and gene therapy carrier *** showed that RDRP method could improve the therapeutic effect and reduce the dosage and side effects of the ***,by means of RDRP,the original materials can be modified to develop intelligent polymer materials as membrane materials with selective permeability and surface modification.

关键词： Biomolecule-polymer hybrids RDRP Biomedical applications Drug release Nanotechnology

New Insight into Competition between Decomposition Pathways of Hydroperoxymethyl Formate in Low Temperature DME Oxidation

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Chemical Physics 2015年第5期28卷 -页

作者： Li-li Xing xiao-yuan zhang Zhan-dong Wang Shuang Li Li-dong zhang National Synchrotron Radiation Laboratory University of Science and Technology of China Hefei 230029 China

Hydroperoxymethyl formate is a crucial intermediate formed during the low-temperature oxidation of dimethyl ether. The decomposition pathways of HOOCH2OCHO were calculated at QCISD(T)/CBS//B3LYP/6-311++G(d,p) level. The temperature- and pressure-dependent rate constants are computed using microcanonical variational transition state theory coupled with the RRKM/master equation calculations. The calculations show that a pathway leads to the formation of formic acid and a Criegee intermediate does exist, besides the direct dissociation channel to OH and OCH2OCHO radicals. However, formation of the Criegee intermediate has never been considered as an intermediate in dimethyl ether combustion before. The computed rate constants indicate that the newly confirmed pathway is competitive to the direct dissociation route and it is promising to reduce the low-temperature oxidation reactivity. Also electronic effect of groups, e.g. -CHO and O atom, is taken into account. Moreover, Hirshfeld atomic charge and natural bond order analysis are performed to explain this phenomenon from a perspective of chemical nature.

关键词： Hydroperoxymethyl formate RRKM/master equation calculations Low temperature oxidation Dimethyl ether Chain branching

Growth hormone ameliorates hepatopulmonary syndrome and nonalcoholic steatohepatitis secondary to hypopituitarism in a child:A case report

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2022年第18期10卷 6211-6217页

作者： xiao-yuan zhang Ke yuan Yan-Lan Fang Chun-Lin Wang Department of Pediatrics The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003Zhejiang ProvinceChina

BACKGROUND Craniopharyngioma is a benign tumor that usually develops in children;however,it is located in the center and close to sensitive structures,such as the pituitary gland and *** the hypothalamus plays a crucial role in the homeostasis of anterior pituitary hormone synthesis,damage to the hypothalamus leads to multiple pituitary hormone deficiencies and non-alcoholic fatty liver disease,including hepatopulmonary syndrome(HPS).HPS has limited treatment and poor *** SUMMARY A girl aged 13 years and 6 mo underwent surgery for craniopharyngioma 6 years *** craniotomy was performed with total resection via the corpus callosum approach,and the tumor at the base was approximately 3.5 cm×3.5 cm×4.0 *** 1 year postoperatively,she exhibited abdominal distension and weakness,and the laboratory tests revealed fatty liver ***,she had not visited the outpatient clinic for 2 *** years ago,she developed decreased activity endurance,severe cyanosis,chest tightness,wheezing,and intermittent and recurrent low fever after mild physical *** ultrasonography,liver biopsy,and contrast echocardiography of the right heart showed cirrhosis and multiple pituitary hormone deficiencies,indicating *** 1 year of treatment with recombinant human growth hormone,the liver function and oxygenation improved;she did not undergo liver *** Craniopharyngioma surgery can easily cause hypopituitarism,which can lead to nonalcoholic steatohepatitis and HPS in *** growth hormone therapy is important to improve the prognosis of these diseases.

关键词： Craniopharyngioma Nonalcoholic fatty liver disease Hypopituitarism Hepatopulmonary syndrome Growth hormone Children Case report

Intra-day variability of BL Lacertae from 2016 to 2018

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Research in Astronomy and Astrophysics 2021年第10期21卷 187-196页

作者： Tian Li Jiang-Hua Wu Nan-Kun Meng Yan Dai xiao-yuan zhang Department of Astronomy Beijing Normal UniversityBeijing 100875China

We monitored BL Lacertae in the B,V,R and I bands for 14 nights during the period of *** source showed significant intra-day variability on 12 *** performed color-magnitude analysis and found that the source exhibited bluer-when-brighter *** bluer-when-brighter behavior is at least partly caused by the larger variation amplitude at shorter *** variations at different wavelengths are correlated well and show no inter-band time lag.

关键词： galaxies:active BL Lacertae objects:individual:BL Lacertae galaxies:photometry

An end-to-end anastomosis model of guinea pig bile duct:A 6-mo observation

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2011年第6期17卷 789-795页

作者： xiao-Qing zhang yuan-Hu Tian Zhi Xu Li-Xin Wang Chun-Sheng Hou xiao-Feng Ling xiao-Si Zhou Department of General Surgery Peking University Third Hospital Beijing 100191 China

AIM:To establish the end-to-end anastomosis (EEA) model of guinea pig bile duct and evaluate the healing process of bile ***:Thirty-two male guinea pigs were randomly divided into control group,2-,3-,and 6-mo groups after establishment of EEA ***,immunohistochemical and serologic tests as well as measurement of bile contents were *** bile duct diameter and the diameter ratio (DR) were measured to assess the formation of relative ***:Acute and chronic inflammatory reactions occurred throughout the healing process of bile *** test and bile content measurement showed no formation of persistent stricture in 6-mo *** DR revealed a transient formation of relative stricture in 2-mo group in comparation to control group (2.94 ± 0.17 vs 1.89 ± 0.27,P=0.004).However,this relative stricture was released in 6-mo group (2.14 ± 0.18,P=0.440).CONCLUSION:A simple and reliable EEA model of guinea pig bile duct can be established with a good reproducibility and a satisfactory survival rate.

关键词： Animal model Guinea pig Anastomosis Common bile duct Wound healing

New mutation in EPCAM for congenital tufting enteropathy:A case report

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2020年第20期8卷 4975-4980页

作者： Yan-Qiong Zhou Guo-Sheng Wu yuan-Mei Kong xiao-yuan zhang Chun-Lin Wang Department of Pediatrics The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003Zhejiang ProvinceChina Department of Colorectal and Anal Surgery The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003Zhejiang ProvinceChina

BACKGROUND Congenital tufting enteropathy(CTE)is a rare cause of diarrhea in ***,it can result in early-onset of chronic diarrhea and failure to *** with this disease have to depend on total parenteral nutrition(TPN),and eventually small intestine *** epithelial cell adhesion molecule(EPCAM)gene was identified to be associated with ***,we present a case of an infant with CTE due to a mutation not reported in the literature *** SUMMARY A 1-year and 7-mo infant boy exhibited intractable watery diarrhea and mushy stool within 1 wk after birth,for which he had required medical treatment and hospitalization several *** sister presented similar symptoms and died at the age of *** admission,his body weight was 5700 g(-4.8 SDS)and measured 66 cm(-5.4 SDS)in ***,he cannot speak or *** exhibited mild anemia,hypocalcemia,hypomagnesemia,and an infection in the upper respiratory *** sparse and vacuolar degeneration of epithelial cells were reported by small intestine ***-exome sequencing showed a novel homozygous splice mutation(c.657+1[IVS6]G>A)in the EPCAM *** was treated with TPN and recombinant human growth *** 2 mo,his body weight was up to 8500 g and he has been waiting for small bowel *** CTE is rare but *** with CTE require rapid diagnosis and therapy to improve their survival.

关键词： Congenital tufting enteropathy Congenital diarrhea Failure to thrive Children Case report

Microneedle patch loaded with ferritin-nanocaged doxorubicin for locally targeted drug delivery and efficient skin cancer treatment

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Particuology 2024年第5期88卷 282-289页

作者： Feng Li yuan Yang Hua Yue Shuang Wang xiao zhang Wei Wei State Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing100190China Key Laboratory of Biopharmaceutical Preparation and Delivery Chinese Academy of SciencesBeijing100190China School of Chemical Engineering University of Chinese Academy of SciencesBeijing100049China

Ferritin has emerged as a promising nanocarrier for delivering therapeutic agents to ***,the limited drug loading and the off-target impacts after systemic administration remain challenges for cancer treatment with ferritin-based ***,we develop a microneedle patch loaded with ferritin-nanocaged doxorubicin(DoxFe@Fn/MN)for skin cancer ***,doxorubicin(Dox)is encapsulated in ferritin(Fn)using an iron core-assisted strategy,which results in a 3.4-fold increase in Dox loading compared to the direct loading ***,a polyvinyl alcohol-based microneedle(MN)patch is used for the transdermal delivery of DoxFe@Fn,enabling targeted tumour accumulation of DoxFe@Fn and preventing off-target *** released DoxFe@Fn can bind to CD71 highly expressed on skin cancer cells,facilitating its *** a result,the DoxFe@Fn/MN therapy presents a robust antitumour effect in a melanoma tumour model,showing its potential as a promising therapeutic modality for skin cancer treatment.

关键词： Ferritin Microneedle Skin cancer Drug delivery

Potassium variability during hospitalization and outcomes after discharge in patients with acute myocardial infarction

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Geriatric Cardiology 2021年第1期18卷 10-19页

作者： Xi-Ling zhang Heng-Xuan CAI Shan-Jie WANG xiao-yuan zhang Xin-Ran HAO Shao-Hong FANG Xue-Qin GAO Bo YU Department of Cardiology Second Affiliated Hospital of Harbin Medical UniversityHarbinChina The Key Laboratory of Myocardial Ischemia Chinese Ministry of Education246 Xuefu RoadNangang DistrictHarbinChina Department of Neurobiology Neurobiology Key LaboratoryHarbin Medical UniversityEducation Department of Heilongjiang ProvinceHarbinChina

BACKGROUND The variability of metabolic biomarkers has been determined to provide incremental prognosis information,but the implications of electrolyte variability remained *** We investigate the relationships between electrolyte fluctuation and outcomes in survivors of acute myocardial infarction(n=4386).Ion variability was calculated as the coefficient of variation,standard deviation,variability independent of the mean(VIM)and *** ratios(HR)were estimated using the multivariable-adjusted Cox proportional regression *** During a median follow-up of 12 months,161(3.7%)patients died,and heart failure occurred in 550(12.5%)participants after discharge,*** with the bottom quartile,the highest quartile potassium VIM was associated with increased risks of all-cause mortality(HR=2.35,95%CI:1.36–4.06)and heart failure(HR=1.32,95%CI:1.01–1.72)independent of cardiac troponin I(c Tn I),N terminal pro B type natriuretic peptide(NT-pro BNP),infarction site,mean potassium and other traditional factors,while those associations across sodium VIM quartiles were *** trend remains across the strata of variability by other three *** associations were consistent after excluding patients with any extreme electrolyte value and diuretic *** Higher potassium variability but not sodium variability was associated with adverse outcomes *** findings highlight that potassium variability remains a robust risk factor for mortality regardless of clinical dysnatraemia and dyskalaemia.

关键词： AMI BNP Potassium variability during hospitalization and outcomes after discharge in patients with acute myocardial infarction

Realizing quantum imaginary time evolution in experiment

在线全文

学校读者我要写书评

暂无评论

Science China(Physics,Mechanics & Astronomy) 2024年第4期67卷 167-168页

作者： xiao yuan Center on Frontiers of Computing Studies Peking UniversityBeijing 100871China School of Computer Science Peking UniversityBeijing 100871China

NISQ,or Noisy Intermediate-Scale Quantum computing,represents a pivotal and the state-of-the-art quantum technology[1].Characterized by intermediate-scale quantum devices that are beyond classical computational capabilities yet fall short of the error-correction thresholds required for fault-tolerant quantum computing,NISQ devices exhibit both promise and *** devices hold immense potential in solving certain computational problems that surpass classical capabilities,with wide applications in optimization,machine learning,and quantum chemistry.

关键词： quantum imaginary correction

A comprehensive review of recent advancements and developments in heat exchanger network synthesis techniques

在线全文

学校读者我要写书评

暂无评论

Science China(Technological Sciences) 2024年第2期67卷 335-356页

作者： XU Yue LIU WeiWei zhang Lu CUI Guo Min xiao yuan zhang GuanHua YANG QiGuo School of Energy and Power Engineering University of Shanghai for Science and TechnologyShanghai 200093China

The rapid development of computational technology and the increasing energy demand have improved heat exchanger network(HEN)*** HEN synthesis involves several optimizations of matches,distributions of heat loads,and stream splitting of heat ***,obtaining good results at high efficiency has been the main standard for evaluating the techniques in the research area of HEN *** paper first summarizes and analyzes the main contributions of the existing HEN synthesis *** compare related data quantitively,information on ten typical cases is presented in this ***,recently improved solutions for commonly encountered existing literature cases demonstrate the evolution and competition trends in the field of HEN *** comparison data presented in this paper not only provide a useful reference for future research but also present the optimization *** on the findings of this study,it is noted that there is still a large room for improvement,and current approaches are incapable of dealing with all HEN ***,it is still difficult to escape a local optimum and overcome structural constraints when seeking the global *** a follow-up to the current work,the parallel computing mode and adaptively coordinating the ratio of global and local searching abilities are major development trends for future investigation.

关键词： heat integration heat exchanger network synthesis sequential synthesis method simultaneous synthesis method optimization techniques development optimization quality