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Development and validation of a prediction model for early screening of people at high risk for colorectal cancer

World Journal of Gastroenterology 2024年第5期30卷 450-461页

作者： Ling-Li Xu Yi Lin Li-yuan Han yue Wang Jian-Jiong Li xiao-yu dai Department of General Surgery Ningbo No.2 HospitalNingbo 315000Zhejiang ProvinceChina Center for Health Economics Faculty of Humanities and Social SciencesUniversity of NottinghamNingbo 315100Zhejiang ProvinceChina Department of Global Health Ningbo Institute of Life and Health IndustryUniversity of Chinese Academy of SciencesNingbo 315000Zhejiang ProvinceChina School of Public Health Medical College of Soochow UniversitySuzhou 215123Jiangsu ProvinceChina

BACKGROUND Colorectal cancer(CRC)is a serious threat *** early screening is suggested to be the most effective method to prevent and control CRC,the current situation of early screening for CRC is still not *** China,the incidence of CRC in the Yangtze River Delta region is increasing dramatically,but few studies have been ***,it is necessary to develop a simple and efficient early screening model for *** To develop and validate an early-screening nomogram model to identify individuals at high risk of *** Data of 64448 participants obtained from Ningbo Hospital,China between 2014 and 2017 were retrospectively *** cohort comprised 64448 individuals,of which,530 were excluded due to missing or incorrect *** 63918,7607(11.9%)individuals were considered to be high risk for CRC,and 56311(88.1%)were *** participants were randomly allocated to a training set(44743)or validation set(19175).The discriminatory ability,predictive accuracy,and clinical utility of the model were evaluated by constructing and analyzing receiver operating characteristic(ROC)curves and calibration curves and by decision curve ***,the model was validated internally using a bootstrap resampling *** Seven variables,including demographic,lifestyle,and family history information,were *** logistic regression analysis revealed that age[odds ratio(OR):1.03,95%confidence interval(CI):1.02-1.03,P<0.001],body mass index(BMI)(OR:1.07,95%CI:1.06-1.08,P<0.001),waist circumference(WC)(OR:1.03,95%CI:1.02-1.03 P<0.001),lifestyle(OR:0.45,95%CI:0.42-0.48,P<0.001),and family history(OR:4.28,95%CI:4.04-4.54,P<0.001)were the most significant predictors of high-risk *** lifestyle was a protective factor,whereas family history was the most significant risk *** area under the curve was 0.734(95%CI:0.723-0.745)for the final validation set ROC curve and 0.735(95%CI:0.728-0.742)for the training s

关键词： Colorectal cancer Early screening model High-risk population Nomogram model Questionnaire survey Dietary habit Living habit

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Giant Goos–Hnchen shifts of waveguide coupled long-range surface plasmon resonance mode

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Chinese Physics B 2018年第8期27卷 30-34页

作者： Qi You jia-Qi Zhu ]un Guo Lei-Ming Wu xiao-yu dai yuan-Jiang Xiang SZU-NUS Collaborative Innovation Center for Optoelectronic Science ＆ Technology Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province College of Optoelectronic EngineeringShenzhen UniversityShenzhen 518060China

A hybrid structure based on a planar waveguide （PWG） mode coupling a long-range surface plasmon resonance （LRSPR） mode is proposed to enhance the GH shift. Both the PWG mode and LRSPR mode can be in strong resonance, and these two modes can be coupled together due to the normal-mode splitting. The largest GH shift of PWG-coupled LRSPR structure is 4156 times that of the incident beam, which is 23 times and 3.6 times that of the surface plasmon resonance （SPR） structure and the LRSPR structure, respectively. As a GH shift sensor, the highest sensitivity of 4.68 x 107 λ is realized in the coupled structure. Compared with the sensitivity of the traditional SPR structure, the sensitivity of our structure is increased by more than 2 orders, which theoretically indicates that the proposed configuration can be applied to the field of high-sensitivity sensors in the future.

关键词： Goos-Hfinchen (GH) shift planar waveguide (PWG) long-range surface plasmon polartons (LR-SPPs)

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Enhanced and tunable Imbert–Fedorov shift based on epsilon-near-zero response of Weyl semimetal

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Chinese Physics B 2023年第3期32卷 515-520页

作者：伍计鹏项元江戴小玉 College of Railway Transportation Hunan University of TechnologyZhuzhou 412007China College of Electrical and Information Engineering Hunan UniversityChangsha 410082China

We theoretically investigate the reflected spatial Imbert–Fedorov(IF)shift of transverse-electric(TE)-polarized beam illuminating on a bulk Weyl semimetal(WSM).The spatial IF shift is enhanced significantly at two different frequencies close to the epsilon-near-zero(ENZ)frequency,where large values of reflection coefficients|r_(pp)|/|r_(ss)|are obtained due to the ENZ response induced different rapid increasing trends of|r_(pp)|and|r_(ss)|.Particularly,the tunable ENZ effect with tilt degree of Weyl cones and Fermi energy enables the enhanced spatial IF shift at different *** enhanced spatial IF shift also shows the adjustability of WSM thickness,incident angle and Weyl node *** findings provide easy and available methods to enlarge and adjust the reflected IF shift of TE-polarized light with a WSM.

关键词： Imbert–Fedorov shift Weyl semimetal epsilon-near-zero reflection

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Study of the potential mechanism of acupuncture treatment for functional dyspepsia based on association rule mining and bioinformatics/network pharmacology approach

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Gastroenterology & Hepatology Research 2023年第2期5卷 6-15页

作者： An-Lan Zhao Ling-Yong xiao Hong-yue Niu Lian Liu xiao-yu dai Department of Acupuncture First Teaching Hospital of Tianjin University of Traditional Chinese MedicineTianjin 300193China National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion Tianjin 300381Chian College of Acupuncture and Massage Tianjin University of Traditional Chinese MedicineTianjin 300000China

Objective:To explore the main acupoint prescription and mechanism of acupuncture in treating Functional dyspepsia(FD)by analyzing the clinical randomized controlled trial literature on acupoints and targets of acupuncture in the treatment of FD combined with association rule mining and bioinformatics/network pharmacology ***:Search relevant clinical randomized controlled trial literature on acupoints and therapeutic targets of acupuncture in the treatment of FD from eight databases from their inception to June 18th,*** obtained acupuncture selection points,meridian,and therapeutic targets and established acupoints database for acupuncture treatment of ***-related targets were collected from GeneCards,DisGeNET,OMIM,and DrugBank *** obtained the potential targets of acupuncture on FD by taking the intersection of acupuncture for FD therapeutic targets and FD-related *** performed the protein-protein interaction network,Gene Ontology(GO)analysis,and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway enrichment ***:In this study,26 Randomized Controlled Trials related to acupuncture treatment of FD were *** obtained 29 acupoints,17 acupuncture for FD therapeutic targets,and 10 intersection *** necrosis factor(TNF),Interleukin(IL)-1,and Neuropeptide Y(NPY)are key targets of acupuncture in the treatment of ***:ST36-CV12-PC6-LR3 is the main acupoint prescription for *** may affect Neuroactive ligand-receptor interaction,Gastric acid secretion,and IL-17,TNF signaling pathways by regulating related key targets,and play a synergistic role in the treatment of FD by inhibiting gastric acid secretion,alleviating inflammatory response,regulating the brain-gut axis,improving mood and other aspects.

关键词： acupuncture functional dyspepsia network acupuncture mechanism

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中国古代服饰的伦理美学意蕴

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湖南科技大学学报（社会科学版） 2017年第2期20卷 162-166页

作者：肖宇强戴端中南大学建筑与艺术学院湖南长沙410083 湖南女子学院艺术设计系湖南长沙410004

中国古代的伦理观念以儒家思想中的"礼"为核心,尊"礼"守"德"的行为规范即为美的象征。中国古代的伦理思想与美学观念紧密相连。这种伦理美学观在古代服饰的形制、材料、色彩、图案中有所体现,它是古人崇天敬地、万物有灵的哲学观念与人... 详细信息

中国古代的伦理观念以儒家思想中的"礼"为核心,尊"礼"守"德"的行为规范即为美的象征。中国古代的伦理思想与美学观念紧密相连。这种伦理美学观在古代服饰的形制、材料、色彩、图案中有所体现,它是古人崇天敬地、万物有灵的哲学观念与人性道德论相结合的产物,是我国古代哲学思想中的宝贵财富,对当代人们的伦理与审美观念仍具有深刻的影响。

关键词：伦理美学中国古代服饰哲学思想

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Observation of acoustic hybrid topological phases induced by the p-d orbital interactions

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 132-139页

作者： xiao Xiang Feng Gao yu-Gui Peng Peng Wu Zong-Lin Li Xue-Feng Zhu School of Physics and Innovation Institute Huazhong University of Science and Technology

In spinless systems,growing attention has recently been attracted to synthetic gauge fields,which redefine the fundamental crystal symmetries by utilizing the projective algebraic ***,synthetic gauge fields have been commonly investigated in single orbital systems,and explorations on hybrid orbitals remain elusive in ***,we report the experimental observation of hybrid topological phases induced by hybrid synthetic gauge flux,which is formed by the interaction between p and d orbitals embedded in acoustic *** breaking the translation symmetries of Lxand/or Ly,we unambiguously demonstrate the first-order M?bius edge states and higher-order corner *** work establishes a platform for seeking exotic topological phases induced by hybrid-orbitals interactions and initializing the framework of hybrid-orbitalsrelated topological *** applications can be anticipated in scenarios such as high-quality sensing and robust wave trapping due to the stepwise energy distribution of the hybrid topological phase.

关键词： topological insulator synthetic gauge field projective symmetry corner states

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Experimental Observing Damage Evolution in Cement Pastes Exposed to External Sulfate Attack by in situ X-ray Computed Tomography

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Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 164-170页

作者： WU Min CAO Kailei xiao Weirong yu Zetai CAO Jierong DING Qingjun LI Jinhui China Railway Construction Corporation Harbour and Channel Engineering Bureau Group Co. LTDZhuhai 519000China Con-struction Headquarters of Zhoushan Liuheng Bridge Phase II Project Zhoushan 316000China China Railway Construction Bridge En-gineering Bureau Group Co. LTDTianjin 300000China State Key Laboratory of Silicate Material for Architecture(Wuhan University of Technology) Wuhan 430070China College of Materials Science and Engineering Wuhan Textile UniversityWuhan 430200China

The paper presents experimental investigation results of crack pattern change in cement pastes caused by external sulfate attack(ESA).To visualize the formation and development of cracks in cement pastes under ESA,an X-ray computed tomography(X-ray CT)was used,i e,the tomography system of Zeiss Xradia 510 *** results indicate that X-CT can monitor the development process and distribution characteristics of the internal cracks of cement pastes under ESA with attack *** addition,the C3A content in the cement significantly affects the damage mode of cement paste specimens during sulfate *** damage of ordinary Portland cement(OPC)pastes subjected to sulfate attack with high C3A content are severe,while the damage of sulfate resistant Portland cement(SRPC)pastes is much smaller than that of OPC ***,a quadratic function describes the correlation between the crack volume fraction and development depth for two cement pastes immermed in sulfate solution.

关键词： concrete external sulfate attack damage evolution situ X-ray computed tomography

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一测多评法测定艾叶中6个有机酸类成分的含量

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药物分析杂志 2016年第12期36卷 2131-2138页

作者：于晓戴衍朋周倩孙立立山东中医药大学济南250355 烟台山医院烟台264001 山东省中医药研究院济南250014

目的:建立同时测定艾叶中6个有机酸类成分含量的一测多评法。方法:采用Thermo Syncronis C18色谱柱(4.6 mm×250 mm,5μm),流动相为0.1%甲酸水溶液-乙腈,梯度洗脱,流速0.8 m L·min^(-1),检测波长325 nm,柱温30℃。以绿原酸为内参物,分... 详细信息

目的:建立同时测定艾叶中6个有机酸类成分含量的一测多评法。方法:采用Thermo Syncronis C18色谱柱(4.6 mm×250 mm,5μm),流动相为0.1%甲酸水溶液-乙腈,梯度洗脱,流速0.8 m L·min^(-1),检测波长325 nm,柱温30℃。以绿原酸为内参物,分别计算与新绿原酸、隐绿原酸、3,4-二咖啡酰奎宁酸、3,5-二咖啡酰奎宁酸、4,5-二咖啡酰奎宁酸的相对校正因子,实现一测多评。同时利用外标法和一测多评法测定6个有机酸类成分的含量。比较2种方法的测定结果是否存在差异。结果:一测多评法与外标法测定结果无显著差异。实验所测得的相对校正因子重复性良好。6批不同产地艾叶样品中新绿原酸、绿原酸、隐绿原酸、3,4-二咖啡酰奎宁酸、3,5-二咖啡酰奎宁酸、4,5-二咖啡酰奎宁酸的含量范围分别为0.15~0.58、0.50~2.65、0.27~0.89、0.62~4.29、1.18~10.72、0.99~6.69 mg·g^(-1)。结论:一测多评法可以用于艾叶中6个有机酸类成分的含量测定,且具有可行性与经济性。

关键词：艾叶有机酸类成分绿原酸新绿原酸隐绿原酸二咖啡酰奎宁酸一测多评相对校正因子

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miRNA-21-5p is an important contributor to the promotion of injured peripheral nerve regeneration using hypoxia-pretreated bone marrow-derived neural crest cells

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Neural Regeneration Research 2025年第1期20卷 277-290页

作者： Meng Cong Jing-Jing Hu Yan yu xiao-Li Li xiao-Ting Sun Li-Ting Wang Xia Wu Ling-Jie Zhu xiao-Jia Yang Qian-Ru He Fei Ding Hai-Yan Shi School of Medicine Nantong UniversityNantongJiangsu ProvinceChina Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education and Coinnovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina Department of Physiology Jiangsu Health Vocational CollegeNanjingJiangsu ProvinceChina Department of Pathology Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina

Our previous study found that rat bone marrow–derived neural crest cells(acting as Schwann cell progenitors)have the potential to promote long-distance nerve ***-based therapy can enhance peripheral nerve repair and regeneration through paracrine bioactive factors and intercellular ***,the complex contributions of various types of soluble cytokines and extracellular vesicle cargos to the secretome remain *** investigate the role of the secretome and extracellular vesicles in repairing damaged peripheral nerves,we collected conditioned culture medium from hypoxia-pretreated neural crest cells,and found that it significantly promoted the repair of sensory neurons damaged by oxygen-glucose *** mRNA expression of trophic factors was highly expressed in hypoxia-pretreated neural crest *** performed RNA sequencing and bioinformatics analysis and found that miR-21-5p was enriched in hypoxia-pretreated extracellular vesicles of neural crest ***,to further clarify the role of hypoxia-pretreated neural crest cell extracellular vesicles rich in miR-21-5p in axonal growth and regeneration of sensory neurons,we used a microfluidic axonal dissociation model of sensory neurons in vitro,and found that hypoxia-pretreated neural crest cell extracellular vesicles promoted axonal growth and regeneration of sensory neurons,which was greatly dependent on loaded ***,we constructed a miR-21-5p-loaded neural conduit to repair the sciatic nerve defect in rats and found that the motor and sensory functions of injured rat hind limb,as well as muscle tissue morphology of the hind limbs,were obviously *** findings suggest that hypoxia-pretreated neural crest extracellular vesicles are natural nanoparticles rich in ***-21-5p is one of the main contributors to promoting nerve regeneration by the neural crest cell *** helps to explain the mechanism of action of the secretome and e

关键词： axotomy cell-free therapy conditioned medium extracellular vesicles hypoxic preconditioning microRNA oxygen-glucose deprivation peripheral nerve injury Schwann cell precursors

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Homologous CoS2 interface with directed electron transfer and strong chloridion repulsion for efficient seawater oxidation

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Science China Chemistry 2025年

作者： yuan Tian Jiang-Bo Chen Jie Ying Ge Tian yu-Xuan xiao Yi Lu Si-Ming Wu Wei Geng Ling Shen xiao-yu Yang State Key Laboratory of Advanced Technology for Materials Synthesis and Processing and School of Materials Science and Engineering and Shenzhen Research Institute & Laoshan Laboratory Wuhan University of Technology School of Chemical Engineering and Technology Sun Yat-Sen University National Energy Key Laboratory for New Hydrogen-Ammonia Energy Technologies Foshan Xianhu Laboratory

Seawater electrolysis is a highly promising method to produce high energy density hydrogen,especially in dry areas that have scarce freshwater ***,application of seawater electrolysis is confronted by two major problems associated with catalysts employed for the anodic oxygen evolution reaction （OER） including the competitive hypochlorite evolution reaction（HCER） and strong chloridion （Cl–） triggered *** studies aimed at overcoming these problems,a facile method has been developed to synthesize a homologous CoS2heterojunction as an OER *** to a difference in work functions at the interface and increased electron density,this material has directed electron transfer and strong chloridion repulsion properties,*** have shown that CoS2achieves low overpotentials of 289 and 322 mV at 10 mA cm-2current density in respective alkaline （1 M KOH） and alkaline simulated seawater ***,the outstanding stability of CoS2is reflected in a negligible decline in activity during promotion of the OER for 100 *** of density functional theory calculations reveal that the homologous CoS2heterojunction promotes directed electron transport for optimizing adsorption/desorption of reactive species and heightens the Cl-adsorption energy for strongly repulsing Cl-,phenomena that enhance OER performance in alkaline simulated seawater.

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