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Trends of alkaline phosphatase to prealbumin ratio in patients with hepatitis B linked to hepatocellular carcinoma development

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World Journal of Gastroenterology 2025年第2期31卷 42-51页

作者： Wen-Chong Zhen Jing Sun Xue-Ting Bai Qian Zhang Zi-Han Li Yi-Xin Zhang Rong-xuan Xu Wei Wu Zhi-Han Yao Chun-Wen Pu xiao-Feng Li School of Public Health Dalian Medical UniversityDalian 116044Liaoning ProvinceChina Graduate School Dalian Medical UniversityDalian 116044Liaoning ProvinceChina Dalian Public Health Clinical Center Dalian Municipal Research Institute for Public HealthDalian 116001Liaoning ProvinceChina Department of Epidemiology and Health Statistics Dalian Medical UniversityDalian 116044Liaoning ProvinceChina

BACKGROUND Chronic hepatitis B often progresses silently toward hepatocellular carcinoma(HCC),a leading cause of mortality *** detection of HCC is crucial,yet *** To investigate the role of dynamic changes in alkaline phosphatase to prealbumin ratio(APR)in hepatitis B progression to *** Data from 4843 patients with hepatitis B(January 2015 to January 2024)were *** incidence rates in males and females were compared using the log-rank *** were evaluated using Kaplan–Meier *** Linear Mixed-Effects Model was applied to track the fluctuation of APR levels over ***,Joint Modeling of Longitudinal and Survival data was employed to investigate the temporal relationship between APR and HCC *** The incidence of HCC was higher in *** ensure the model’s normality assumption,this study applied a logarithmic transformation to APR,yielding *** levels were higher in females(t=5.26,P<0.01).A 1-unit increase in ratio correlated with a 2.005-fold higher risk of HCC in males(95%CI:1.653-2.431)and a 2.273-fold higher risk in females(95%CI:1.620-3.190).CONCLUSION Males are more prone to HCC,while females have higher APR *** no baseline APR link,rising APR indicates a higher HCC risk.

关键词： Alkaline phosphatase to prealbumin ratio Chronic hepatitis B patients Hepatocellular carcinoma Retrospective cohort study Linear Mixed-Effect Mode Joint Modelling of Longitudinal and Survival data

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Burden of mental disorders and risk factors in the Western Pacific region from 1990 to 2021

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World Journal of Psychiatry 2025年第1期15卷 93-105页

作者： Ya-Xin Xu xiao-xuan Niu Wen-Chang Jia Jing Wen Xue-Lin Cheng Yan Han Ming-hui Peng Jing Zhou Yao Liu Sun-Fang Jiang xiao-Pan Li Department of Health Management Centre Zhongshan HospitalFudan UniversityShanghai 200030China Department of General Practice Zhongshan HospitalFudan UniversityShanghai 200030China Department of Nutrition Zhongshan HospitalFudan UniversityShanghai 200032China School of Public Health Fudan UniversityShanghai 200032China

BACKGROUND The burden of mental disorders(MD)in the Western Pacific Region(WPR)re-mains a critical public health concern,with substantial variations across demogra-phics and *** To analyze the burden of MD in the WPR from 1990 to 2021,along with associated risk factors,to reveal changing trends and emerging *** We used data from the Global Burden of Disease 2021,analyzing prevalence,incidence,and disability-adjusted life years(DALYs)of MD from 1990 to *** methods included age-standardisation and uncertainty analysis to address variations in population structure and data *** Between 1990 and 2021,the prevalence of MD rose from 174.40 million cases[95%uncertainty interval(UI):160.17-189.84]to 234.90 million cases(95%UI:219.04-252.50),with corresponding DALYs increasing from 22.8 million(95%UI:17.22-28.79)to 32.07 million(95%UI:24.50-40.68).During this period,the burden of MD shifted towards older age *** and anxiety disorders were predominant,with females showing higher DALYs for depressive and anxiety disorders,and males more affected by conduct disorders,attention-deficit hyperactivity disorder,and autism spectrum ***,New Zealand,and Malaysia reported the highest burdens,whereas Vietnam,China,and Brunei Darussalam reported the ***,childhood sexual abuse and bullying,and intimate partner violence emerged as significant risk *** This study highlights the significant burden of MD in the WPR,with variations by age,gender,and *** coronavirus disease 2019 pandemic has exacerbated the situation,emphasizing the need for a coordinated response.

关键词： Mental disorders Western pacific region Global Burden of Disease Risk factors Disability-adjusted life years

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Molecular Genetics of Pollen Tube Growth in Arabidopsis

Molecular Genetics of Pollen Tube Growth in Arabidopsis

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植物分子生物学与现代农业——2010全国植物生物学研讨会

作者： Chuan Xia,Yu-Jiao Wang,Yan Liang,Qian-Kun Nin,Jing-Jing Zhou,xiao-xuan hu,Li-Qun Chen,Xue-Qin Zhang and De Ye~* State Key Laboratory of Plant Physiology and Biochemistry,College of Biological Sciences,China Agricultural University,2 Yuanmingyuan Xilu,Beijing 100193,China

Growth of pollen tube is essential for delivery of the male gametes to the female gametophyte in flowering *** has shown that thousands of genes are involved in the process in Arabidopsis,which could be classified into at least six functional groups:transcription factor genes,cell wall formation and modification genes,cell signaling genes,transportation genes,cytoskeleton genes and environmental

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土壤重金属生物有效性评价技术进展

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现代化工 2019年第S1期39卷 89-94,98页

作者：黄迪杨燕群肖选虎张振强陈四海黄志红肖惠宁圣清环保股份有限公司云南昆明650100 南京林业大学轻工与食品学院江苏南京210037

土壤重金属生物有效性是衡量土壤重金属污染状况、治理修复效果的关键参数。对国内外土壤重金属生物有效性评价技术的研究进展及应用现状进行了较系统的分析,并提出了今后土壤重金属生物有效性评价技术在工程应用领域的发展方向。

关键词：土壤修复重金属生物有效性

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珠海市医务人员慢性疲劳状况与心理健康的相关性分析

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工业卫生与职业病 2017年第2期43卷 140-144,148页

作者：林红汪小清胡轩张小珍翟巾帼蔡文智南方医科大学护理学院广东广州510515 中山大学附属第五医院广东珠海519100 南方医科大学深圳医院广东深圳518000

目的分析医务人员慢性疲劳状况与心理健康的相关性。方法采用抽样方法于2015年3-4月对珠海市54家不同等级医疗机构医务人员进行网络调查,分别采用疲劳量表FS-14及症状自评量表SCL-90对2 111名医务人员慢性疲劳状况及心理健康情况进行测... 详细信息

目的分析医务人员慢性疲劳状况与心理健康的相关性。方法采用抽样方法于2015年3-4月对珠海市54家不同等级医疗机构医务人员进行网络调查,分别采用疲劳量表FS-14及症状自评量表SCL-90对2 111名医务人员慢性疲劳状况及心理健康情况进行测评,并进行相关性分析。结果疲劳评分随医院等级、科室/部门、学历、锻炼及睡眠呈正相关,随之升高其疲劳评分亦升高;性别及月收入与其心理健康情况无统计学相关性,职称、学历、医院等级、用餐情况、健康状况等与心理健康情况呈现正相关;健康状况、学历、月支出情况等为影响医务人员慢性疲劳状况的因素;离职想法、健康状况、用餐、月支出情况为影响医务人员心理健康因素;医务人员心理健康状况与疲劳状况呈正相关。结论医务人员慢性疲劳状况与其心理健康情况有关,若心理健康状况越好,则慢性疲劳程度较轻;反之,疲劳程度加重。

关键词：医务人员慢性疲劳心理健康珠海市

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Tumor inflammation-specific self-amplifying fluorescent molecular probes induce an anti-tumor immune response

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Science China Chemistry 2025年第01期 273-287页

作者： Shuguang Yang Lijun hu Hong xiao Zecong xiao Xintao Shuai PCFM Lab of Ministry of Education School of Materials Science and Engineering Sun Yat-sen University Department of Ultrasound The Fifth Affiliated Hospital Sun Yat-sen University Department of Medical Ultrasound The Third Affiliated Hospital of Sun Yat-sen University Nanomedicine Research Center The Third Affiliated Hospital of Sun Yat-sen University

Enhancing the concentration of exogenous molecular drugs within the tumor microenvironment through enzyme-catalyzed polymerization presents a novel strategy for cancer therapy. Nonetheless, the optimization of the catalytic efficiency is often impeded by the inefficient expression of enzymes. Herein, we reported a self-amplifying fluorescent molecular probe, Bis-HTPICG, for photodynamic therapy(PDT) and subsequent PDT-induced immunoreaction. The Bis-HTP-ICG probe possesses a noticeable enzyme-catalyzed polymerization facilitated by myeloperoxidase(MPO), a crucial enzyme secreted by neutrophils at inflammation sites. Upon exposure to laser irradiation, Bis-HTP-ICG showed a high PDT efficacy, inducing an acute inflammatory response that stimulates further recruitment of neutrophils and then elevated MPO secretion. The heightened level of MPO enhances the accumulation of the Bis-HTP-ICG via self-polymerization or binding with intratumoral proteins following MPO enzyme catalysis, instigating a self-amplifying chain reaction cycle involving Bis-HTP-ICG, neutrophils and ***, PDT efficiently incites immunogenic cell death(ICD) in tumor cells, initiating an anti-tumor immune response including dendritic cells(DCs) maturation, T cell proliferation and reprogramming of tumor-associated neutrophils(TANs). This work portrays a promising strategy for self-amplification of fluorescent molecular probes through adjustable enzyme levels,potentially offering a unique avenue to enhance the tumor accumulation of molecular drugs for improved tumor therapy.

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Correlation between gut microbiota and tumor immune microenvironment:A bibliometric and visualized study

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World Journal of Clinical Oncology 2025年第2期16卷 110-129页

作者： Zheng-Jun hu hui-Rong Zhu Yong-Jie Jin Pan Liu xiao-Wei Yu Yu-Ren Zhang Department of Oncology Shanghai Jiading District Hospital of Traditional Chinese MedicineShanghai 200000China Department of Oncology Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghai 200000China School of Chinese Medicine Anhui University of Traditional Chinese MedicineHefei 230000Anhui ProvinceChina

BACKGROUND In recent years,numerous reports have been published regarding the relationship between the gut microbiota and the tumor immune microenvironment(TIME).However,to date,no systematic study has been conducted on the relationship between gut microbiota and the TIME using bibliometric *** To describe the current global research status on the correlation between gut microbiota and the TIME,and to identify the most influential countries,research institutions,researchers,and research hotspots related to this *** We searched for all literature related to gut microbiota and TIME published from January 1,2014,to May 28,2024,in the Web of Science Core Collection *** then conducted a bibliometric analysis and created visual maps of the published literature on countries,institutions,authors,keywords,references,etc.,using CiteSpace(6.2R6),VOSviewer(1.6.20),and bibliometrics(based on R 4.3.2).RESULTS In total,491 documents were included,with a rapid increase in the number of publications starting in *** country with the highest number of publications was China,followed by the United *** has the highest number of citations in *** a centrality perspective,the United States has the highest influence in this *** institutions with the highest number of publications were Shanghai Jiao Tong University and Zhejiang ***,the institution with the most citations was the United States National Cancer *** authors,Professor Giorgio Trinchieri from the National Institutes of Health has the most local impact in this *** most cited author was Fan *** results of journal publications showed that the top three journals with the highest number of published papers were Frontiers in Immunology,Cancers,and Frontiers in *** three most frequently used keywords were gut microbiota,tumor microenvironment,and *** This study systematically elaborates on the research progress re

关键词： Gut microbiota Tumor immune microenvironment Bibliometric CiteSpace VOSviewer R-bibliometrics

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Extracting compressive stress-strain curve based on stick-slip shear banding process in bulk metallic glasses

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Journal of Iron and Steel Research International 2017年第4期24卷 372-377页

作者： Jing hu Yun-xuan Weng xiao-li Li Bao-an Sun School of Material and Mechanical Engineering Beijing Technology and Business University Herbert Gleiter Institute of Nanoscience Nanjing University of Science & Technology

Based on the stick-slip process,an effective method to extract the stress-strain curve directly from the crosshead displacement-load raw data in compression of bulk metallic glasses was *** method was tested in two bulk metallic glass samples with different plasticities and shear band *** extracted stress-strain curves were found to well resemble the stress-strain curve measured by a laser *** addition,the extracted curve could resolve fine structures of serrated flow much better than that measured by extensometer,thus facilitating the study of shear banding *** obtained by this method made the stick-slip dynamics of shear banding valid,and this method could be employed to obtain the real strain of small-sized metallic glass samples where extensometer cannot be applied.

关键词： Serrated flow Shear banding Stick-slip Stress-strain curve

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羧甲基纤维素和瓜尔胶对造纸法再造烟叶片基的影响

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造纸化学品 2017年第2期29卷 14-19页

作者：朱红琴刘维涓肖选虎余磊卫青云南瑞升烟草技术集团有限公司云南昆明650106

研究了羧甲基纤维素（CMC）和瓜尔胶2种助剂对再造烟叶片基吸收性的影响。结果表明：随着助剂用量的增加，再造烟叶片基的吸收性先增大、后减小：当瓜尔胶用量为0．2％～0．3％（以绝干浆质量为基数计，下同），CMC的用量为0．1％～0．... 详细信息

研究了羧甲基纤维素（CMC）和瓜尔胶2种助剂对再造烟叶片基吸收性的影响。结果表明：随着助剂用量的增加，再造烟叶片基的吸收性先增大、后减小：当瓜尔胶用量为0．2％～0．3％（以绝干浆质量为基数计，下同），CMC的用量为0．1％～0．2％时，造纸法再造烟叶片基各性能达到最佳。

关键词：再造烟叶瓜尔胶羧甲基纤维素吸收性

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麦粒灸对阿霉素心肌毒性心脏保护作用的临床研究

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针灸临床杂志 2016年第12期32卷 39-42页

作者：陈昊王艳谈晓东胡轩铭顾一煌南京中医药大学江苏南京210023 南京市红十字医院江苏南京210001 无锡市中医医院江苏无锡214071

目的:观察麦粒灸对阿霉素心肌毒性的心脏保护作用。方法:将收治的乳腺癌患者68例随机分为试验组和对照组两组,试验组采用麦粒灸联合FAC化疗方案治疗,对照组仅采用FAC化疗方案。两组均经6个周期的化疗,分别观察两组发生心功能指标心肌激... 详细信息

目的:观察麦粒灸对阿霉素心肌毒性的心脏保护作用。方法:将收治的乳腺癌患者68例随机分为试验组和对照组两组,试验组采用麦粒灸联合FAC化疗方案治疗,对照组仅采用FAC化疗方案。两组均经6个周期的化疗,分别观察两组发生心功能指标心肌激酶同工酶(CK-MB),心肌肌钙蛋白(cTnl)和利钠肽(BNP)及心电图出现异常的时间及例数。治疗结束后,经COX比例风险回归模型分析两组出现心脏毒性的风险。结果:试验组相对于对照组心功能指标异常的相对危险度RR为0.53(95%CI:0.312-0.901)。试验组相对于对照组心电图的相对危险度RR为0.341(95%CI:0.197-0.592)。结论:麦粒灸可以降低阿霉素化疗方案引起的心肌毒性的风险,可以在临床作为辅助方案配合含有阿霉素的化疗。

关键词：麦粒灸阿霉素心肌毒性临床研究

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