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System design and validation of Queqiao-2 lunar relay communication satellite

中国空间科学技术(中英文) 2024年第5期44卷 23-39页

作者： ZHANG Lihua xiong Liang SUN Ji CHEN Luojing xiao Chuan ZHOU Wenyan wang Yong LIU wangwang GUAN Yifeng CHEN Tao YU xiaochuan XU Jin CHEN Guohui CAO xiaoping DFH Satellite Co. Ltd. Beijing Institute of Spacecraft System Engineering Beijing Institute of Control Engineering Academy of Space Information Systems

In order to provide relay communication supports for future Chinese lunar exploration program, Queqiao-2 relay communication satellite was ***-2 can perform scientific observations with three kinds of scientific instruments on *** system design of Queqiao-2,including mission orbit and transfer orbit design, configuration and layout design, housekeeping and information flow design, power supply and distribution design, GNC and propulsion system design, communication links design, etc.,was accomplished through comprehensive tradeoff and evaluation on technical maturity, availability, schedule, cost, and so *** a view to reducing development risk, both the platform and relay communication payloads were developed based on significant heritage from previous Queqiao relay satellite and other relevant ***-2 features flexible system architecture to support multiple frequencies, modulations, data rates and software reconfigurations to meet new user *** to a successful launch on March 20,2024,by means of 5 orbit maneuvers, Queqiao-2 was inserted into a highly elliptical frozen mission orbit around the moon with a 24h period on *** on-orbit tests and calibrations, Queqiao-2 has possessed the capacity to provide reliable relay communication services to multiple lunar exploration missions, as well as the capacity to perform scientific *** the support of Queqiao-2,Chang′e-6 achieved its ambitious mission goal to collect and return samples from the moon′s mysterious far *** the meanwhile, Queqiao-2 has also paved the way for the following Chinese lunar exploration missions including Chang′e-7 and Chang′*** design life time of Queqiao-2 is more than 8 *** from flexibility and extensibility of relay communication system design, it is convenient to provide relay communication services for future lunar exploration missions of both China and other *** addition, innovative

关键词： lunar explorations relay communication Queqiao system design test validation

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Biomimetic natural biomaterials for tissue engineering and regenerative medicine:new biosynthesis methods,recent advances,and emerging applications

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Military Medical Research 2024年第1期11卷 50-79页

作者： Shuai Liu Jiang-Ming Yu Yan-Chang Gan xiao-Zhong Qiu Zhe-Chen Gao Huan wang Shi-Xuan Chen Yuan xiong Guo-Hui Liu Si-En Lin Alec McCarthy Johnson V.John Dai-Xu Wei Hong-Hao Hou Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering the Fifth Affiliated HospitalSchool of Basic Medical ScienceSouthern Medical UniversityGuangzhou 510900China Department of Orthopedics Tongren HospitalShanghai Jiao Tong UniversityShanghai 200336China The Eighth Affiliated Hospital Sun Yat-Sen UniversityShenzhen 518033GuangdongChina Engineering Research Center of Clinical Functional Materials and Diagnosis&Treatment Devices of Zhejiang Province Wenzhou InstituteUniversity of Chinese Academy of SciencesWenzhou 325011ZhejiangChina Department of Orthopedics Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Department of Orthopaedics and Traumatology Faculty of Medicinethe Chinese University of Hong KongHong Kong SAR 999077China Department of Functional Materials Terasaki Institute for Biomedical InnovationLos AngelesCA 90064USA Mary&Dick Holland Regenerative Medicine Program College of MedicineUniversity of Nebraska Medical CenterOmahaNE 68130USA Zigong Affiliated Hospital of Southwest Medical University Zigong Psychiatric Research CenterZigong Institute of Brain ScienceZigong 643002SichuanChina Key Laboratory of Resource Biology and Biotechnology in Western China Ministry of EducationSchool of MedicineDepartment of Life Sciences and MedicineNorthwest UniversityXi’an 710127China

Biomimetic materials have emerged as attractive and competitive alternatives for tissue engineering(TE)and regenerative *** contrast to conventional biomaterials or synthetic materials,biomimetic scaffolds based on natural biomaterial can offer cells a broad spectrum of biochemical and biophysical cues that mimic the in vivo extracellular matrix(ECM).Additionally,such materials have mechanical adaptability,micro-structure interconnectivity,and inherent bioactivity,making them ideal for the design of living implants for specific applications in TE and regenerative *** paper provides an overview for recent progress of biomimetic natural biomaterials(BNBMs),including advances in their preparation,functionality,potential applications and future *** highlight recent advances in the fabrication of BNBMs and outline general strategies for functionalizing and tailoring the BNBMs with various biological and physicochemical characteristics of native ***,we offer an overview of recent key advances in the functionalization and applications of versatile BNBMs for TE ***,we conclude by offering our perspective on open challenges and future developments in this rapidly-evolving field.

关键词： Biomimic Scaffold Biosynthesis Natural biomaterial Tissue engineering

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In-flight Energy Calibration of the GECAM Gamma-ray Detectors

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Research in Astronomy and Astrophysics 2024年第10期24卷 48-57页

作者： Rui Qiao Dong-Ya Guo Wen-Xi Peng Yan-Qiu Zhang Shuo xiao Shao-Lin xiong Chao Zheng Chao-Yang Li Jia-Cong Liu wang-Chen Xue Jian-Jian He Zheng-Hua An Da-Li Zhang Xin-Qiao Li Li-Ming Song Shi-Jie Zheng Ke Gong Ya-Qing Liu Xin-Ying Song xiao-Yun Zhao Xiang-Yang Wen Yan-Bing Xu Xiang Ma xiao-Bo Li Ping wang Yue Huang Ce Cai Qi-Bin Yi Yi Zhao Chen-Wei wang Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Beijing 100049China China West Normal University Nanchong 637002China Xiangtan University Xiangtan 411105China Beijing Normal University Beijing 100875China

The Gravitational wave high-energy Electromagnetic Counterpart All-sky Monitor(GECAM)mission is designed to monitor the Gamma-Ray Bursts(GRBs)associated with gravitational waves and other high-energy transient *** mission consists of two microsatellites which are planned to operate at the opposite sides of the *** GECAM satellite could detect and localize GRBs in about 8 keV-5 MeV with its 25 Gamma-Ray Detectors(GRDs).In this work,we report the in-flight energy calibration of GRDs using the characteristic gamma-ray lines in the background spectra,and show their performance evolution during the commissioning ***,a preliminary cross-calibration of energy response with Fermi GBM data is also presented,validating the energy response of GRDs.

关键词： (stars:)gamma-ray burst:general instrumentation:detectors methods:data analysis

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Multidimensional Analgesia of Acupuncture by Increasing Expression of MD2 in Central Nervous System

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Chinese Journal of Integrative Medicine 2024年第11期30卷 1035-1044页

作者： LI Wan-rong REN Lu-lu ZHAO Tian-tian DAI Dan-qing GAO xiao-fei LIANG Hua-zheng xiong Li-ze Shanghai Key Laboratory of Anesthesiology and Brain Functional Modulation Shanghai Fourth People's Hospital School of Medicine Tongji University Clinical Research Center for Anesthesiology and Perioperative Medicine Shanghai Fourth People's Hospital School of Medicine Tongji University Translational Research Institute of Brain and Brain-Like Intelligence Shanghai Fourth People's Hospital School of Medicine Tongji University Department of Anesthesiology and Perioperative Medicine Shanghai Fourth People's Hospital School of Medicine Tongji University School of Rehabilitation Southwest Jiaotong University Monash Suzhou Research Institute

Objective:To investigate changes of myeloid differentiation factor 2（MD2） in inflammationinduced pain and acupuncture-mediated ***:Mice were randomly divided into three groups by a random number table method:saline group（n=16）,complete Freund's adjuvant（CFA） group（n=24） and CFA+electroacupuncture（EA） group（n=26）.Inflammation-induced pain was modelled by injecting CFA to the plantar surface of the hind paw of mice and EA was applied to bilateral Zusanli（ST 36） to alleviate *** mice in the CFA+EA group received EA treatment（30 min/d for 2 weeks） 24 h after *** in the saline and CFA groups received sham ***-Frey test and Hargreaves test were used to assess the pain *** and spinal tissues were collected for immunofluorescence staining or Western blotting to quantify changes of MD2 ***:CFA successfully induced plantar pain and EA significantly alleviated pain 3 days after modelling（P0.05）.Fluorescence staining showed significant decrease in the level of MD2 in periagueductal gray（PAG） and locus coeruleus（LC） after CFA injection on day 7（P<0.01 for PAG,P<0.05 for LC） and EA significantly reversed this decrease（P<0.01 for PAG,P<0.05 for LC）.Conclusion:The unique changes of MD2 suggest that EA may exert the analgesic effect through modulating neuronal activities of the superficial laminae of the spinal cord and certai

关键词： dorsal horn electroacupuncture inflammation-induced pain locus coeruleus myeloid differentiation factor 2 periaqueductal gray

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Enhanced soft magnetic properties of SiO_(2)-coated FeSiCr magnetic powder cores by particle size effect

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Chinese Physics B 2024年第10期33卷 405-412页

作者： Mingyue Ge Likang xiao xiaoru Liu Lin Pan Zhangyang Zhou Jianghe Lan Zhengwei xiong Jichuan Wu Zhipeng Gao Joint Laboratory for Extreme Conditions Matter Properties School of Mathematics and PhysicsSouthwest University of Science and TechnologyMianyang 621010China Southwest Institute of Applied Magnetism Mianyang 621010China Institute of Fluid Physics China Academy of Engineering PhysicsMianyang 621900China Sichuan Civil-military Integration Institute Mianyang 621010China

It has been known that metal FeSiCr powders with large average particle sizes have been typically employed to prepare magnetic powder cores(SMCs),with few studies reported on the influence of magnetic properties for original powders with various average particle sizes less than 10*** this work,SiO_(2)-coated FeSiCr SMCs with different small particle sizes were synthesized using the sol-gel *** contribution of SiO_(2)coating amount and voids to the soft magnetic properties was *** mechanism was revealed such that smaller particle sizes with less voids could be beneficial for reducing core loss in the *** optimizing the core structure,permeability and magnetic loss of 26 and 262 kW/cm^(3)at 100 kHz and 50 mT were achieved at a particle size of 4.8m and ethyl orthosilicate addition of 0.1 mL/*** best DC stacking performance,reaching 87%,was observed at an ethyl orthosilicate addition rate of 0.25 mL/g under 100 *** to other soft magnetic composites(SMCs),the FeSiCr/SiO_(2)SMCs exhibit significantly reduced magnetic *** further reduces the magnetic loss of the powder core,providing a new strategy for applications of SMCs at high frequencies.

关键词： FeSiCr SiO_(2) size effect magnetic properties DC superposition

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Research Progress of Different Fertilization Models in Farmland Based on Bibliometrics

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Agricultural Biotechnology 2024年第2期13卷 50-52页

作者： xiao wang Wenzhao LI xiong YAN Changling SUI Zhuang ZHAO Fengxue GONG Zunyi Normal University Zunyi 563006China

In order to grasp the research status of different fertilization modes in China s farmland more comprehensively, with papers in core journals of Chinese Peking University collected in CNKI database from 2003 to 2022 as the main research object, this paper analyzed the research status of different fertilization modes from the perspectives of annual number of published papers, published journals, keywords and highly cited papers applying the bibliometrics research method. This study provides reference for the research in this field.

关键词： CNKI Core journals Different fertilization modes Bibliometrics

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Synergistic effect of additional anlotinib and immunotherapy as second‐line or later‐line treatment in pancreatic cancer:A retrospective cohort study

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Cancer Innovation 2024年第4期3卷 57-66页

作者： Boyu Qin Qi xiong Lingli Xin Ke Li Weiwei Shi Qi Song Qiong Sun Jiakang Shao Jing Zhang xiao Zhao Jinyu Liu Jinliang wang Bo Yang Department of Oncology The Fifth Medical Center of Chinese PLA General HospitalBeijingChina Department of Gynaecology and Obstetrics PLA Rocket Force Characteristic Medical CenterBeijingChina Department of Graduate Administration Chinese PLA General HospitalBeijingChina Department of Oncology The First Medical Center of Chinese PLA General HospitalBeijingChina Department of Pharmacy Medical Supplies Center of Chinese PLA General HospitalBeijingChina

Background:Pancreatic ductal adenocarcinoma(PDAC)is in urgent need of a second‐line or later‐line treatment *** aimed to analyze the efficacy and safety of additional anlotinib,specifically anlotinib in combination with immunotherapy,in patients with PDAC who have failed first‐line ***:Patients with pathological diagnosis of PDAC were additionally treated with anlotinib,and some patients were treated with anti‐PD‐1 agents at the same time,which could be retrospectively *** efficacy and safety of additional anlotinib were ***:A total of 23 patients were *** patients treated with additional anlotinib,the overall median progression‐free survival(PFS)was 1.8 months and the median overall survival(OS)was 6.3 months,regardless of anti‐PD‐1 *** patients receiving additional anlotinib in combination with anti‐PD‐1 agents,median PFS and OS were 1.8 and 6.5 months,*** events(AEs)were observed in 16 patients(69.6%).In patients treated with additional anlotinib,the majority of AEs were grade 1–*** analysis revealed that patients with baseline red blood cell distribution width(RDW)<14%treated with additional anlotinib plus anti‐PD‐1 agents had significantly longer OS than patients with baseline RDW≥14%(p=0.025).Patients with additional anlotinib plus anti‐PD‐1 agents as second‐line therapy had a longer OS than those treated as later‐line therapy(p=0.012).Multivariate analysis showed that baseline RDW was the only independent risk factor for OS(p=0.042).Conclusion:The combination of anlotinib and immunotherapy represents an effective add‐on therapy with tolerable AEs as second‐or later‐line therapy in patients with PDAC,particularly in patients with baseline RDW<14%.

关键词： anlotinib efficacy immunotherapy independent risk factors pancreatic ductal adenocarcinoma

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Observation of spectral lines in the exceptional GRB 221009A

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Science China(Physics,Mechanics & Astronomy) 2024年第8期67卷 187-206页

作者： Yan-Qiu Zhang Shao-Lin xiong Ji-Rong Mao Shuang-Nan Zhang wang-Chen Xue Chao Zheng Jia-Cong Liu Zhen Zhang Xi-Lu wang Ming-Yu Ge Shu-Xu Yi Li-Ming Song Zheng-Hua An Ce Cai Xin-Qiao Li Wen-Xi Peng Wen-Jun Tan Chen-Wei wang Xiang-Yang Wen Yue wang Shuo xiao Fan Zhang Peng Zhang Shi-Jie Zheng Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Beijing 100049China Yunnan Observatories Chinese Academy of SciencesKunming 650011China Center for Astronomical Mega-Science Chinese Academy of SciencesBeijing 100012China Key Laboratory for the Structure and Evolution of Celestial Objects Chinese Academy of SciencesKunming 650216China College of Physics and Hebei Key Laboratory of Photophysics Research and Application Hebei Normal UniversityShijiazhuang 050024China Guizhou Provincial Key Laboratory of Radio Astronomy and Data Processing Guizhou Normal UniversityGuiyang 550001China College of Electronic and Information Engineering Tongji UniversityShanghai 201804China

As the brightest gamma-ray burst ever observed,GRB 221009A provided a precious opportunity to explore spectral line *** this article,we performed a comprehensive spectroscopy analysis of GRB 221009A jointly with GECAM-C and Fermi/GBM data to search for emission and absorption *** the first time we investigated the line feature throughout this GRB including the most bright part where many instruments suffered problems,and identified prominent emission lines in multiple time *** central energy of the Gaussian emission line evolves from about 37 to 6 MeV,with a nearly constant ratio(about 10%)between the line width and central ***,we find that both the central energy and the energy flux of the emission line evolve with time as a power law decay with power law index of–1 and–2,*** suggest that the observed emission lines most likely origin from the blue-shifted electron positron pair annihilation 511 ke V *** find that a standard high latitude emission scenario cannot fully interpret the observation,thus we propose that the emission line comes from some dense clumps with electron positron pairs traveling together with the *** this scenario,we can use the emission line to directly,for the first time,measure the bulk Lorentz factor of the jet(Γ)and reveal its time evolution(i.e.,Γ~t^(-1))during the prompt ***,we find that the flux of the annihilation line in the co-moving frame keeps *** discoveries of the spectral line features shed new and important lights on the physics of GRB and relativistic jet.

关键词： GRB GRB 221009A emission line

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A review on WO_(3)-based composite photocatalysts:synthesis,catalytic mechanism and diversified applications

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Rare Metals 2024年第8期43卷 3441-3459页

作者： Xue Zhang Zi-Qi Zhang Yan-Dong Sun xiao-Jia Ma Feng-Xian Jin Fang-Yuan Zhang Wei-Guang Han Bo-xiong Shen Sheng-Qi Guo College of Energy and Environmental Engineering Hebei University of TechnologyTianjin 300401China Department of Food and Chemical Engineering Liuzhou Institute of TechnologyLiuzhou 545616China

Photocatalysis as an emerging "green" energy conversion technology has attracted domestic and international *** technology uses semiconductor photocatalysts to convert solar energy into directly usable chemical energy,showing great potential for application in environmental pollutant purification and clean energy production,with broad development *** many semiconductor materials,tungsten trioxide(WO_(3)) is favored by researchers in the field of photocatalysis because of its good visible light response and excellent valence band hole oxidation ***,a large number of photocatalysts based on WO_(3),in particular W03-based composite photocatalysts,have been reported,and their applications cover a wide range of *** order to promote the development of WO_(3)-based photocatalysts and provide a reference for colleagues,we present a systematic summary of the applications and research progress of W03-based composites in the field of photocatalysis in recent *** from the structural properties of WO_(3)itself,this article summarizes the preparation methods and structure-activity relationships of WO_(3)-based composite ***,it introduces the current application status of existing WO_(3)-based composite photocatalysts in CO_(2) reduction,hydrogen production,nitrogen fixation,and pollutant ***,the development prospects were analyzed.

关键词： WO_(3)-based composite photocatalysts Intrinsic characteristic Preparation method Reaction mechanism Applications

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Cognitive dysfunction in schizophrenia patients caused by downregulation of γ-aminobutyric acid receptor subunits

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World Journal of Psychiatry 2024年第6期14卷 784-793页

作者： Xi Chen Ya-Nan Zhou xiao-Zi Lu Ren-Jiao Li Yi-Fan xiong Xia Sheng Wei-Wei Zhu Department of Child and Adolescent Psychiatric Brain Hospital of Hunan ProvinceThe Second People’s Hospital of Hunan ProvinceChangsha 410007Hunan ProvinceChina Department of Psychiatry Qingdao Mental Health CenterQingdao 266034Shandong ProvinceChina Department of Psychiatry Brain Hospital of Hunan ProvinceThe Second People’s Hospital of Hunan ProvinceChangsha 410007Hunan ProvinceChina Department of Sleep Disorders and Neurosis Brain Hospital of Hunan ProvinceThe Second People’s Hospital of Hunan ProvinceChangsha 410007Hunan ProvinceChina

BACKGROUND The expression pattern of gamma aminobutyric acid(GABA)receptor subunits are commonly altered in patients with schizophrenia,which may lead to nerve excitation/inhibition problems,affecting cognition,emotion,and *** To explore GABA receptor expression and its relationship with schizophrenia and to provide insights into more effective *** This case-control study enrolled 126 patients with schizophrenia treated at our hospital and 126 healthy volunteers who underwent physical examinations at our hospital during the same *** expression levels of the GABA receptor subunits were detected using 1H-magnetic resonance *** recognized cognitive battery tool,the MATRICS Consensus Cognitive Battery,was used to evaluate the scores for various dimensions of cognitive *** correlation between GABA receptor subunit downregulation and schizophrenia was also *** Significant differences in GABA receptor subunit levels were found between the case and control groups(P0.05).CONCLUSION Downregulation of the GABA receptor subunits is positively correlated with *** other words,when GABA receptor subunits are downregulated in patients,cognitive impairment becomes more severe.

关键词： Cognitive function Schizophrenia Downregulation Gamma-aminobutyric acid receptor subunits Correlation

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