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Resolution Enhancement of SOHO/MDI Magnetograms

Research in Astronomy and Astrophysics 2024年第6期24卷 358-367页

作者： ying Qin Kai-fan Ji Hui Liu xiao-Guang Yu Yunnan Observatories Chinese Academy of SciencesKunming 650011China University of Chinese Academy of Sciences Beijing 100049China Yunnan Key Laboratory of Solar Physics and Space Science Kunming 650216China Key Laboratory for the Structure and Evolution of Celestial Objects Chinese Academy of SciencesKunming 650216China

Research on the solar magnetic field and its effects on solar dynamo mechanisms and space weather events has benefited from the continual improvements in instrument resolution and measurement *** augmentation and assimilation of historical observational data timelines also play a significant role in understanding the patterns of solar magnetic field *** the realm of astronomical data processing,super-resolution(SR)reconstruction refers to the process of using a substantial corpus of training data to learn the nonlinear mapping between low-resolution(LR)and high-resolution(HR)images,thereby achieving higherresolution astronomical *** paper is an application study in high-dimensional nonlinear *** learning models were employed to perform SR modeling on SOHO/MDI magnetograms and SDO/HMI magnetograms,thus reliably achieving resolution enhancement of full-disk SOHO/MDI magnetograms and enhancing the image resolution to obtain more detailed *** this study,a data set comprising 9717pairs of data from 2010 April to 2011 February was used as the training set,1332 pairs from 2011 March were used as the validation set and 1034 pairs from 2011 April were used as the test *** data preprocessing,we randomly cropped 128×128 sub-images as the LR cases from the full-disk MDI magnetograms,and the corresponding 512×512 sub-images as HR ones from the HMI full-disk magnetograms for model *** tests conducted have shown that the study successfully produced reliable 4×SR reconstruction of full-disk MDI *** MESR model's results(0.911)were highly correlated with the target HMI magnetographs as indicated by the correlation coefficient ***,the method achieved the best PSNR,SSIM,MAE and RMSE values,indicating that the MESR model can effectively reconstruct magnetograms.

关键词： magnetic fields techniques:image processing virtual observatory tools Sun:magnetic fields

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Methods,Mechanisms,and Application Prospects for Enhancing Extracellular Vesicle Uptake

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Current Medical Science 2024年第2期44卷 247-260页

作者： ying-peng XU Tao JIANG xiao-fan YANG Zhen-bing CHEN Department of Hand Surgery Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022China

Extracellular vesicles(EVs)are considered to be a new generation of bioinspired nanoscale drug delivery systems due to their low immunogenicity,natural functionality,and excellent ***,limitations such as low uptake efficiency,insufficient production,and inhomogeneous performance undermine their *** address these issues,numerous researchers have put forward various methods and applications for enhancing EV uptake in recent *** this review,we introduce various methods for the cellular uptake of EVs and summarize recent advances on the methods and mechanisms for enhancing EV *** addition,we provide further understanding regarding enhancing EV uptake and put forward prospects and challenges for the development of EV-based therapy in the future.

关键词： extracellular vesicles exosomes extracellular vesicle uptake extracellular vesiclebased therapy

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A brand new green coating technology for realizing the regulation of spherical propellant energy release process

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Defence Technology（防务技术） 2024年第6期36卷 78-94页

作者： Wenhao fan Yajun Ding Zhongliang xiao School of Chemistry and Chemical Engineering Nanjing University of Science and TechnologyNanjing210094China Key Laboratory of Special Energy Materials Nanjing University of Science and TechnologyMinistry of EducationNanjing 210094China

To achieve the controllable release of energy of nitrocellulose-based propellants,this paper combines the cellulose-based nanocomposites aqueous coating(Surelease®-NC)with fluidized bed coating equipment to successfully prepare the coated spherical propellant for the first *** effects of fluidized bed coating temperature,air velocity,flow speed and atomization pressure on the adhesion rate,coating integrity and coating uniformity of the coated spherical propellant were investigated,and the preparation of coated spherical propellant with homogeneous size and structural integrity was achieved for the first *** microscopic morphology,chemical structure,water vapor adsorption behavior,combustion performance,and ageing resistance property of the coated spherical propellant were systematically investigated by,Fourier transforms infrared spectroscopy(FTIR),Micro confocal raman spectrometer,field scanning electron microscopy(SEM),dynamic vapor adsorption techniques,and closed bomb test,confirming the surface core-shell structure and the tightly bonded interfacial structure of coated spherical ***,the coated spherical propellant has good hygroscopic,excellent progressive burning and long storage stability.

关键词： Nanocomposites aqueous coating Fluidized bed coating equipment Coated spherical propellant Controllable release of energy Long storage stability

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Field experimental study on the effect of thawed depth of frozen alpine meadow soil on rill erosion by snowmelt waterflow

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International Soil and Water Conservation Research 2024年第1期12卷 54-63页

作者： ying Zheng xiaonan Shi fan Zhang Tingwu Lei Chen Zeng Xiong xiao Li Wang Guanxing Wang State Key Laboratory of Tibetan Plateau Earth System Resources and Environment(TPESRE)Institute of Tibetan Plateau ResearchChinese Academy of SciencesBeijing100101China University of Chinese Academy of Sciences Beijing100101China State Key Laboratory of Hydrology-Water Resources and Hydraulic Engineering Hohai UniversityNanjing210098China College of Water Resources and Civil Engineering China Agricultural UniversityBeijing100083China College of Geographic Science Hunan Normal UniversityChangsha410081China

Soil erosion by snow or ice melt waterflow is an important type of soil erosion in many high-altitude and high-latitude regions and is further aggravated by climate *** snowmelt waterflow erosion process is affected by soil freeze-thaws and is highly dynamically *** this study,a methodology was developed to conduct in situ field experiments to investigate the effects of the thawed depth of the frozen soil profile on snowmelt waterflow *** method was implemented on an alpine meadow soil slope at an altitude of 3700 m on the northeastern Tibetan *** erosion experiments involved five thawed soil depths of 0,10,30(35),50,and 80(100)mm under two snowmelt waterflow rates(3 and 5 L/min).When the topsoil was fully frozen or shallow-thawed(≤10 mm),its hydrothermal and structural properties caused a significant lag in the initiation of runoff and delayed soil erosion in the initial *** runoff and sediment concentration curves for fully frozen and shallow-thawed soil showed two-stage patterns characteristic of a sediment supply limited in the early stage and subject to hydrodynamic-controlled processes in the later ***,this effect did not exist where the thawed soil depth was greater than 30 *** deep-thawed cases(≥30 mm)showed normal hydrograph and sedigraph patterns similar to those of the unfrozen *** findings of this study are important for understanding the erosion rates of partially thawed soil and for improving erosion simulations in cold regions.

关键词： Snowmelt waterflow erosion Hillslope erosion process Soil freeze and thaw Runoff generation In situ experimental method

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Anomalies of Precipitation over China on Days with Tropical Cyclone Activity over the Bay of Bengal: Role of Moisture Transport

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Journal of Meteorological Research 2024年第2期38卷 368-382页

作者： Na WEI ying LI xiaoting fan Nanjing Joint Institute for Atmospheric Sciences Nanjing 210041 State Key Laboratory of Severe Weather Chinese Academy of Meteorological SciencesChina Meteorological AdministrationBeijing 100081 Department of Atmospheric and Oceanic Sciences and Institute of Atmospheric Sciences Fudan UniversityShanghai 200433

Tropical cyclones over the Bay of Bengal(BoBTC)affect the precipitation over China,with distinct seasonal and daily *** study quantitatively examines the daily standardized precipitation anomalies(SPAs)over China on the days with BoBTC activities(storm-days)and related circulations,based on rainfall measurements at surface meteorological stations and ECMWF reanalysis data on a 0.25°×0.25°resolution during *** positive SPA is found over the stations in the two adjacent regions around BoB(Southwest China in May/November and southern Tibetan Plateau in October)and three distant regions(Southeast China and the northeastern boundary of the Qinghai-Tibet Plateau in May,and central North China in October).The SPA distributions are remarkably consistent with the integrated water vapor transport(IVT)*** IVT is found associated with the interaction between southwesterly(southerly)of the BoBTC circulation and low-level monsoonal flow in May(midlevel westerly in winter months).The probabilities of extreme precipitation(EP)occurrences over the above regions all increase on *** adjacent regions,EP is significantly correlated with the northward IVT anomalies to the east of BoBTC circulation,which strengthen the water vapor input through the southern *** IVT anomalies are stronger in May,benefited by the deep monsoonal southwesterlies than those in *** distant regions,EP is more closely related to the IVT anomaly extending back from *** moisture from BoB concentrates along a local low-level convergence line over Southeast China,being further facilitated by coexistence of the BoBTC depression and midlevel westerly trough in *** results highlight the interactions between BoBTCs and local weather systems that influence the general precipitation anomalies and occurrence of EP over China,especially over distant regions.

关键词： tropical cyclone Bay of Bengal precipitation anomaly moisture transport

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Facile preparation of Fe/N-based biomass porous carbon composite towards enhancing the thermal decomposition of DAP-4

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Defence Technology（防务技术） 2024年第1期31卷 288-294页

作者： Er-hai An xiao-xia Li Cun-juan Yu ying-xin Tan Zi-jun fan Qing-xia Li Peng Deng Xiong Cao School of Environment and Safety Engineering North University of ChinaTaiyuan030051PR China College of Safety and Emergency Management Engineering Taiyuan University of Science and TechnologyTaiyuan030024PR China

Fe/N-based biomass porous carbon composite(Fe/N-p Carbon) was prepared by a facile high-temperature carbonization method from biomass,and the effect of Fe/N-p Carbon on the thermal decomposition of energetic molecular perovskite-based material DAP-4 was *** porous carbonaceous materials was considered as the micro/nano support layers for in situ deposition of Fe/N ***/Np Carbon was prepared simply by the high-temperature carbonization *** was found that it showed the inherent catalysis properties for thermal decomposition of *** heat release of DAP-4/Fe/N-p Carbon by DSC curves tested had increased slightly,compared from DAP-4/Fe/N-p *** decomposition temperature peak of DAP-4 at the presence of Fe/N-p Carbon had reduced by 79°C from384.4°C(pure DAP-4) to 305.4°C(DAP-4/Fe/N-p Carbon-3).The apparent activation energy of DAP-4thermal decomposition also had decreased by 29.1 J/*** possible catalytic decomposition mechanism of DAP-4 with Fe/N-p Carbon was proposed.

关键词： Biomass materials Porous carbon DAP-4 Thermal decomposition Facile method

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Prognostic significance and clinical relevance of Sprouty 2 protein expression in human hepatocellular carcinoma

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Hepatobiliary & Pancreatic Diseases International 2012年第2期11卷 177-184页

作者： Kang Song,Qiang Gao,Jian Zhou,Shuang-Jian Qiu,xiao-Wu Huang,xiao-ying Wang and Jia fan Liver Cancer Institute, Zhongshan Hospitaland Institute of Biomedical Sciences , Fudan University, Shanghai 200032, China Liver Cancer Institute Zhongshan Hospital Fudan University Shanghai 200032 China Institute of Biomedical Sciences Fudan University Shanghai 200032 China

BACKGROUND:In vitro experiments and mice models have confirmed the importance of Sprouty 2(Spry2) in inhibiting tumorigenesis and the progression of human ***,the prognostic value of Spry2 in cancer patients remains *** study is aimed to investigate the clinical relevance and prognostic significance of Spry2 expression in patients with hepatocellular carcinoma(HCC).METHODS:With samples from 240 randomly-selected HCC patients who underwent surgery,immunohistochemistry was used to investigate Spry2 expression on tissue *** correlation of Spry2 expression with survival was estimated by the Kaplan-Meier method and univariate/multivariate Cox proportional hazard regression ***2,ERK and phospho-ERK expression in HCC cell lines was detected by Western ***:Among the patients,86.3%(207 of 240) exhibited down-regulation of Spry2 *** negative for Spry2 showed poorer survival(P=0.002) and increased recurrence(P=0.003).Multivariate analysis further established Spry2 as an independent predictor of postoperative recurrence in HCC patients(HR=1.47;95% CI,1.02-2.08;P=0.037).Downregulation of Spry2 was associated with highly malignant phenotypes like vascular invasion and advanced tumor stages,and was positively correlated with the metastatic potential of HCC cell ***:In the era of molecular targeted therapy,the expression of Spry2 in HCC may have relevant clinical significance and turn out to be a key factor in prognostic assessment and in treatment planning.

关键词： hepatocellular carcinoma Sprouty 2 tumor suppressor prognosis

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Immediate Effect of Electro-acupuncture on Endometrial Blood Flow in Patients with Recurrent Implantation Failure:A Randomized Controlled Trial

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Chinese Journal of Integrative Medicine 2024年第4期30卷 291-298页

作者： LAI Yuan-yuan LIU Li-ying WU Yong-na HUANG Lei ZHENG xiao-yan GAN Di YU Si-yi ZHONG ying LIANG fan-rong ZHOU ying YANG Jie Acupuncture and Tuina School Chengdu University of Traditional Chinese MedicineChengdu(610032)China Sichuan Jinxin Xi'nan Women's and Children's Hospital Chengdu(610032)China Yuan TCM Wellness Pte.Ltd.(999002) Pulse TCM SingaporeSingapore

Objective To investigate the immediate effects of electro-acupuncture(EA)on endometrial blood flow among recurrent implantation failure(RIF)*** Eighty RIF patients,enrolled from March 2022 to December 2022,were randomly allocated into either the EA group(40 cases)or the waiting-list(WL)group(40 cases)by using a random number *** EA group underwent acupuncture at points of Shenting(GV 24),Baihui(GV 4),Benshen(GB 13),bilateral Zigong(EX-CA 1),Huangshu(KI 16),Sanyinjiao(SP 6)and Xuehai(SP10),and electric acupuncture apparatus was connected to EX-CA 1,KI 16,SP 6,and SP 10 with disperse-dense waves at 4/20 Hz frequencies for 30 min after transvaginal ultrasound,while the WL group received no *** primary outcome measured was the endometrial volume blood *** secondary outcomes included the bilateral uterine artery index,endometrial volume,endometrial blood flow type,vascular distribution index(VI^(MV))for endometrial and ovary,clinical pregnancy rate,and embryo implantation *** In the EA group,there was a notable decrease in the bilateral pulsatility index and a significant improvement in the endometrial blood flow type post-EA(P0.05).Besides,no adverse events related to EA were *** EA can promptly ameliorate VI^(MV) for the endometrial and right ovary,and endometrial blood flow *** randomized controlled trials are warranted to investigate the long-term effects of EA on blood flow of RIF patients and its implications for pregnancy outcomes.(Trial registration ***2200057377

关键词： electro-acupuncture recurrent implantation failure transvaginal ultrasound endometrial receptivityanalysis randomized controlledtrial

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Stretchable and self-healing conductive fibers from hierarchical silver nanowires-assembled network

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Nano Research 2024年第2期17卷 763-770页

作者： ying-ying Wu Hong Chen fan Zhang Pan Guo Haili Qin Huai-Ping Cong Anhui Province Key Laboratory of Advanced Catalytic Materials and Reaction Engineering School of Chemistry and Chemical EngineeringHefei University of TechnologyHefei 230009China

Conductive fibers(CFs)with features of high conductivity,stretchability,self-healability,and electromechanical stability are key components of the increasingly popular wearable ***,since the lack of structural design of conductive network and interfacial interaction between soft polymer and conductive additives,it is still hard to enable CFs to meet above ***,we describe a facial drawing method from a hydrogel reservoir which is remolded into ultrathin and stretchable CFs with excellent multi-responsive *** hydrogel reservoir was fabricated in synergy of an ice-templating method and in situ polymerization using the assembled framework as a *** on the effective fabrication mechanism,the diameter of CFs could be well-tuned from 90 to 400μm by adjusting the dipping depth of the glass rod,accompanied with conductivity increased from 0.75 to 2.5 S/*** the hierarchical network structure was well maintained in the CFs,professional performances have been proved on the stretchability and electromechanical *** presence of massive hydrogen bonding and Ag–S bond enabled the CFs with excellent self-healability under the conditions of contact,electric field,and near infrared light,***,the CFs with high sensing property could be integrated into an advanced textile sensor through an effective healing-induced integration strategy,demonstrating its great potentials as superior two-dimensional(2D)electronic skins.

关键词： conductive fibers self-assembled silver nanowires Ag–S coordination self-healing flexible sensors

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Construction and validation of a pancreatic cancer prognostic model based on genes related to the hypoxic tumor microenvironment

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World Journal of Gastroenterology 2024年第36期30卷 4057-4070页

作者： fan Yang Na Jiang xiao-Yu Li Xing-Si Qi Zi-Bin Tian ying-Jie Guo Department of Gastroenterology The Affiliated Hospital of Qingdao UniversityQingdao 266000Shandong ProvinceChina

BACKGROUND Pancreatic cancer is one of the most lethal malignancies,characterized by poor prognosis and low survival *** prognostic factors for pancreatic cancer offer inadequate predictive accuracy,often failing to capture the complexity of the *** hypoxic tumor microenvironment has been recognized as a significant factor influencing cancer progression and resistance to *** study aims to develop a prognostic model based on key hypoxia-related molecules to enhance prediction accuracy for patient outcomes and to guide more effective treatment strategies in pancreatic *** To develop and validate a prognostic model for predicting outcomes in patients with pancreatic cancer using key hypoxia-related *** This pancreatic cancer prognostic model was developed based on the expression levels of the hypoxia-associated genes CAPN2,PLAU,and *** results were validated in an independent *** study also examined the correlations between the model risk score and various clinical features,components of the immune microenvironment,chemotherapeutic drug sensitivity,and metabolism-related ***-time quantitative PCR verification was conducted to confirm the differential expression of the target genes in hypoxic and normal pancreatic cancer cell *** The prognostic model demonstrated significant predictive value,with the risk score showing a strong correlation with clinical features:It was significantly associated with tumor grade(G)(bP<0.01),moderately associated with tumor stage(T)(aP<0.05),and significantly correlated with residual tumor(R)status(bP<0.01).There was also a significant negative correlation between the risk score and the half-maximal inhibitory concentration of some chemotherapeutic ***,the risk score was linked to the enrichment of metabolism-related pathways in pancreatic *** The prognostic model based on hypoxia-related genes effectively predicts pancreati

关键词： Pancreatic cancer Hypoxia Prognostic model Immune microenvironment Metabolism pathway

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