检索结果-南通市图书馆

Integrative medicine in the era of cancer immunotherapy: Challenges and opportunities

在线全文

学校读者我要写书评

暂无评论

Journal of Integrative Medicine 2021年第4期19卷 291-294页

作者： Ning Zhang xiao-he xiao Department of Liver Disease the Fifth Medical Center of Chinese People's Liberation Army General HospitalBeijing 100039China

Cancer immunotherapy has led to a new era of cancer treatment strategies, and transforming healthcare for cancer patients. Meanwhile, reports of immune-related adverse events have been increasing, greatly hindering the use of cancer immunotherapy. Traditional Chinese medicine(TCM), which has been widely used in Asian countries for thousands of years, is known to play a complementary role in the treatment of cancer. Taken in combined with conventional modern therapies, such as resection, ablation and radiotherapy, TCM exerts its main anti-cancer effects in two ways: health-strengthening(Fu-Zheng) and pathogen-eliminating(Qu-Xie). Theoretically, pathogen-eliminating TCM can promote the release of tumor-related antigens and should be able to increase the effect of immunotherapy, while healthstrengthening TCM may have immune-enhancing mechanisms that overlap with immunotherapy. In the era of cancer immunotherapy, it is important to balance the use of TCM and immunotherapy, with the goal of enhancing immune efficacy and antagonizing immune toxicity. In this article, we discuss this issue by considering the mechanism of tumor immunotherapy, alongside the theoretical basis of TCM treatment of tumors, with the aim of bringing new insights to future research in this field.

关键词： Cancer Immunotherapy Traditional Chinese medicine Risk prevention Treatment pattern

A facile route for shape-selective synthesis of silica nanostructures using poly-L-lysine as template

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2013年第2期24卷 99-102页

作者： Ding-Geng he xiao-xiao he Ke-Min Wang Ying-Xiang Zhao State Key Laboratory of Chemo/Biosensing and Chemometrics College of Chemistry and Chemical EngineeringHunan University Key Laboratory for Bio-Nanotechnotogy and Molecule Engineering of Hunan Province College of BiologyHunan University Key Laboratory for Bio-Nanotechnology and Molecule Engineering of Hunan Province College of Biology.Hunan University Key Laboratory for Bio-Nanotechnology and Molecule Engineering of Hunan Province College of BiologyHunan University

Received 12 December 2012 Received in revised form 7 January 2013 Accepted 9 January 2013 Available online 8 February 2013

关键词： Poly-l-lysineReverse microemulsionSilica nanostructureTEOS

Disease-based Toxicology on Safety Assessment Strategy and Application for herbal and Traditional Medicines

在线全文

学校读者我要写书评

暂无评论

World Journal of Traditional Chinese Medicine 2019年第3期5卷 139-144页

作者： Jia-Bo Wang Zhuo Shi xiao-he xiao The Fifth Medical Center China Military Institute of Chinese MedicineGeneral Hospital of PLA Clinical Pharmacokinetics Laboratory School of Basic Medicine and Clinical PharmacyChina Pharmaceutical UniversityNanjingChina Integrative Medical Center The Fifth Medical CenterGeneral Hospitalof PLABeijing

The safety issue on herbal and traditional medicines(H&TM) is one of the most challenging problems and serious concern worldwide. With scientific endeavor and further exploration, we came to realize that there are great differences between H&TM and synthetic drugs in many aspects, such as medical theory, medication experience, compatibility, processing, toxicological characteristics, and safety evaluating requirements. In the current preclinical models for synthetic drugs, the safety assessment results of some conventional deemed 'nontoxic' H&TM were not well consistent with clinical situations, which resulted in major difficulties to understand the mechanisms and guide the safe and rational uses of these H&TM. Thus, based on the traditional Chinese medicine toxicity theory called You Gu Wu Yun, this paper introduces a novel safety assessment strategy for H&TM, named as disease-based toxicology. It aims to cognize the relativity and susceptibility of the toxicity of H&TM, and then to enhance controllability in new drug development and clinical applications. It also provides a theoretical practice for the traditional Chinese medicine toxicity theory and a methodological promotion for the future development of the precision toxicology for H&TM.

关键词： Disease-based toxicology idiosyncratic toxicity safety of herbal and traditional medicines susceptibility syndrome differentiation-based toxicity attenuation

Guidelines for the Diagnosis and Management of herb-Induced Liver Injury

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Integrative Medicine 2018年第9期24卷 696-706页

作者： WANG Jia-bo ZHU Yun BAI Zhao-fang WANG Fu-sheng LI Xiu-hui xiao xiao-he Integrative Medical Center 302 Military Hospital of China Research Center for Biological Therapy 302 Military Hospital of China Integrative Medical Center Beijing You An HospitalCapital Medical University

herb-induced liver injury （HILl） is a type of adverse drug reactions related to using Chinese medicine （CM） or herbal medicine （HM）, and is now a growing segment of drug-induced liver injury （DILl） worldwide. Owing to the complicated compositions and miscellaneous risk factors associated with the clinical usage of CM or HM, it is more challenging to diagnose and manage HILl than DILl. In the present guideline issued by the China Association of Chinese Medicine （CACM）, the authors present an evidence chain-based workflow with 9 structured judgment criteria for diagnosing HILl. The 3 diagnostic ending points--suspected diagnosis, clinical diagnosis, and confirmed diagnosis--could be reached according to the length of the evidence chain acquired in the structured diagnostic workflow. Either identifying the species of CM or HM or excluding adulterations and toxin contaminants was strongly recommended to improve the level of evidence for a clinical diagnosis of HILl. In addition, the authors report that the improper use of CM, which violates the general law of CM theory, is one of the most important factors that contributes to HILl and should be avoided. By contrast, based on syndrome differentiation, some CM can also be used to treat HILl if used in accordance with the general law of CM theory. Therefore, 9 recommendations are put forward in this guideline.

关键词： herb-induced liver injury diagnosis treatment management Chinese medicine guideline

Schisandra chinensis Oil Attenuates Aristolochic Acid Ⅰ-Induced Nephrotoxicity in vivo and in vitro

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Integrative Medicine 2022年第7期28卷 603-611页

作者： YANG Yan GE Fei-lin ZHAN xiao-yan MU Wen-qing LI Zhi-yong LIN Li WEI Zi-ying BAI Zhao-fang SUN Qin xiao xiao-he School of Integrated Traditional Chinese and Western Medicine Southwest Medical UniversityLuzhouSichuan Province 646000China Senior Department of hepatology the Fifth Medical Center of PLA General HospitalBeijing 100039China China Military Institute of Chinese Materia the Fifth Medical Center of PLA General HospitalBeijing 100039China

Objective: To investigate the protective effects of Schisandra chinensis oil(SCEO) against aristolochic acid Ⅰ(AAⅠ)-induced nephrotoxicity in vivo and in vitro and elucidate the underlying ***: C57BL/6 mice were randomly divided into 5 groups according to a random number table, including control group, AAⅠ group, and AAⅠ+SCEO(0.25, 0.5 and 1 g/kg) groups(n=5 per group). Pretreatment with SCEO was done for 2 days by oral administration, while the control and AAⅠ groups were treated with sodium carboxymethyl cellulose. Mice of all groups except for the control group were injected intraperitoneally with AAⅠ(5 mg/kg) from day 3 until day 7. Histopathological examination and apoptosis of kidney tissue were observed by hematoxylin and eosin and TdT-mediated dUTP nick-end labeling(TUNEL) staining, respectively. The levels of serum alanine aminotransferase(ALT), aspartate aminotransferase(AST), blood urea nitrogen(BUN), and serum creatinine(SCr), as well as renal malondialdehyde(MDA), glutathione, r-glutamyl cysteingl+glycine(GSH), and superoxide dismutase(SOD) were analyzed using enzyme-linked immunosorbent assay(ELISA).Expressions of hepatic cytochrome P450 1A1(CYP1A1), CYP1A2, and nad(p)hquinonedehydrogenase1(NQO1) were analyzed using ELISA, quantitative real-time polymerase chain reaction(qPCR) and Western blot,respectively. In vitro, SCEO(40 μg/mL) was added 12 h before treatment with AAⅠ(40 μmol/mL for 48 h) in human renal proximal tubule cell line(HK-2), then apoptosis and reactive oxygen species(ROS) were analyzed by flow cytometry. Results: SCEO 0.5 and 1 g/kg ameliorated histopathological changes and TUNEL+ staining in the kidney tissues of mice with AAⅠ-induced nephrotoxicity, and reduced serum levels of ALT, AST, BUN and SCr(Phe ROS generation in kidney, containing MDA,GSH and SOD(Phe expressions of CYP1A1 and CYP1A2 and decreased NQO1 level in the liver tiss

关键词： aristolochic acidⅠ nephrotoxicity Schisandra chinensis oil metabolic enzymes apoptosis reactive oxygen species

Effects of Two Curcuminoids on Candida albicans

在线全文

学校读者我要写书评

暂无评论

Chinese herbal Medicines 2012年第3期4卷 205-212页

作者： ZHANG Da LUO Jiao-yang YAN Dan JIN Cheng DONG xiao-ping xiao xiao-he China Military Institute of Chinese Materia Medica Military 302 HospitalBeijing 100039China Institute of Medicinal Plant Development Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100193China College of Pharmacy Chengdu University of Traditional Chinese MedicineChengdu 610075China

Objective To investigate and compare the action of curcuminoids on the causal pathogens of Candida albicans growth. Methods The effects of curcumin (CUR) and demethoxycurcumin (DMC) on C. albicans growth were first investigated and compared by microcalorimetry coupled with multiple analytical methods. The quantitative thermo-kinetic parameters obtained from these curves were analyzed to show difference of the actions. Results By analyzing the main parameters screened from principal component analysis together with 50% inhibiting concentration values, it was demonstrated that both CUR and DMC showed good antifungal activities and CUR was stronger. It was further concluded from structure-activity relationship that the existence of methoxy group might enhance lipophilicity of the mother nucleus, which made it easier for the molecular to enter into the cell membrane of fungi to inhibit its growth. Conclusion This study provides a new method for screening new antifungal agents with high efficacy and low toxicity. Meanwhile, it contributes to the application of curcuminoids as food additive, colorant, and drug. Microcalorimetry is real-time, online, and dynamic, and it could be used to characterize the subtle difference among the effects of synthetic and natural products on the vital process of fungi.

关键词： antifungal agents Candida albicans comparative study curcuminoids microcalorimetry

Idiosyncratic Drug-Induced Liver Injury Linked to Polygonum multiflorum:A Case Study by Pharmacognosy

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Integrative Medicine 2017年第8期23卷 625-630页

作者： LI Chun-yu he Qin GAO Dan LI Rui-yu ZHU Yun LI Hui-fang FENG Wu-wen YANG Mei-hua xiao xiao-he WANG Jia-bo Institute of Medicinal Plant Development Chinese Academy of Medical Sciences & Peking Union Medical College China Military Institute of Chinese Medicine 302 Military Hospital School of Pharmacy Hunan University of Traditional Chinese Medicine School of Pharmacy Shanxi University of Traditional Chinese Medicine

The use of Chinese medicinal herbs（CMH）continues to expand rapidly across the world with a deep belief that herbs are safe because they are＂natural＂.（1）However,a survey of the literature indicates that CMH related hepatotoxicity is increasing and has been a worldwide problem.（2,3）Polygonum multiflorum Thunb.（***）,officially listed in the Pharmacopoeia of the People＇s Republic of China.

关键词： Idiosyncratic Drug-Induced Liver Injury Linked to Polygonum multiflorum:A Case Study by Pharmacognosy UHPLC DILI

Dynamic monitoring of the cytotoxic effects of protoberberine alkaloids from Rhizoma Coptidis on hepG2 cells using the xCELLigence system

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Natural Medicines 2014年第6期12卷 428-435页

作者： ZHANG Le-Le MA Li-Na YAN Dan ZHANG Cong-En GAO Dan XIONG Yin SheNG Fei-Ya DONG xiao-Ping xiao xiao-he College of Pharmacy Chengdu University of Traditional Chinese Medicine China Military Institute of Chinese Materia Medica 302 Military Hospital

AIM: To investigate the cytotoxic effects of the six protoberberine alkaloids(PAs) from Rhizoma Coptidis on hepG2 cells. METHOD: A systematic screening was conducted to investigate the dynamic response of hepG2 cells to the PAs using the impedance-based xCELLigence system. Cisplatin was selected as the positive control. The real time, concentration-response curves and the 50% inhibitory concentrations(IC50) were acquired to evaluate the anticancer activity of the PAs. RESULTS: All of the six PAs inhibited cell growth and induce death in hepG2 cells in a time- and concentration-dependent manner. The IC50 values of cisplatin, berberine, columbamine, coptisine, epiberberine, jatrorrhizine, and palmatine were 5.13, 42.33, 226.54, 36.90, 302.72, 383.54, and 456.96 μg·mL-1, respectively. The results obtained using the xCELLigence system corresponded well with those of the conventional methods. CONCLUSION: The xCELLigence system is a reliable and efficient tool for real-time screening of the cytotoxic effect of compounds in cell-based in vitro assays. Coptisine and berberine, with methylenedioxy group at C2 and C3 on the phenyl ring showed stronger *** the other four PAs. However, compared with cisplatin, the six PAs didn't show obvious cytotoxic effect on hepG2 *** results provided some useful data for the evaluation of the anticancer compounds, and the clinical application of traditional Chinese medicine.

关键词： Rhizoma Coptidis Protoberberine alkaloids hepG2 cells Cytotoxic effect xCELLigence system

One pot synthesis of Ru(bpy)_3^(2+) doped graphene oxide-silica composite film for constructing high performance solid-state electrochemiluminescent sensor

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2014年第12期25卷 1520-1524页

作者： Gen-Ping Yan xiao-xiao he Ke-Min Wang Yong-Hong Wang Jin-Quan Liu Li-Xin Jian Yin-Fei Mao State Key Laboratory of Chemo/Biosensing and Chemometrics College of Chemistry and Chemical EngineeringCollege of BiologyKey Laboratory for Bio-nanotechnology and Molecular Engineering of Hunan ProvinceHunan University

The Ru（bpy）3^2＋ doped graphene oxide-silica composite film（Ru/GO-SiCF） was synthesized by one pot hydrolysis and condensation of tetraethylorthosilicate（TEOS） in the water-alcohol solution of graphene oxide and Ru（bpy）3^2＋ at room *** prepared Ru/GO-SiCF modified glassy carbon electrode（GCE） showed excellent electrochemiluminescence（ECL） behavior for the determination of tripropylamine（TPA） with high sensitivity and good *** expected this simple and novel material will find further application in construction of other targets sensors.

关键词： Graphene oxide(GO)-silica composite Electrochemiluminescence(ECL) Ru(bpy)3^2+ Sensor