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Perception Enhanced Deep Deterministic Policy Gradient for Autonomous Driving in Complex Scenarios

Computer Modeling in Engineering & Sciences 2024年第7期140卷 557-576页

作者： Lyuchao liao Hankun xiao Pengqi xing Zhenhua Gan Youpeng He Jiajun Wang Fujian Provincial Key Laboratory of Automotive Electronics and Electric Drive Fujian University of TechnologyFuzhou350118China Fujian Provincial Universities Engineering Research Center for Intelligent Driving Technology Fuzhou350118China

Autonomous driving has witnessed rapid advancement;however,ensuring safe and efficient driving in intricate scenarios remains a critical *** particular,traffic roundabouts bring a set of challenges to autonomous driving due to the unpredictable entry and exit of vehicles,susceptibility to traffic flow bottlenecks,and imperfect data in perceiving environmental information,rendering them a vital issue in the practical application of autonomous *** address the traffic challenges,this work focused on complex roundabouts with multi-lane and proposed a Perception EnhancedDeepDeterministic Policy Gradient(PE-DDPG)for AutonomousDriving in the ***,themodel incorporates an enhanced variational autoencoder featuring an integrated spatial attention mechanism alongside the Deep Deterministic Policy Gradient framework,enhancing the vehicle’s capability to comprehend complex roundabout environments and make ***,the PE-DDPG model combines a dynamic path optimization strategy for roundabout scenarios,effectively mitigating traffic bottlenecks and augmenting throughput *** experiments were conducted with the collaborative simulation platform of CARLA and SUMO,and the experimental results show that the proposed PE-DDPG outperforms the baseline methods in terms of the convergence capacity of the training process,the smoothness of driving and the traffic efficiency with diverse traffic flow patterns and penetration rates of autonomous vehicles(AVs).Generally,the proposed PE-DDPGmodel could be employed for autonomous driving in complex scenarios with imperfect data.

关键词： Autonomous driving traffic roundabouts deep deterministic policy gradient spatial attention mechanisms

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Study on the development and usage of a cardiopulmonary resuscitation time point recorder

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World Journal of Emergency Medicine 2017年第3期8卷 195-199页

作者： Ling Zhou Hui Li Hong-yan Wei Chun-lin Hu xiao-li Jing Hong Zhan xiao-xing liao Xin Li Fire Corps Medical Department of Hunan Province Department of Emergency Medicine The First Affi liated Hospital Sun Yat-sen University Department of Emergency Medicine Department of Emergency and Critical Care medicine Guangdong General Hospital Guangdong Academy of Medical Sciences

BACKGROUND: To invent a novel cardiopulmonary resuscitation(CPR) time point recorder to synchronously and automatically record the time and to identify its effectiveness in ***: A CPR time point recorder was invented after the doctors were familiar with the traditional Utstein recovery registration mode and mastered the registration time points required. The progress of CPR was simulated. The standard and correct times were recorded, and the doctors performing the recovery collected the data about the times using our CPR time point recorder or the memory registration ***: The deviation times were 21.4±24.7 seconds for the memory group and 3.57±4.58 seconds for CPR time point recorder group. The deviation of times increased signifi cantly depending on the increase of the operation items in the memory group. A similar phenomenon was found in the timer group but with a smaller difference(P<0.01).CONCLUSION: A CPR time point recorder could reduce the deviation of operate-time, especially after a long-time operation, and for procedures with more operating items, compared with the memory mode. It was a more advantageous and accurate method for the Utstein registration.

关键词： Cardiopulmonary resuscitation Time point recorder Utstein registration

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Numerical and experimental study on the falling film flow characteristics with the effect of co-current gas flow in hydrogen liquefaction process

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Petroleum Science 2024年第2期21卷 1369-1384页

作者： Chong-Zheng Sun Yu-xing Li Hui Han xiao-Yi Geng xiao Lu College of Energy Storage Technology Shandong University of Science and TechnologyQingdao 266590ShandongChina College of Pipeline and Civil Engineering/Shandong Provincial Key Laboratory of Oil&Gas Storage and Transportation Safety China University of PetroleumQingdao 266580ShandongChina

Liquid hydrogen storage and transportation is an effective method for large-scale transportation and utilization of hydrogen energy. Revealing the flow mechanism of cryogenic working fluid is the key to optimize heat exchanger structure and hydrogen liquefaction process(LH2). The methods of cryogenic visualization experiment, theoretical analysis and numerical simulation are conducted to study the falling film flow characteristics with the effect of co-current gas flow in LH2spiral wound heat *** results show that the flow rate of mixed refrigerant has a great influence on liquid film spreading process, falling film flow pattern and heat transfer performance. The liquid film of LH2mixed refrigerant with column flow pattern can not uniformly and completely cover the tube wall surface. As liquid flow rate increases, the falling film flow pattern evolves into sheet-column flow and sheet flow, and liquid film completely covers the surface of tube wall. With the increase of shear effect of gas-phase mixed refrigerant in the same direction, the liquid film gradually becomes unstable, and the flow pattern eventually evolves into a mist flow.

关键词： Hydrogen liquefaction Spiral wound heat exchanger Flow pattern transition Falling film flow

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Understanding the failure mechanism towards developing high-voltage single-crystal Ni-rich Co-free cathodes

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Green Energy & Environment 2024年第6期9卷 1045-1057页

作者： Jixue Shen Bao Zhang Changwang Hao xiao Li Zhiming xiao Xinyou He xing Ou Engineering Research Center of the Ministry of Education for Advanced Battery Materials School of Metallurgy and EnvironmentCentral South UniversityChangsha410083China Zhejiang Power New Energy Co. Ltd.Zhuji311899China Material Science and Chemistry Engineering College China University of GeosciencesWuhan430074China

Benefited from its high process feasibility and controllable costs,binary-metal layered structured LiNi_(0.8)Mn_(0.2)O_(2)(NM)can effectively alleviate the cobalt supply crisis under the surge of global electric vehicles(EVs)sales,which is considered as the most promising nextgeneration cathode material for lithium-ion batteries(LIBs).However,the lack of deep understanding on the failure mechanism of NM has seriously hindered its application,especially under the harsh condition of high-voltage without sacrifices of reversible ***,singlecrystal LiNi_(0.8)Mn_(0.2)O_(2) is selected and compared with traditional LiNi_(0.8)Co_(0.1)Mn_(0.1)O_(2)(NCM),mainly focusing on the failure mechanism of Cofree cathode and illuminating the significant effect of Co element on the Li/Ni antisite defect and dynamic ***,the presence of high Li/Ni antisite defect in NM cathode easily results in the extremely dramatic H2/H3 phase transition,which exacerbates the distortion of the lattice,mechanical strain changes and exhibits poor electrochemical performance,especially under the high cutoff ***,the reaction kinetic of NM is impaired due to the absence of Co element,especially at the single-crystal ***,the negative influence of Li/Ni antisite defect is controllable at low current densities,owing to the attenuated ***,Co-free NM can exhibit better safety performance than that of NCM *** findings are beneficial for understanding the fundamental reaction mechanism of single-crystal Ni-rich Co-free cathode materials,providing new insights and great encouragements to design and develop the next generation of LIBs with low-cost and high-safety performances.

关键词： Li/Ni antisite defect Dynamic characteristic High-voltage Single-crystal Ni-rich Co-free cathodes Lithium-ion batteries

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Base editor-mediated large-scale screening of functional mutations in bacteria for industrial phenotypes

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Science China(Life Sciences) 2024年第5期67卷 1051-1060页

作者： Yaomeng Yuan Xihao liao Shuang Li Xin-Hui xing Chong Zhang MOE Key Laboratory for Industrial Biocatalysis Institute of Biochemical EngineeringDepartment of Chemical EngineeringTsinghua UniversityBeijing 100084China Institute of Biopharmaceutical and Health Engineering Tsinghua Shenzhen International Graduate SchoolShenzhen 518055China Institute of Biomedical Health Technology and Engineering Shenzhen Bay LaboratoryShenzhen 440300China Center for Synthetic and Systems Biology Tsinghua UniversityBeijing 100084China

Base editing,the targeted introduction of point mutations into cellular DNA,holds promise for improving genome-scale functional genome screening to single-nucleotide *** efforts in prokaryotes,however,remain confined to loss-of-function screens using the premature stop codons-mediated gene inactivation library,which falls far short of fully releasing the potential of base ***,we developed a base editor-mediated functional single nucleotide variant screening pipeline in Escherichia *** constructed a library with 31,123 sgRNAs targeting 462 stress response-related genes in ***,and screened for adaptive mutations under isobutanol and furfural selective *** by the screening results,we successfully identified several known and novel functional *** pipeline might be expanded to the optimization of other phenotypes or the strain engineering in other microorganisms.

关键词： base editor high-throughput large-scale screening Escherichia coli functional mutation

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Early embryonic failure caused by a novel mutation in the TUBB8 gene:A case report

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World Journal of Clinical Cases 2024年第12期12卷 2092-2098页

作者： xiao-Yu Zhang xing-xing Zhang Lei Wang Department of Reproductive Center Zaozhuang Maternal and Child Healthcare HospitalZaozhuang 277000Shandong ProvinceChina

BACKGROUND This study aimed to explore the relationship between gene mutations and early embryonic development arrest and to provide more possibilities for the diagnosis and treatment of repeated implantation *** SUMMARY Here,we collected and described the clinical data of a patient with early embryonic development stagnation after repeated in vitro fertilization attempts for primary infertility at the Department Reproductive Center of Zaozhuang Maternal and Child Healthcare *** also detected the whole-exon gene of the patient's spouse and parents,and conducted bioinformatics analysis to determine the pathogenesis of the *** A novel mutant of the TUBB8 gene[c.602G>T(p.C201F)]was identified,and this mutant provided new data on the genotype-phenotype relationships of related diseases.

关键词： Genes Mutation Embryonic development Fertilization in vitro Intracytoplasmic sperm injection Case report

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Study on the vertical deformations induced by terrestrial water storage changes in Huang-Huai-Hai river basin

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Geodesy and Geodynamics 2024年第4期15卷 352-365页

作者： Liansheng Deng Yugang xiao Qusen Chen Feifei liao Zhao Li School of Electrical and Electronic Information Engineering Hubei Polytechnic UniversityHuangshi 435003China Hubei Luojia Laboratory GNSS Research CenterWuhan UniversityWuhan 430079.China Changjiang Spatial Information Technology Engineering Co. Ltd.Wuhan 430010China

Terrestrial water storage(TWs)variations are associated with water mass movements,which may cause the deformation displacements of the Global Navigation Satellite System(GNSS)*** study investigates the spatio-temporal Tws variations and addresses the relationship between deformation variations observed in the Huang-Huai-Hai River Basin(HHHRB)and local hydrological *** indicate that the vertical velocities at the GNSS stations induced by TWS changes are relatively small,and the impacts of the terrestrial water storage changes are mainly reflected in the changes of seasonal *** there is a downward TWS trend from 2011 to 2022 in most HHHRB areas,velocities from the vertical displacements of both Gravity Recovery and Climate Experiment(GRACE)and GRACE Follow-On(GFO)and the GNSS reflect that the HHHRB is undergoing an uplift process,while the magnitude of the GRACE/GFO derived velocities is much smaller than that of the GNSS *** hydrological deformations estimated from GRACE/GFO and GNSS measurements reveal that the TWS-derived displacements can explain 54.5%of the GNSS seasonal variations,with the phases of terrestrial water storage advancing by about one month relative to GNss common signal ***,the decrease of the groundwater storage in the HHHRB has been accelerating since *** reaching its lowest level around mid-2020,it began to rise rapidly,which might be closely related to the implementation of the South-North Water Transfer Central Project.

关键词： Terrestrial waterstorage GRACE GNSS Vertical deformations Huang-Huai-Hairiverbasin

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Remazolam combined with transversus abdominis plane block in gastrointestinal tumor surgery:Have we achieved better anesthetic effects?

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World Journal of Gastrointestinal Oncology 2024年第8期16卷 3368-3371页

作者： Jing Cao xing-liao Luo Qiang Lin Department of Anesthesiology North China Petroleum Bureau General HospitalRenqiu 062552Hebei ProvinceChina Department of Oncology North China Petroleum Bureau General HospitalHebei Medical UniversityRenqiu 062552Hebei ProvinceChina

Laparoscopic surgery is the main treatment method for patients with gastrointestinal malignant *** laparoscopic surgery is minimally invasive,its tool stimulation and pneumoperitoneum pressure often cause strong stress reactions in *** the other hand,gastrointestinal surgery can cause stronger pain in patients,compared to other *** abdominis plane block(TAPB)can effectively inhibit the transmission of nerve impulses caused by surgical stimulation,alleviate patient pain,and thus alleviate stress *** is an acting,safe,and effective sedative,which has little effect on hemodynamics and is suitable for most *** combined with remazolam can reduce the dosage of total anesthetic drugs,reduce adverse reactions,reduce stress reactions,and facilitate the rapid postoperative recovery of patients.

关键词： Transversus abdominis plane block Remazolam Hemodynamics Gastrointestinal tumor surgery Oxidative stress

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FPR1 Antagonist (BOC-MLF) Inhibits Amniotic Epithelial-mesenchymal Transition

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Current Medical Science 2024年第1期44卷 187-194页

作者： xiao-mei HUANG E liao Jun-qun liao Ya-ling LIU Yong SHAO Department of Obstetrics and Gynecology The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400042China Department of Obstetrics Maternal and Child Health Hospital of Hubei ProvinceWuhan 430070China Medical Laboratory Science The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400042China Department of Obstetrics Yubei Maternity and Child Healthcare HospitalChongqing 400042China

Objective:Premature rupture of membranes(PROM)is a common pregnancy disorder that is closely associated with structural weakening of fetal *** have found that formyl peptide receptor 1(FPR1)activates inflammatory pathways and amniotic epithelial-mesenchymal transition(EMT),stimulates collagen degradation,and leads to membrane weakening and membrane *** purpose of this study was to investigate the anti-inflammatory and EMT inhibitory effects of FPR1 antagonist(BOC-MLF)to provide a basis for clinical prevention of ***:The relationship between PROM,FPR1,and EMT was analyzed in human fetal membrane tissue and plasma samples using Western blotting,PCR,Masson staining,and ELISA ***(LPS)was used to establish a fetal membrane inflammation model in pregnant rats,and BOC-MLF was used to treat the LPS rat *** detected interleukin(IL)-6 in blood from the rat hearts to determine whether the inflammatory model was successful and whether the anti-inflammatory treatment was *** used electron microscopy to analyze the structure and collagen expression of rat fetal ***:Western blotting,PCR and Masson staining indicated that the expression of FPR1 was significantly increased,the expression of collagen was decreased,and EMT appeared in *** rat model indicated that LPS caused the collapse of fetal membrane epithelial cells,increased intercellular gaps,and decreased ***-MLF promoted an increase in fetal membrane collagen,inhibited EMT,and reduced the weakening of fetal ***:The expression of FPR1 in the fetal membrane of PROM was significantly increased,and EMT of the amniotic membrane was ***-MLF can treat inflammation and inhibit amniotic EMT.

关键词： formyl peptide receptor 1 BOC-MLF epithelial-mesenchymal transition premature rupture of membranes

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Long-Chain Alkenones in the South Yellow Sea Sediments and Their Indicative Significance for Haptophytes Species

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Journal of Ocean University of China 2024年第5期23卷 1287-1296页

作者： XU Yakun YANG Xinxin xiao Rui xing Lei Key Laboratory of Marine Chemistry Theory and Engineering Technology Ministry of Education Ocean University of China Laboratory of Marine Ecology and Environment Science Qingdao National Laboratory for Marine Science and Technology

Long-chain alkenones（LCAs） have been widely used as important biomarkers in palaeoceanographic ***,the commonly used LCAs proxies are mainly based on C37alkenones,and it is still lack of the studies about the distribution and indications of LCAs with different chain lengths other than ***,the composition and distribution of LCAs were analyzed in surface sediments from the southern Yellow Sea（SYS） and a sedimentary core（A02-C） from the central Yellow Sea（YS）mud *** results showed that C37,C38and C39alkenones were the major LCAs in surface sediments of the SYS,and the relative contents of C38:2Et,C37:2Me,C37:3Me,C38:2Me,C38:3Et,C38:3Me,C39:2Et and C39:3Et were 18.3%-59.8%,22.6%-41.2%,7.4%-23.0%,6.6%-15.4%,3.8%-13.3 %,3.6%-8.7%,2.8%-6.0% and 0.7%-3.0%,*** the relationships of U38MeK-U38EtKand U37K'-U38EtKindicate that LCAs are mainly derived from Emiliania huxleyi（***）.High ratios of total C37alkenones to total C38alkenones(K37/K38)（1-1.2） were found in the central SYS,corresponding to the relatively high abundance of ***;while low ratios of K37/K38（0.7-0.9） were observed at nearshore area of the SYS where Gephyrocapsa oceanica（***） has relatively high *** spatial distribution of K37/K38ratio is also consistent with that of coccolithophores nannofossil in the *** addition,K37/K38ratio in core A02-C varied from 0.7 to 1.1 with a gradual decreasing trend during the past 5.5 *** suggests that the relative abundance of *** decreased gradually,caused by the changes in the Yellow Sea Warm Current（YSWC） and the East Asian Winter Monsoon（EAWM） during this period.

关键词： alkenones sediment southern Yellow Sea Yellow Sea Warm Current

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