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miRNA-21-5p is an important contributor to the promotion of injured peripheral nerve regeneration using hypoxia-pretreated bone marrow-derived neural crest cells

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Neural Regeneration Research 2025年第1期20卷 277-290页

作者： Meng Cong Jing-Jing Hu Yan yu xiao-Li Li xiao-Ting Sun Li-Ting Wang Xia Wu Ling-Jie Zhu xiao-Jia Yang Qian-Ru He Fei Ding Hai-Yan Shi School of Medicine Nantong UniversityNantongJiangsu ProvinceChina Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education and Coinnovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina Department of Physiology Jiangsu Health Vocational CollegeNanjingJiangsu ProvinceChina Department of Pathology Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina

Our previous study found that rat bone marrow–derived neural crest cells(acting as Schwann cell progenitors)have the potential to promote long-distance nerve ***-based therapy can enhance peripheral nerve repair and regeneration through paracrine bioactive factors and intercellular ***,the complex contributions of various types of soluble cytokines and extracellular vesicle cargos to the secretome remain *** investigate the role of the secretome and extracellular vesicles in repairing damaged peripheral nerves,we collected conditioned culture medium from hypoxia-pretreated neural crest cells,and found that it significantly promoted the repair of sensory neurons damaged by oxygen-glucose *** mRNA expression of trophic factors was highly expressed in hypoxia-pretreated neural crest *** performed RNA sequencing and bioinformatics analysis and found that miR-21-5p was enriched in hypoxia-pretreated extracellular vesicles of neural crest ***,to further clarify the role of hypoxia-pretreated neural crest cell extracellular vesicles rich in miR-21-5p in axonal growth and regeneration of sensory neurons,we used a microfluidic axonal dissociation model of sensory neurons in vitro,and found that hypoxia-pretreated neural crest cell extracellular vesicles promoted axonal growth and regeneration of sensory neurons,which was greatly dependent on loaded ***,we constructed a miR-21-5p-loaded neural conduit to repair the sciatic nerve defect in rats and found that the motor and sensory functions of injured rat hind limb,as well as muscle tissue morphology of the hind limbs,were obviously *** findings suggest that hypoxia-pretreated neural crest extracellular vesicles are natural nanoparticles rich in ***-21-5p is one of the main contributors to promoting nerve regeneration by the neural crest cell *** helps to explain the mechanism of action of the secretome and e

关键词： axotomy cell-free therapy conditioned medium extracellular vesicles hypoxic preconditioning microRNA oxygen-glucose deprivation peripheral nerve injury Schwann cell precursors

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Thiele重心型矩阵值混合有理插值算法

大学数学 2013年第2期29卷 50-55页

作者：郑涛唐烁余小磊合肥工业大学数学学院安徽合肥230009

利用Samelson型矩阵广义逆,构造了一种基于Thiele型连分式插值与重心有理插值的相结合的二元矩阵值混合有理插值格式,这种新的混合矩阵值有理插值函数继承了连分式插值和重心插值的优点,它的表达式简单,计算方便,数值稳定性好.该算法满... 详细信息

利用Samelson型矩阵广义逆,构造了一种基于Thiele型连分式插值与重心有理插值的相结合的二元矩阵值混合有理插值格式,这种新的混合矩阵值有理插值函数继承了连分式插值和重心插值的优点,它的表达式简单,计算方便,数值稳定性好.该算法满足有理插值问题所给的插值条件,同时给出了误差估计分析.最后用数值算例验证了插值算法的有效性.

关键词： Thiele连分式重心有理插值偏倒差商

Perilipin-2 mediates ferroptosis in oligodendrocyte progenitor cells and myelin injury after ischemic stroke

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Neural Regeneration Research 2025年第7期20卷 2015-2028页

作者： Jian Yang Jiang Wu Xueshun Xie Pengfei Xia Jinxin Lu Jiale Liu lei Bai Xiang Li Zhengquan yu Haiying Li Department of Neurosurgery&Brain and Nerve Research Laboratory The First Affiliated Hospital of Soochow UniversitySuzhouJiangsu ProvinceChina Institute of Stroke Research Soochow UniversitySuzhouJiangsu ProvinceChina

Differentiation of oligodendrocyte progenitor cells into mature myelin-forming oligodendrocytes contributes to *** of remyelination due to oligodendrocyte progenitor cell death can result in severe nerve *** is an iron-dependent form of regulated cell death caused by membrane rupture induced by lipid peroxidation,and plays an important role in the pathological process of ischemic ***,there are few studies on oligodendrocyte progenitor cell *** analyzed transcriptome sequencing data from GEO databases and identified a role of ferroptosis in oligodendrocyte progenitor cell death and myelin injury after cerebral *** analysis suggested that perilipin-2(PLIN2)was involved in oligodendrocyte progenitor cell ***2 is a lipid storage protein and a marker of hypoxia-sensitive lipid droplet *** further investigation,we established a mouse model of cerebral ischemia/*** found significant myelin damage after cerebral ischemia,as well as oligodendrocyte progenitor cell death and increased lipid peroxidation levels around the infarct *** ferroptosis inhibitor,ferrostatin-1,rescued oligodendrocyte progenitor cell death and subsequent myelin *** also found increased PLIN2 levels in the peri-infarct area that co-localized with oligodendrocyte progenitor ***2 knockdown rescued demyelination and improved neurological *** findings suggest that targeting PLIN2 to regulate oligodendrocyte progenitor cell ferroptosis may be a potential therapeutic strategy for rescuing myelin damage after cerebral ischemia.

关键词： bioinformatics bulk RNA sequencing ferroptosis ischemic stroke myelin injury oligodendrocyte progenitor cell perilipin-2 single-cell RNA sequencing

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建筑装饰行业工业化发展的研究与分析

建筑技术开发 2018年第4期45卷 1-2页

作者：虞晓磊王秀芳浙江亚厦装饰股份有限公司杭州310020

随着工业化发展的进程越来越快,建筑装饰行业的工业化之路也稳步向前。目前行业存在自主研发能力不足,成本过高等问题。分析目前在建筑装饰行业工业化发展之路上所存在的种种问题,提出提升技术创新能力等相应对策,未来发展前景良好。

关键词：建筑装饰工业化 3D打印三维扫描

基于VB6.0的PC机与AT89c51的温度智能检测系统的实现

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煤炭技术 2005年第5期24卷 113-114页

作者：黄伟力虞晓磊河北工程学院信电学院河北邯郸056038

介绍了采用AT89c5 1单片机系统和数字温度传感器DS18b2 0实现温度自动智能测量的原理及实现方法。并介绍了使用单片机语言和VB软件实现上位机和单片机之间的通信的方法。该系统具有良好的人机界面并且操作方便。

关键词：监测系统 VB 通信界面

武汉地区地基GPS遥感水汽与气象因子的相关性分析

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地理与地理信息科学 2012年第1期28卷 55-58,89,F0002页

作者：余晓磊巫兆聪江万寿赵政武汉大学遥感信息工程学院湖北武汉430079 武汉大学测绘遥感信息工程国家重点实验室湖北武汉430079 中国国土资源航空物探遥感中心北京100083

地基GPS可以适时准确地反演大气可降水含量,而常规气象观测站点一般具有长时期的历史观测数据。若将这两种数据融合,可以加强数值天气预报的准确性,因此需要探讨二者之间的相关性。通过处理2006年、2007年全球卫星导航服务组织(IGS)提... 详细信息

地基GPS可以适时准确地反演大气可降水含量,而常规气象观测站点一般具有长时期的历史观测数据。若将这两种数据融合,可以加强数值天气预报的准确性,因此需要探讨二者之间的相关性。通过处理2006年、2007年全球卫星导航服务组织(IGS)提供的武汉站地基GPS观测数据,计算武汉地区上空日平均水汽含量。利用一元和多元回归分析GPS遥感水汽与地面气象观测因子之间的关系,发现武汉地区GPS遥感水汽含量同包括气温、气压等在内的多种气象因子都有一定程度的相关性,其中与气温的相关性最大,且武汉地区上空的大气水汽含量的季节性变化大,在夏季其日平均变化十分明显。

关键词： GPS 大气可降水气象因子回归分析

Atomically precise nickel-sulfur clusters for efficient electrochemical 2,5-hydroxymethylfurfural oxidation

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Nano Research 2025年第1期18卷 140-148页

作者： Fen Wang Lu-yu Liu Sha-Sha Cui Ting-Ting Li xiao-Meng Yang Zhijuan Liu Yanyong Wang Henan Key Laboratory of Crystalline Molecular Functional Materials Henan International Joint Laboratory of Tumor Theranostical Cluster MaterialsGreen Catalysis Centerand College of ChemistryZhengzhou UniversityZhengzhou 450001China State Key Laboratory of Chem/Bio-sensing and Chemometrics College of Chemistry and Chemical EngineeringHunan UniversityChangsha 410082China

Nickel sulfide exhibits excellent catalytic activity in the electrochemical 2,5-hydroxymethylfurfural oxidation reaction(HMFOR).However,due to the polydispersity of nanoparticles,it is difficult to establish a clear structure-activity relationship at the atomic *** this work,we have successfully synthesized atomically precise Ni_(6)(PET)_(12)and Ni_(4)(PET)_(8)clusters(PET:2-phenylethanethiol)for ***^(2+)and S_(2)-with atomic ratio of 1:2 was mainly existed in Ni_(6)(PET)_(12)and Ni_(4)(PET)_(8)to form Ni-S *** electrochemical test results have suggested both Ni_(6)(PET)_(12)and Ni_(4)(PET)_(8)displayed outstanding electrocatalytic ability for *** Ni_(6)(PET)_(12)exhibited better electrocatalytic ability than Ni_(4)(PET)_(8)with higher current density,lower overpotential and faster reaction *** superior electrochemical ability of Ni_(6)(PET)_(12)may be due to the enhanced adsorption towards HMF molecule with strong interaction towards hydroxyl group and furan ***,it found that the Ni^(2+)species in Ni_(6)(PET)_(12)could rapidly oxidized into Ni^(3+)species,which could spontaneously capture electron and proton from HMF for *** theoretical calculation demonstrated that the Ni_(6)(PET)_(12)process lower free energy barrier than Ni_(4)(PET)_(8)to display excellent electrocatalytic *** work is of great significance for designing efficient electrocatalysts for HMFOR.

关键词： atomically precise nickel nanoclusters 2 5-hydroxymethylfurfural electro-oxidation Ni3+species

基于图像匹配和小波神经网络的RFID标签三维位置坐标测量法

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测控技术 2018年第10期37卷 26-29页

作者：俞晓磊庄笑刘振鲁国家射频识别产品质量监督检验中心(江苏) 江苏南京210029 南京航空航天大学理学院江苏南京210016

针对现代智慧仓储物流中货物的出入库信息采集与货物盘点的需求,提出一种基于图像匹配和小波神经网络的RFID多标签网络三维分布结构坐标测量新方法。首先,利用垂直和水平双CCD系统从不同角度获取RFID多标签网络的图像;随后,利用小波阈... 详细信息

针对现代智慧仓储物流中货物的出入库信息采集与货物盘点的需求,提出一种基于图像匹配和小波神经网络的RFID多标签网络三维分布结构坐标测量新方法。首先,利用垂直和水平双CCD系统从不同角度获取RFID多标签网络的图像;随后,利用小波阈值去噪的方法对图像中的噪声进行去除,利用模板匹配算法获取各标签的三维坐标;最后,基于小波神经网络建立了RFID多标签网络三维坐标分布与对应识读距离之间的非线性关系模型。利用实验获取的数据,对模型进行验证,实验结果表明,该模型平均预测相对误差小于0.0131,可为现场测试环境下实时预测多标签最优三维几何分布提供参考。

关键词：图像匹配三维结构测量 RFID标签小波神经网络双CCD系统

基于数字岸线系统分析塔里木河英巴扎至乌斯满河道演变特性

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泥沙研究 2024年第5期49卷 42-49页

作者：高久洲李琳戴文鸿池苗苗肖玉磊新疆农业大学水利与土木工程学院新疆乌鲁木齐830052 新疆水利工程安全与水灾害防治重点实验室新疆乌鲁木齐830052 新疆维吾尔自治区塔里木河流域干流管理局新疆库尔勒841000 河海大学水利水电学院江苏南京210098

为了探明塔里木河干流英巴扎至乌斯满河道的演变规律和趋势,对该河道1993—2022年间的Landsat系列卫星影像进行了解译,通过数字岸线系统分析了河道变迁速率。从1993年至2022年,英巴扎至乌斯满河段弯曲系数总体呈现上升趋势,河道呈淤积... 详细信息

为了探明塔里木河干流英巴扎至乌斯满河道的演变规律和趋势,对该河道1993—2022年间的Landsat系列卫星影像进行了解译,通过数字岸线系统分析了河道变迁速率。从1993年至2022年,英巴扎至乌斯满河段弯曲系数总体呈现上升趋势,河道呈淤积态势。英巴扎至沙子河口生态闸段相比于沙子河口至乌斯满段演变幅度更加剧烈,且河道往南北两岸的最大迁移速率分别为20.01 m/a和40.36 m/a。2010—2011年裁弯取直现象频发,平均变迁速率最大为72.27 m/a。基于卡尔曼滤波器对2032年河势演变趋势进行预测,河道上段最大迁移距离可达730 m,下段为218 m。应对河道上段进行整治,调整水流和控制河势,以确保河道两岸防洪安全和岸线的合理利用,提高向下游生态输水的保证率。

关键词：河势演变 Landsat 数字岸线系统(DSAS) 塔里木河蜿蜒型河段