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Retinal stem cells transplantation combined with copolymer-1 immunization reduces interferon-gamma levels in an experimental model of glaucoma

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International Journal of Ophthalmology(English edition) 2011年第6期4卷 594-598页

作者： xia Zhou xiao-Bo xia Department of Ophthalmology Xiangya Hospital of Central South University Changsha 410006 Hunan Province China

AIM: To explore the effect of immunization with copolymer-1 (COP-1) and retinal stem cells (RSCs) transplantation on interferon-gamma (IFN-gamma) levels in a rat experimental glaucoma model. METHODS: An experimental glaucoma was induced by argon laser photocoagulation of the episcleral veins and limbal plexus in the right eye of rats. Immediately following glaucoma induction, rats were immunized with COP-1. RSCs were cultured and transplanted intravitreally into the eyes of glaucoma model animals 1 week post-laser treatment. Six experimental groups were used: COP-1/RSC, PBS/RSC, COP-1/PBS, PBS/PBS, glaucoma model group, and a normal control group. The concentration of IFN-gamma in aqueous humor (AH) and serum was measured by enzyme-linked immunosorbent assay (ELISA) in each of the six groups. Retinal ganglion cell (RGC) survival was assessed by quantifying apoptosis using Hoechst staining. RESULTS: Concentrations of IFN-gamma in AH and serum of rats that had undergone glaucoma induction were higher than those of non-induced control rats. The concentrations of IFN-gamma in AH and serum of the COP-1/RSCs treated group were determined to be 2371.9ng/L and 710.9ng/L, respectively, which were significantly lower than those in the other treated groups (P<0.05). In fact, IFN-gamma levels in the dual treated group were reduced to background levels. The COP-1/RSC group had lower number of apoptotic RGCs than the other three experimental groups (P<0.05). CONCLUSION: The reduced levels of IFN-gamma in AH and serum of the COP-1/RSC group may be related to synergistic effects between RSCs transplantation and COP-1 immune modulation. It is likely that the lower levels of IFN-gamma prevented RGCs glaucomatous apoptasis.

关键词： glaucoma interferon-gamma RSC transplantation COP-1 immunization

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Membrane-type Ⅰ matrix metalloproteinase(MT1-MMP),lipid metabolism,and therapeutic implications

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Journal of Molecular Cell Biology 2021年第7期13卷 513-526页

作者： xiao-Dan xia Adekunle Alabi Maggie Wang Hong-Mei gu Rui Zhe Yang gui-Qing Wang Da-Wei Zhang Department of Orthopedics The Sixth Affiliated Hospital(Qingyuan People’s Hospital)Guangzhou Medical UniversityQingyuan 511500China Department of Pediatrics and Group on the Molecular and Cell Biology of Lipids Faculty of Medicine and DentistryUniversity of AlbertaEdmontonAB T6R 2G3Canada

Lipids exert many essential physiological functions,such as serving as a structural component of biological membranes,storing energy,and regulating cell signal *** of lipid metabolism can lead to dyslipidemia related to various human diseases,such as obesity,diabetes,and cardiovascular ***,lipid metabolism is strictly regulated through multiple mechanisms at different levels,including the extracellular ***-type I matrix metalloproteinase(MT1-MMP),a zinc-dependent endopeptidase,proteolytically cleaves extracellular matrix components,and non-matrix proteins,thereby regulating many physiological and pathophysiological *** evidence supports the vital role of MT1-MMP in lipid *** example,MT1-MMP mediates ectodomain shedding of low-density lipoprotein receptor and increases plasma low-density lipoprotein cholesterol levels and the development of *** also increases the vulnerability of atherosclerotic plaque by promoting collagen ***,it can cleave the extracellular matrix of adipocytes,affecting adipogenesis and the development of ***,the activity of MT1-MMP is strictly regulated by multiple mechanisms,such as autocatalytic cleavage,endocytosis and exocytosis,and post-translational ***,we summarize the latest advances in MT1-MMP,mainly focusing on its role in lipid metabolism,the molecular mechanisms regulating the function and expression of MT1-MMP,and their pharmacotherapeutic implications.

关键词： matrix metalloproteinase low-density lipoprotein receptor extracellular matrix atherosclerosis cardiovascular disease obesity

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Discrete numerical modeling of granular materials considering crushability

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Journal of Mountain Science 2017年第4期14卷 758-770页

作者： QIAN Jian-gu gu Jian-bo gu xiao-qiang HUANG Mao-song Key Laboratory of Geotechnieal and Underground Engineering of Ministry of Education Tongji UniversityShanghai 200092China Department of Geotechnical Engineering Tongji UniversityShanghai 200092China

The aim of this study is to numerically investigate the influence of particle breakage on the mechanical behavior of granular materials using a discrete element method(DEM). To enable particle crushing, non-crushable elementary particles are boned together to represents the granular aggregates which can be crushed when the external force exceeds its strength. The flaw of the aggregate was also modeled by randomly distributed void. Single particle crushing tests were carried out to determine the distribution of particle strength. The results of single particle crushing tests illustrate that the simulated single particle fracture strength and pattern agree well with the Weibull's distribution *** oedometer tests, drained monotonic and cyclic triaxial tests were also carried out to investigate the crushing of the aggregates and the associated mechanical behaviors. The effect of confining pressure on the crushing of aggregates and the mechanical behavior was also analyzed. It was found that the peak stress and dilation decrease significantly when particle crushing was *** deformation behavior of the specimen is essentially controlled by two factors: particle rearrangement-induced dilation and particle crushing-induced contraction. The increase of permanent strain and the reduction of dilation were observed during cyclic loading and they tend to reach a stable state after a certain number of cycles. The crushing of aggregate is most significant in the first two cycles. The results also indicated that for the same axial strain the volumetric strain and the bound breakage in the cyclic loading tests are significantly larger than that in the monotonic loading tests,especially at high cyclic stress ratio.

关键词： DEM simulation Granular materials Crushing Monotonic and Cyclic triaxial test

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Rational fabrication of ordered porous solid strong bases by utilizing the inherent reducibility of metal-organic frameworks

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Nano Research 2022年第4期15卷 2905-2912页

作者： Song-Song Peng xiang-Bin Shao Yu-xia Li Yao Jiang Chen gu Manish Kumar Dinker xiao-Qin Liu(✉) Lin-Bing Sun State Key Laboratory of Materials-Oriented Chemical Engineering Jiangsu National Synergetic Innovation Center for Advanced Materials(SICAM)College of Chemical EngineeringNanjing Tech University30 South Puzhu RoadNanjing 211816China

Ordered porous solid strong bases(OPSSBs)have attracted great research interest due to the excellent performance as heterogeneous catalysts in various *** main obstacle for fabricating OPSSBs is the requirement of high temperature to produce strong basicity on ordered porous *** example,the temperatures of 600-650℃ are required for the decomposition of base precursor NaNO_(3)to basic sites on mesoporous silica SBA-15 and zeolite *** high decomposition temperatures are energy-intensive and harmful to the structure of ***,we report the fabrication of OPSSBs by utilizing the redox interaction between base precursor and low-valence metal centers(e.g.,Cr^(3+))in metal-organic frameworks(MOFs).The base precursor NaNO_(3)on MIL-101(Cr)can be converted to basic sites entirely at 300℃,which is quite lower than those of the conventional thermal conversion on SBA-15 and zeolite Y(600-650℃).The exploration on decomposition mechanism reveals that the valence change of Cr^(3+)to Cr^(6+)takes place during the conversion of NaNO_(3)to basic *** this way,MOFs-derived base catalysts have been synthesized successfully by the host-guest redox strategy and exhibit high catalytic activity in typical base-catalyzed reactions.

关键词： metal-organic frameworks ordered porous solid strong bases host–guest redox interaction transesterification reaction Cr centers

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Schatten-p Class(0

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Acta Mathematica Sinica,English Series 2015年第4期31卷 703-714页

作者： Lian Hua xiao xiao Feng WANG Jin xia School of Mathematics and Information Science and Key Laboratory of Mathematics and Interdisciplinary Sciences of the guangdong Higher Education Institute Guangzhou University

In this paper, we discuss the Schatten-p class （0 〈 p≤∞ ） of Toeplitz operators on generalized Foek space with the symbol in positive Borel measure. It makes a great difference from other papers by using the estimates of the kernel and the weight together instead of separately estimating each other. We also get the equivalent conditions when a Toeplitz operator is in the Schatten-p class.

关键词： Schatten class generalized Fock space compact operator

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Analysis on the Spatio-Temporal Changes of Sustainable Land Use in Tibet

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Wuhan University Journal of Natural Sciences 2006年第4期11卷 937-944页

作者： gu Shixian XU xia LIU Shuzhen Institute of Mountain Hazards and Environment Chinese Academy of Sciences Chengdu 610041 Sichuan China Graduated University of Chinese Academy of Sciences Beijing 100049 China School of Geography Beijing Normal University Beijing 100875 China

By constructing evaluation indicator system of sustainable land use of Tibet from three aspects of ecological environment, economic development, resources and social advancement, this article studies the following contents respectively in two dimensions of time and space： the changes of sustainable land use of Tibet in recent 20 years and spatial characteristics of sustainable land use of Tibet in 2002. The following conclusions can be drawn from evaluation results .① With regard to com- prehensive evaluation value of sustainable land use, the trend of Tibet sustainable land use evaluation values from 1983 to 2002 are very close to the comprehensive evaluation values of ecological environment, which is up trend; ② sustainable utilization degree of land use in eastern region of Tibet is much higher than that of western region. ③ the sustainable land use evaluation value of Nyingtri County is the highest, and the counties with relatively higher land sustainable use values include Lhasa, Lhoka, Chamdo. While Nakchu, Ngari, Shigatse counties have the relatively lower evaluation values; ④ By analyzing each evaluation indicator＇s weight on sustainable land use, it can be concluded that the key limiting factors of sustainable Tibet land resource utilization are land desertification, grassland degradation and low economic level.

关键词： spatio-temporal changes sustainable land use ecological environment economic development resources and social advancement

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Design and synthesis of 3＇-(prop-2-yn-1-yloxy)-biphenyl substituted cyclic acylguanidine compounds as BACE1 inhibitors

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Chinese Chemical Letters 2016年第6期27卷 961-963页

作者： Jia-Kuo Liu Wei gu xiao-Rui Cheng Jun-Ping Cheng Ai-Hua Nie Wen-xia Zhou Beijing Institute of Pharmacology and Toxicology Beijing 100850 China

Based on the lead compounds 1 and 2, a series of novel BACE1 inhibitors were designed and synthesized,among which compound 9h exhibited a 60 fold improvement in potency over the lead compound 1. This represents a good lead for the discovery of more promising BACE1 inhibitors for the potential treatment of AD. The result also showed that the prop-2-yn-1-yloxy is a suitable fragment for modification of cyclic acylguanidine BACE1 inhibitors.

关键词： Alzheimer’s disease BACE1 inhibitor Prop-2-yn-1-yloxy Cyclic acylguanidine

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Design and synthesis of 5-cyclopropyl substituted cyclic acylguanidine compounds as BACE1 inhibitors

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Chinese Chemical Letters 2016年第10期27卷 1626-1629页

作者： Jia-Kuo Liu Wei gu xiao-Rui Cheng Jun-Ping Cheng Ai-Hua Nie Wen-xia Zhou Beijing Institute of Pharmacology and Toxicology Beijing100850China

By taking compound 1 as a lead, a series of 5-cyclopropyl substituted cyclic acylguanidine compounds were designed and synthesized as BACE1 inhibitors, compound 4d exhibited 84-fold improved inhibition efficiency than lead compound 1. The diphenyl fragment at the P3 position and the substituents at the second phenyl ring were essential for the compounds to achieve improved inhibition efficiency. This SAR studies provides new insights into the design and synthesis of more promising BACE1 inhibitors for the potential treatment of AD.

关键词： Alzheimer's diseaseBACE inhibitor SecretaseDrug discoveryCyclic acylguanidine

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Design and synthesis of cyclic acylguanidines as BACE1 inhibitors

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Chinese Chemical Letters 2015年第10期26卷 1327-1330页

作者： Jia-Kuo Liu Wei gu xiao-Rui Cheng Jun-Ping Cheng Wen-xia Zhou Ai-Hua Nie Beijing Institute of Pharmacology and Toxicology

Based on the lead compound 1 reported in literature, a series of novel BACE1 inhibitors were designed and synthesized, among which compound 11 exhibited a 14-fold improvement in potency over the lead compound 1. This ... 详细信息

关键词： Alzheimer’s disease BACE1 inhibitor Cyclic acylguanidine

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Synthesis and Characterization of Poly (hydroxylethyl, octanediamine)-DL-aspartamide: a New Tissue Engineering Scaffolds

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Chinese Chemical Letters 2006年第2期17卷 191-194页

作者： gu Ping TANG xiao xiao SONG Da LI Department of Chemistry Zhejiang University Hangzhou 310028 Department of Medical Zhejiang University Hangzhou 310006

Poly （hydroxyethyl, octanediamine）-DL-aspartamide （PHOA） hydrogels were prepared by adding mixture of 1,8-octanediamine and ethanolamine to PA in DMF at room temperature. The properties of the hydrogels were inves... 详细信息

关键词： Octanediamine aspartamide hydrogel cell adhesion.

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