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Analysis of the anti-T2DM components in dichloromethane fraction of Schisandra sphenanthera and its mechanism

Traditional Medicine Research 2025年第1期10卷 27-43页

作者： Shi-Bo Feng Hai-Hui Jiang Hui-Li Kang yi Jiang Hua-Wei Zhang xiao-Mei Song Yu-Ze Li Wen-Li Huang Dong-Dong Zhang Chong Deng School of Pharmacy Shaanxi University of Chinese MedicineXianyang 712046China School of Pharmacy and Shaanxi Qinling Application Development and Engineering Center of Chinese Herbal Medicine Shaanxi University of Chinese MedicineXianyang 712046China Key Laboratory for Research and Development of“Qin Medicine”of Shaanxi Administration of Traditional Chinese Medicine Xianyang 712046China Shaanxi Key Laboratory of Research and Application of“Taibai Qi Yao” Xianyang 712046China

Background:The type 2 diabetes mellitus(T2DM)pharmacodynamic study of various parts of Schisandra sphenanthera was conducted in the previous stage,and it was found that dichloromethane extracted part(SDP)had a significant hypoglycemic ***,the components of SDP were analyzed,and the specific mechanism of its anti-T2DM was ***:We used a high-fat,high-sugar diet in combination with streptozotocin to induce a T2DM rat model,and the model rats were divided into two groups according to body weight and blood ***,oral glucose tolerance test,fasting blood glucose,low density lipoprotein cholesterol,superoxide dismutase,insulin,glycated hemoglobin,total cholesterol,nonesterified free fatty acids,alanine aminotransferase,high-density lipoprotein cholesterol,aspartate aminotransferase,malondialdehyde,and glutathione peroxidase were measured,organ indices were calculated,and pathological sections of pancreas and liver were *** 16S rRNA V3–V4 region of intestinal flora was sequenced to explore the effect of SDP on biochemical indicators and intestinal *** on the above indicators,the anti-T2DM mechanism of SDP in Schisandra sphenanthera was ***:After six weeks of administration,the biochemical indices of diabetic rats were diminished compared to the control *** SDP could significantly increase the gut microbialα-diversity index,resulting in significant changes in the flora of T2DM rats,with increased richness and diversity,reduced harmful flora,and significantly back-regulated the levels of acetic acid,propionic acid,and butyric ***:SDP can improve the symptoms associated with elevated blood glucose,dyslipidemia,elevated fasting insulin levels,and damaged glucose tolerance in *** against T2DM may be through the control of intestinal flora to normalize and exert anti-diabetic effect;its main active components may be lignans and terpenoids.

关键词： Schisandra sphenanthera T2DM intestinal flora HPLC

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Using a fretsaw in treating chronic penial incarceration:A case report

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World Journal of Clinical Cases 2022年第2期10卷 747-752页

作者： yi Zhao xiao-Qiang Xue hou-Feng Huang yi Xie Zhi-Gang Ji Xin-Rong Fan Department of Urology Peking Union Medical College HospitalBeijing 100730China

BACKGROUND Penial incarceration(PI)is a rare *** is usually caused by a foreign object which strangulates at the base of the *** may derive from pranks,sexual demand,mental disease,or intention to prohibit urinary ***,these situations are emergent and immediate treatments are *** of chronic PI are less reported,and their treating methods are yet to be *** SUMMARY We reported a case on treating a 73-year-old male who had PI with a metallic hoop for three *** multidisciplinary consultation,the operation was performed successfully with the help of a *** the chronic strangulation,the prognosis of the patient was *** the best of our knowledge,this case was rare and precious as it featured the longest strangulating time,which might enlighten the treating process of future PI ***,we have reviewed and summarized major published cases to encapsulate appropriate approaches when facing diverse strangulation *** The selection of surgical tools depends on the material of the strangulating objects,the availability of equipment,and the severity of the penial *** urination function may not be affected after three months of incarceration as in our case,whilst prudent preoperative measures and multidisciplinary evaluations are always *** using a fretsaw is comparatively slow,it is safe and feasible to treat metallic penial incarceration.

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China's Energy Consumption Forecasting by GMDH Based Auto-Regressive Model

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Journal of Systems Science & Complexity 2017年第6期30卷 1332-1349页

作者： XIE Ling xiao Jin HU yi ZHAO Hengjun xiao yi Business School Sichuan University School of Economics and Management University of Chinese Academy of Sciences School of Economics and Management Sichuan Radio and TV University School of Information Management Central China Normal University

It is very significant for us to predict future energy consumption accurately. As for China's energy consumption annual time series, the sample size is relatively small. This paper combines the traditional auto-regressive model with group method of data handling(GMDH) suitable for small sample prediction, and proposes a novel GMDH based auto-regressive(GAR) model. This model can finish the modeling process in self-organized manner, including finding the optimal complexity model, determining the optimal auto-regressive order and estimating model parameters. Further, four different external criteria are proposed and the corresponding four GAR models are constructed. The authors conduct empirical analysis on three energy consumption time series, including the total energy consumption, the total petroleum consumption and the total gas consumption. The results show that AS-GAR model has the best forecasting performance among the four GAR models, and it outperforms ARIMA model, BP neural network model, support vector regression model and GM(1, 1) ***, the authors give the out of sample prediction of China's energy consumption from 2014 to 2020 by AS-GAR model.

关键词： Auto-regressive model energy demand prediction GMDH small sample forecasting

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Stark splitting of intense red emission for Er^(3+)in O_(h) symmetry sites realizing optical temperature sensing in biological applications

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Rare Metals 2024年第3期43卷 1263-1274页

作者： Yue Guo Lin-Jun Qin Jing Xu xiao-Ping Jiang xiao-Yu Yue yi hou Hao Shi Li-Xi Wang Qi-Tu Zhang Collage of Materials Science and Engineering Nanjing Tech UniversityNanjing211816China Jiangsu Collaborative Innovation Center for Advanced Inorganic Function Composites Nanjing211816China

Optical temperature sensing based on the fluorescence intensity ratio(FIR)of red emission for lanthanide ions holds significant relevance in non-contact temperature measurement for biological *** this study,the perovskite-structured KZnF_(3)is utilized as a host material for Er^(3+)to achieve a high-purity upconversion(UC)red *** observed Stark splitting of the red emission peak provides evidence of the energy level splitting of Er^(3+).Group theory is employed to decompose the spectral branching of Er^(3+)under the point group symmetry of KZnF_(3),allowing for the derivation of Stark splitting energy levels induced by the crystal field *** optical temperature-sensing behavior of the red UC luminescence was investigated,specifically examining the FIR of the splitting sub-peaks,which exhibited an exponential relationship with *** KZnF_(3):Yb^(3+),Er^(3+)demonstrated a relative sensitivity(S_(r))of 0.00182%·K^(-1)at 298 K,highlighting its excellent response to *** vivo bio-thermometry experiments conducted on chicken breast validated the material's ability to penetrate biological tissues and showed its significant sensitivity of the FIR to *** results establish KZnF_(3):Yb^(3+),Er^(3+)as a promising material for optical thermometry in various biological applications.

关键词： KZnF_(3) Er^(3+) Upconversion luminescence Stark splitting Temperature sensing

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Solution-Processed Silver Nanowire as Flexible Transparent Electrodes in Organic Solar Cells

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Chinese Journal of Chemistry 2021年第8期39卷 2315-2329页

作者： yi Yang Bowei Xu Jianhui hou State Key Laboratory of Polymer Physics and Chemistry Beijing National Laboratory for Molecular SciencesInstitute of ChemistryChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China

Organic solar cells(OSCs)have attracted much attention due to their advantages in fabricating flexible and semi-transparent ***,the light weight,flexibility and spectral adjustability make OSCs superior to silicon,perovskite and other thin film based solar cells in applications of integrated photovoltaic devices and wearable *** flexible and semi-transparent OSCs,transparent conducting electrodes(TCEs)play a key role in obtaining high *** various TCEs,silver1 n anowire(AgNW)has become a promisi ng can didate due to its low sheet resistance,high optical transparency,excellent mechanical flexibility and solution *** this article,we review the recent advances in AgNW-based TCEs and their applications in the field of ***,we introduce the general properties of AgNW including optoelectronic and mechanical ***,the preparation methods of AgNW are discussed,along with some approaches on the optimization of AgNW to overcome the shortcomings of ***,we discuss the applications of AgNW as TCEs in fabricating flexible and semi-transparent OSCs,including the use of AgNW as bottom and top ***,we point out the challenges in AgNW-based TCEs and suggest several guidelines for preparing AgNW so as to meet the demands for the practical use of OSCs.

关键词： Silver Nanostructures Conducting materials Electrode Organic solar cells

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Continental chemical weathering during the Early Cretaceous Oceanic Anoxic Event(OAE1b): a case study from the Fuxin fluvio-lacustrine basin, Liaoning Province,NE China

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Journal of Palaeogeography 2020年第2期9卷 246-266页

作者： xiao-Tao Xu Long-yi Shao Bo Lan Shuai Wang Jason Hilton Jian-yi Qin Hai-Hai hou Jie Zhao College of Geoscience and Surveying Engineering China University of Mining and Technology(Beijing)Beijing 100083China Shandong Key Laboratory of Depositional Mineralization&Sedimentary Mineral Shandong University of Science and TechnologyQingdao 266590China Northeast China Coalfield Geology Bureau 107 Exploration Team Fuxin 123000China School of Geography Earth and Environmental SciencesUniversity of BirminghamEdgbastonBirmingham B152TTUK College of Mining Liaoning Technical UniversityFuxin 123000China.

This study focuses on Early Cretaceous mudstones from the Shahai and Fuxin formations in the Fuxin continental basin. We analyse chemical weathering, land surface temperatures and palaeoclimates based on chemical weathering indices, and emphasize the implications of continental chemical weathering on nutrient fluxes into lakes and *** to Cr and Ni abundance, Al2O3-TiO2, La/Sc-Th/Co and V-Ni-Th×10 plots, as well as rare earth element(REE)analysis, mudstone samples from the Shahai and Fuxin formations were derived from the same type of provenance comprising mainly felsic igneous rocks. Chemical weathering trends reflected by the Chemical Index of Alteration(CIA),Weathering Index of Parker(WIP) and the Mafic Index of Alteration for Oxidative weathering environments(MIA(O)) are consistent with each other and allow the geological succession to be divided into four stages. Land surface temperatures of the Shahai and Fuxin formations are estimated based on the linear relationship of CIA to temperature,and also can be divided into four stages consistent with those determined from chemical weathering trends. During Stage A(early part of the late Aptian) chemical weathering and land surface temperatures were relatively low and showed characteristic high fluctuations, while Stage B(latest Aptian) represented a transitional period where weathering rates and temperatures increased, and high amplitude fluctuations continued. Conditions changed markedly in Stage C(early Albian) with very high and stable weathering, and warm, humid climates, while in Stage D(middle and late Albian) conditions returned to low chemical weathering and land surface temperatures. These stages of chemical weathering and land surface temperature fluctuations represent responses to global climate fluctuations during the Early Cretaceous, with the early Albian high weathering intensities and warm, humid climates combining to create high nutrient levels that would have flushed through rivers int

关键词： Chemical weathering indices Land surface temperature Mudstone Greenhouse conditions Ocean Anoxic Event 1 b Black shales

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Molecular characterization of the SAUR gene family in sweet cherry and functional analysis of PavSAUR55 in the process of abscission

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Journal of Integrative Agriculture 2023年第6期22卷 1720-1739页

作者： hou Qian-dong HONG yi WEN Zhuang SHANG Chun-qiong LI Zheng-chun CAI xiao-wei QIAO Guang WEN xiao-peng Key Laboratory of Plant Resource Conservation and Germplasm Innovation in Mountainous Region(Ministry of Education) College of Life Sciences/Institute of Agro-bioengineeringGuizhou UniversityGuiyang 550025P.R.China College of Forestry/Institute for Forest Resources&Environment of Guizhou Guizhou UniversityGuiyang 550025P.R.China

Small auxin up RNA(SAUR) is a large gene family that is widely distributed among land plants. In this study, a comprehensive analysis of the SAUR family was performed in sweet cherry, and the potential biological functions of PavSAUR55 were identified using the method of genetic transformation. The sweet cherry genome encodes 86 SAUR members, the majority of which are intron-less. These genes appear to be divided into seven subfamilies through evolution. Gene duplication events indicate that fragment duplication and tandem duplication events occurred in the sweet cherry. Most of the members mainly underwent purification selection pressure during evolution. During fruit development, the expression levels of Pav SAUR16/45/56/63 were up-regulated, and conversely, those of Pav SAUR12/61were down-regulated. Due to the significantly differential expressions of PavSAUR13/16/55/61 during the fruitlet abscission process, they might be the candidate genes involved in the regulation of physiological fruit abscission in sweet cherry. Overexpression of PavSAUR55 in Arabidopsis produced earlier reproductive growth, root elongation, and delayed petal abscission. In addition, this gene did not cause any change in the germination time of seeds and was able to increase the number of lateral roots under abscisic acid(ABA) treatment. The identified SAURs of sweet cherry play a crucial role in fruitlet abscission and will facilitate future insights into the mechanism underlying the heavy fruitlet abscission that can occur in this fruit crop.

关键词： sweet cherry small auxin up RNA gene family expression profile fruitlet abscission

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Liposome-based anchoring and core-encapsulation for combinatorial cancer therapy

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Chinese Chemical Letters 2022年第9期33卷 4191-4196页

作者： Qingqing xiao xiaotong Li Chang Liu yi Yang Yuqi hou ying Wang Mengxiang Su Wei He School of Pharmacy China Pharmaceutical UniversityNanjing 211198China

Downregulated pro-apoptotic protein in cancer cells compromises the chemotherapy by a cytotoxic ***,we report co-delivery of a pro-apoptotic protein,caspase 3(Cas 3),and cytotoxic agent,oridonin(ORD),for synergistic cancer treatment,using a method of liposome-based anchoring and core ***,ORD is modified with hyaluronic acid(HA)to improve its ***,the targeted co-delivery system is prepared by assembling the conjugate HA-ORD onto the Cas 3-loaded liposomes,which the surface HA can target the CD44 receptor on cancer *** vitro,the co-loaded liposomes(120 nm)are specifically taken up by 4T1 cells and endow a 1.5-fold increase of Cas *** intravenous injection into the tumor-bearing mice,the liposomes accumulate in the tumor with high efficacy and significantly inhibit tumor growth via promoting apoptosis and anti-proliferation of cancer ***,the co-delivery works synergistically by upregulating the activated Cas form,cleaved-Cas 3.

关键词： Liposomes Co-delivery Chemotherapy Pro-apoptotic protein Tumor targeting

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低温冷冻酶解法制备牛骨粉工艺研究

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安庆师范学院学报（自然科学版） 2016年第4期22卷 92-96页

作者：陈静怡肖厚荣杨红张靖华张佩佩朱许燕合肥学院生物与环境工程系安徽合肥230601 安徽华伊美科技企业集团安徽合肥230088

以牛骨为原料,采用低温冷冻和生物酶解相结合的技术制备超微骨粉。在单因素实验基础上,根据中心组合实验设计原理采用响应面实验法,以超微牛骨粉得率和钙生物利用率算术加权(即综合得分)为考察指标,对制备的技术参数进行优化。研究结果... 详细信息

以牛骨为原料,采用低温冷冻和生物酶解相结合的技术制备超微骨粉。在单因素实验基础上,根据中心组合实验设计原理采用响应面实验法,以超微牛骨粉得率和钙生物利用率算术加权(即综合得分)为考察指标,对制备的技术参数进行优化。研究结果表明:实验范围内,最佳的技术参数为酶用量0.22 g,酶解时间4.20 h,酶解温度41℃;在该条件下,综合得分最高为76.23。

关键词：牛骨低温冷冻酶解响应面

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An efficient GPU-based parallel tabu search algorithm for hardware/software co-design

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Frontiers of Computer Science 2020年第5期14卷 135-152页

作者： Neng hou Fazhi He yi Zhou yilin Chen School of Computer Science Wuhan UniversityWuhan430072China School of Computer Science Yangtze UniversityJingzhou434023China School of Information Science and Engineering Wuhan University of Science and TechnologyWuhan430081China

Hardware/software partitioning is an essential step in hardware/software *** large size problems,it is difficult to consider both solution quality and *** paper presents an efficient GPU-based parallel tabu search algorithm(GPTS)for HW/SW partitioning.A single GPU kernel of compacting neighborhood is proposed to reduce the amount of GPU global memory accesses theoretically.A kernel fusion strategy is further proposed to reduce the amount of GPU global memory accesses of *** further minimize the transfer overhead of GPTS between CPU and GPU,an optimized transfer strategy for GPU-based tabu evaluation is proposed,which considers that all the candidates do not satisfy the given *** show that GPTS outperforms state-of-the-art work of tabu search and is competitive with other methods for HW/SW *** proposed parallelization is significant when considering the ordinary GPU platform.

关键词： hardware/software co-design hardware/software partitioning graphics processing unit GPU-based parallel tabu search single kernel implementation kernel fusion strategy optimized transfer strategy

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