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A double-blind, double-dummy, randomized controlled, multicenter trial of ^(99)Tc-methylene diphosphonate in patients with moderate to severe rheumatoid arthritis

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Chinese Medical Journal 2021年第12期134卷 1457-1464页

作者： Qiong Fu Ping Feng Ling-Yun Sun xiao-xia zuo Dong-Bao Zhao Dong-Yi He Hua-xiang Wu Wei Zhang Wei Zhang Fang Du Chun-De Bao Department of Rheumatology Renji Hospital of Shanghai Jiaotong University School of MedicineShanghai 200000China National Medical Products Administration Key Laboratory for Clinical Research and Evaluation of Innovative Drugs Institute of Clinical TrialsWest China HospitalSichuan UniversityChengduSichuan 610041China Department of Rheumatology Nanjing Drum Tower HospitalNanjing University Medical SchoolNanjingJiangsu 210008China Department of Rheumatology Xiangya HospitalCentral South UniversityChangshaHunan 410008China Department of Rheumatology and Immunology Changhai HospitalShanghai 200433China Department of Rheumatology Shanghai Guanghua Hospital of Integrated Traditional Chinese and Western MedicineShanghai 200052China Department of Rheumatology The Second Affiliated Hospital of Zhejiang University School of MedicineHangzhouZhejiang 310009China Department of Quality Control Cheng Fei HospitalChengduSichuan 610091China

Background:Clinical observational studies revealed that ^(99)Tc-methylene diphosphonate(^(99)Tc-MDP)could reduce joint pain and swollenness in rheumatoid arthritis(RA)*** multicenter,randomized,double-blind,double-dummy study aimed to evaluate the effects of ^(99)Tc-MDP plus methotrexate(MTX)*** alone or ^(99)Tc-MDP alone on disease activity and structural damage in MTX-naïve Chinese patients with moderate to severe ***:Eligible patients with moderate to severely active RA were randomized to receive ^(99)Tc-MDP plus MTX(n=59)***(n=59)alone or ^(99)Tc-MDP(n=59)alone for 48 weeks from six study sites across four provinces in *** primary outcomes were the American College of Rheumatology 20%improvement(ACR20)response rates at week 24 and changes in modified total Sharp score at week ***:At week 24,the proportion of participants achieving ACR20 was significantly higher in the MTX+^(99)Tc-MDP combination group(69.5%)than that in the MTX group(50.8%)or ^(99)Tc-MDP group(47.5%)(P=0.03 for MTX+^(99)Tc-MDP ***,and MTX+^(99)Tc-MDP vs.^(99)Tc-MDP,respectively).The participants in the MTX+^(99)Tc-MDP group and the ^(99)Tc-MDP group had significantly less important radiographic progression than the participants in the MTX group over the 48 weeks(MTX+^(99)Tc-MDP ***:P=0.03,^(99)Tc-MDP ***:P=0.03,respectively).There was no significant difference in terms of adverse events(AEs)among the *** serious AEs were ***:This study demonstrated that the combination of ^(99)Tc-MDP with MTX inhibited structural damage and improved disease activity in RA patients compared with MTX and ^(99)Tc-MDP monotherapies,without increasing the rate of *** clinical studies of ^(99)Tc-MDP therapy in patients with RA are *** Registration:***,ChiCTR-IPR-14005684;http://***/***?proj=10088.

关键词： Rheumatoid arthritis Methotrexate ^(99)Tc-MDP Efficacy Safety

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miRNA-21-5p is an important contributor to the promotion of injured peripheral nerve regeneration using hypoxia-pretreated bone marrow-derived neural crest cells

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Neural Regeneration Research 2025年第1期20卷 277-290页

作者： Meng Cong Jing-Jing Hu Yan Yu xiao-Li Li xiao-Ting Sun Li-Ting Wang xia Wu Ling-Jie Zhu xiao-Jia Yang Qian-Ru He Fei Ding Hai-Yan Shi School of Medicine Nantong UniversityNantongJiangsu ProvinceChina Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education and Coinnovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina Department of Physiology Jiangsu Health Vocational CollegeNanjingJiangsu ProvinceChina Department of Pathology Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina

Our previous study found that rat bone marrow–derived neural crest cells(acting as Schwann cell progenitors)have the potential to promote long-distance nerve ***-based therapy can enhance peripheral nerve repair and regeneration through paracrine bioactive factors and intercellular ***,the complex contributions of various types of soluble cytokines and extracellular vesicle cargos to the secretome remain *** investigate the role of the secretome and extracellular vesicles in repairing damaged peripheral nerves,we collected conditioned culture medium from hypoxia-pretreated neural crest cells,and found that it significantly promoted the repair of sensory neurons damaged by oxygen-glucose *** mRNA expression of trophic factors was highly expressed in hypoxia-pretreated neural crest *** performed RNA sequencing and bioinformatics analysis and found that miR-21-5p was enriched in hypoxia-pretreated extracellular vesicles of neural crest ***,to further clarify the role of hypoxia-pretreated neural crest cell extracellular vesicles rich in miR-21-5p in axonal growth and regeneration of sensory neurons,we used a microfluidic axonal dissociation model of sensory neurons in vitro,and found that hypoxia-pretreated neural crest cell extracellular vesicles promoted axonal growth and regeneration of sensory neurons,which was greatly dependent on loaded ***,we constructed a miR-21-5p-loaded neural conduit to repair the sciatic nerve defect in rats and found that the motor and sensory functions of injured rat hind limb,as well as muscle tissue morphology of the hind limbs,were obviously *** findings suggest that hypoxia-pretreated neural crest extracellular vesicles are natural nanoparticles rich in ***-21-5p is one of the main contributors to promoting nerve regeneration by the neural crest cell *** helps to explain the mechanism of action of the secretome and e

关键词： axotomy cell-free therapy conditioned medium extracellular vesicles hypoxic preconditioning microRNA oxygen-glucose deprivation peripheral nerve injury Schwann cell precursors

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狼疮性膀胱炎的临床特征及危险因素分析

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中国现代医学杂志 2017年第11期27卷 63-67页

作者：戴晓丹肖亦之蒋莹谢晓韵黄婧谢艳莉宁旺斌赵洪军罗卉游运辉左晓霞周亚欧中南大学湘雅医院风湿免疫科湖南长沙410008

目的分析狼疮性膀胱炎患者的临床特征及危险因素。方法选取27例确诊的狼疮性膀胱炎的住院患者作为病例组,并选取性别、年龄及病程相匹配的无狼疮性膀胱炎的系统性红斑狼疮(SLE)住院患者共135例作为对照组,回顾性分析两组间临床表现、实... 详细信息

目的分析狼疮性膀胱炎患者的临床特征及危险因素。方法选取27例确诊的狼疮性膀胱炎的住院患者作为病例组,并选取性别、年龄及病程相匹配的无狼疮性膀胱炎的系统性红斑狼疮(SLE)住院患者共135例作为对照组,回顾性分析两组间临床表现、实验室检查与影像学的差异;通过Logistic回归分析初步探讨狼疮性膀胱炎的危险因素。结果狼疮性膀胱炎的发生率1.3%,主要表现为下尿路症状、双侧输尿管扩张及肾积水等;与对照组相比,狼疮性膀胱炎患者的胃肠道症状的发生率高于无狼疮性膀胱炎的患者,但狼疮性肾炎和蛋白尿的发生率低于后者,差异有统计学意义(P<0.05);SLE合并狼疮性膀胱炎组患者补体低于对照组,抗SSA抗体的阳性率高于对照组(P<0.05);狼疮性膀胱炎组SLEDAI评分低于对照组(P<0.05);Logistic回归分析发现胃肠道症状、低补体为狼疮性膀胱炎的危险因素。结论胃肠道症状及低补体为狼疮性膀胱炎的危险因素,抗SSA抗体与狼疮性膀胱炎密切相关。

关键词：狼疮性膀胱炎危险因素临床特征输尿管扩张肾积水胃肠道症状抗SSA抗体

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STUDY ON THE INTERACTION BETWEEN POLYVINYLPYRROLIDONE AND PLATINUM METALS DURING THE FORMATION OF THE COLLOIDAL METAL NANOPARTICLES

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Chinese Journal of Polymer Science 2008年第1期26卷 23-29页

作者： Tu, Wei-xia zuo, xiao-bin Liu, Han-fan Beijing Inst Chem Technol Minist Educ Key Lab Nanomat Div Mol & Mat Simulat Beijing 100029 Peoples R China Chinese Acad Sci Inst Chem Beijing 100080 Peoples R China

Several PVP-stabilized colloidal platinum metals nanoparticles have been synthesized and characterized by FTIR and *** with the pure PVP,carbonyl groups of PVP in the mixture of PVP and the metal precursors or in the PVP-stabilized metal nanoparticles have obvious peak shifts in FTIR *** peak shifts reveal the interaction between PVP and the metal *** interaction between PVP and metal precursors has effect on the formation of the colloidal metal *** of the intera...

关键词： Colloidal metal nanoparticles Metal precursor PVP Interaction

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Self-healing Polymeric Hydrogels:Toward Multifunctional Soft Smart Materials

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Chinese Journal of Polymer Science 2021年第10期39卷 1262-1280,I0006页

作者： xiao-Ling zuo Shao-Fan Wang xiao-xia Le Wei Lu Tao Chen College of Materials Science and Engineering Guizhou Minzu UniversityGuiyang 550025China Key Laboratory of Bio-Based Polymeric Materials Technology and Application of Zhejiang Province Ningbo Institute of Material Technology and EngineeringChinese Academy of SciencesNingbo 315201China School of Chemical Sciences University of Chinese Academy of SciencesBeijing 100049China

The concept of self-healing that involves a built-in ability to heal in response to damage wherever and whenever it occurs in a material,analogous to the healing process in living organisms,has emerged a couple of decades *** primarily by the demands for life-like materials and soft smart materials,therefore,the development of self-healing polymeric hydrogels has continually attracted the attention of the scientific ***,this review is intended to give an in-depth overview of the state-of-the-art advances in the field of self-healing polymeric ***,recently emerging trends in self-healing polymeric hydrogels are summarized,and notably,recommendations to endow these hydrogels with fascinating multi-functionalities including luminescence,conductivity/magnetism and shape memory etc are *** close,the current challenges and future opportunities in this field are also discussed.

关键词： Polymeric hydrogels Self-healing Multi-functionalities Smart materials

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Numerical Study on the Pulsation Characteristics of An Attached Air Bubble Under A Nearby Oscillating Bubble

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China Ocean Engineering 2023年第2期37卷 299-311页

作者： JIANG Ming-zuo LIU Kun WANG Jia-xia WEN xiao-hu College of Automation Jiangsu University of Science and TechnologyZhenjiang 212003China School of Naval Architecture and Ocean Engineering Jiangsu University of Science and TechnologyZhenjiang 212003China

Numerical simulations of the non-spherical evolution of a pulsating bubble interacting with a stationary air bubble attached to a fixed structure were performed using a three-dimensional boundary integral method by implementing the mirror image method to simplify the processing of the numerical model. Code validation was accomplished by comparing the numerical results with the laboratory experimental data obtained in our previous study. Complex phenomena were observed, including three types of bubble jet forms, which depended strongly on the distance parameter with respect to the initial location of the bubble from the plate, the bubble strength parameter and the initial air bubble radius parameters. The results of the simulations provide detail insight into interesting bubble jetting phenomena,such as bubble splitting, jets moving away from the plate, and bubble shedding. The dimensionless distance parameter and the initial air bubble radius parameter play a major role in determining the shapes of two bubbles and the jetting direction. The air bubble strength parameter did not change the bubble jet direction but influenced the bubble *** detachment of the attached air bubble under oscillating bubble suction was easily observed for a small initial air bubble. These results showed that bubble jetting toward the plate was manipulated through the effect of attached air bubble, and that cavitation-based applications and underwater explosion bubble may benefit from this erosion mitigation approach.

关键词： bubble dynamics attached air bubble bubble collapse liquid jet

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Effects of mechanical strain amplitude on the isothermal fatigue behavior of H13

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International Journal of Minerals,Metallurgy and Materials 2017年第9期24卷 1004-1009页

作者： Yan Zeng Peng-peng zuo xiao-chun Wu Shu-wen xia School of Materials Science and Engineering Shanghai UniversityShanghai 200072China

Isothermal fatigue (IF) tests were performed on H13 tool steel subjected to three different mechanical strain amplitudes at a constant temperature to determine the effects of mechanical strain amplitude on the microstructure of the steel samples. The samples' extent of damage after IF tests was compared by observation of their cracks and calculation of their damage parameters. Optical microscopy (OM) and scanning electron microscopy (SEM) were used to observe the microstructure of the samples. Cracks were observed to initiate at the surface because the strains and stresses there were the largest during thermal cycling. Mechanical strain accelerated the damage and softening of the steel. A larger mechanical strain caused greater deformation of the steel, which made the precipitated carbides easier to gather and grow along the deformation direction, possibly resulting in softening of the material or the initiation of cracks.

关键词： tool steel hardness microstructure isothermal fatigue mechanical strain

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Chondroitinase ABC combined with Schwann cell transplantation enhances restoration of neural connection and functional recovery following acute and chronic spinal cord injury

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Neural Regeneration Research 2025年第5期20卷 1467-1482页

作者： Wenrui Qu xiangbing Wu Wei Wu Ying Wang Yan Sun Lingxiao Deng Melissa Walker Chen Chen Heqiao Dai Qi Han Ying Ding Yongzhi xia George Smith Rui Li Nai-Kui Liu xiao-Ming Xu Spinal Cord and Brain Injury Research Group Stark Neurosciences Research InstituteDepartment of Neurological SurgeryIndiana University School of MedicineIndianapolisINUSA Department of Hand Surgery the Second Hospital of Jilin UniversityChangchunJilin ProvinceChina Shriners Hospitals Pediatric Research Center Temple University School of MedicinePhiladelphiaPAUSA Department of Anatomy&Cell Biology Indiana University School of MedicineIndianapolisINUSA

Schwann cell transplantation is considered one of the most promising cell-based therapy to repair injured spinal cord due to its unique growth-promoting and myelin-forming properties.A the Food and Drug Administration-approved Phase I clinical trial has been conducted to evaluate the safety of transplanted human autologous Schwann cells to treat patients with spinal cord injury.A major challenge for Schwann cell transplantation is that grafted Schwann cells are confined within the lesion cavity,and they do not migrate into the host environment due to the inhibitory barrier formed by injury-induced glial scar,thus limiting axonal reentry into the host spinal *** we introduce a combinatorial strategy by suppressing the inhibitory extracellular environment with injection of lentivirus-mediated transfection of chondroitinase ABC gene at the rostral and caudal borders of the lesion site and simultaneously leveraging the repair capacity of transplanted Schwann cells in adult rats following a mid-thoracic contusive spinal cord *** report that when the glial scar was degraded by chondroitinase ABC at the rostral and caudal lesion borders,Schwann cells migrated for considerable distances in both rostral and caudal *** Schwann cell migration led to enhanced axonal regrowth,including the serotonergic and dopaminergic axons originating from supraspinal regions,and promoted recovery of locomotor and urinary bladder ***,the Schwann cell survival and axonal regrowth persisted up to 6 months after the injury,even when treatment was delayed for 3 months to mimic chronic spinal cord *** findings collectively show promising evidence for a combinatorial strategy with chondroitinase ABC and Schwann cells in promoting remodeling and recovery of function following spinal cord injury.

关键词： axonal regrowth bladder function chondroitinase ABC functional recovery glial scar lentivirus migration Schwann cell spinal cord injury transplantation

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Potential dependence in electrocatalysis: a theoretical perspective

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Science China Chemistry 2025年第1期 21-25页

作者： Leyu Liu Zhaoming xia Zeyu Wang Yinjuan Chen Hai xiao Department of Chemistry Tsinghua University Fundamental Science Center of Rare Earths Ganjiang Innovation Academy Chinese Academy of Sciences Key Laboratory of Advanced Catalytic Materials and Technology Advanced Catalysis and Green Manufacturing Collaborative Innovation Center Changzhou University

Electrocatalysis is a key technology for the new energy era and sustainable development, serving as the interface for interconversion of electrical and chemical energies, which spans a wide spectrum of applications in sustainable energy and environmental engineering. Electrocatalytic reactions including electrochemical CO2reduction reaction （eCO2RR）, hydrogen evolution reaction （HER）, and oxygen evolution/reduction reactions （OER/ORR）, hold essential promise for renewable energy technologies as well as complement the biogeochemical carbon and oxygen cycles.

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Corrosion Fatigue Behavior of 7A85 Aluminum Alloy Thick Plate in NaCl Solution

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Acta Metallurgica Sinica(English Letters) 2015年第8期28卷 1047-1054页

作者： zuo-Yan Ye Dao-Xin Liu xiao-Hua Zhang xiao-Ming Zhang Ming-xia Lei Zhi Yang Corrosion and Protection Research Laboratory Northwestern Polytechnical University AVIC the First Aircraft Institute

The S–N curves of 7A85-T7452 aluminum alloy in laboratory air and in neutral 3.5 wt% NaCl solution were obtained by axial fatigue tests. Results show that the detrimental effect of the aggressive solution was not noticeable at high-cyclic-stress regions, but the effect was significant at low-stress region. Corrosion fatigue mechanism was discussed by corrosion morphology analysis, fracture surface analysis and microstructure characterization. It was found that the corrosion fatigue crack commonly initialed at the localized intergranular corrosion site. TEM analysis showed that the microstructures of 7A85-T7452 aluminum alloy were characterized by fine and homogeneously distributed matrix precipitates, as well as continually distributed anodic grain boundary precipitates. The types of microstructures are the reason for its intergranular corrosion susceptibility. The corrosion fatigue process of 7A85 aluminum alloy in 3.5 wt% NaCl solution can be divided into four stages： the crack initiation stage, the stable growth stage with low and high growth rate and the final rupture stage. The sodium chloride solution mainly affected the crack initiation stage and the stable growth stage with low growth rate, and when the crack growth rate reached a threshold, the effect was reduced.

关键词： Corrosion fatigue Intergranular corrosion Microstructure 7A85 aluminum alloy

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