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Investigation on long-term progressive deformation of engineering slope based on comprehensive monitoring

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Journal of Mountain Science 2022年第6期19卷 1576-1587页

作者： ZHANG Shi-shu GUO Song-feng QI Sheng-wen tang Feng-jiao HU Jin-shan ZHAO xiao-ping RAN Cong-yan WANG Xin ZOU Yu HUANG xiao-lin ZHENG Bo-wen LIANG Ning Chengdu Engineering Corporation Limited Power ChinaChengdu 610072China Key Laboratory of Shale Gas and Geoengineering Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100029China Innovation Academy for Earth Science Chinese Academy of SciencesBeijing 100029China University of Chinese Academy of Sciences Beijing 100049China Key Laboratory of Ministry of Education on Safe Mining of Deep Metal Mines Northeastern UniversityShenyang 110819China

A landslide always results from a progressive process of slope deformation. In recent years, an increasing number of slope instabilities have occurred with regard to human engineering activities such as hydropower or traffic construction in mountainous area, which cause even greater casualties and economic loss compared with the natural hazards. The development of such earth surface process may hold long period with mechanisms still not fully understood. Using monitoring technology is an effective and intuitive approach to assist analyzing the slope deformation process and their driving factors. This study presents an engineering slope excavated during the construction of Changheba Hydropower Station, which is located in the upper reaches of Dadu River, Sichuan Province, southwest China. The engineering slope experienced and featured a five-year continuous deformation which caused continuous high risks to the engineering activities. We conducted in-depth analysis for such a long-term deformation process based on ground and subsurface monitoring data, collected successive data with a series of monitoring equipment such as automated total station, borehole inclinometers and other auxiliary apparatus, and identified the deformation process based on the comprehensive analysis of monitoring data as well as field investigation. After analyzing the effects of engineering activities and natural factors on the continuous deformation, we found that the overburden strata provided deformable mass while the excavation-produced steep terrain initiated the slope deformation in limit equilibrium state over a long period of time;afterwards, the intense rainwater accelerated slope deformation in the rainy season.

关键词： Engineering slope Mountainous area Long-term deformation Landslides Monitoring Stability

Safety, pharmacokinetics, and biomarkers of F-652, a recombinant human interleukin-22 dimer, in healthy subjects

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Cellular & Molecular Immunology 2019年第5期16卷 473-482页

作者： Kai-yang tang Jason Lickliter Zhi-Hua Huang Zong-Shu Xian Han-yang Chen Cheng Huang Chong xiao Yu-Peng Wang Ying Tan Lin-Feng Xu Yu-Liang Huang xiao-Qiang yan Generon(Shanghai)Corporation Ltd. Zhangjiang Hi-Tech ParkShanghaiChina Nucleus Network MelbourneVICAustralia

F-652 is a recombinant fusion protein consisting of two human interleukin-22(IL-22)molecules linked to an immunoglobulin constant region(IgG 2-Fc).IL-22 plays critical roles in promoting tissue repair and suppressing bacterial *** safety,pharmacokinetics(PK),tolerability,and biomarkers of F-652 were evaluated following a single dose in healthy male volunteers in a randomized,double-blind,placebo-controlled *** single-dose subcutaneous(SC)injection of F-652 at 2.0µg/kg into healthy subjects,six out of six subjects experienced delayed injection site reactions,which presented as erythematous and/or discoid eczematous lesions 10 to 17 days post-dosing.F-652 was then administered to the healthy subjects via an intravenous(IV)infusion at 2.0,10,30,and 45µg/*** severe adverse event(SAE)was observed during the *** the IV-dosed cohorts,eye and skin treatment emergent adverse events(TEAEs)were observed in the 30 and 45µg/kg cohorts.F-652 IV dosing resulted in linear increases in C max and AUC(0–t),and the T 1/2 ranged from 39.4 to 206h in the *** IV injection of F-652 induced dose-dependent increases in serum marker serum amyloid A,C-reactive protein,and FIB,and decreased serum *** serum levels of 36 common pro-inflammatory cytokines/chemokines were not altered by the treatment of F-652 at 45μg/*** conclusion,IV administration of F-652 to healthy male volunteers is safe and well-tolerated and demonstrates favorable PK and pharmacodynamic *** results warrant further clinical development of F-652 to treat inflammatory diseases.

关键词： Interleukin-22 F-652 Pharmacokinetics Pharmacodynamics Safety

Biliary cystadenocarcinoma diagnosed with real-time contrast-enhanced ultrasonography:Report of a case with diagnostic features

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World Journal of Gastroenterology 2010年第1期16卷 131-135页

作者： Ren, xiao-Long yan, Rui-Ling Yu, xiao-Hui Zheng, Ying Liu, Jun-E Hou, xiao-Bin Zuo, Si-yang Fu, xiao-yan Chang, Hong Lu, Jian-Hong Gen Hosp Lanzhou Mil Area Command Dept Ultrasonog Lanzhou 730050 Gansu Peoples R China

Biliary cystadenocarcinoma is a very rare malignant cystic tumor of the liver,which is often misdiagnosed due to a poor recognition of *** report a case of a 60-year-old man with biliary cystadenocarcinoma with his real time contrast enhanced ultrasound(CEUS)characteristics compared to those of computed tomography(CT)and magnetic resonance imaging(MRI),which were correlated with the surgical and pathologic *** wall enhancement,internal septations and intra-cystic solid portions in the arterial phase were observed on CEUS after contrast agent *** enhancement was washed out progressively and depicted as hypo-enhancement in the portal and late *** revealed a large irregular cystic lesion in the left liver lobe with no clear septations and solid *** showed an irregular cystic occupying lesion with septations.

关键词： Biliary cystadenocarcinoma Cystic neoplasm Hepatic disease Contrast medium Ultrasonography

Mineral formation on dentin induced by nano-bioactive glass

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Chinese Chemical Letters 2016年第9期27卷 1509-1514页

作者： Xu-yan Sheng Wei-Yu Gong Qing Hu xiao-feng Chen yan-Mei Dong Department of Cariology and Endodontology Peking University School and Hospital of Stomatology School of Materials Science and Engineering Jingdezhen Ceramic Institute National Engineering Research Center for Tissue Restoration and Reconstruction South China University of Technology

The object of this study was to evaluate the effect of bioactive glass （BG） size on mineral formation on dentin surfaces. Totally demineralized dentin discs were treated using BG suspensions with different particle sizes： i.e., microscale bioactive glass （m-BG）, submicroscale bioactive glass （sm-BG） and nanoscale bioactive glass （n-BG）. Field-emission scanning electron microscopy and 3D profile measurement laser microscopy were used to observe the surface morphology and roughness. It was found that all BG particles could promoted mineral formation on dentin surfaces, while plug-like depositions were observed on the dentin discs treated by n-BG and they were more acid-resistant. The present results may imply that n-BG has potential clinical application for dentin hypersensitivity treatment.

关键词： Bioactive glass Dentin hypersensitivity Mineralization Nano Sol-gel method

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188例女性盆底功能筛查结果分析

中国妇幼保健 2024年第5期39卷 854-858页

作者：贺杰吕小娟刘睿唐佳松长春中医药大学吉林长春130117 吉林省人民医院

目的探讨各种因素与盆底功能的相关性。方法采用回顾性分析法对2022年1月—2023年6月吉林省人民医院妇产科收治的188例行盆底功能障碍筛查的女性患者为研究对象,其中有盆底功能障碍性疾病者112例(障碍组),无盆底功能障碍者76例(正常组)... 详细信息

目的探讨各种因素与盆底功能的相关性。方法采用回顾性分析法对2022年1月—2023年6月吉林省人民医院妇产科收治的188例行盆底功能障碍筛查的女性患者为研究对象,其中有盆底功能障碍性疾病者112例(障碍组),无盆底功能障碍者76例(正常组),通过logistic回归分析影响盆底功能的因素。结果盆底功能障碍性疾病发生率为59.57%,两组年龄、孕产次、分娩方式、职业性质以及是否有合并症(高血压、糖尿病及肥胖等)盆底肌电评估(Glazer评估)中快速收缩阶段、紧张收缩阶段、放松时间、耐力收缩阶段、后静息阶段及手测肌力方面比较,差异均有统计学意义(均P0.05)。其中年龄、多次分娩、盆底快慢肌协调不足及从事重体力劳动是盆底功能障碍性疾病的独立危险因素。结论肌肉电信号可作为盆底功能障碍性疾病的初筛,盆底肌肉电信号表达异常时患病概率增大,临床应多关注此类妇女,应扩大盆底康复治疗对象,预防性地给予指导意见,从而延缓或避免盆底功能障碍性疾病的发生。

关键词：盆底功能障碍性疾病影响因素盆底肌电评估

基于ABC-X模型的育龄期HIV/AIDS患者生育忧虑的质性研究

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中国艾滋病性病 2024年第4期30卷 382-386页

作者：谢鹏万彬曾艳赵霞杨文璐肖旭珏谭娟成都市公共卫生临床医疗中心成都610066 成都中医药大学护理学院成都610032

目的在ABC-X模型的指导下,解析育龄期HIV/AIDS患者的生育忧虑,为医疗及护理干预育龄期HIV/AIDS患者的生育忧虑提供参考依据。方法采用现象学研究的目的选样法,对成都市某三甲传染病专科医院的12名育龄期HIV/AIDS患者进行面对面半结构... 详细信息

目的在ABC-X模型的指导下,解析育龄期HIV/AIDS患者的生育忧虑,为医疗及护理干预育龄期HIV/AIDS患者的生育忧虑提供参考依据。方法采用现象学研究的目的选样法,对成都市某三甲传染病专科医院的12名育龄期HIV/AIDS患者进行面对面半结构化访谈,运用主题分析法对访谈资料进行分析、归纳和提炼主题。结果分析中出现了3个主要主题:生育忧虑产生的原因、生育忧虑的表现、生育忧虑的影响。生育忧虑产生的原因包括3个副主题:生育问题让患者倍感压力、个人拥有的资源难以应对生育问题、对生育问题的错误认知;生育忧虑的表现包括5个副主题:对个人健康的担忧、对疾病传播及后果的担忧、对孕前/孕期干预措施的担忧、对歧视和偏见的担忧、对照护能力的担忧;生育忧虑的影响包括2个副主题:加重患者的负性情绪、破坏家庭的和谐关系。结论育龄期HIV/AIDS患者容易产生生育忧虑,进而影响其身心健康,建议医务人员重视生育忧虑,积极采取措施干预。

关键词：艾滋病病毒感染者/艾滋病患者生育忧虑育龄期 ABC-X模型质性研究

Impacts of warming on root biomass allocation in alpine steppe on the north Tibetan Plateau

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Journal of Mountain Science 2017年第8期14卷 1615-1623页

作者： MA Xing-xing yan yan HONG Jiang-tao LU Xu-yang WANG xiao-dan Key Laboratory of Mountain Surface Processes and Ecological Regulation Institute of Mountain Hazards and EnvironmentChinese Academy of Sciences University of Chinese Academy of Sciences

Biomass is an important component of global carbon cycling and is vulnerable to climate change. Previous studies have mainly focused on the responses of aboveground biomass and phenology to warming, while studies of root architecture and of root biomass allocation between coarse and fine roots have been scarcely reported in grassland ecosystems. We conducted an open-top-chamber warming experiment to investigate the effect of potential warming on root biomass and root allocation in alpine steppe on the north Tibetan Plateau. The results showed that Stipa purpurea had significantly higher total root length, root surface area and tips than Carex moocroftii. However,there were no differences in total root volume, mean diameter and forks for the two species. Warming significantly increased total root biomass(27.60%), root biomass at 0–10 cm depth(27.84%) and coarse root biomass(diameter > 0.20 mm, 57.68%) in the growing season(August). However, warming had no significant influence on root biomass in the non-growing season(April). Root biomass showed clear seasonalvariations: total root biomass, root biomass at 0–10 cm depth and coarse root biomass significantly increased in the growing season. The increase in total root biomass was due to the enhancement of root biomass at 0–10 cm depth, to which the increase of coarse root biomass made a great contribution. This research is of significance for understanding biomass allocation, carbon cycling and biological adaptability in alpine grassland ecosystems under future climate change.

关键词： Coarse root Fine root Root architecture Warming Climate change Open-top chambers

基于CRISPR/Cas技术的传染性病原精准便携化检测系统

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分析化学 2024年第2期52卷 187-197页

作者：刘一辰赵茹健吕佰阳宋德锋唐艺丹姜艳芳李冰凌中国科学技术大学应用化学与工程学院中国科学院长春应用化学研究所电分析化学国家重点实验室吉林大学中日联谊医院普通外科吉林大学第一医院基因诊断中心

以核酸为检测靶向的分子诊断方法是传染性病原体检测的金标准，但将其应用于便携化或现场快速诊断时仍存在多种限制和挑战，如特异性差、操作繁琐和便携化难等。规律间隔成簇短回文重复序列（CRISPR）/CRISPR相关蛋白（Cas）-荧光检测... 详细信息

以核酸为检测靶向的分子诊断方法是传染性病原体检测的金标准，但将其应用于便携化或现场快速诊断时仍存在多种限制和挑战，如特异性差、操作繁琐和便携化难等。规律间隔成簇短回文重复序列（CRISPR）/CRISPR相关蛋白（Cas）-荧光检测方法有望大幅提升核酸识别的特异性和信噪比。本研究开发了环介导等温扩增（LAMP）-CRISPR/Cas-便携化灰度读取仪检测系统。在CRISPR RNA (crRNA)存在下，利用CRISPR/Cas12a体系实现了对自主设计的甲型和乙型流感病毒核酸LAMP扩增反应体系的精准荧光检测，验证了CRISPR/Cas体系的高选择性和通用性。配套自主开发的便携化灰度读取仪，可同时实现荧光信号的低成本采集和高可靠性可视化判读，检测结束后直接输出样品的阳/阴性结果。利用本检测系统对实际样本进行了分析，验证了其可靠性和实用性，证明了本系统能够实现流感病毒的高灵敏、高特异性便携化分析。

关键词：等温扩增 CRISPR-Cas 荧光便携化检测流行性病原灰度读取仪

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女性婴儿尿标本收集装置的设计及应用

中国医疗器械信息 2024年第9期30卷 40-43页

作者：夏燕红李琳玉童孝笑章赛春杭州市儿童医院浙江杭州310021

目的:介绍一种女婴儿尿液标本收集装置,并探讨其在采集女婴尿液标本中的使用效果。方法:选取2022年9月~12月在本院新生儿科住院的女婴67例,随机分为2组,观察组34例,对照组33例。对照组采用集尿袋+无菌棉球采集尿标本;观察组采用女婴尿... 详细信息

目的:介绍一种女婴儿尿液标本收集装置,并探讨其在采集女婴尿液标本中的使用效果。方法:选取2022年9月~12月在本院新生儿科住院的女婴67例,随机分为2组,观察组34例,对照组33例。对照组采用集尿袋+无菌棉球采集尿标本;观察组采用女婴尿标本收集装置采集尿标本。对2组患儿尿标本的一次性采集成功率、成功采集时间及尿袋脱落率、大便污染率、尿量不足率进行比较。结果:观察组的一次性采集成功率比对照组高,成功采集花费的时间比对照组少,差异有统计学意义(P<0.001);观察组的尿袋脱落率、尿标本受大便污染率均低于对照组(P<0.05)。结论:改良女婴尿液标本收集装置具有成功率高、时间花费少等优点,且操作简便、患儿舒适度高,是一种较好的女婴非侵入性采集尿液标本的方法,有利于提高女婴尿液标本采集成功率。

关键词：女性婴儿尿标本收集设备设计