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Development and validation of a predictive model for patients with post-extubation dysphagia

World Journal of Emergency Medicine 2023年第1期14卷 49-55页

作者： Jia-ying Tang Xiu-qin Feng xiao-xia huang Yu-ping Zhang Zhi-ting Guo Lan Chen Hao-tian Chen xiao-xiao ying Nursing Department the Second Affiliated Hospital of Zhejiang University School of MedicineHangzhou 310009China

BACKGROUND:Swallowing disorder is a common clinical symptom that can lead to a series of complications,including aspiration,aspiration pneumonia,and *** study aimed to investigate risk factors of post-extubation dysphagia(PED)in intensive care unit(ICU)patients with endotracheal intubation,and to develop a risk-predictive model for PED,which could serve as an assessment tool for the prevention and control of ***:Patients retrospectively selected from June to December 2021 in a tertiary hospital served as the derivation *** recruited from the same hospital from March to June 2022served as the external validation cohort for the predictive *** used a combination of variable screening and least absolute shrinkage and selection operator(LASSO)regression to select the most useful candidate predictors and checked the multicollinearity of independent variables using the variance inflation factor *** logistic regression analysis was performed to calculate the odds ratio(OR;95%confidence interval[95%CI])and P-value for each variable to predict *** screened risk factors were introduced into R software to build a nomogram *** performance of the model,including discrimination ability,calibration,and clinical benefit,was evaluated by plotting the receiver operating characteristic(ROC),calibration,and decision ***:A total of 305 patients were included in this *** them,235 patients(53PED vs.182 non-PED)were enrolled in the derivation cohort,while 70 patients(17 PED vs.53 nonPED)were enrolled in the validation *** independent predictors included age,pause of sedatives,level of consciousness,activities of daily living(ADL)score,nasogastric tube,sore throat,and voice *** predictors were used to establish the predictive nomogram *** model demonstrated good discriminative ability,and the area under the ROC curve(AUC)was 0.945(95%CI 0.904-0.970).Applying the predictive model

关键词： Post-extubation dysphagia Nomogram Predictive model

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Drought tolerance in three hybrid poplar clones submitted to different watering regimes

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Journal of Plant Ecology 2010年第2期3卷 79-87页

作者： xiao-Yun Guo Xin-Shi Zhang Zhen-ying huang State Key Laboratory of Vegetation and Environmental Change Institute of BotanyChinese Academy of SciencesBeijing 100093China Graduate University of Chinese Academy of Sciences Beijing 100049China

Aims Poplars grownin North Chinamay experience water-deficient periods in their life *** aim of the present paper was to quantify the response of three clones to different watering regimes and to determine whichcloneamongthe three is the best adapted to drought *** Three hybrid poplar clones(clone DN-34,R-247 and OP-367)were used in the present *** seedlings of the three clones were grown under four watering regimes:control(well watered,100%field water capacity(FC))and three drought treatments(drought stress I,50%FC;drought stress II,40%FC;drought stress III,30%FC).Changes in morphological,physical and biochemical indicators of the three hybrid poplar clones were *** Findings Drought treatment(50%,40%and 30%FC)decreased net photosynthetic rate(Pn),transpiration rate(Tr),stomatal conductance(gs),shoot height,total biomass and chlorophyll(Chl)content in all the three clones and it increased activities of antioxidant enzymes and free proline *** highest values of the above-mentioned morphological and physiological parameters were recorded in clone OP-367 under 30%FC,followed by clone DN-34 and *** leaf water content(RWC)and stem diameter(sd)markedly declined in clone R-247 and DN-34 under drought stress I,II and III,whereas RWC and sd declined in clone OP-367 only under drought stress II and *** OP-367 had more RWC and sd than DN-34 and *** the 30%FC induced an increase in the root-to-shoot ratio(rs)and water use efficiency(WUE)in all the three ***-367 was the most efficient clone in water absorption and use,for plants of the clone had the highest values of rs and *** data demonstrate that among the three clones,OP-367 was better able to maintain photosynthesis and growth and lower the damage caused by drought.

关键词： antioxidant enzyme drought tolerance growth hybrid poplar clone leaf gas exchange

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Photoinduced radical sulfur dioxide insertion with asymmetric cyclization of alkenes: accessing β-chiral sulfones bearing S-stereocentric cyclic sulfinamides

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Science China Chemistry 2025年第1期 257-263页

作者： Jiapian huang Chenxin Wang Xu Wang xiaoyu Zhou Wei xiao Jie Wu School of Pharmaceutical and Chemical Engineering & Institute for Advanced Studies Taizhou University State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic Chemistry Chinese Academy of Sciences School of Chemistry and Chemical Engineering Henan Normal University

The generation of various β-chiral sulfones bearing chiral cyclic sulfinamides through photoredox-catalyzed sulfur dioxide insertion with asymmetric radical cyclization is described. This method features a broad substrate scope and excellent stereospecificity. Computational studies reveal that the dispersion interaction between sulfinyl group and CH2SO2Ph group plays a crucial role in the stereoselectivity control.

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Insight into the magnetic behavior and magnetocaloric effect of a borophene monolayer

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Communications in Theoretical Physics 2023年第11期75卷 142-151页

作者： ying An Wei Wang Bo-wen xiao Si-yu huang Zhen-yao Xu School of Science Shenyang University of TechnologyShenyang 110870China School of Electrical Engineering Shenyang University of TechnologyShenyang110870China

The successful discovery of borophene has opened a new door for the development of 2D *** to its excellent chemical,electronic and thermal properties,borophene has shown considerable potential in supercapacitors,hydrogen storage and *** this paper,the thermodynamic characteristics and magnetocaloric effect of borophene are specifically studied using the Monte Carlo *** find that there is an opposite impact between the spin quantum number and the crystal field on the magnetization,magnetic susceptibility,specific heat and magnetic entropy of the ***,increasing the spin quantum number or decreasing the absolute value of the crystal field can improve the relative cooling power,the coercivity(h_(c)),and the remanence(M_(R))and the area of the loop.

关键词： borophene monolayer Ising model magnetic behavior magnetocaloric effect Monte Carlo method

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The Method and Experiment Research on Down-stroke Abrasive Belt Grinding under Micro Feeding for Noise Reduction Surface

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Journal of Bionic Engineering 2021年第4期18卷 958-973页

作者： ying Liu Shayu Song Guijian xiao Yi He Yun huang Shuai Liu Suolang Jiahua College of Mechanical and Vehicle Engineering Chongqing UniversityChongqing400044China

This paper proposes a down-stroke abrasive belt grinding under micro feeding for noise reduction ***,a physical model of processing under micro feeding for noise reduction structure was *** on the flexible contact characteristics of abrasive belt grinding and Hertz contact theory,a mathematical model suitable for this method was established,considering vibration and abrasive belt ***,a simulation analysis was carried ***,an experimental platform was built to analyze the influence of process parameters on surface roughness and surface microstructure,with the model ***,the propeller with pit structure was simulated,and the noise reduction performance of the propeller under this method and general abrasive belt grinding was compared and *** results show that the maximum error of the model based on proposed method does not exceed 10%,and the coincidence degree of the minimum error point can reach 90%at lower feed speed and higher linear velocity of the abrasive *** noise reduction effect of the propeller with pit-shaped surfaces can reach 35%.Through the above analysis,the proposed method can be used for the processing of noise reduction surfaces.

关键词： abrasive belt grinding noise reduction surface non-smooth surfaces micro feeding processing

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Modeling and monitoring of nonlinear multi-mode processes based on similarity measure-KPCA

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Journal of Central South University 2017年第3期24卷 665-674页

作者： WANG xiao-gang huang Li-wei ZHANG ying-wei College of Information Science and Engineering Northeastern University Shenyang 110819 China

A new modeling and monitoring approach for multi-mode processes is *** method of similarity measure(SM) and kernel principal component analysis(KPCA) are integrated to construct SM-KPCA monitoring scheme,where SM method serves as the separation of common subspace and specific *** with the traditional methods,the main contributions of this work are:1) SM consisted of two measures of distance and angle to accommodate process *** different monitoring effect involves putting on the different weight,which would simplify the monitoring model structure and enhance its reliability and robustness.2) The proposed method can be used to find faults by the common space and judge which mode the fault belongs to by the specific *** of algorithm analysis and fault detection experiments indicate the validity and practicability of the presented method.

关键词： process monitoring kernel principal component analysis (KPCA) similarity measure subspace separation

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Theoretical and numerical simulation study on jet formation and penetration of different liner structures driven by electromagnetic pressure

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Defence Technology（防务技术） 2021年第3期17卷 846-858页

作者： Jian-hao Dou Xin Jia Zheng-xiang huang xiao-hui Gu ying-min Zheng Bin Ma Qiang-qiang xiao School of Mechanical Engineering Nanjing University of Science and TechnologyNanjing210094JiangsuChina

The use of a shaped liner driven by electromagnetic force is a new means of forming jets. To study the mechanism of jet formation driven by electromagnetic force, we considered the current skin effect and the characteristics of electromagnetic loading and established a coupling model of "ElectriceMagnetic eForce" and the theoretical model of jet formation under electromagnetic force. The jet formation and penetration of conical and trumpet liners have been calculated. Then, a numerical simulation of liner collapse under electromagnetic force, jet generation, and the stretching motion were performed using an ANSYS multiphysics processor. The calculated jet velocity, jet shape, and depth of penetration were consistent with the experimental results, with a relative error of less than 10%. In addition, we calculated the jet formation of different curvature trumpet liners driven by the same loading condition and obtained the influence rule of the curvature of the liner on jet formation. Results show that the theoretical model and the ANSYS multiphysics numerical method can effectively calculate the jet formation of liners driven by electromagnetic force, and in a certain range, the greater the curvature of the liner is, the greater the jet velocity is.

关键词： Electromagnetic field Shaped charge jet formation Theoretical calculation Numerical simulation

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Enhance liquid nitrogen fracturing performance on hot dry rock by cyclic injection

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Petroleum Science 2023年第2期20卷 951-972页

作者： Chun-Yang Hong Rui-Yue Yang Zhong-Wei huang xiao-ying Zhuang Hai-Tao Wen xiao-Li Hu State Key Laboratory of Petroleum Resources and Prospecting China University of PetroleumBeijing102249China Chair of Computational Science and Simulation Technology Faculty of Mathematics and PhysicsLeibniz Universität HannoverHannover30167Germany

Producing complex fracture networks in a safe way plays a critical role in the hot dry rock (HDR) geothermal energy exploitation. However, conventional hydraulic fracturing (HF) generally produces high breakdown pressure and results only in single main fracture morphology. Furthermore, HF has also other problems such as the increased risk of seismic events and consuption of large amount of water. In this work, a new stimulation method based on cyclic soft stimulation (CSS) and liquid nitrogen (LN2) fracturing, known as cyclic LN2 fracturing is explored, which we believe has the potential to solve the above issues related to HF. The fracturing performances including breakdown pressure and fracture morphology on granites under true-triaxial stresses are investigated and compared with cyclic water fracturing. Cryo-scanning electron microscopy (Cryo-SEM) tests and X-ray computed tomography (CT) scanning tests were used for quantitative characterization of fracture parameters and to evaluate the cyclic LN2 fracturing performances. The results demonstrate that the cyclic LN2 fracturing results in reduced breakdown pressure, with between 21% and 67% lower pressure compared with using cyclic water fracturing. Cyclic LN2 fracturing tends to produce more complex and branched fractures, whereas cyclic water fracturing usually produces a single main fracture under a low number of cycles and pressure levels. Thermally-induced fractures mostly occur around the interfaces of different particles. This study shows the potential benefits of cyclic LN2 fracturing on HDR. It is expected to provide theoretical guidance for the cyclic LN2 fracturing application in HDR reservoirs.

关键词： Hot dry rock Liquid nitrogen fracturing Cyclic injection Thermal stress Fatigue damage

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Horticultural Plant Journal 2023年第4期9卷 826-836页

作者： Bingqian Han Songyi huang Guilian huang Xin Wu Haixiang Jin ying Liu Yiqiang xiao Renchao Zhou State Key Laboratory of Biocontrol and Guangdong Provincial Key Laboratory of Plant Resources School of Life SciencesSun Yat-sen UniversityGuangzhouGuangdong 510275China School of Architecture South China University of TechnologyGuangzhouGuangdong 510640China Guangzhou Landscaping Company GuangzhouGuangdong 510440China

Ceiba species have high ornamental value and are widely cultivated in tropical ***,genetic background of cultivated Ceiba plants remains *** understand the genetic relatedness of cultivated Ceiba plants and genetic basis of key horticultural traits,here we explored the genetic relatedness of 153 accessions of Ceiba plants cultivated in Southern China and identified SNPs associated with five horticultural traits,based on 11704 SNPs derived from double-digest restriction-site associated DNA sequencing(ddRAD-seq).Clustering analysis revealed that these accessions were composed of three groups:*** group,*** group,and hybrid *** GWAS identified two,four,two,three,and four SNPs related to petal color,petal striation number,flowering time,trunk shape,and prickles on the trunk and branches,*** to two candidate genes were found near the SNPs strongly associated with these *** study revealed the genetic relatedness in the Ceiba plants cultivated in Southern China and presented the first GWAS analysis for five horticultural traits for them,laying a foundation for phenotype-related marker selection and molecular breeding.

关键词： Ceiba Horticultural traits ddRAD-seq Genetic relatedness GWAS Candidate gene

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Age and mean platelet volume-based nomogram for predicting the therapeutic efficacy of metoprolol in Chinese pediatric patients with vasovagal syncope

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World Journal of Pediatrics 2024年第9期20卷 957-965页

作者： xiao-Juan Du Ya-Qian huang Xue-ying Li ying Liao Hong-Fang Jin Jun-Bao Du Department of Pediatrics Peking University First HospitalNo.1 Xi’anmen StreetWest DistrictBeijing100034China State Key Laboratory of Vascular Homeostasis and Remodeling Peking UniversityNo.38Xueyuan RoadHaidian DistrictBeijing100191China Department of Statistics Peking University First HospitalBeijing100034China

Background Vasovagal syncope(VVS)is the most common type of orthostatic intolerance in *** investigated whether platelet-related factors related to treatment efficacy in children suffering from VVS treated with *** Metoprolol-treated VVS patients were *** median duration of therapy was three *** were followed and divided into two groups,treament-effective group and treatment-ineffective *** and least absolute shrinkage selection operator regressions were used to examine treatment outcome ***-operating characteristic(ROC)curves,precision-recall(PR)curves,calibration plots,and decision curve analyses were used to evaluate the nomogram *** Among the 72 patients who complete the follow-up,treatment-effective group and treatment-ineffective group included 42(58.3%)and 30(41.7%)cases,*** patients in the treatment-effective group exhibited higher mean platelet volume(MPV)[(11.0±1.0)fl vs.(9.8±1.0)fl,P<0.01]and platelet distribution width[12.7%(12.3%,14.3%)vs.11.3%(10.2%,12.2%),P<0.01]than those in the treatment-ineffective *** sex ratio was significantly different(P=0.046).A fit model comprising age[odds ratio(OR)=0.766,95%confidence interval(CI)=0.594-0.987]and MPV(OR=5.613,95%CI=2.297-13.711)might predict therapeutic *** area under the curve of the ROC and PR curves was computed to be 0.85 and 0.9,*** P value of the Hosmer-Lemeshow test was *** decision curve analysis confirmed that managing children with VVS based on the predictive model led to a net advantage ranging from 0.01 to *** nomogram is convenient for clinical *** A novel nomogram based on age and MPV can predict the therapeutic benefits of metoprolol in children with VVS.

关键词： Metoprolol Nomogram Retrospective study Therapeutic effect Vasovagal syncope

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