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Evaluation of spectral domain optical coherence tomography parameters in discriminating preperimetric glaucoma from high myopia

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International Journal of Ophthalmology(English edition) 2019年第1期12卷 58-65页

作者： xiao-yu xu Hui xiao Jing-Yi Luo Xing Liu State Key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Yat-sen University

AIM: To evaluate the diagnostic ability of macular ganglion cell-inner plexiform layer(GCIPL) thickness o b t a i n e d b y s p e c t r a l-d o m a i n o p t i c a l c o h e r e n c e tomography(SD-OCT) in discriminating non-highly myopic eyes with preperimetric glaucoma(PPG) from highly myopic healthy eyes. METHODS: A total of 254 eyes, including 76 normal controls(NC), 116 eyes with high myopia(HM) and 62 non-highly myopic eyes with PPG were enrolled. The diagnostic ability of OCT parameters was accessed by the areas under the receiver operating characteristic(AUROC) curve in two distinguishing groups: PPG eyes with nonglaucomatous eyes including NC and HM(Group 1), and PPG eyes with HM eyes(Group 2). Differences in diagnostic performance between GCIPL and RNFL parameters were evaluated. RESULTS: The minimum(AUROC curve of 0.782), inferotemporal(0.758) and inferior(0.705) GCIPL thickness were the top three GCIPL parameters in discriminating PPG from non-glaucomatous eyes, all of which had statistically significant lower diagnostic ability than average RNFL thickness(0.847). In discriminating PPG from HM, the best GCIPL parameter was minimum(0.689), statistically significant lower in diagnostic ability than average RNFL thickness(0.789) and three other RNFL thickness parameters of temporal and inferotemporal clock-hour sectors. CONCLUSION: The minimum GCIPL thickness is the best GCIPL parameter to detect non-highly myopic PPG from highly myopic eyes, whose diagnostic ability is inferiorto that of average RNFL thickness and RNFL thickness of several temporal and inferotemporal clock-hour sectors. The average RNFL thickness is recommended for discriminating PPG from highly myopic healthy eyes in current clinical practice in a Chinese population.

关键词： ganglion cell-inner plexiform layer diagnostic ability preperimetric glaucoma high myopia.

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International Journal of Ophthalmology(English edition) 2018年第11期11卷 1842-1847页

作者： Hui xiao xiao-yu xu Yi-Min Zhong Xing Liu State Key Laboratory of Ophthalmology Zhongshan Ophthalmic Center Sun Yat-sun University

AIM： To investigate the variation in the central lamina cribrosa thickness（cLCT）, and the central anterior lamina cribrosa surface depth（cALCSD）, as well as the central prelaminar tissue thickness（cPLTT） related to age in healthy Chinese ***： A total of 96 eyes from 96 Chinese healthy subjects were recruited. According to age, the 96 cases were divided into three groups： the young group（YG, 18-39 y）, middle-age group（MG, 40-59 y） and older-age group（OG, 60 y and above）. Lamina cribrosa images were obtained from all participants using radial linear protocol by enhanced depth imaging spectral-domain optical coherence tomography. The cLCT, cALCSD and cPLTT were calculated from the average value of the lamina cribrosa thickness, anterior lamina cribrosa surface depth and prelaminar tissue thickness in the optic nerve head（ONH） centre point and paracentral points（150 μm from the centre point in the horizontal and vertical directions）. RESULTS： For the total subjects, the mean cLCT, c ALCSD and cPLTT were 235.18±41.27, 358.02±93.80 and 182.02±92.11 μm, respectively. No statistically significant differences in cLCT, cALCSD or cPLTT were found between gender and different eyes（P=0.27-0.92）. The cLCT of the OG was the thickest among the three groups, while the c PLTT of the YG was the thickest among the three groups（P〈0.05）. Age was positively correlated with cLCT（r=0.42, P〈0.001）, and negatively correlated with cPLTT（r=-0.24, P=0.02）. No significant correlation was found between the age and cALCSD（r=-0.06, P=0.55）. And no correlation has been found between axial length and cLCT, cALCSD and c PLTT（P=0.11-0.81）.CONCLUSION： The impact of age on the cLCT and the cPLLTT should be taken into account when analysing glaucoma and other diseases related to lamina cribrosa.

关键词： lamina cribrosa thickness normal subjects optical coherence tomography age

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Determination of Nicotine in Tobacco by Capillary Electrophoresis with Electrochemical Detection

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Chemical Research in Chinese Universities 2012年第3期28卷 415-418页

作者： SUN Jin-ying xu xiao-yu yu Huan YOU Tian-yan State Key Laboratory of Electroanalytical Chemistry Changchun Institute of Applied ChemistryChinese Academy ofSciencesChangchun 130022P.R.China Ministry of Public Security of Jilin Province Changchun 130051P.R.China

A sensitive, simple and low-cost method based on capillary electrophoresis（CE） with electrochemical（EC） detection at a carbon fiber microdisk electrode（CFE） was developed for the determination of nicotine. Effects of de- tection potential, concentration and pH value of the phosphate buffer, and injection time as well as separation voltage were investigated. Under the optimized conditions： a detection potential of 1.20 V, 40 rnmol/L phosphate buffer（pH 2.0）, a sample injection time of 10 s at 10 kV and a separation voltage of 16 kV, the linear range obtained was from 5.0×10^-7 mol/L to 1.0×10^-4 mol/L with a correlation coefficient of 0.9989 and the limit of detection（LOD, S/N=3） obtained was 5.0×10^-8 mol/L. The method was also used to determine the nicotine in cigarettes. Nicotine amount ranged from 0.211 mg/g to 0.583 mg/g in the pipe tobacco of seven brands of cigarette and the amount in one ciga- rette varied from 0.136 mg/cigarette to 0.428 mg/cigarette.

关键词： Capillary electrophoresis Electrochemical detection Nicotine Tobacco

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Novel Metal-organic Framework Compound Pb(C_5H_4NCOO)_2 Showing One-dimensional Channel Defined as Four Leads and Four Nicotinic Acids

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Chemical Research in Chinese Universities 2009年第3期25卷 279-281页

作者： xu xiao-yu ZHOU Rui-sha SONG Jiang-feng xu Ji-qing College of Chemistry and State Key Laboratory of Inorganic Synthesis and Preparative Chemistry Jilin University Changchun 130012 P. R. China

A novel metal-organic framework（MOF） compound of Pb（C5H4NCOO）2 was hydrothermally synthesized and structurally determined by X-ray single-crystal diffraction. The data of unit cell： orthorhombic space group Pccn, a=1.0325（2） nm, b=1.3597（3） nm, c=0.8499（2） nm, V=1.1931（4） nm^3, Z=4, Dc=2.513 g/cm^3, R1=0.047 were obtained on the basis of 1365 reflections with Fo〉2σ（Fo）. PbN2O6 polyhedron adopts the distorted cubic configuration which is assigned to the holodirected geometry. These PbN2O6 polyhedra can form the zigzag chain by edge-sharing mode along（001） direction. Pb atom is connected by six nicotinic acid molecules, leading neutral 3D metal-organic framework with a channel defined by four Pb atoms and four nicotinic acid molecules.

关键词： Metal-organic framework(MOF) Lead Holodirected structure

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Hepatoprotective effects of Hovenia dulcis seeds against alcoholic liver injury and related mechanisms investigated via network pharmacology

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World Journal of Gastroenterology 2020年第24期26卷 3432-3446页

作者： xiao Meng Guo-Yi Tang Cai-Ning Zhao Qing Liu xiao-yu xu Shi-yu Cao Department of Nutrition School of Public HealthSun Yat-Sen UniversityGuangzhou 510080Guangdong ProvinceChina

BACKGROUND Alcoholic liver disease(ALD)is a worldwide health problem,and natural products have been shown to improve ALD due to their antioxidant *** parts of Hovenia dulcis(***),such as roots,peduncles,and stems,provide health ***,the effects and mechanisms of *** seeds on ALD have not yet been fully *** To determine *** antioxidant activity,evaluate its effects against ALD,and investigate the related mechanisms via network *** The antioxidant activity of *** seed was determined by both ferric-reducing antioxidant power and trolox equivalent antioxidant capacity *** total phenolic and flavonoid contents were determined by Folin–Ciocalteu method and aluminum chloride colorimetry,respectively,and polysaccharide was determined by phenol-sulfuric acid *** effects of *** seeds against alcoholic liver injury were investigated in mice with water extract pretreatment for 7 days followed by alcohol ***,the mechanisms of action were explored with network *** The results showed that *** seeds possessed strong antioxidant activity(245.11±10.17μmol Fe2+/g by ferric-reducing antioxidant power and 284.35±23.57μmol TE/g by trolox equivalent antioxidant capacity)and contained remarkable phenols and flavonoids,as well as a few *** seeds attenuated alcohol-induced oxidative liver injury,showing reduced serum alanine and aspartate aminotransferases,alkaline phosphatase,and triglyceride,elevated hepatic glutathione,increased activities of superoxide dismutase and catalase,and reduced malondialdehyde and hepatic *** results of network pharmacology analysis indicated that kaempferol,stigmasterol,and naringenin were the main bioactive compounds in *** seeds and that modulation of oxidative stress,inflammation,gut-derived products,and apoptosis were underlying mechanisms of the protective effects of *** seeds

关键词： Hovenia dulcis Alcoholic liver disease Antioxidant activity Hepatoprotection Oxidative stress Network pharmacology

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Molecular docking-aided AIEgen design: concept, synthesis and applications

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Science China Chemistry 2024年第8期67卷 2614-2628页

作者： Jian-Qing Zhang xiao-yu xu Fu-Sheng Liu Shu-Qiang Cao yu-Xin Gui Yi-Wen Su xiao-yu He Ji-yuan Liang You-Quan Zou Department of Radiation and Medical Oncology Zhongnan Hospital of Wuhan UniversitySchool of Pharmaceutical SciencesWuhan UniversityWuhan 430071China Key Laboratory of Combinatorial Biosynthesis and Drug Discovery Ministry of EducationWuhan UniversityWuhan 430071China Tai Kang Center for Life and Medical Sciences Wuhan UniversityWuhan 430071China Department of Hepatobiliary Pancreatic SurgeryZhongnan Hospital of Wuhan UniversityWuhan 430071China

Aggregate-induced emission luminogens(AIEgens) have been widely used in biological imaging, chemical sensing, and disease treatments. The rational design and construction of AIEgens have received considerable research interests during the last few years. Herein, molecular docking-aided AIEgen design has been reasonably proposed and AIEgen TBQZY with excellent ~1O_(2) generation ability has been synthesized. The newly developed TBQZY could efficiently kill S. epidermidis and methicillinresistant S. epidermidis(MRSE) by tightly binding to bacteria and triggering the accumulation of ~1O_(2) in bacteria. TBQZY specifically regulated the immune system and polarized macrophages from M1 to M2 to accelerate the elimination of biofilm in vivo. In addition, healing acceleration was observed in chronic wounds treated with TBQZY, and side effects were ***, TBQZY had extraordinary potential for combating drug-resistant bacteria in the clinical setting. This research not only provided new concepts for the design of AIEgens, but also shed some lights on the discovery of drugs against drug-resistant bacteria.

关键词： AIEgen molecular docking drug-resistant bacteria biofilm chronic wounds healing

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Improved nuclear mass formula with an additional term from the Fermi gas model

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Nuclear Science and Techniques 2024年第5期35卷 131-138页

作者： xiao-yu xu Li Deng Ai-Xi Chen Hang Yang Amir Jalili Han-Kui Wang School of Science Zhejiang Sci-Tech UniversityHangzhou 310018China

Nuclear mass is a fundamental property of nuclear physics and a necessary input in nuclear *** to the complexity of atomic nuclei and nonperturbative strong interactions,conventional physical models cannot completely describe nuclear binding *** this study,the mass formula was improved by considering an additional term from the Fermi gas *** nuclear masses in the Atomic Mass Evaluation Database were reproduced with a root-mean-square deviation(RMSD)of -1.86 MeV(1.92 MeV).The new mass formula exhibits good performance in the neutron-rich nuclear *** RMSD decreases to 0.393 MeV when the ratio of the neutron number to the proton number is≥1.6.

关键词： Nuclear mass formula Neutron-rich nuclei Fermi-gas model

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Brain structure underlying the empathizing–systemizing difference in children with autism spectrum disorder

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World Journal of Pediatrics 2023年第8期19卷 782-792页

作者： Ning Pan Li-Zi Lin Xin Wang Lei Shi xiao-yu xu yu-Ying Jin Si Tan xiao-Jing Song Jin Jing Xiu-Hong Li Department of Maternal and Child Health School of Public HealthSun Yat-Sen UniversityNo.74 Zhongshan Road 2Yuexiu DistrictGuangzhou510080China Guangdong Provincial Engineering Technology Research Center of Environmental Pollution and Health Risk Assessment Department of Occupational and Environmental HealthSchool of Public HealthSun Yat-Sen UniversityGuangzhou510080China Key Laboratory of Brain Cognition and Education ScienceMinistry of EducationGuangzhouChina Institute for Brain Research and Rehabilitation and Guangdong Key Laboratory of Mental Health and Cognitive ScienceSouth China Normal UniversityGuangzhou510631China JNU-HKUST Joint Laboratory for Neuroscience and Innovative Drug Research College of PharmacyJinan UniversityGuangzhou510632China Chinese Institute for Brain Research Beijing102206China

Background Behavioral research has shown that children with autism spectrum disorder(ASD)have a higher empathizing–systemizing difference(D score)than normal ***,there is no research about the neuroanatomical mechanisms of the empathizing–systemizing difference in children with *** Participants comprised 41 children with ASD and 39 typically developing(TD)children aged 6‒12 ***–systemizing difference was estimated using the D score from the Chinese version of Children’s Empathy Quotient and Systemizing *** quantified brain morphometry,including global and regional brain volumes and surface-based cortical measures(cortical thickness,surface area,and gyrification)via structural magnetic resonance *** We found that the D score was significantly negatively associated with amygdala gray matter volume[β=−0.16;95%confidence interval(CI):−0.30,−0.02;P value=0.030]in children with *** was a significantly negative association between D score and gyrification in the left lateral occipital cortex(LOC)in children with ASD(B=−0.10;SE=0.03;cluster-wise P value=0.006)and a significantly positive association between D score and gyrification in the right fusiform in TD children(B=0.10;SE=0.03;cluster-wise P value=0.022).Moderation analyses demonstrated significant interactions between D score and diagnosed group in amygdala gray matter volume(β=0.19;95%CI 0.04,0.35;P value=0.013)and left LOC gyrification(β=0.11;95%CI 0.05,0.17;P value=0.001)but not in right fusiform gyrification(β=0.08;95%CI−0.02,0.17;P value=0.105).Conclusions Neuroanatomical variation in amygdala volume and gyrification of LOC could be potential biomarkers for the empathizing–systemizing difference in children with ASD but not in TD ***-scale neuroimaging studies are necessary to test the replicability of our findings.

关键词： Autism spectrum disorder Empathy Structural magnetic resonance imaging Systemizing

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Comparisons of ganglion cell-inner plexiform layer loss patterns and its diagnostic performance between normal tension glaucoma and primary open angle glaucoma: a detailed, severity-based study

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International Journal of Ophthalmology(English edition) 2020年第1期13卷 71-78页

作者： xiao-yu xu Kun-Bei Lai Hui xiao Yi-Quan Lin Xin-Xing Guo Xing Liu State Key Laboratory of Ophthalmology Zhongshan Ophthalmic Center Sun Yat-sen University

AIM: To evaluate the patterns of macular ganglion cell-inner plexiform layer(GCIPL) loss in normal tension glaucoma(NTG) and primary open angle glaucoma(POAG) in a detailed, disease severity-matched way;and to assess the diagnostic capabilities of GCIPL thickness parameters in discriminating NTG or POAG from normal ***: A total of 157 eyes of 157 subjects, including 57 normal eyes, 51 eyes with POAG and 49 eyes with NTG were enrolled and strictly matched in age, refraction, and disease severity between POAG and NTG groups. The average, minimum, superotemporal, superior, superonasal, inferonasal, inferior, and inferotemporal GCIPL thickness, and the average, superior, temporal, inferior, and nasal retinal nerve fiber layer(RNFL) thickness were obtained by Cirrus optical coherence tomography(OCT). The diagnostic capabilities of OCT parameters were assessed by area under receiver operating characteristic(AUROC) curves. RESULTS: Among all the OCT thickness parameters, no statistical significant difference between NTG group and POAG group was found(all P>0.05). In discriminating NTG or POAG from normal subjects, the average and inferior RNFL thickness, and the minimum GCIPL thickness had better diagnostic capabilities. There was no significant difference in AUROC curve between the best GCIPL thickness parameter(minimum GCIPL) and the best RNFL thickness parameter in discriminating NTG(inferior RNFL;P=0.076) and indiscriminating POAG(average RNFL;P=0.913) from normal ***: Localized GCIPL loss, especially in the inferior and inferotemporal sectors, is more common in NTG than in POAG. Among all the GCIPL thickness parameters, the minimum GCIPL thickness has the best diagnostic performance in differentiating NTG or POAG from normal subjects, which is comparable to that of the average and inferior RNFL thickness.

关键词： normal tension glaucoma primary open angle glaucoma spectral domain optical coherence tomography ganglion cell-inner plexiform layer thickness pattern

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Self-assembling Process of Alkanethiol Monolayers on Gold Surface via Underpotential Deposition

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Chemical Research in Chinese Universities 2006年第6期22卷 783-786页

作者： HAN Dong-xue xu xiao-yu HOU Peng YANG Gui-fu NIU Li ZHAO Jian-wei State Key Laboratory of Electroanalytical Chemistry Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun 130022 P. R. China College of Chemistry Jilin University Changchun 130021 P. R. China Department of Chemistry Nanjing University Nanjing 210093 P. R. China

It was demonstrated feasible that underpotential deposition（UPD） of copper on a monolayer-modified gold substrate can be used to determine the gold electrode area. The deposition and stripping of a Cu adlayer can take place reversibly and stably at a bared or a self-assembled monolayer modified gold electrode. The growth kinetics of decanethiol/Au was also investigated v/a Cu UPD. The difference between the assembling kinetics determined by UPD and that by quartz crystal microbalance measurements reveals the configuration transmutation of the assembled molecules from a disordered arrangement to an ordered arrangement durinr the self-assembling processes.

关键词： SAM Configuration transmutation UPD QCM

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