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INVESTIGATION　ON　THE　WATER－SOLUBLE　YTTERBIUM　PORPHYRIN　PART　***，COMPOSITION　AND　STRUCTURE

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Chinese Chemical Letters 1995年第2期6卷 147-148页

作者： QianKun ZHUANO xiao xia gao(Department of Chemistry, Peking University, Beijing, 100871) Beijing Univ Dept Chem Beijing 100871 Peoples R China

Water-soluble ytterbium complex of tetra-p-sulfonatophenylporphyrin (H2TPPS)with the formulation Yb·TPPS·OH·2 im·3H2O (im=imidazole), stable in pH5 solution, has been synthesized and characterized by clemental analysis, IR and electronic absorption spectroscopy,Its structure is also proposed. The ytterbium atom exbibits a coordination number of seven with the ytterbium atom out of the prophyrin plane.

关键词： J

Total syntheses of bupleurynol and its analog

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Chinese Chemical Letters 2017年第5期28卷 1035-1038页

作者： Kai-Qing Ma Yan-Hong Miao xiao-xia gao Jian-Bin Chao xiang Zhang Xue-Mei Qin Modern Research Center for Traditional Chinese Medicine Shanxi UniversityTaiyuan 030006China Department of Chemistry University of LouisvilleLouisvilleKY 40208USA Scientific Instrument Center Shanxi UniversityTaiyuan 030006China College of Chemistry and Chemical Engineering Shanxi UniversityTaiyuan 030006China

An efficient route to the natural products bupleurynol and its analog（RB-2）,isolated from Bupleuri Radix,was established based on versatile intermediate（15）.In this synthetic route,Sonogashira and CadiotChodkiewicz coupling as well as Julia-Kocienski olefination are utilized as key *** highly efficient synthetic route provides opportunities to explore the biological behavior of bupleurynol and RB-2.

关键词： Polyacetylenes Natural product Bupleurynol Total synthesis Julia-Kocienski olefination

THE FUNCTION OF La（III） ON ＂ION－GATE＂ OF THE GLUTATHIONE MONOLAYER GOLD ELECTRODE

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Chinese Chemical Letters 1995年第6期6卷 513-516页

作者： Zi Wei JIANG Wen Kuan XIN xiao xia gao(Department of Chemistry,Peking University,Beijing 100871) Peking Univ Dept Chem Beijing 100871 Peoples R China

The regulative function of La3+ on the self-assembled glutathione(GSH)monolayer An electrode for the ion-gate response was studied in aqueous Fe(CN)6 solution at PH 5.6 and compared with the function of Ca2+ It was fo... 详细信息

关键词： FUNCTION OF THE III ELECTRODE La

3D Morphology and Formation Process of the Icosahedral Quasicrystalline Phase in Rapidly Solidified Al-Mn Alloy

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Acta Metallurgica Sinica(English Letters) 2016年第1期29卷 28-31页

作者： Hui-Jun Kang Zhong-Lue Hu xiao-xia gao Zong-Ning Chen Yi-Ping Lu Jin-Chuan Jie Jing-Jie Guo Key Laboratory of Solidification Control and Digital Preparation Technology(Liaoning Province) School of Materials Science and EngineeringDalian University of Technology Department of Mechanical Engineering Texas Tech University School of Materials Science and Engineering Harbin Institute of Technology

Three-dimensional morphology and formation process of icosahedral quasicrystal phase have been investigated in a melt-spun AI-18Mn alloy （in wt%）. Three distinct layers corresponding to varying temperature gradient have been observed on the cross section of the ribbons. 3D morphologies of cellular and dendritic icosahedral phase have been obtained through electro-etching. A model has been proposed to describe the formation process of the icosahedral phase and a-A1 during the rapid solidification. The icosahedral phases are primarily precipitated from the melt into fine cellular and dendritic particles, and subsequently engulfed by the a-A1 which propagates in a planar morphology.

关键词： Rapid solidification Microstructure Icosahedral quasicrystal Aluminum-manganese alloy

NLRP3 and autophagy in retinal ganglion cell inflammation in age-related macular degeneration:potential therapeutic implications

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International Journal of Ophthalmology(English edition) 2024年第8期17卷 1531-1544页

作者： xiao-Li Wang Yun-xia gao Qiong-Zhen Yuan Ming Zhang Department of Ophthalmology West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina

Retinal degenerative diseases were a large group of diseases characterized by the primary death of retinal ganglion cells(RGCs).Recent studies had shown an interaction between autophagy and nucleotide-binding oligomerization domain-like receptor 3(NLRP3)inflammasomes,which may affect RGCs in retinal degenerative *** NLRP3 inflammasome was a protein complex that,upon activation,produces caspase-1,mediating the apoptosis of retinal cells and promoting the occurrence and development of retinal degenerative *** autophagy could inhibit NLRP3 inflammasome activation,while inhibited autophagy can promote NLRP3 inflammasome activation,which leaded to the accelerated emergence of drusen and lipofuscin deposition under the neurosensory *** activated NLRP3 inflammasome could further inhibit autophagy,thus forming a vicious cycle that accelerated the damage and death of *** review discussed the relationship between NLRP3 inflammasome and autophagy and its effects on RGCs in age-related macular degeneration,providing a new perspective and direction for the treatment of retinal diseases.

关键词： autophagy age-related macular degeneration NLRP3 inflammasome retinal degeneration retinal ganglion cells

Protective effects of CY-09 and astaxanthin on NaIO_(3)-induced photoreceptor inflammation via the NLRP3/autophagy pathway

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International Journal of Ophthalmology(English edition) 2024年第7期17卷 1217-1231页

作者： xiao-Li Wang Yun-xia gao Qiong-Zhen Yuan Ming Zhang Department of Ophthalmology West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina

AIM:To study the effect of the NLRP3/autophagy pathway on the photoreceptor inflammatory response and the protective mechanism of CY-09 and astaxanthin(AST).METHODS:ICR mice were intraperitoneally injected NaIO_(3),CY-09,AST successively and divided into 5 groups,including the control,NaIO_(3),NaIO_(3)+CY-09,NaIO_(3)+AST,and NaIO_(3)+CY-09+AST *** domain optical coherence tomography and flash electroretinogram were examined and the retina tissues were harvested for immunohistochemistry,enzyme linked immunosorbent assay(ELISA),and Western *** pigment epithelium cell line(ARPE-19 cells)and mouse photoreceptor cells line(661W cells)were also treated with NaIO_(3),CY-09,and AST *** proliferation was assessed by cell counting kit-8(CCK-8)*** was analyzed by flow *** in autophagosome morphology were observed by transmission electron *** polymerase chain reaction(qPCR)was used to detect NLRP3 and ***3,caspase-1,cleaved caspase-1,p62,Beclin-1,and LC3 protein levels were measured by Western ***-1βand IL-18 were measured by ***:Compared with the control group,the activity of NaIO_(3)-treated 661W cells decreased within 24 and 48h,apoptosis increased,NLRP3,caspase-1,IL-1βand IL-18 levels increased,and autophagy-related protein levels increased(P<0.05).Compared with NaIO_(3) group,CY-09 and AST inhibited apoptosis(P<0.05),reduced NLRP3,caspase-1,IL-1βand IL-18 expression(P<0.05),and inhibited *** with the other groups,CY-09 combined with AST significantly decreased NLRP3 expression and inhibited the expression of the autophagy-related proteins p62,Beclin-1,and LC3 in vitro and in vivo(P<0.05).CONCLUSION:CY-09 and AST inhibit NaIO_(3)-induced inflammatory damage through the NLRP3/autophagy pathway in vitro and in ***-09 and AST may protect retina from inflammatory injury.

关键词： CY-09 astaxanthin retinal degeneration photoreceptor cells inflammation NLRP3

INVESTIGATION　ON　THE　WATER－SOLUBLE　YTTERBIUM　PORPHYRIN　PARTⅡ　THE　ELECTROCHEMICAL　STUDY　OF　THE　YTTERBIUM　PORPHYRIN　COMPLEX

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Chinese Chemical Letters 1995年第1期6卷 63-66页

作者： Qian Kun ZHUANG xiao xia gao Department of Chemistry, Peking University, Beijing, 100871

A two-electron irreversible adsorptive reduction peak was observed for the water-soluble ytterbium complex by cyclic voltammetry at mercury electrode. At the surface of mercury electrode. the Yb-TPPS complex is adsorbed by the porphyrin ring, and tile ytterbium ion is sitting over the porphyrin plane. The centers of adsorption and the redox reaction for tile Yb-TPPS complex are all dependent on the porphyrin ring. The Yb3+ ion, do not take part in the electrochemical processes. A fter reduction, the ytterbium porphyrin complex is very unstable and disintegrates completely.

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An Efficient Multi-objective Approach Based on Golden Jackal Search for Dynamic Economic Emission Dispatch

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Journal of Bionic Engineering 2024年第3期21卷 1541-1566页

作者： Keyu Zhong Fen xiao Xieping gao Key Laboratory of Computing and Stochastic Mathematics of Ministry of Education Hunan Normal UniversityChangsha410081China School of Mathematics and Statistics Hunan Normal UniversityChangsha410081China School of Computer Science Xiangtan UniversityXiangtan411105China Hunan Provincial Key Laboratory of Intelligent Computing and Language Information Processing Hunan Normal UniversityChangsha410081China

Dynamic Economic Emission Dispatch(DEED)aims to optimize control over fuel cost and pollution emission,two conflicting objectives,by scheduling the output power of various units at specific *** many methods well-performed on the DEED problem,most of them fail to achieve expected results in practice due to a lack of effective trade-off mechanisms between the convergence and diversity of non-dominated optimal dispatching *** address this issue,a new multi-objective solver called Multi-Objective Golden Jackal Optimization(MOGJO)algorithm is proposed to cope with the DEED *** proposed algorithm first stores non-dominated optimal solutions found so far into an ***,it chooses the best dispatching solution from the archive as the leader through a selection mechanism designed based on elite selection strategy and Euclidean distance index *** mechanism can guide the algorithm to search for better dispatching solutions in the direction of reducing fuel costs and pollutant ***,the basic golden jackal optimization algorithm has the drawback of insufficient search,which hinders its ability to effectively discover more Pareto *** this end,a non-linear control parameter based on the cosine function is introduced to enhance global exploration of the dispatching space,thus improving the efficiency of finding the optimal dispatching *** proposed MOGJO is evaluated on the latest CEC benchmark test functions,and its superiority over the state-of-the-art multi-objective optimizers is highlighted by performance ***,empirical results on 5-unit,10-unit,IEEE 30-bus,and 30-unit systems show that the MOGJO can provide competitive compromise scheduling solutions compared to published DEED ***,in the analysis of the Pareto dominance relationship and the Euclidean distance index,the optimal dispatching solutions provided by MOGJO are the closest to the ideal solutions for minimizing fuel costs

关键词： Dynamic economic emission dispatch Multi-objective optimization Golden jackal Euclidean distance index

APFA:Ameliorated Pathfinder Algorithm for Engineering Applications

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Journal of Bionic Engineering 2024年第3期21卷 1592-1616页

Pathfinder algorithm(PFA)is a swarm intelligent optimization algorithm inspired by the collective activity behavior of swarm animals,imitating the leader in the population to guide followers in finding the best food *** algorithm has the characteristics of a simple structure and high ***,PFA faces challenges such as insufficient population diversity and susceptibility to local optima due to its inability to effectively balance the exploration and exploitation *** paper proposes an Ameliorated Pathfinder Algorithm called APFA to solve complex engineering optimization ***,a guidance mechanism based on multiple elite individuals is presented to enhance the global search capability of the ***,to improve the exploration efficiency of the algorithm,the Logistic chaos mapping is introduced to help the algorithm find more high-quality potential solutions while avoiding the worst ***,a comprehensive following strategy is designed to avoid the algorithm falling into local optima and further improve the convergence *** three strategies achieve an effective balance between exploration and exploitation overall,thus improving the optimization performance of the *** performance evaluation,APFA is validated by the CEC2022 benchmark test set and five engineering optimization problems,and compared with the state-of-the-art metaheuristic *** numerical experimental results demonstrated the superiority of APFA.

关键词： Pathfinder algorithm Swarm intelligent Metaheuristic Engineering problems