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Journal of Advanced Dielectrics 2016年第3期6卷 81-87页

作者： Ying Yu Hua Ma xiao-xia tian Hong-Liang Du Song xia Shao-Bo Qu School of Science Air Force Engineering UniversityXi'an 710051P.R.China Key Laboratory of Electronic Materials Research of Ministry of Education Xi'an Jiaotong University Xi'an 710049P.R.China

Monodisperse micro-nano nickel powders have been prepared by chemical reduction of aqueous solution NiSO_(4),NaOH and NaH_(2)PO_(2),and the influence of pH value and initial concentration of NiSO_(4) on the size,structure,morphology and microwave absorption properties of nickel powders were *** crystal structure of nickel powders was characterized by X-ray diffraction(XRD).And the morphology of the as-synthesized products was characterized by scanning electron microscopy(SEM)and transmission electron microscopy(TEM).The microwave absorption properties of the composite materials were characterized by network *** result indicates that the growth of nickel powders produced by NiSO_(4) and NaH_(2)PO_(2) at alkaline condition deeply relies on pH value and initial concentration of NiSO_(4) in reaction *** sizes of nickel powders with the diameter of 1.5μm and 180 nm were produced at the pH value of 10 and initial concentration of NiSO_(4) at 0.5 mol/*** network analyzer showed definite microwave absorption properties of nickel powders with different sizes in the range of 0.5-18.0 GHz.

关键词： Micro-nano nickel powders monodisperse size absorption liquid phase reduction method

Dextran Gadolinium Complex Containing Folate Groups as a Potential Magnetic Resonance Imaging Contrast Agent

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Chinese Journal of Polymer Science 2015年第9期33卷 1325-1333页

作者： Hui-juan Du Yan-chun Shen Yu-ping Liu Lin Han Yao Zheng 鄢国平 Yuan-yuan Tu Jiang-yu Wu Qing-zhong Guo Yun-fei Zhang xiao-tian xia xiao-li Lan Yong-xue Zhang School of Material Science and Engineering Wuhan Institute of Technology Center for PET of Union Hospital Tongji Medical College Huazhong University of Science and Technology

Folate-containing dextran ligand （FA-Dextran-DTPA） was synthesized by the incorporation of diethylenetriamine- pentaacetic acid （DTPA） and folate （FA） as a tumor-targeting group into dextran as a polymer carrier. This ligand was further reacted with gadolinium chloride to make a dextran gadolinium complex FA-Dextran-DTPA-Gd. The ligand and its gadolinium complex were characterized by 1H-NMR, FTIR, UV-Vis, average particle sizes and zeta potential, as well. In vitro properties including relaxivity, cytotoxicity assay, cellular uptake assay, and magnetic resonance imaging （MRI） were also evaluated. Compared with Gd-DTPA, FA-Dextran-DTPA-Gd possessed obviously higher relaxation effectiveness and lower cytotoxicity to HeLa cells. FA-Dextran-DTPA-Gd had a high affinity to the H460 and MDA-MB-231 tumor cells and can be taken up selectively by these tumor cells. Moreover, FA-Dextran-DTPA-Gd showed enhanced signal intensities （SI） of MRI and enhanced the contrast of MR images of tumor cells. These results indicated that FA-Dextran-DTPA-Gd showed the potential as a tumor-targeting contrast agent in MRI.

关键词： Magnetic resonance imaging (MRI) Contrast agent Tumor-targeting Dextran Diethylenetriamine-pentaaceticacid (DTPA) Folic acid (FA).

Effect of artesunate supplementation on bacterial translocation and dysbiosis of gut microbiota in rats with liver cirrhosis

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World Journal of Gastroenterology 2016年第10期22卷 2949-2959页

作者： Yun-xia Chen Li-Na Lai Hui-Ying Zhang Yang-Hui Bi Li Meng Xu-Jiong Li xiao-xia tian Li-Min Wang Yi-Min Fan Zhong-Fu Zhao De-Wu Han Cheng Ji Department of Microbiology Changzhi Medical College Department of Pharmacology Changzhi Medical College Department of Pathophysiology Changzhi Medical College Department of Physiology Changzhi Medical College Functional Integrative Laboratory Department of PathophysiologyChangzhi Medical College Institute of Hepatology Changzhi Medical College Institute of Hepatology Shanxi Medical University USC Research Center for Liver Disease Department of MedicineUniversity of Southern California

AIM: To evaluate the effect of artesunate(AS) supplementation on bacterial translocation(BT) and gut microbiota in a rat model of liver cirrhosis. METHODS: Fifty-four male Sprague-Dawley rats were randomly divided into a normal control group(N), a liver cirrhosis group(M) and a liver cirrhosis group intervened with AS(MA). Each group was sampled at 4, 6 and 8 wk. Liver cirrhosis was induced by injection of carbon tetrachloride(CCl4), intragastric administration of 10% ethanol, and feeding a high fat diet. Rats in the MA group were intragastrically administered with AS(25 mg/kg body weight, once daily). Injuries of the liver and intestinal mucosa were assessed by hematoxylineosin or Masson's trichrome staining. Liver index was calculated as a ratio of the organ weight(g) to body weight(g). The gut microbiota was examined by automated ribosomal intergenic-spacer analysis of fecal DNA. BT was assessed by standard microbiological techniques in the blood, mesenteric lymph nodes(MLNs), liver, spleen, and kidney. RESULTS: Compared to group N, the body weight was reduced significantly in groups M and MA due to the development of liver cirrhosis over the period of 8 wk. The body weight was higher in group MA than in group M. The liver indices were significantly elevated at 4, 6 and 8 wk in groups M and MA compared to group N. AS supplementation partially decreased the liver indices in group MA. Marked histopathologic changes in the liver and small intestinal mucosa in group M were observed, which were alleviated in group MA. Levels of pro-inflammatory interleukin-6 and tumor necrosis factor-α were significantly elevated at 8 wk in ileal homogenates in group M compared to group N, which were decreased after AS supplementation in group MA. The dysbiosis of gut microbiota indicated by the mean diversity(Shannon index) and mean similarity(Sorenson index) was severe as the liver cirrhosis developed, and AS supplementation had an apparent intervention effect on the dysbiosis of gu

关键词： Hepatic cirrhosis Gut microbiota Bacterial translocation Artesunate Intervention

Generalized Product of Iteration Function System

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Computer Aided Drafting,Design and Manufacturing 2005年第2期15卷 44-49页

作者： ZHAO Ting-ting WEI xiao-peng xia Jun-tian SANG Lin University Key Lab of Information Science ＆ Engineering Dalian University Dalian 116622 China

The definition of generalized product of fractal is first put forward for the research on the relations between original fractal and its product of fractal when the transformations of iteration function system （IFS） are incomplete. Then the representations of generalized product of IFS are discussed based on the theory of the product of fractal. Furthermore, the dimensional relations between the product of fractal and its semi-product are obtained. The dimensional relations of self-similar set are discussed. Finally, the examples for rendering fractal graphs are given. These results posses potentials in image compression and pattern recognition.

关键词： fractal iteration function system product of fractal semi-product of fractal generalized product of fractal

新型核素报告基因系统hERL／核素标记雌二醇的实验研究

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中华核医学与分子影像杂志 2012年第1期32卷 10-15页

作者：兰晓莉覃春霞田月丽夏晓天何勇袁辉张永学华中科技大学同济医学院附属协和医院核医学科、分子影像湖北省重点实验室、生物靶向治疗教育部重点实验室武汉430022

目的在体外细胞摄取实验及在体显像基础上，评价新型核素报告基因系统人ER配体结合域（hERL）／核素标记雌二醇（E2）应用的可行性，为其用于基因治疗的监测提供依据。方法以内部核糖体进入位点序列（IRES）方式构建携带hERL和治疗VEGF... 详细信息

目的在体外细胞摄取实验及在体显像基础上，评价新型核素报告基因系统人ER配体结合域（hERL）／核素标记雌二醇（E2）应用的可行性，为其用于基因治疗的监测提供依据。方法以内部核糖体进入位点序列（IRES）方式构建携带hERL和治疗VEGF165的重组质粒***165（简写为EIV），将其用腺病毒包装构建重组腺病毒复合体（Ad-EIV）。采用悬浮贴壁法从sD大鼠股骨和胫骨原代提取骨髓MSCs并培养。将Ad-EIV和脂质体2000包裹重组质粒（Lipo-EIV）分别转染MSCs，利用RT-PCR和Westernblot，对hERL和VEGF165mRNA和蛋白质水平的表达分别进行检测。测定***组、***组和未转染组MSCs对125I-E在不同时间（1、3,6、9、12和24h）的摄取率。将转染Ad-EIV的MSCs注射至大鼠左前肢、未转染MSCs注射至右前肢后1d，注射16a-^18TMF-17a-E2（^18F-FES）进行micro PET／CT活体显像。2组间均数比较采用t检验，相关性研究采用Pearson相关分析。结果Ad—EIV转染MSCs后RT—PCR检测示hERL和VEGFl65mRNA的表达随着感染滴度的增加而增加，且呈正相关（r2分别为0．953和0．966，P均〈0．05）；感染复数（MOI）=25、50、75和100时，其mRNA表达高于Lipo-EIV组。Westernblot检测蛋白质水平的表达也得到同样的结果。Ad-EIV组和Lipo-EIV组MSCs对^125I-E2的摄取率均随时间延长逐渐增高，24h最高，分别达到（10．94±0．30）％和（8．934-0．18）％；各个时间点2种载体转染组均明显高于未转染对照组（3．54％-5．52％；t值分别为15．489-26．560、10．523-24．204，P均〈0．05），而Ad-EIV组摄取率高于Lipo-EIV组（t=g．132—16．168，P均〈0．05）。MicroPET／CT大鼠活体显像显示注射Ad-EIV转染的MSCs之左前肢放射性浓聚明显高于对侧。结论报告基因hERL可以通过腺病毒转染、脂质体包裹等多种形式转染细胞并成功表达，应用核素标记E2可以对其进行探测和显像。应用腺病毒转染报告基因的方式转染率更高。

关键词：基因,报告雌激素受体配体结合域放射性核素显像雌二醇同位素标记大鼠

Potential dependence in electrocatalysis: a theoretical perspective

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Science China Chemistry 2025年第1期 21-25页

作者： Leyu Liu Zhaoming xia Zeyu Wang Yinjuan Chen Hai xiao Department of Chemistry Tsinghua University Fundamental Science Center of Rare Earths Ganjiang Innovation Academy Chinese Academy of Sciences Key Laboratory of Advanced Catalytic Materials and Technology Advanced Catalysis and Green Manufacturing Collaborative Innovation Center Changzhou University

Electrocatalysis is a key technology for the new energy era and sustainable development, serving as the interface for interconversion of electrical and chemical energies, which spans a wide spectrum of applications in sustainable energy and environmental engineering. Electrocatalytic reactions including electrochemical CO2reduction reaction （eCO2RR）, hydrogen evolution reaction （HER）, and oxygen evolution/reduction reactions （OER/ORR）, hold essential promise for renewable energy technologies as well as complement the biogeochemical carbon and oxygen cycles.

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高淳台地磁异常与地震关系

华北地震科学 2011年第2期29卷 49-52页

作者：夏孝田江苏省高淳县地震台江苏高淳211300

应用差分法分析了高淳台、溧阳台、高邮台、连云港台、宿迁台、海安台地磁垂直分量Z的变化,以加卸载响应比方法研究地磁极值的变化,用Z极小值时间进行地磁低点位移分析,对这些台站资料进行相关分析,研究发现中强震前高淳台的地磁场存在... 详细信息

应用差分法分析了高淳台、溧阳台、高邮台、连云港台、宿迁台、海安台地磁垂直分量Z的变化,以加卸载响应比方法研究地磁极值的变化,用Z极小值时间进行地磁低点位移分析,对这些台站资料进行相关分析,研究发现中强震前高淳台的地磁场存在明显的异常变化。

关键词：地磁异常地磁场加卸载响应比高淳台

Alternative Strategy for Development of Dielectric Calcium Copper Titanate‑Based Electrolytes for Low‑Temperature Solid Oxide Fuel Cells

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Nano-Micro Letters 2025年第1期17卷 310-332页

作者： Sajid Rauf Muhammad Bilal Hanif Zuhra Tayyab Matej Veis MAKYousaf Shah Naveed Mushtaq Dmitry Medvedev Yibin tian Chen xia Martin Motola Bin Zhu College of Mechatronics and Control Engineering Shenzhen UniversityShenzhen 518060People’s Republic of China Department of Inorganic Chemistry Faculty of Natural SciencesComenius University BratislavaIlkovicova684215 BratislavaSlovakia Energy Storage Joint Research Center School of Energy and EnvironmentSoutheast UniversityNanjing 210096People’s Republic of China Hydrogen Energy Laboratory Ural Federal University620002 EkaterinburgRussia Laboratory of Electrochemical Devices Based on Solid Oxide Proton Electrolytes Institute of High Temperature Electrochemistry620066 EkaterinburgRussia School of Microelectronics Hubei UniversityWuhan 430062People’s Republic of China

The development of low-temperature solid oxide fuel cells(LT-SOFCs)is of significant importance for realizing the widespread application of *** has stimulated a substantial materials research effort in developing high oxide-ion conductivity in the electrolyte layer of *** this context,for the first time,a dielectric material,CaCu_(3)Ti_(4)O_(12)(CCTO)is designed for LT-SOFCs electrolyte application in this *** individual CCTO and its heterostructure materials with a p-type Ni_(0.8)Co_(0.15)Al_(0.05)LiO_(2−δ)(NCAL)semiconductor are evaluated as alternative electrolytes in LT-SOFC at 450–550℃.The single cell with the individual CCTO electrolyte exhibits a power output of approximately 263 mW cm^(-2) and an open-circuit voltage(OCV)of 0.95 V at 550℃,while the cell with the CCTO–NCAL heterostructure electrolyte capably delivers an improved power output of approximately 605 mW cm^(-2) along with a higher OCV over 1.0 V,which indicates the introduction of high hole-conducting NCAL into the CCTO could enhance the cell performance rather than inducing any potential short-circuiting *** is found that these promising outcomes are due to the interplay of the dielectric material,its structure,and overall properties that led to improve electrochemical mechanism in CCTO–***,density functional theory calculations provide the detailed information about the electronic and structural properties of the CCTO and NCAL and their heterostructure CCTO–*** study thus provides a new approach for developing new advanced electrolytes for LT-SOFCs.

关键词： LT-SOFCs Dielectric CaCu_(3)Ti_(4)O_(12) Semiconductor Ni_(0.8)Co_(0.15)Al_(0.05)LiO_(2−δ) Ionic conductivity Heterostructure electrolyte

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FOLFOX4方案在治疗晚期胃癌中的应用

中华肿瘤防治杂志 2007年第8期14卷 610-612页

作者：仲琴冯永贾正飞夏晓天南京医科大学附属淮安一院肿瘤内科江苏淮安223300

目的:探索草酸铂/5-FU/CF组成的FOLFOX4方案在治疗晚期胃癌中的近期疗效和毒副作用。方法:103例晚期胃癌(ⅢB～Ⅳ期)患者随机分为2组:采用PLF方案化疗组52例及采用FOLFOX4方案化疗组51例,至少治疗2周期后按WHO标准进行疗效及毒副作用评... 详细信息

目的:探索草酸铂/5-FU/CF组成的FOLFOX4方案在治疗晚期胃癌中的近期疗效和毒副作用。方法:103例晚期胃癌(ⅢB～Ⅳ期)患者随机分为2组:采用PLF方案化疗组52例及采用FOLFOX4方案化疗组51例,至少治疗2周期后按WHO标准进行疗效及毒副作用评价。各组中,化疗药物用法分别为PLF方案组:CF200mg/m2d1～d5,5-FU500mg/m2d1～d5,DDP25mg/m2d1～d3;每28d为1个周期。FOLFOX4方案组:FOLFOX4方案,即OXA85mg/m2,静脉滴入2h,d1、d15;亚叶酸钙(CF)200mg/m2,静脉滴入d1、d2、d15和d16;5-FU400mg/m2,静脉推注d1、d2、d15和d16,600mg/m2,持续静脉输注22h,d1、d2、d15和d16;每28d为1个周期。结果:FOLFOX4方案组的短期有效率及1年生存率与疾病无进展时间均高于PLF方案组,并且1年生存率与疾病无进展时间的差异具有统计学意义(29.1%vs11.7%,P=0.031;10.1±3.2vs8.7±2.9,P=0.037)。结论:FOLFOX4方案是治疗晚期胃癌相对理想化疗方案,可以作为一线或二线化疗方案应用,值得进一步应用和研究。

关键词：胃肿瘤/药物疗法抗肿瘤联合化疗方案/治疗应用氟尿嘧啶/投药和剂量醛氢叶酸/治疗应用有机铂化合物/投药和剂量治疗结果

多西紫杉醇/顺铂化疗同步放疗对局部晚期非小细胞肺癌疗效观察

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山东大学学报（医学版） 2008年第9期46卷 898-900页

作者：贾正飞冯永仲琴夏晓天南京医科大学附属淮安一院肿瘤内科江苏淮安223300

目的研究多西紫杉醇／顺铂化疗同步放疗对晚期非小细胞肺癌的疗效及毒副作用。方法76例Ⅲ期非小细胞肺癌患者被随机分为两组，多西紫杉醇，顺铂化疗同步放疗组（同步组），多西紫杉醇，顺铂化疗序贯放疗组（序贯组）；两组放疗方法相同... 详细信息

目的研究多西紫杉醇／顺铂化疗同步放疗对晚期非小细胞肺癌的疗效及毒副作用。方法76例Ⅲ期非小细胞肺癌患者被随机分为两组，多西紫杉醇，顺铂化疗同步放疗组（同步组），多西紫杉醇，顺铂化疗序贯放疗组（序贯组）；两组放疗方法相同，放疗剂量肌60～70Gy，每次2Gv，每周5次，化疗方案为多西紫杉醇40mg／m^2，第1、8天用药，顺铂20mg／d，第1、5天用药。21天为一周期。同步组化疗第1天即开始放疗，序贯组在化疗2周期后放疗。结杲同步组和序贯组的有效率分别为65．7％和41．5％（P〈0．05），两组的完全缓解率分别为17．1％和7．3％（P〉0．05），放射性肺炎及食管炎发生率同步组高于序贯组（P〈0．05）。结论放疗同步多西紫杉醇／顺铂化疗治疗晚期非小细胞肺癌疗效优于序贯化放疗方法，副反应虽增加，但可耐受。

关键词：多西紫杉醇顺铂肺肿瘤同步化放疗