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Lung adenocarcinoma with initial binocular symptoms

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International Journal of Ophthalmology(English edition) 2024年第5期17卷 982-984页

作者： xiao-Lan Zhao Yan-Qing Jiang Zhen yang Chao-Qun liu xiao-li yang Department of Ophthalmology Affiliated Hospital of North Sichuan Medical CollegeNanchong 637000Sichuan ProvinceChina Department of Ophthalmology North Sichuan Medical CollegeNanchong 637000Sichuan ProvinceChina

Dear Editor,Lung adenocarcinoma with choroidal metastasis is a common form of cancer,with breast cancer accounting for 40%-53%and lung cancer accounting for 20%-29%of primary cases with choroidal metastases[1].This type of metastatic cancer typically affects people aged 40-70y,and is more prevalent in women than men[1].Ocular symptoms,including vision loss,can be an early indication of the disease,as many tumors are asymptomatic in their early *** have shown that 40.3%of cases involve the macular region,which explains why ocular symptoms are often the first manifestation of the disease[2].When choroidal metastasis is suspected in patients without a history of cancer,a combination of diagnostic tools should be used to identify the primary source of the *** tumors can serve as an indication of future lung cancer diagnosis in some patients with lung cancer[1].In this report,we present a case of bilateral lung adenocarcinoma where ocular symptoms were the first indication of the disease.

关键词： Lung symptoms adenocarcinoma

Development of a diagnostic nomogram for alpha-fetoproteinnegative hepatocellular carcinoma based on serological biomarkers

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World Journal of Gastrointestinal Oncology 2024年第6期16卷 2463-2475页

作者： li He Cui Zhang Lan-Lan liu li-Ping Huang Wen-Jing Lu Yuan-Yuan Zhang De-Yong Zou Yu-Fei Wang Qing Zhang xiao-li yang School of Clinical Medicine Weifang Medical UniversityWeifang 261053Shandong ProvinceChina Department of Organ Transplantation The Third Medical Centre of Chinese PLA General HospitalBeijing 100039China Department of Laboratory Medicine The Third Medical Centre of Chinese PLA General HospitalBeijing 100039China Department of Laboratory Medicine Jingyu County People’s HospitalBaishan 135200Jilin ProvinceChina School of Laboratory Medicine Weifang Medical UniversityWeifang 261053Shandong ProvinceChina

BACKGROUND Hepatocellular carcinoma(HCC)is the third leading cause of cancer-related death *** biomarkers play an important role in the early diagnosis and prognosis of *** a certain percentage of HCC patients are negative for alpha-fetoprotein(AFP),the diagnosis of AFP-negative HCC is essential to improve the detection rate of *** To establish an effective model for diagnosing AFP-negative HCC based on serum tumour *** A total of 180 HCC patients were enrolled in this *** expression levels of GP73,des-γ-carboxyprothrombin(DCP),CK18-M65,and CK18-M30 were detected by a fully automated chemiluminescence *** variables were selected by logistic regression *** models were constructed using stepwise backward logistic *** performance of the models was compared using the C statistic,integrated discrimination improvement,net reclassification improvement,and calibration *** clinical utility of the nomogram was assessed using decision curve analysis(DCA).RESULTS The results showed that the expression levels of GP73,DCP,CK18-M65,and CK18-M30 were significantly greater in AFP-negative HCC patients than in healthy controls(Plity(area under the curve=0.946)and good goodness of *** DCA curves indicated the good clinical utility of the *** Our study identified GP73 and CK18-M65 as serum biomarkers with certain application value in the diagnosis of AFP-negative *** diagnostic nomogram based on CK18-M65 combined with GP73 demonstrated good performance and effectively identified high-risk groups of patients with HCC.

关键词： Hepatocellular carcinoma Alpha-fetoprotein-negative Diagnostic Nomogram Biomarker

Development of a nomogram for predicting liver transplantation prognosis in hepatocellular carcinoma

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World Journal of Gastroenterology 2024年第21期30卷 2763-2776页

作者： li He Wan-Sheng Ji Hai-Long Jin Wen-Jing Lu Yuan-Yuan Zhang Hua-Guang Wang Yu-Yu liu Shuang Qiu Meng Xu Zi-Peng Lei Qian Zheng xiao-li yang Qing Zhang Department of Organ Transplantation The Third Medical Centre of Chinese PLA General HospitalBeijing 100039China School of Clinical Medicine Shandong Second Medical UniversityWeifang 261053Shandong ProvinceChina Clinical Research Center The Affiliated Hospital of Shandong Second Medical UniversityWeifang 261053Shandong ProvinceChina Department of Laboratory Medicine The Third Medical Centre of Chinese PLA General HospitalBeijing 100039China Physiatry Department Naval Aviation UniversityYantai 100071Shandong ProvinceChina

BACKGROUND At present,liver transplantation(LT)is one of the best treatments for hepatocellular carcinoma(HCC).Accurately predicting the survival status after LT can significantly improve the survival rate after LT,and ensure the best way to make rational use of liver *** To develop a model for predicting prognosis after LT in patients with *** Clinical data and follow-up information of 160 patients with HCC who underwent LT were collected and *** expression levels of alphafetoprotein(AFP),des-gamma-carboxy prothrombin,Golgi protein 73,cytokeratin-18 epitopes M30 and M65 were measured using a fully automated chemiluminescence *** best cutoff value of biomarkers was determined using the Youden *** regression analysis was used to identify the independent risk factors.A forest model was constructed using the random forest *** evaluated the accuracy of the nomogram using the area under the curve,using the calibration curve to assess consistency.A decision curve analysis(DCA)was used to evaluate the clinical utility of the *** The total tumor diameter(TTD),vascular invasion(VI),AFP,and cytokeratin-18 epitopes M30(CK18-M30)were identified as important risk factors for outcome after *** nomogram had a higher predictive accuracy than the Milan,University of California,San Francisco,and Hangzhou *** calibration curve analyses indicated a good *** survival and recurrence-free survival(RFS)of high-risk groups were significantly lower than those of low-and middle-risk groups(Plinical *** The study developed a predictive nomogram based on TTD,VI,AFP,and CK18-M30 that could accurately predict overall survival and RFS after *** can screen for patients with better postoperative prognosis,and improve longterm survival for LT patients.

关键词： Hepatocellular carcinoma liver transplantation liver cancer Nomogram Prognosis

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老年人数字排斥的影响因素与理论解释

应用心理学 2024年第5期30卷 387-399页

作者：杨晓莉巨高乐西北师范大学心理学院甘肃省行为与心理健康重点实验室兰州730070

数字排斥是指当周围环境整体的数字化水平不断提升,迫使人们不得不使用网络数字技术时,老年人由于缺乏能力或资源限制,导致其不能享受数字化技术带来的便利,甚至影响正常的生活,从而产生被排斥感。本文概括了主客观因素对老年人数字排... 详细信息

数字排斥是指当周围环境整体的数字化水平不断提升,迫使人们不得不使用网络数字技术时,老年人由于缺乏能力或资源限制,导致其不能享受数字化技术带来的便利,甚至影响正常的生活,从而产生被排斥感。本文概括了主客观因素对老年人数字排斥的影响及相关的应对策略。能力-环境压力理论、相对剥夺理论、创新扩散理论为数字排斥的解释提供了理论依据。未来研究可关注老年群体内部网络数字使用差异、老年群体网络数字技术使用与否的主观意愿以及其互联网使用动机对数字排斥感的影响,以丰富老年人数字排斥领域的研究成果。

关键词：数字排斥数字鸿沟老年人

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社会排斥对跨期决策的影响:自我控制的中介作用和归属需求的调节作用

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中国临床心理学杂志 2024年第4期32卷 908-911,842页

作者：杨晓莉冯琳邹妍刘晶莎西北师范大学心理学院甘肃省行为与心理健康重点实验室兰州730070

目的:探讨社会排斥对跨期决策的影响,以及自我控制和归属需求在二者关系中的作用。方法:以265名大学生为被试,采用单因素被试间实验设计,自变量为情景类型(社会排斥/社会接纳),因变量为跨期决策时间折扣率,中介变量为状态自我控制,调节... 详细信息

目的:探讨社会排斥对跨期决策的影响,以及自我控制和归属需求在二者关系中的作用。方法:以265名大学生为被试,采用单因素被试间实验设计,自变量为情景类型(社会排斥/社会接纳),因变量为跨期决策时间折扣率,中介变量为状态自我控制,调节变量为归属需求。结果:(1)社会排斥正向预测时间折扣率;(2)自我控制在社会排斥和时间折扣率间起部分中介作用;(3)归属需求在社会排斥影响自我控制的路径中起调节作用。在被排斥个体中,相较于低归属需求的个体,高归属需求个体的自我控制资源下降得更多。结论:社会排斥会导致自我控制资源的下降,进而导致短视决策,但这一路径会因为个体归属需求的差异而不同。

关键词：社会排斥自我控制归属需求跨期决策

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Safety thickness analysis of tunnel floor in karst region based on catastrophe theory

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Journal of Central South University 2016年第9期23卷 2364-2372页

作者： yang xiao-li xiao Hai-bo School of Civil Engineering Central South University Changsha 410075 China

Based on the tunnel shape, span and depth, the previous elliptical plate model and clamped beam model were *** modified model was applied to different situations. For the elliptical plate model, the water effects were considered. For the clamped beam model, water and horizontal stress were considered. Corresponding potential functions and cusp catastrophe models of rock system were established based on the catastrophe theory. The expressions of critical safety thickness were derived with necessary and sufficient conditions. The method was applied to the practical engineering. Some parameters related to the stability were discussed. The results show that elastic modulus and thickness are advantageous to the floor stability, and that the load, span,horizontal stress and water are disadvantageous to the floor stability.

关键词： karst catastrophe theory safety thickness tunnel floor stability water

Study on curing reaction of 4-aminophenoxyphthalonitrile/bisphthalonitrile

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Chinese Chemical Letters 2010年第6期21卷 743-747页

作者： xiao li yang xiao Bo liu Research Branch of Advanced Functional Materials Institute of Microelectronic and Solid State ElectronicUniversity of Electronic Science and Technology of ChinaChengdu 610054China

A series of phthalonitrile blending resins were prepared from 4-aminophenoxyphthalonitrile(APN) and 4,4'-bis(3,4- dicyanophenoxy)biphenyl(BPH) by directly powder-mixing and *** scanning calorimeter(DSC) and dynamic rheology were used to study the curing reaction behaviors of APN/BPH blends,and the results indicated that the introduction of APN accelerated the curing rate of BPH,and the existence of BPH decreased the curing temperature of APN/BPH *** thermal stability of postcured APN/BPH resins was investigated by thermogravimetric analysis(TGA),and the TGA results indicated that the crosslinked polymers of APN/BPH systems possessed good thermal stability.

关键词： 4-Aminophenoxyphthalonitril 4,4’-Bis(3,4-dicyanophenoxy) iphenyl Curing reaction

Pseudo-dynamic analysis of a 3D tunnel face in inclined weak strata

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Underground Space 2023年第5期12卷 156-166页

作者： Sheng Xu Jing liu xiao-li yang School of Civil Engineering Central South UniversityHunan 410075China

A new discretization technique is proposed for a three-dimensional(3D)tunnel face in weak strata with a random position in *** method limits the angle,height,and thickness of the strata on the tunnel *** original whole piece of soil is separated by a series of parallel planes,and two parallel planes are used as a *** radial discrete plane is separated when it passes through the strata,and the change in the soil properties of discrete points on the truncated plane is considered separately inside the *** the spatial and temporal characteristics of seismic waves,a pseudo-dynamic analysis of the tunnel face is carried *** tunnel face active damage types under earthquake conditions are quantitatively analyzed,and the corresponding support pressure design diagrams are given for the case without weak *** the case containing weak strata,the presence of weak strata can have adverse effects on the *** failure mechanism of the weak strata is given by the discretization *** different friction angles,the presence of the weak strata changes the friction angles of the *** the thickness,location and angle of the weak strata,the variation in the support pressure is given in this *** more intuitively depict the change in the failure mechanism in the presence of weak strata,the change in the failure mechanism under different thicknesses and weaknesses of weak strata is plotted.

关键词： Tunnel face 3D discretization technique Weak strata Pseudo-dynamic

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穿河输流管道自埋特性试验研究

水电能源科学 2024年第2期42卷 122-124,182页

作者：李新杨校礼吴嘉轩邓西平吴龙华易晨立河海大学水利水电学院江苏南京210098 中国电建集团中南勘测设计研究院有限公司湖南长沙410014

针对穿河输流管道易受水流冲刷破坏,导致输运介质泄露的问题,通过试验研究穿河输流管道自埋特性,观测了管道自埋过程和地形剖面特征,分析了管道自埋程度的影响因素。结果表明,在一定水力条件下,当穿河管道具有一定的初始嵌入度时,管道... 详细信息

针对穿河输流管道易受水流冲刷破坏,导致输运介质泄露的问题,通过试验研究穿河输流管道自埋特性,观测了管道自埋过程和地形剖面特征,分析了管道自埋程度的影响因素。结果表明,在一定水力条件下,当穿河管道具有一定的初始嵌入度时,管道底部河床泥沙不会冲穿,管道反被泥沙掩埋,具有明显的自埋特性,穿河输流管道前后掩埋斜坡坡度均趋于稳定值;管后相对掩埋距离L/D随弗劳德数Fr增大而增大,随初始嵌入度e/D增大而减小。

关键词：穿河输流管道自埋特性单向来流试验研究管后相对掩埋距离