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Additive Manufacturing of Nickel-Based Superalloy Single Crystals with IN-738 Alloy

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Acta Metallurgica Sinica(English Letters) 2022年第3期35卷 369-374页

作者： Yang Li Ye-Feng yu Zhi-Bin Wang xiao-yu liang Wen-Bin Kan Feng Lin Department of Mechanical Engineering Tsinghua UniversityBeijing 100084China Key Laboratory for Advanced Materials Processing Technology Ministry of Education of ChinaBeijing 100084China Bio-Manufacturing and Rapid Forming Technology Key Laboratory of Beijing Beijing 100084China

The production of non-weldable nickel-based superalloys,especially single-crystal superalloys,is important for additive ***-crystal specimens of non-weldable nickel-based superalloys were produced by electron beam selective melting using an IN-738 *** this study,single-crystal nickel-based superalloy specimens of diff erent sizes were prepared by a multiple preheating process and tight control of the melting parameters without the need for a grain selector or single-crystal seed for the first *** backscattered diff raction measurements were performed to confi rm the presence of a single *** transition boundaries between the polycrystalline and single-crystal regions at the edges and bottom of the samples were characterized to analyze the formation of single crystals.

关键词： Non-weldable superalloys Electron beam selective melting Single crystal Grain selection

Silencing of transcription factor E93 inhibits adult morphogenesis and disrupts cuticle, wing and ovary development in Locusta migratoria

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Insect Science 2022年第2期29卷 333-343页

作者： xiao-Jian Liu Guo Jun xiao-yu liang Xue-Yao Zhang Ting-Ting Zhang Wei-Min Liu Jian-Zhen Zhang Min Zhang Research Institute of Applied Biology Shanxi UniversityTaiyuanChina

Ecdysone-induced protein 93F(E93)plays important roles during the metamorphosis process in *** this study,a cDNA of the LmE93 gene was identified from the transcriptome of Locusta migratoria,which consists of the 3378-nucleotide open-reading frame(ORF)and encodes 1125 amino acids with helix–turn–helix(HTH)*** transcription quantitative polymerase chain reaction analysis revealed that LmE93 was highest expressed in *** LmE93 expression level was markedly low from the 3rd to 4th instar nymphs,and greatly increased in 1-day-old 5th instar nymphs with a peak on middle nymphal days,then declined in the late nymphal ***,injected dsLmE93 into 4th and 5th instar nymphs greatly reduced LmE93 transcripts,respectively,and prevented the process of metamorphosis,causing supernumerary nymphal ***–eosin staining of the integument showed that the apolysis occurred in advance in 4th instar nymphs,and old cuticle degradation was decreased in dsLmE93-injected locusts of 5th instar *** and no fully developed wings with reduced columns between the anterior and posterior regions were found in N6 and N7 supernumerary *** addition,the development of the ovary in dsLmE93-injected locusts was severely blocked,the yolk was almost not formed and there was no development of *** results indicated that LmE93 play key roles in the metamorphosis,cuticle,wing and ovarian development of locusts.

关键词： expression function Locusta migratoria RNA interference transcription factor E93

Low-dose metronomic chemotherapy improves tumor control in nasopharyngeal carcinoma

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Cancer Communications 2022年第10期42卷 909-912页

作者： yu-Pei Chen Jia-Yi Shen Zhen-Ji Deng Ying Sun xiao-yu liang Jia-Wei Lv Jun Ma State Key Laboratory of Oncology in South China Collaborative Innovation Center of Cancer MedicineGuangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and TherapyCenter for Precision Medicine of Sun Yat-sen UniversitySun Yat-sen University Cancer CenterGuangzhouGuangdong 510060P.R.China

1 BACKGROUND Nasopharyngeal carcinoma(NPC)is a unique head and neck malignancy prevalent in East Asia[1].It is highly malignant,with the non-keratinizing pathological subtype constituting approximately 95%of NPC cases in endemic *** in combination with radiotherapy is recommended for locoregionally advanced NPC(LANPC),especially in subgroups at higher risk of distant metastasis(e.g.,N2-3 vs.N0-1 diseases,high *** plasma Epstein-Barr virus[EBV]DNA copy number)[2,3].Concurrent chemoradiotherapy with or without induction chemotherapy is considered the backbone of the current chemoradiotherapy strategies for NPC[2,3].Nevertheless,although complete clinical remission could be achieved in more than 90%of patients after definitive chemoradiotherapy,about 20%-30%of patients will have disease recurrence subsequently[4,5],which might be caused minimal residual disease(MRD),either at locoregional or distant sites[6,7].Thus,adjuvant therapy is needed to improve tumor control.

关键词： chemotherapy nasopharyngeal metastasis

A NEW TRITERPENE SAPONIN FROM THE ROOT OF ARALIA SPINIFOLIA

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Chinese Chemical Letters 1992年第4期3卷 289-290页

作者： shi shan yu, De Quan yu, xiao Tian liang Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing 100050

A new triterpene saponin; 3-0-{β-D-xylopyranosyl(1-2) [β-D-glucuronopyranosyl(1-3)]}β-D-glucopyranosyl-oleanolic acid (Ⅲ) along with two known triterpene saponins has been isolated from the root of Aralia spinifol... 详细信息

关键词： A NEW TRITERPENE SAPONIN FROM THE ROOT OF ARALIA SPINIFOLIA ROOT

THE STRUCTURES OF YIYEliangWANOSIDE Ⅶ AND Ⅷ FROM THE BARK OF NOTHOPANAX DA VIDII(FRANCH)HARMS

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Chinese Chemical Letters 1993年第2期4卷 133-136页

作者： Shi Shan yu De Quan yu xiao Tian liang Institute of Materia Medica,Chinese Academy of Medical Sciences,Beijing,China,100050

Twonew oleanane type saponins wereisolated from the alcoholic extract of the bark of Nothopanax davidii(Franch)Harms(Araliaceae).Their structures have been determined on th e basis of spectral and chemical data as 3-O-β-(2',4'-O-diacetyl)-D-xylopyranosyl-3β-hydroxyolean-12-ene- 28,29-dioic acid-28-O-[α-L-rhamnopyranosyl(1-4)-β-D-glucopyranosyl(1-6)-β-D-glucopyranosyl] ester(1),named yiyeliangwanoside Ⅷ;3-O-β-(3'-O-acetyl)-D-xylopyranosyl-3β-hydroxyolean-12- ene-28,29-dioic acid-28-O-[O-L-rhamnopyranosyl(1-4)-β-D-glucopyranosyl(1-6)-β-D- glucopyranosyl] ester(Ⅱ),named yiyeliangwanoside Ⅷ.

关键词： FROM THE BARK OF NOTHOPANAX DA VIDII THE STRUCTURES OF YIYEliangWANOSIDE AND GIC FAB DA

THE STRUCTURE OF ARMILLARIZIN,A NEW PROTOILLUDANE SESQUITERPENOID AROMATIC ESTER FROM ARMILLARIA MELLEA(*** FR)QUEL.

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Chinese Chemical Letters 1990年第2期1卷 173-174页

作者： Jun Shan YANG Ya Lun SU yu Lan WANG xiao Zhang FENG De Quan yu xiao Tian liang Institute of Materia Medica,Chinese Academy of Medical Sciences,Beijing,100050

A new protoilludane sesquiterpenoid aromatic ester,named armillarizin (1)has been isolated from the artificially cultured mycelium of Armillaria me- llea(*** Fr)Quel.(Tricholomataceae).Its structure was deduced on the ba- sis of spectral *** relative configuration was established from the nuclear Overhauser effects and from the values of ~1H-~1H coupling constants.

关键词： FR THE STRUCTURE OF ARMILLARIZIN,A NEW PROTOILLUDANE SESQUITERPENOID AROMATIC ESTER FROM ARMILLARIA MELLEA VAHL.EX FR)QUEL

Fiber Bragg Grating Sensor Array System Based on Digital Phase Generated Carrier Demodulation and Reference Compensation Method

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Journal of Electronic Science and Technology of China 2008年第4期6卷 389-392页

作者： Jun He Fang Li Hao xiao yu-liang Liu Optoelectronic System Laboratory Institute ofSemiconductors Chinese Academy of Sciences Beijing 100083 China

A novel fiber Bragg grating （FBG） sensor array system based on digital phase generated carrier （PGC） demodulation and reference compensation method is proposed and set up. Experimental results confirm that the digital PGC demodulation can be used for wavelength-division-multiplexed FBG sensor array and the reference compensation method can reduce the environmental interference by approximately 40 dB in the frequency range from 20 Hz to 2 kHz. The minimum detectable wavelength-shift of the sensor system is 1 × 10^-3 pm/Hz^1/2.

关键词： Fiber Bragg grating (FBG) sensor,phase generated carrier (PGC) reference compensation method wavelength division multiplexing.

Effects of Shenqi Xiangyi granules in advanced gastric cancer chemotherapy

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 169-175页

作者： xiao-Jing Shi yu Song Xue-Xue liang Ting Chen Huang-yu Hao Xue Han Ya-Nan Chen Department of Oncology Zhangjiagang First People's HospitalSuzhou 215600Jiangsu ProvinceChina

BACKGROUND Owing to the absence of specific symptoms in early-stage gastric cancer,most patients are diagnosed at intermediate or advanced *** a result,treatment often shifts from surgery to other therapies,with chemotherapy and targeted therapies being the primary options for advanced gastric cancer treatment.A total of 116 patients with advanced gastric cancer,admitted from January 2021 to December 2023,were selected and divided into two groups of 58 each using the random number table *** control group received FOLFOX4 chemothe-rapy(oxaliplatin+calcium+folinate+5-fluorouracil)combined with intravenous *** observation group received the same treatment as the control group,supplemented by oral administration of Senqi Shiyiwei *** groups underwent treatment cycles of 3 weeks,with a minimum of two *** therapeutic efficacy,immune mechanisms,and treatment-related toxicity and side effects were compared between the *** objective remission rate in the observation group(55.17%)was higher than that of the control group(36.21%)(P0.05).CONCLUSION Adjuvant therapy with Shenqixian granules may enhance the efficacy of simudizumab combined with FOLFOX4 chemotherapy in advanced gastric cancer and the immune function by increasing immune cell counts,making it a valuable option in clinical treatment.

关键词： Sindilizumab FOLFOX4 chemotherapy Advanced gastric cancer Ginseng Qi Xiangyi granule Clinic treatment

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“元以曲取士”说与明清士人的戏曲观

齐鲁学刊 2020年第5期 122-129页

作者：于小亮大连民族大学文法学院辽宁大连116600

“元以曲取士”说是戏曲研究领域耳熟能详的议题,明清两朝对该说多有讨论。将明清士人的论述还原至各自具体语境中考察可以发现,以易代为界,两朝人物对该说的考察视角和解读阐释存在明显变化:明人之言论具有多种潜在目的,其中均包含着... 详细信息

“元以曲取士”说是戏曲研究领域耳熟能详的议题,明清两朝对该说多有讨论。将明清士人的论述还原至各自具体语境中考察可以发现,以易代为界,两朝人物对该说的考察视角和解读阐释存在明显变化:明人之言论具有多种潜在目的,其中均包含着对明代戏曲“文学史”地位的强烈关注;清人多致力于考辨该说的真实性,无论其结论如何,讨论的出发点与明人大不相同。明清曲家对各自所属王朝的身份认同深刻影响了戏曲观念的生发和转变。

关键词：元以曲取士元代戏曲明清曲论