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Immunomodulation of adipose-derived mesenchymal stem cells on peripheral blood mononuclear cells in colorectal cancer patients with COVID-19

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 2113-2122页

作者： Jun-Feng Wang xiao-xia yang Jian Zhang Yan Zheng Fu-Qing Zhang xiao-Feng Shi Yu-Liang Wang Department of Colorectal Oncology Tianjin Medical University Cancer Institute and HospitalNational Clinical Research Center for CancerTianjin’s Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjin 300060China Department of Neurology Tianjin First Center HospitalTianjin 300192China Prosthodontics Studio Tianjin Stomatological HospitalTianjin 300041China Department of Clinical Laboratory Medicine Tianjin Institute of UrologyThe Second Hospital of Tianjin Medical UniversityTianjin 300211China Department of Emergency Tianjin First Central HospitalTianjin 300192China

BACKGROUND Accumulating evidence has shown that adipose tissue-derived mesenchymal stem cells(ADSCs)are an effective therapeutic approach for managing coronavirus disease 2019(COVID-19);however,further elucidation is required to determine their underlying immunomodulatory effect on the mRNA expression of T helper cell-related transcription factors(TFs)and cytokine release in peripheral blood mononuclear cells(PBMCs).AIM To investigate the impact of ADSCs on the mRNA expression of TFs and cytokine release in PBMCs from colorectal cancer(CRC)patients with severe COVID-19(CRC^(+)patients).METHODS PBMCs from CRC^(+)patients(PBMCs-C+)and age-matched CRC patients(PBMCs-C)were stimulated and cultured in the presence/absence of *** mRNA levels of T-box TF TBX21(T-bet),GATA binding protein 3(GATA-3),RAR-related orphan receptor C(RORC),and forkhead box P3(FoxP3)in the PBMCs were determined by reverse transcriptase-polymerase chain *** supernatants were evaluated for levels of interferon gamma(IFN-γ),interleukin 4(IL-4),IL-17A,and transforming growth factor beta 1(TGF-β1)using an enzyme-linked immunosorbent *** Compared with PBMCs-C,PBMCs-C+exhibited higher mRNA levels of T-bet and RORC,and increased levels of IFN-γ and ***,a significant decrease in FoxP3 mRNA and TGF-β1,as well as an increase in Tbet/GATA-3,RORC/FoxP3,IFN-γ/IL-4,and IL-17A/TGF-β1 ratios were observed in PBMCs-C+.Furthermore,ADSCs significantly induced a functional regulatory T cell(Treg)subset,as evidenced by an increase in FoxP3 mRNA and TGF-β1 release *** was accompanied by a significant decrease in the mRNA levels of T-bet and RORC,release of IFN-γ and IL-17A,and T-bet/GATA-3,RORC/FoxP3,IFN-γ/IL-4,and IL-17A/TGF-β1 ratios,compared with the PBMCs-C+*** The present in vitro studies showed that ADSCs contributed to the immunosuppressive effects on PBMCs-C+,favoring Treg ***,ADSC-based cell therapy could be a beneficial approach for p

关键词： Colorectal cancer COVID-19 Adipose-derived mesenchymal stem cells T helper cell Immunomodulation

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Mid-to-Far Infrared Spectral Energy Distribution of Galaxies in the Spitzer First Look Survey Field

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Chinese Journal of Astronomy and Astrophysics 2007年第2期7卷 187-198页

作者： xiao-Qing Wen Hong Wu Chen Cao xiao-yang xia Department of Physics Tianjin Normal University Tianjin 300074 National Astronomical Observatories Chinese Academy of Sciences Beijing 100012

We made model fitting to the mid-to-far infrared spectral energy distributions （SEDs） for different categories of galaxies in the main extragalactic field of the Spitzer First Look Survey with the aid of spectroscopic information from the Sloan Digital Sky Survey. We find that the mid-to-far infrared SEDs of HII galaxies, mixture type galaxies and LINERs can be well fitted by the one-parameter （α） dust model of Dale et al. plus the 13 Gyr dust-free elliptical galaxy model. The statistics of α values indicates that all these galaxies tend to be quiescent, although the HII galaxies are relatively more active than the LINERs. The midinfrared SEDs of absorption galaxies are well fitted simply by the 13 Gyr dust-free elliptical galaxy template, and the near-to-mid infrared SEDs of QSOs can be represented by AGN NGC 5506.

关键词： galaxies general - infrared: galaxies - galaxies: active - galaxies statistics

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The Evolution of Advanced Merger (U)LIRGs on the Color-Stellar Mass Diagram

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Research in Astronomy and Astrophysics 2016年第8期16卷 89-94页

作者： Rui Guo Cai-Na Hao xiao-yang xia National Astronomical Observatories Chinese Academy of Sciences Beijing 100012 China University of Chinese Academy of Sciences Beijing 100049 China Tianjin Astrophysics Center Tianjin Normal University Tianjin 300387 China

Based on a sample of 79 local advanced merger （adv-merger）（U）LIRGs, we search for evidence of quenching processes by investigating the distributions of star formation history indicators （EW（Ha）, EW（HfiA） and D,（4000）） on the NUV-r color-mass and SFR-M, diagrams. The distributions of EW（Ha） and Dn（4000） on the NUV-r color-mass diagram show clear trends that at a given stellar mass, galaxies with redder NUV-r colors have smaller EW（Ha） and larger Dn （4000）. The reddest adv-merger （U）LIRGs close to the green valley mostly have Dn（4000）〉 1.4. In addition, in the SFR-M, diagram, as the SFR decreases, the EW（Ha） decreases and the Dn （4000） increases, implying that the adv-merger （U）LIRGs on the star formation main sequence have more evolved stellar populations than those above the main sequence. These results indicate that a fraction of the adv-merger （U）LIRGs have already exhibited signs of fading from the starburst phase and that the NUV-r reddest adv-merger （U）LIRGs are likely at the initial stage of post-starbursts with an age of - 1 Gyr, which is consistent with the gas exhaustion time-scales. Therefore, our results offer additional support for the fast evolutionary track from the blue cloud to the red sequence.

关键词： galaxies: evolution -- galaxies formation -- galaxies interactions -- galaxies starburst -- infrared: galaxies

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Revisiting the dichotomy of early-type galaxies

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Research in Astronomy and Astrophysics 2014年第2期14卷 144-158页

作者： Yan-Qin He Cai-Na Hao xiao-yang xia University of Chinese Academy of Sciences National Astronomical Observatories Chinese Academy of Sciences Tianjin Astrophysics Center Tianjin Normal University

We study the relationship between isophotal shapes, central light profiles and kinematic properties of early-type galaxies （ETGs） based on a compiled sample of 184 ETGs. These sample galaxies are included in Data Release 8 of the Sloan Digital Sky Survey and have central light profiles and kinematic properties available from the literature, which were compiled from observations by the Hubble Space Telescope and the ATLAS3D integral-field spectrograph, respectively. We find that there is only a weak correlation between the isophotal shape （a4/a） and the central light profile （within 1 kpc） of ETGs. About two-fifths of ＂core＂ galaxies have disky isophotes, and one-third of ＂power-law＂ galaxies are boxy. Our statistical results also show that there are weak correlations between galaxy luminosity and dynamical mass with a4/a, but such correlations are tighter with a central light profile. Moreover, no clear link has been found between the isophotal shape and the Sersic index. Comparisons show that there are similar correlations between a4/a and ellipticity, and between a4/a and specific angular momentum ARo/2 for ＂power-law＂ ETGs, but there are no such correlations for ＂core＂ ETGs. Therefore, we speculate that the bimodal classifications of ETGs are not as simple as previously thought, though we also find that the disky ETGs with highest a4/a are more elongated and fast rotators.

关键词： galaxies: elliptical and lenticular cD -- galaxies: kinematics and dynamics -- galaxies: photometry -- galaxies: structure

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Fluorinated graphite nanosheets for ultrahigh-capacity lithium primary batteries

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Rare Metals 2021年第7期40卷 1708-1718页

作者： xiao-xia yang Guan-Jun Zhang Bao-Sheng Bai Yu Li Yi-xiao Li Yong yang xian Jian Xi-Wen Wang Tianjin Lishen Special Power Supply Science and Technology Joint-Stock Co. Tianjin 300393China Tianjin Lishen Battery Joint-Stock Co. LtdTianjin 300384China School of Materials Science and Engineering Tianjin UniversityTianjin 300354China State Key Laboratory for Physical Chemistry of Solid Surface Department of ChemistryCollege of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005China School of Materials and Energy University of Electronic Science and Technology of ChinaChengdu 611731China

For better performances of Ni-based catalysts at low temperatures,Ni/SiC catalyst doped with a little amount of additive La was successfully *** catalytic CO methanation activity tests showed that 3%La-Ni/SiC catalyst was excellent at a low reaction temperature(95.9%CO conversion and 85.1%CH4 selectivity at250℃)with a superior stability compared with Ni/SiC(3.4%CO conversion and 0%CH4 selectivity at 250℃).This can be attributed to that the addition of La can markedly improve the dispersibility of active metal Ni and reduce the particle sizes of Ni nanoparticles or clusters,and can also regulate the interaction between active components and ***,the high thermal conductivity and thermal stability could avoid the generation of hot spots in the catalyst *** results will promote the development of highly active Ni-based catalysts for the low-temperature methanation reaction.

关键词： Graphite nanosheets Carbon fluoride Primary battery Electrolyte Soft pack battery

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Performance of Hybrids between Weedy Rice and Insect-resistant Transgenic Rice under Field Experiments: Implication for Environmental Biosafety Assessment

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Journal of Integrative Plant Biology 2009年第12期51卷 1138-1148页

作者： Qian-Jin Cao Hui xia xiao yang Bao-Rong Lu Ministry of Education Key Laboratory for Biodiversity Science and Ecological Engineering Institute of Biodiversity Science Fudan University Shanghai 200433 China

Transgene escape from genetically modified （GM） rice into weedy rice via gene flow may cause undesired environmental consequences. Estimating the field performance of crop-weed hybrids will facilitate our understanding of potential introgression of crop genes （including transgenes） into weedy rice populations, allowing for effective biosafety assessment. Comparative studies of three weedy rice strains and their hybrids with two GM rice lines containing different insect- resistance transgenes （CpTI or Bt/CpTI） indicated an enhanced relative performance of the crop-weed hybrids, with taller plants, more tillers, panicles, and spikelets per plant, as well as higher 1000-seed weight, compared with the weedy rice parents, although the hybrids produced less filled seeds per plant than their weedy parents. Seeds from the F1 hybrids had higher germination rates and produced more seedlings than the weedy parents, which correlated positively with 1000-seed weight. The crop-weed hybrids demonstrated a generally enhanced relative performance than their weedy rice parents in our field experiments. These findings indicate that transgenes from GM rice can persist to and introgress into weedy rice populations through recurrent crop-to-weed gene flow with the aid of slightly increased relative fitness in F1 hybrids.

关键词： biosafety ecological consequences fitness GM rice insect-resistance transgene Oryza sativa f. spontanea.

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Extended state observer-based control with an adjustable parameter for a large ground-based telescope

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Research in Astronomy and Astrophysics 2021年第12期21卷 509-518页

作者： xiao-xia yang Yong-Ting Deng Bin Zhang Jian-Li Wang Changchun Institute of Optics Fine Mechanics and PhysicsChinese Academy of SciencesChangchun 130033China

The high-precision requirements will always be constrained due to the complicated operating conditions of the ground-based telescope. Owing to various internal and external disturbances, it is necessary to study a control method, which should have a good ability on disturbance rejection and a good adaptability on system parameter variation. The traditional proportional-integral(PI) controller has the advantage of simple and easy adjustment, but it cannot deal with the disturbances well in different situations. This paper proposes a simplified active disturbance rejection control law, whose debugging is as simple as the PI controller, and with better disturbance rejection ability and parameter adaptability. It adopts a simplified second-order extended state observer(ESO) with an adjustable parameter to accommodate the significant variation of the inertia during the different design stages of the telescope. The gain parameter of the ESO can be adjusted online with a recursive least square estimating method once the system parameter has changed significantly. Thus, the ESO can estimate the total disturbances timely and the controller will compensate them accordingly. With the adjustable parameter of the ESO, the controller can always achieve better performance in different applications of the telescope. The simulation and experimental verification of the control law was conducted on a 1.2-meter ground based telescope. The results verify the necessity of adjusting the parameter of the ESO, and demonstrate better disturbance rejection ability in a large range of speed variations during the design stages of the telescope.

关键词： extended state observer large ground based telescope recursive least square disturbance rejection

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Structural Properties of Early-Type Galaxies from the SDSS DR2

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Chinese Journal of Astronomy and Astrophysics 2008年第5期8卷 503-521页

作者： Feng-Shan Liu Zu-Gan Deng Hong Wu xiao-yang xia National Astronomical Observatories Chinese Academy of Sciences Beijing 100012 China Graduate School of Chinese Academy of Sciences Beijing 100049 China Department of Physics Tianjin Normal University Tianjin 300074 China

Two-dimensional bulge/disk light decomposition with GIM2D in both the r- and g-bands has been applied to a sample of 129 early-type galaxies brighter than 13.5 magnitude in the r-band, selected from the Sloan Digital Sky Survey Data Release 2. Intensity-weighted Fourier coefficient （α4/α） was also derived for each sample galaxy. Our analysis shows that there are correlations between bulge-to-total light ratio （B/T） with bulge Sersic index nB and between bulge and disk scale sizes. Isophotal shape parameter （α4/α） is not correlated with BIT and riB. Both bulge and disk components satisfy a color-magnitude relation. The space Fundamental Plane analysis shows that galaxies with larger B/T tend to lie tighter and closer to the line of k1 ＋ k2 = 8 （the so-called ＂zone of avoidance＂） than the galaxies with smaller B/T. It indicates that existence of the disk component may lead to scatter of the distribution on the Fundamental Plane. Our analysis also shows that k1 ＋ k2 correlates with （g-r） color and B/T, but does not correlate with （α4/α） for early-type galaxies. The fitted parameters and other retrieved parameters used in this paper for all sample galaxies are available online.

关键词： galaxies elliptical and lenticular, cD -galaxies photometry -galaxies structure - galaxies

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Observational evidence for the evolution of nuclear metallicity and star formation rate with the merger stage

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Research in Astronomy and Astrophysics 2016年第7期16卷 113-124页

作者： Rui Guo Cai-Na Hao xiao-yang xia Peng Wei Xin Guo National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100012China University of Chinese Academy of Sciences Beijing 100049China Tianjin Astrophysics Center Tianjin Normal UniversityTianjin 300387China School of Astronomy and Space Science Nanjing UniversityNanjing 210093China

We investigate the evolution of nuclear gas-phase oxygen abundance and star formation rate（SFR） of local far-infrared selected star-forming galaxies along the merger sequence, as traced by their optical morphologies. The sample was drawn from a cross-correlation analysis of the IRAS Point Source Catalog Redshift Survey and 1 Jy ultraluminous infrared galaxy sample with the Sloan Digital Sky Survey Data Release 7 database. The investigation is done by comparing our sample to a control sample matched in the normalized redshift distribution in two diagnostics, which are the nuclear gas-phase metallicity *** mass and the nuclear SFR vs. stellar mass diagrams. Galaxies with different morphological types show different mass-metallicity relations（MZRs）. Compared to the MZR defined by the control sample,isolated spirals have comparable metallicities with the control sample at a given stellar mass. Spirals in pairs and interacting galaxies with projected separations of rp 〉 20 kpc show a mild metallicity dilution of0.02–0.03 dex. Interacting galaxies with rp 〈 20 kpc, pre-mergers and advanced mergers are underabundant by～0.06,～0.05 and～0.04 dex, respectively. This shows an evolutionary trend that the metallicity is increasingly depressed as the merging proceeds and it is diluted most dramatically when two galaxies are closely interacting. Afterwards, the interstellar medium（ISM） is enriched when the galaxies *** is the first time that such ISM enrichment at the final coalescence stage has been observed, which demonstrates the importance of supernova explosions in affecting the nuclear metallicity. Moreover, the central SFR enhancement relative to the control sample evolves simultaneously with the nuclear gas-phase oxygen abundance. Our results support the predictions from numerical simulations.

关键词： galaxies abundances galaxies evolution galaxies interactions galaxies starburst galaxies star formation infrared galaxies

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Harmonic Transfer Function Based Single-input Single-output Impedance Modeling of LCC-HVDC Systems

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Journal of Modern Power Systems and Clean Energy 2024年第4期12卷 1327-1332页

作者： yang Wang Fei xia Ying Wang xianyong xiao College of Electrical Engineering Sichuan UniversityChengdu 610065China

This study presents a harmonic transfer function(HTF)based single-input single-output(SISO)impedance modeling *** method converts an HTF from phase domain to sequence domain and then transforms it into an SISO impedance while preserving the frequency coupling information of different sequences and different *** of this method to a line-commutated converter based high-voltage direct current(LCC-HVDC)system are *** results demonstrate the accuracy of the derived SISO impedance,and a truncation-order selection is *** case study shows that the proposed method facilitates simpler impedance measurements and associated stability analysis.

关键词： Line-commutated converter based high-voltage direct current(LCC-HVDC) harmonic transfer function(HTF) single-input single-output(SISO)impedance frequency coupling

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