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Coordination-reduction leaching process of ion-adsorption type rare earth ore with ascorbic acid

Journal of Rare Earths 2023年第8期41卷 1225-1233,I0004页

作者： Jinfa Chen Jiang Qiu Li huang Xin Chen ying Yang Yanfei xiao Faculty of Materials Metallurgy and Chemistry Jiangxi University of Science and TechnologyGanzhou 341000China Ganzhou Engineering Technology Research Center of Green Metallurgy and Process Intensification Ganzhou 341000China Key Laboratory of Ionic Rare Earth Resources and Environment Ministry of Natural ResourcesGanzhou 341000China Key Laboratory of Testing and Tracing of Rare Earth Products for State Market Regulation Ganzhou 341000China

The magnesium sulfate(MgSO_(4))-ascorbic acid(Vc)compound leaching technique can extract rare earth elements(REEs)existing in ion-exchangeable phase and colloidal phase from ion-adso rption type rare earth ore through the synergy effect of coordination and reduction,but its reaction process and mechanism remain *** this paper,the coordination-reduction leaching mechanism was analyzed from the perspectives of leaching thermodynamics and kinetics,which provide theoretical guidance for the compound leaching *** the case of neodymium,about 45%of dissolved neodymium will exist as the complex species of NdVc_(()3(aq))in Nd-Vc-sulfate *** on this,it is deduced that the Gibbs free energy of the leaching reaction of ion-exchangeable phase REEs will change to a more negative value through the coordination of REEs cations and Vc anions in the MgSO_(4)leaching *** addition,the E_(h)-pH diagrams of Ce-SO_(4)^(2-)-H_(2)O and Fe-SO_(4)^(2-)-H_(2)O together with the dissolution experiments confirm that the added Vc initiates the leaching process of colloidal phase REEs through reduction-dissolution *** the study of leaching kinetics,the leaching of REEs is controlled by diffusion and chemical reaction in the co mpound leaching system since colloidal phase REEs are ***,the addition of Vc can shift the leaching equilibrium to a more favorable state and accelerate leaching *** rare earth leaching efficiency of ion-exchangeable phase and colloidal phase can be effectively improved by increasing the reaction temperature,the conce ntrations of leaching agent and Vc,and the leaching agent acidity.

关键词： Ion-adsorption type rare earth ore Ascorbic acid Coordination Reduction Leaching Mechanism

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Defect band formation in high pressure die casting AE44 magnesium alloy

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China Foundry 2022年第3期19卷 201-210页

作者： ying-ying Hou Meng-wu Wu Feng huang xiao-bo Li Shou-mei Xiong Hubei Key Laboratory of Advanced Technology for Automotive Components Wuhan University of TechnologyWuhan 430070China School of Materials Science and Engineering Tsinghua UniversityBeijing 100084China

The characteristics of defect bands in the microstructure of high pressure die casting(HPDC)AE44 magnesium alloy were *** attention was paid to the effects of process parameters during the HPDC process and casting structure on the distribution of defect *** show that the defect bands are solute segregation bands with the enrichment of Al,Ce and La elements,which are basically in the form of Al_(11)RE_(3) *** is no obvious aggregation of porosities in the defect *** width of the inner defect band is 4-8 times larger than that of the outer *** variation trends of the distribution of the inner and outer defect bands are not consistent under different process parameters and at different locations of *** is due to the discrepancy between the formation mechanisms of double defect *** filling and solidification behavior of the melt near the chilling layer is very complicated,which finally leads to a fluctuation of the width and location of the outer defect *** affecting the content and aggregation degree of externally solidified crystals(ESCs)in the cross section of die castings,the process parameters and casting structure have a great influence on the distribution of the inner defect band.

关键词： high pressure die casting magnesium alloy AE44 defect band microstructure

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Exploration of Artificial-intelligence Oriented Power System Dynamic Simulators

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Journal of Modern Power Systems and Clean Energy 2023年第2期11卷 401-411页

作者： Tannan xiao ying Chen Jianquan Wang Shaowei huang Weilin Tong Tirui He Department of Electrical Engineering Tsinghua UniversityBeijing 100084China College of Electrical Engineering Zhejiang UniversityHangzhou 310027China Wuxi Power Supply Company of State Grid Wuxi 214125China

With the rapid development of artificial intelligence(AI),it is foreseeable that the accuracy and efficiency of dynamic analysis for future power system will be greatly improved by the integration of dynamic simulators and *** explore the interaction mechanism of power system dynamic simulations and AI,a general design for AI-oriented power system dynamic simulators is proposed,which consists of a high-performance simulator with neural network supportability and flexible external and internal application programming interfaces(APIs).With the support of APIs,simulation-assisted AI and AIassisted simulation form a comprehensive interaction mechanism between power system dynamic simulations and AI.A prototype of this design is implemented and made public based on a highly efficient electromechanical *** of this prototype are carried out in four scenarios including sample generation,AI-based stability prediction,data-driven dynamic component modeling,and AI-aided stability control,which prove the validity,flexibility,and efficiency of the design and implementation for AI-oriented power system dynamic simulators.

关键词： Power system dynamic simulator artificial intelligence application programming interface parallel computing

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Pharmacological targeting cGAS/STING/NF-κB axis by tryptanthrin induces microglia polarization toward M2 phenotype and promotes functional recovery in a mouse model of spinal cord injury

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Neural Regeneration Research 2025年第11期20卷 3287-3301页

作者： Ziwei Fan Mengxian Jia Jian Zhou Zhoule Zhu Yumin Wu xiaowu Lin Yiming Qian Jiashu Lian Xin Hua Jianhong Dong Zheyu Fang Yuqing Liu Sibing Chen Xiumin Xue Juanqing Yue Minyu Zhu ying Wang Zhihui huang Honglin Teng Department of Orthopedics(Spine Surgery) the First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang ProvinceChina School of Pharmacy Hangzhou Normal UniversityHangzhouZhejiang ProvinceChina Department of Neurology The First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang ProvinceChina Department of Pathology Affiliated Hangzhou First People’s HospitalSchool of MedicineWestlake UniversityHangzhouZhejiang ProvinceChina Department of Clinical Research Center Affiliated Hangzhou First People’s HospitalSchool of MedicineWestlake UniversityHangzhouZhejiang ProvinceChina

The M1/M2 phenotypic shift of microglia after spinal cord injury plays an important role in the regulation of neuroinflammation during the secondary injury phase of spinal cord *** of shifting microglia polarization from M1(neurotoxic and proinflammatory type)to M2(neuroprotective and anti-inflammatory type)after spinal cord injury appears to be *** possesses an anti-inflammatory biological ***,its roles and the underlying molecular mechanisms in spinal cord injury remain *** this study,we found that tryptanthrin inhibited microglia-derived inflammation by promoting polarization to the M2 phenotype in *** promoted M2 polarization through inactivating the cGAS/STING/NF-κB ***,we found that targeting the cGAS/STING/NF-κB pathway with tryptanthrin shifted microglia from the M1 to M2 phenotype after spinal cord injury,inhibited neuronal loss,and promoted tissue repair and functional recovery in a mouse model of spinal cord ***,using a conditional co-culture system,we found that microglia treated with tryptanthrin suppressed endoplasmic reticulum stress-related neuronal *** together,these results suggest that by targeting the cGAS/STING/NF-κB axis,tryptanthrin attenuates microglia-derived neuroinflammation and promotes functional recovery after spinal cord injury through shifting microglia polarization to the M2 phenotype.

关键词： cGAS/STING functional recovery microglia neuroinflammation neuroprotection nuclear factor-κB polarization spinal cord injury tryptanthrin

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Outcomes of catheter-directed thrombolysis versus systemic thrombolysis in the treatment of pulmonary embolism: a metaanalysis

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Journal of Geriatric Cardiology 2023年第6期20卷 459-468页

作者： huang-Tai MIAO ying LIANG xiao-ying LI xiao WANG Hui-Juan ZUO Zhe-Chun ZENG Shao-Ping NIE Center for Coronary Artery Disease Beijing Anzhen HospitalCapital Medical UniversistyBeijingChina Emergency&Critical Care Center Beijing Anzhen HospitalCapital Medical UniversityBeijingChina Department of Health Care for Cadres Beijing Jishuitan HospitalBeijingChina Department of Clinical&Community Cardiovascular Disease Prevention Beijing Institute of Heart Lung and Blood Vessel DiseaseBeijing Anzhen HospitalCapital Medical UniversityBeijingChina

OBJECTIVE To evaluate the safety and efficacy of catheter-directed thrombolysis(CDT)versus systemic thrombolysis(ST)in the treatment of pulmonary embolism(PE).METHODS The Cochrane Library,PubMed,and Embase databases were searched to collect the literature on the comparison of the results of CDT and ST in the treatment of PE from the beginning of their records to May 2020,and meta-analysis was performed by STATA software(version 15.1).Using standardized data-collection forms,the authors screened the studies and independently extracted data,and assessed the quality of the studies using the Newcastle-Ottawa Scale for cohort *** studies that examined the following results were included in the current study:in-hospital mortality,all-cause bleeding rate,gastrointestinal bleeding rate,intracranial hemorrhage rate,the incidence of shock,and hospital length of *** A total of eight articles,with 13,242 participants,involving 3962 participants in the CDT group and 9280 participants in the ST group were *** compared with ST in the treatment of PE can significantly affect in-hospital mortality rate[odds ratio(OR)=0.41,95%CI:0.30–0.56,P<0.05],all-cause bleeding rate(OR=1.20,95%CI:1.04–1.39,P=0.012),gastrointestinal bleeding rate(OR=1.43,95%CI:1.13–1.81,P=0.003),the incidence of shock(OR=0.46,95%CI:0.37–0.57,P<0.05),and hospital length of stay[standard mean difference(SMD)=0.16,95%CI:0.07–0.25,P<0.05].However,there was no significant effect on intracranial hemorrhage rate in patients with PE(OR=0.70,95%CI:0.47–1.03,P=0.070).CONCLUSIONS CDT is a viable alternative to ST in the treatment of PE,as it can significantly reduce in-hospital mortality rate,all-cause bleeding rate,gastrointestinal bleeding rate,and incidence of ***,CDT may prolong hospital length of stay to a certain *** research is needed to evaluate the safety and efficacy of CDT and ST in the treatment of acute PE and other clinical outcomes.

关键词： thrombolysis mortality treatment

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Current status of screening, diagnosis, and treatment of neonatal congenital heart disease in China

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World Journal of Pediatrics 2018年第4期14卷 313-314页

作者： xiao-Jing Ma Guo-ying huang Heart Center Children’s Hospital of Fudan University399 Wanyuan RoadShanghai 201102China National Children’s Medical Center 399 Wanyuan RoadShanghai 201102China Shanghai Key Lab of Bir th Defects 399 Wanyuan RoadShanghai 201102China

Congenital heart disease (CHD) has become the most com-mon birth defect in China. According to the 'Report on the Prevention and Control of Birth Defects in China (2012)' [ 1 ], in 2011, the prevalence of CHD was 4.095 of every 1000 live births, which accounted for the first place in all birth defects in recent years. Because of the large population base in China, the number of new cases of CHD per year is huge. It is estimated that more than 130 thousand patients with CHD will be added per year in China. According to another study reported in 2014, CHD was present in 8.94 of every 1000 live births in China, among which, the incidence of critical CHD (CCHD), causing death or requiring invasive intervention during the first month of life, was 2.91‰ [ 2 ].

关键词： Current status screening diagnosis treatment of neonatal congenital heart disease

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监狱警察工作倦怠、心理健康及两者的关系

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山东精神医学 2005年第4期18卷 235-237页

作者：李岩段晓英黄慧王存文上海大学法学院 03级研究生201701 上海政法学院 201701

目的了解监狱警察的工作倦怠、心理健康状况及两者的关系。方法采用李超平、时勘修订的Maslach倦怠量表—通用版(MBI-GS)、症状自评量表(SCL-90)对506名监狱警察进行调查。结果不同教育程度的干警在玩世不恭方面有显著差异;不同年龄组... 详细信息

目的了解监狱警察的工作倦怠、心理健康状况及两者的关系。方法采用李超平、时勘修订的Maslach倦怠量表—通用版(MBI-GS)、症状自评量表(SCL-90)对506名监狱警察进行调查。结果不同教育程度的干警在玩世不恭方面有显著差异;不同年龄组、不同工作年限干警在玩世不恭和职业效能方面有显著差异;被试在SCL-90量表上有五个因子分数高于常模,一个因子分低于常模;情绪衰竭和玩世不恭两个维度与SCL-90各因子显著相关。结论青年干警是工作倦怠的重点预防和干预对象,心理健康水平的提高和工作倦怠的降低密切联系。

关键词：监狱警察工作倦怠心理健康

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冠心病、高血压病患者血清高密度脂蛋白-胆固醇及其他脂质含量的分析

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武汉医学院学报 1984年第1期 26-29页

作者：肖瑛朱志佐黄永章熊秀敏武汉医学院郧阳分院生化教研室

本文测定了183名健康人,52名冠心病和56名高血压患者血清总胆固醇(TC)、高密度脂蛋白-胆固醇(HDL-C)、甘油三酯(TG)含量。冠心病组HDL-C、HDL-C/LDL-C、HDL-C/TC值显著低于健康组(P<0.001)。提示HDL-C为冠心病的“危险降低因子”。高血... 详细信息

本文测定了183名健康人,52名冠心病和56名高血压患者血清总胆固醇(TC)、高密度脂蛋白-胆固醇(HDL-C)、甘油三酯(TG)含量。冠心病组HDL-C、HDL-C/LDL-C、HDL-C/TC值显著低于健康组(P<0.001)。提示HDL-C为冠心病的“危险降低因子”。高血压病组HDL-C/TC、HDL-C/LDL-C比值显著低于健康组,HDL-C差异不显著。不论TG浓度高、中、低,冠心病发病率均与HDL-C/TC及HDL-C/LDL-C比值呈负相关,与HDL-C呈不规律现象。提示作为冠心病早期预测指标,HDL-C/TC、HDL-C/LDL-C比值比HDL-C及其他脂质水平更有实用价值。

关键词：冠心病患者 LDL TC HDL 高血压病患者脂质含量胆固醇胆甾醇

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Relationship Between Polymorphism of Cystathionine beta Synthase Gene and Congenital Heart Disease in Chinese Nuclear Families

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Biomedical and Environmental Sciences 2006年第6期19卷 452-456页

作者： xiao-MING SONG xiao-ying ZHENG WEN-LI ZHU LEI huang YONG LI Department of Nutrition and Food Hygiene School of Public Health Laboratory of Molecular Toxicology and Developmental Molecular Biology Peking University Beijing 100083 China Institute of Population Research Peking University Beijing 100871 China.

Objective To study the relationship between polymorphism of cystathionine beta synthase （CBS） gene and development of congenital heart disease （CHD）. Methods One hundred and twenty-seven CHD case-parent triads were recruited from Liaoning Province as patient group, and 129 healthy subjects without family history of birth defect were simultaneously recruited as control group together with their biological parents. For all subjects the polymorphism of CBS gene G919A locus was examined by PCR-ARMS method, Results The frequencies of three genotypes （w/w, w/m, and m/m） in control group were 27.2%, 58,4%, and 14.4%, respectively, with no significant difference in gender. A significant difference in the allele frequency was found between CHD patients and controls, the wild allele frequency was 67,9% in patients and 55.7% in controls CHD parents＇ genotype distribution was significantly different from that in controls. Further comparison of each type of CHD showed that genotype frequencies in several CHD subtypes were significantly different from those in their corresponding controls. The results of TDT analysis showed that no allele transmission disequilibrium existed in CHD nuclear families. Conclusions CBS gene G919A mutation is associated with the development of CHD, and the mutated allele may decrease the risk of CHD.

关键词： Congenital heart disease Gene polymorphism Cystathionine beta synthase Case-control family study

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前列腺癌骨转移的临床诊断:MRI与同位素骨扫描的比较

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实用放射学杂志 2007年第4期23卷 500-504页

作者：何静王霄英黄嵘李飞宇许玉峰蒋学祥北京大学第一医院医学影像科北京大学深圳医院放射科北京大学第一医院医学影像科北京100034

目的比较盆腔MRI和全身骨扫描对前列腺癌骨转移的临床诊断效能。方法收集183例前列腺疾病患者的资料,包括盆腔MRI和全身骨扫描检查结果。根据临床综合诊断结果,将所有患者分为骨转移组和非骨转移组。对获得的资料进行统计学分析。结果①... 详细信息

目的比较盆腔MRI和全身骨扫描对前列腺癌骨转移的临床诊断效能。方法收集183例前列腺疾病患者的资料,包括盆腔MRI和全身骨扫描检查结果。根据临床综合诊断结果,将所有患者分为骨转移组和非骨转移组。对获得的资料进行统计学分析。结果①183例患者中,37例确诊临床骨转移,146例无临床骨转移。37例骨转移患者的转移灶位置,5例位于盆腔内,3例位于盆腔外,29例位于盆腔内外。②盆腔MRI检查诊断24例骨转移,均经临床综合评价确诊为骨转移(100%,24/24)。全身骨扫描诊断27例骨转移,96.4%(27/28)经临床综合评价确诊为骨转移。其它骨转移的确诊均经临床综合诊断。③将盆腔MRI和同位素骨扫描的结果进行比较,盆腔MRI检查未见明确骨转移灶的患者共159例,其中仅有4例患者(4/159,2.52%)全身骨扫描可明确诊断骨转移。④评价2种影像检查方法对全身骨转移的预测和诊断效果,盆腔MRI对全身骨转移预测的敏感性、特异性和准确性分别为78.38%、87.0%和85.25%;全身骨扫描对骨转移的诊断敏感性、特异性和准确性分别为94.59%、62.33%和68.85%。MRI的特异性和准确性高于同位素骨扫描(χ2=23.458,P=0.000;χ2=13.906,P=0.000),同位素骨扫描的敏感性高于MRI(χ2=4.163,P=0.041)。结论盆腔MRI也可用作前列腺癌全身骨转移的诊断。当盆腔MRI检查未见骨转移灶时,发生全身骨转移的机会较低。

关键词：前列腺癌骨转移磁共振成像骨扫描

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