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Genetic Manipulation of Non-Classic Oilseed Plants for Enhancement of Their Potential as a Biofactory for Triacylglycerol Production

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Engineering 2018年第4期4卷 523-533页

作者： xiao-yu xu Hong-Kun Yang Surinder P. Singh Peter J. Sharp Qing Liu CSIRO Agriculture and Food Canberra ACT 2601 Australia Plant Breeding Institute and Sydney Institute of Agriculture School of Life and Environmental Sciences The University of Sydney Sydney NSW 2006 Australia

Global demand for vegetable oil is anticipated to double by 2030. The current vegetable oil production platforms, including oil palm and temperate oilseeds, are unlikely to produce such an expansion. Therefore, the exploration of novel vegetable oil sources has become increasingly important in order to make up this future vegetable oil shortfall. Triacylglycerol （TAG）, as the dominant form of vegetable oil, has recently attracted immense interest in terms of being produced in plant vegetative tissues via genetic engineering technologies. Multidiscipline-based ＂-omics＂ studies are increasingly enhancing our understanding of plant lipid biochemistry and metabolism. As a result, the identification of biochemical pathways and the annotation of key genes contributing to fatty acid biosynthesis and to lipid assembly and turnover have been effectively updated. In recent years, there has been a rapid development in the genetic enhancement of TAG accumulation in high-biomass plant vegetative tissues and oilseeds through the genetic manipulation of the key genes and regulators involved in TAG biosynthesis. In this review, current genetic engineering strategies ranging from single-gene manipulation to multigene stacking aimed at increasing plant biomass TAG accumulation are summarized. New directions and suggestions for plant oil production that may help to further alleviate the potential shortage of edible oil and biodiesel are discussed.

关键词： Plant vegetable oil Triacylglycerol Genetic engineering Edible oil Biodiesel

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Assessment of prognosis and curative effect in patients with chronic severe hepatitis using the model for end-stage liver disease scores

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Chinese Medical Journal 2006年第2期119卷 148-150页

作者： WU Chi-hong TIAN Geng-shan xu xiao-yuan yu Yan-yan LU Hai-ying Department of Infectious Disease Peking University First Hospital Beijing 100034 China

Severe hepatitis is the most severe liver disease, with poor prognosis and high mortality. We explored the practical use of the model for end-stage liver disease （MELD） on clinical and the molecular adsorbents recirculating system （MARS） on chronic severe hepatitis to predict the short-term prognosis of patients with chronic severe hepatitis using the MELD score and the curative effect of MARS treatment.

关键词： chronic severe hepatitis end-stage liver disease molecular adsorbents recirculating system

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山区城镇建设中地质环境资源开发利用的预控制管理研究——以三峡库区巴东、巫山、奉节为例

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国土资源科技管理 2013年第3期30卷 132-138页

作者：徐潇宇中国地质大学(武汉)经济与管理学院湖北武汉430074

城镇化已成为我国社会经济发展的重要内容,但山区沿江城镇建设与发展却常受到特殊地形和崩塌、滑坡、水库塌岸等地质灾害的限制和约束。在城镇化建设过程中,人为扩大增加地质环境容量很容易造成过度开发,对城市地质环境造成不可逆的损... 详细信息

城镇化已成为我国社会经济发展的重要内容,但山区沿江城镇建设与发展却常受到特殊地形和崩塌、滑坡、水库塌岸等地质灾害的限制和约束。在城镇化建设过程中,人为扩大增加地质环境容量很容易造成过度开发,对城市地质环境造成不可逆的损伤和破坏。以三峡库区移民迁建城市中的巴东、巫山、奉节三座城镇为例,通过预控制管理的理念来指导沿江三城镇土地资源的科学合理的开发利用,对其建设中实施的预控制措施及成效进行了梳理分析,为同类型城市地质环境资源开发利用保护提供借鉴,为进一步研究地质环境资源保护预控制管理提出了思路和参考意见。

关键词：预控制管理城镇建设地质环境资源开发利用三峡库区

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动态更新失真代价的自适应JPEG隐写算法

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通信学报 2017年第9期38卷 1-8页

作者：汤光明孙艺徐潇雨王宇中国人民解放军信息工程大学河南郑州450001 吉林省四平军分区吉林四平136000

以往的自适应JPEG隐写算法大多只在秘密信息嵌入之前计算图像失真,无法在嵌入过程中动态地调节失真代价。考虑到信息嵌入时的交互影响,提出一种动态更新失真代价的自适应JPEG隐写算法。首先,分析量化步长、待嵌DCT(discrete cosine tran... 详细信息

以往的自适应JPEG隐写算法大多只在秘密信息嵌入之前计算图像失真,无法在嵌入过程中动态地调节失真代价。考虑到信息嵌入时的交互影响,提出一种动态更新失真代价的自适应JPEG隐写算法。首先,分析量化步长、待嵌DCT(discrete cosine transform)系数绝对值以及扰动误差3种影响嵌入波动的因素。进而,提出失真代价更新策略EUS(embedding update strategy),使图像的失真代价能够动态地更新。最后,结合此策略设计并实现一种自适应JPEG隐写算法。实验表明该算法能够显著提高JPEG隐写的安全性。

关键词：信息安全自适应隐写失真函数 JPEG

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Fuzzy neural network control of underwater vehicles based on desired state programming

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Journal of Marine Science and Application 2006年第3期5卷 1-4页

作者： LIANG xiao LI Ye xu yu-ru WAN Lei QIN Zai-bai School of Shipbuilding Engineering Harbin Engineering University Harbin 150001 China

Due to the nonlinearity and uncertainty, the precise control of underwater vehicles in some intelligent operations hasn’t been solved very well yet. A novel method of control based on desired state programming was presented, which used the technique of fuzzy neural network. The structure of fuzzy neural network was constructed according to the moving characters and the back propagation algorithm was deduced. Simulation experiments were conducted on general detection remotely operated vehicle. The results show that there is a great improvement in response and precision over traditional control, and good robustness to the model’s uncertainty and external disturbance, which has theoretical and practical value.

关键词： underwater vehicle motion control fuzzy neural network desired state programming

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频域OCT测量黄斑区节细胞-内丛状层厚度在青光眼早期诊断中的应用

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眼科 2016年第1期25卷 1-5页

作者：刘杏徐晓宇中山大学中山眼科中心眼科学国家重点实验室广州510060

SD-OCT测量黄斑区节细胞-内丛状层(GCIPL)厚度有可能较视盘周围视网膜神经纤维层(RNFL)厚度、黄斑区节细胞复合体(GCC)更早地发现青光眼性结构损害。GCIPL在东方人群中鼻上方最厚、下方最薄。年龄及眼轴是影响GCIPL的重要因素。目前GCIP... 详细信息

SD-OCT测量黄斑区节细胞-内丛状层(GCIPL)厚度有可能较视盘周围视网膜神经纤维层(RNFL)厚度、黄斑区节细胞复合体(GCC)更早地发现青光眼性结构损害。GCIPL在东方人群中鼻上方最厚、下方最薄。年龄及眼轴是影响GCIPL的重要因素。目前GCIPL厚度与RNFL厚度具有相似的临床诊断效能。其与视野、RNFL厚度、视盘参数相互整合,是提高青光眼早期检出率的关键。

关键词：频域相干光断层扫描青光眼早期诊断节细胞-内丛状层

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Al-SBA-15介孔分子筛及其吸附脱氮研究

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化学工程 2014年第12期42卷 30-33,38页

作者：徐晓宇沈健辽宁石油化工大学化学化工与环境学部辽宁抚顺113001

采用嫁接法制备了Al-SBA-15介孔分子筛,并对硅铝比、焙烧温度等影响产物的制备因素进行了考察。通过XRD,BET,FT-IR,NH3-TPD等分析手段对所得样品进行了分析。将所得产物Al-SBA-15与SBA-15在相同条件下进行了吸附脱除碱性氮化物对比实验... 详细信息

采用嫁接法制备了Al-SBA-15介孔分子筛,并对硅铝比、焙烧温度等影响产物的制备因素进行了考察。通过XRD,BET,FT-IR,NH3-TPD等分析手段对所得样品进行了分析。将所得产物Al-SBA-15与SBA-15在相同条件下进行了吸附脱除碱性氮化物对比实验。结果表明:Al-SBA-15保留了SBA-15高度有序的二维六方介孔结构。AlSBA-15具有比SBA-15更好的吸附脱氮能力,在焙烧温度550℃、硅铝比(原子比)为50的条件下,Al-SBA-15(50)介孔分子筛最高脱氮率为68.02%,此时饱和吸附量为30.6 mg/g。

关键词：介孔分子筛 Al-SBA-15 碱性氮化物

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Review for treatment and signaling pathway regulation of kidney-tonifying traditional Chinese medicine on osteoporosis

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中国药理学与毒理学杂志 2017年第10期31卷 1005-1005页

作者： Ya-ping xiao Jie ZENG Lin-na JIAO xiao-yu xu College of Pharmaceutical Sciences & Chinese Medicine Southwest University Chongqing 400715 China Chongqing Key Laboratory of New Drug Screening from Traditional Chinese Medicine Chongqing 400715 China Pharmacology of Chinese Materia Medica-the Key Discipline Constructed by the State Administration of Traditional Chinese Medicine Chongqing 400715 China

The treatment and signaling pathway regulation effects of kidney-tonifying traditional Chinese medicine on osteoporosis have been widely studied,but without a systematic summary *** review comprehensively collected and analyzed the traditional Chinese medicine on the treatment and signaling pathway regulation of osteoporosis in recent ten years,such as Epimedium,Drynariae Rhizoma,Cnidium,Eucommia,Psoralen and *** on the existing findings,we concluded the following conclusions:(1)kidney-tonifying traditional Chinese medicine treats osteoporosis mainly through BMP-Smads,Wnt/β-catenin,MAPK,PI3K/AKT signaling pathway to promote osteoblast bone formation and through OPG/RANKL/RANK,estrogen,CTSK signaling pathway to inhibit osteoclasts of bone resorption.(1)Epimedium,Drynariae Rhizoma,Cnidium and Psoralen up-regulate the key proteins and genes of BMP-Smads and Wnt/β-catenin signaling pathways to promote bone formation.(2)Epimedium,Drynariae Rhizoma,Cnidium,Eucommia,Psoralen,Dipsacusinhibit the bone resorption by mediating the OPG/RANKL/RANK signaling pathway.(2)Kidney-tonifying traditional Chinese medicine prevent and treat osteoporosis through a variety of ways:Icariin,Naringin,Osthol,Psoralen can regulate BMP-Smads,Wnt/β-catenin signaling pathway to promote bone formation,but also activate OPG/RANKL/RANK,CTSK and other signaling pathway to inhibit bone resorption.(3)The crosstalk of the signaling pathways and the animal experiments of the traditional Chinese medicine on the prevention and treatment of osteoporosis as well as their multi-target mechanism and comprehensive regulation need further clarification.

关键词： kidney-tonifying traditional Chinese medicine osteoporosis signaling pathways bone metabolism osteoblast osteoclast

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Surgical Outcomes of Trabeculotomy in Newborns with Primary Congenital Glaucoma

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Chinese Medical Journal 2016年第18期129卷 2178-2183页

作者： Jie-Lei Huang Jing-Jing Huang Yi-Min Zhong Xin-Xing Guo Xiang-Xi Chen xiao-yu xu Xing Liu Zhongshan Ophthalmic Center State Key Laboratory of Ophthalmology Sun Yat-sen University Guangzhou Guangdong 510060 China

Background： Early surgical intervention is required for the primary congenital glaucoma （PCG）. There are currently few reports on the surgical outcomes in infants with PCG. This study aimed to evaluate the efficacy and safety oftrabeculotomy and the postoperative visual outcomes in Chinese newborns with PCG within 4 weeks of birth. Methods： A total of 21 eyes of 12 patients with PCG who underwent primary trabeculotomy within 4 weeks of birth were retrospectively studied. Preoperative and postoperative intraocular pressure （lOP）, corneal clarity and diameter, axial length and optic disc cupping, visual acuity and postoperative refractive error, success rates, and complications were evaluated. Kaplan-Meier survival analysis was applied to evaluate the success rates. Results： The mean follow-up time was 46.9 ~ 34.4 months （range： 12-122 months）. The postoperative lOP was significantly lower than the preoperative lOP at all of the follow-up visits （P 〈 0.001 ）. The complete success rates for all eyes at 1,2, 3, and 5 years postoperatively were 90.5%, 85.7%, 85.7%, and 85.7%, respectively. The lOPs of the three patients who needed antiglaucomatous medications postoperatively were also well controlled. At the last visit, the cornea became clear, and the cup-to-disc ratio decreased significantly （P = 0.01） although the horizontal corneal diameter did not change significantly （P = 0.11 ）. Visual acuities were able to be recorded in eight eyes at the last visit, among which six eyes had a best-corrected visual acuity of 20/40 or better. There were no severe intraoperative or postoperative complications. Conclusions： Trabeculotomy proves to be a safe and effective treatment in reducing lOP in this group of Chinese newborns with PCG. The outcomes of vision function were satisfactory in most of the patients.

关键词： Glaucoma Primary Congenital Newborn Trabeculotomy

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Hepatoprotective Effects of Yintian Granule on Experimental Liver Injury in Mice

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Chinese Herbal Medicines 2014年第3期6卷 247-252页

作者： Yan-jun Li Sheng Yang Yan-jing Zhou Fang-hong Shang xiao-yu xu College of Pharmaceutical Sciences & College of Traditional Chinese Medicine and Pharmacology Southwest University Institute of Chinese Medicine Southwest University Pharmacology of Chinese Materia Medica Key Constructing Discipline by the State Administrative Bureau of Traditional Chinese Medicine

Objective Yintian Granule （YTG）, as a type of local preparation and applied for Chinese patent, is mainly composed of several traditional Chinese herbs used as both drug and food such as Lonicera macranthoides, Gardenia jasminoides, and Asparagus cochinchinenis, and has been reported to demonstrate the beneficial effects on human health in other researches, in this paper, the protective effects of YTG against experimental acute liver injury of mice were investigated to assess the value of this innovative Chinese herbal compound. Methods Carbon tetrachloride （CCl4） and 50% ethanol were used respectively to induce the acute liver injury model in mice pre- administered with YTG. Lai＇s method was used to detect the level of alanine aminotransferase （ALT） and aspartate aminotransferase （AST） in serum, Coomassie brilliant blue method was used for the determination of superoxide dismutase （SOD） activity and malondialdehyde （MDA） content, and hematoxylin-eosin （HE） staining was used for the observation of liver histomorphometry. Results YTG significantly lowered the elevated ALT and AST levels, increased the SOD activity, decreased the MDA content, and inhibited the deterioration of liver. Conclusion YTG exerts protective effected against hepatocyte damage in mice induced by CCl4 and 50% ethanol, respectively.

关键词： Hepatoprotection liver injury Yintian Granule

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