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Prediction of early recurrence of hepatocellular carcinoma after liver transplantation based on computed tomography radiomics nomogram

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Hepatobiliary & Pancreatic Diseases International 2022年第6期21卷 543-550页

作者： Jing-Wei Zhao Xin Shu xiao-xia chen Jia-Xiong Liu Mu-Qing Liu Ju Ye Hui-Jie Jiang Gui-Sheng Wang Department of Radiology the Third Medical CenterChinese PLA General HospitalThe Training Site for Postgraduate of Jinzhou Medical UniversityBeijing 100039China Department of Radiology the Third Medical CenterChinese PLA General HospitalBeijing 100039China Medical School of Chinese PLA Beijing 100853China Department of Radiology the Second Affiliated Hospital of Harbin Medical UniversityHarbin 150086China

Background:Early recurrence results in poor prognosis of patients with hepatocellular carcinoma(HCC)after liver transplantation(LT).This study aimed to explore the value of computed tomography(CT)-based radiomics nomogram in predicting early recurrence of patients with HCC after LT.Methods:A cohort of 151 patients with HCC who underwent LT between December 2013 and July 2019 were retrospectively enrolled.A total of 1218 features were extracted from enhanced CT images.The least absolute shrinkage and selection operator algorithm(LASSO)logistic regression was used for dimension reduction and radiomics signature building.The clinical model was constructed after the analysis of clin-ical factors,and the nomogram was constructed by introducing the radiomics signature into the clinical model.The predictive performance and clinical usefulness of the three models were evaluated using re-ceiver operating characteristic(ROC)curve analysis and decision curve analysis(DCA),respectively.Cali-bration curves were plotted to assess the calibration of the nomogram.Results:There were significant differences in radiomics signature among early recurrence patients and non-early recurrence patients in the training cohort(P<0.001)and validation cohort(P<0.001).The nomogram showed the best predictive performance,with the largest area under the ROC curve in the training(0.882)and validation(0.917)cohorts.Hosmer-Lemeshow testing confirmed that the nomogram showed good calibration in the training(P=0.138)and validation(P=0.396)cohorts.DCA showed if the threshold probability is within 0.06-1,the nomogram had better clinical usefulness than the clinical model.Conclusions:Our CT-based radiomics nomogram can preoperatively predict the risk of early recurrence in patients with HCC after LT.

关键词： Radiomics Nomogram Liver transplantation Early recurrence Hepatocellular carcinoma

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Identification of potential key molecules and signaling pathways for psoriasis based on weighted gene co-expression network analysis

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World Journal of Clinical Cases 2022年第18期10卷 5965-5983页

作者： Xin Shu xiao-xia chen Xin-Dan Kang Min Ran You-Lin Wang Zhen-Kai Zhao cheng-Xin Li Department of Dermatology The Third Medical Center of Chinese PLA General HospitalBeijing 100039China Chinese PLA Medical School Beijing 100853China Department of Radiology The Third Medical Center of Chinese PLA General HospitalBeijing 100039China Department of Comprehensive Surgical The Second Medical Center of Chinese PLA General HospitalBeijing 100089China Department of Endocrine The Third Medical Center of Chinese PLA General HospitalBeijing 100039China Department of Dermatology The First Medical Center of Chinese PLA General HospitalBeijing 100853China

BACKGROUND Psoriasis is a chronic inflammatory skin disease,the pathogenesis of which is more complicated and often requires long-term treatment.In particular,moderate to severe psoriasis usually requires systemic treatment.Psoriasis is also associated with many diseases,such as cardiometabolic diseases,malignant tumors,infections,and mood disorders.Psoriasis can appear at any age,and lead to a substantial burden for individuals and society.At present,psoriasis is still a treatable,but incurable,disease.Previous studies have found that micro RNAs(mi RNAs)play an important regulatory role in the progression of various diseases.Currently,mi RNAs studies in psoriasis and dermatology are relatively new.Therefore,the identification of key mi RNAs in psoriasis is helpful to elucidate the molecular mechanism of psoriasis.AIM To identify key molecular markers and signaling pathways to provide potential basis for the treatment and management of psoriasis.METHODS The mi RNA and m RNA data were obtained from the Gene Expression Omnibus database.Then,differentially expressed m RNAs(DEm RNAs)and differentially expressed mi RNAs(DEmi RNAs)were screened out by limma R package.Subsequently,DEm RNAs were analyzed for Gene Ontology and Kyoto Encyclopedia of Genes and Genomics functional enrichment.The“WGCNA”R package was used to analyze the co-expression network of all mi RNAs.In addition,we constructed mi RNA-m RNA regulatory networks based on identified hub mi RNAs.Finally,in vitro validation was performed.All experimental procedures were approved by the ethics committee of Chinese PLA General Hospital(S2021-012-01).RESULTS A total of 639 DEm RNAs and 84 DEmi RNAs were identified.DEm RNAs screening criteria were adjusted P(adj.P)value1.DEmi RNAs screening criteria were adj.P value1.5.KEGG functional analysis demonstrated that DEm RNAs were significantly enriched in immune-related biological functions,for example,tolllike receptor signaling pathway,cytokine-cytokine receptor i

关键词： Psoriasis MicroRNAs Weighted gene co-expression network analysis Functional enrichment MicroRNA-mRNA regulatory network

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Structure,nitridation efficiency and magnetic properties of SmFe powders and its nitrides

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Rare Metals 2023年第6期42卷 1983-1988页

作者： xiao-xia chen Yang Luo Zhou Hu Wen-Long Yan Ning-Tao Quan Shuo Lu Dun-Bo Yu Jia-Jun Xie National Engineering Research Center for Rare Earth Grirem Advanced Materials Co.Ltd.Beijing100088China

The effect of annealing temperature(TA) at600-900℃ on structure and magnetic properties of the melt-spun Sm_(8.6)Fe_(85.9)Co_(4.3)Zr_(1.2) alloys and its nitrides was investigated.Results show that the melt-spun powder is TbCu7-type SmFe_(9) single phase.X-ray diffractometer(XRD) Rietveld refinement shows that the lattice parameter a increases,c and c/a decrease with the increase in T_(A) at600-700℃.This is due to the tendency of nitrogen entering into the 3f site(1/2,0,0) during the nitridation process,which is good for the magnetic properties.The phase transforms from TbCu7-type SmFe_(9) to Th_(2)Zn_(17)-type Sm_(2)Fe_(17) at above 800 0C.Scanning electron microscopy(SEM) images show that the amount of surface defects of melt-spun powder which are harmful for magnetic properties decreases at first and then increases as TA increases.The coercivity(H_(cj)) and maximum magnetic energy product((BH)_(max)) of its nitrides increase first and then decrease as a function of TA.And the remanence(B_(r))always shows a decrease.The optimal magnetic properties of H_(cj)=748 kA·m^(-1),B_(r)=0.92 T,(BH)_(max)=118 kJ·m^(-3) are obtained by annealing at 675℃ for 2 h and then nitriding at 460℃ for 10 h.

关键词： Melt-spun alloy Annealing temperature Magnetic property XRD Rietveld refinement

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A Novel Amperometric Nitric Oxide Sensor Based on Polythionine/Nation Modified Glassy Carbon Electrode

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Chinese Chemical Letters 2006年第4期17卷 496-498页

作者： xiao xia chen Fang WANG Yan xia XU Sheng Shui HU Depatment of Chemistry Wuhan University Wuhan 430072 State Key Laboratory of Transducer Technology Chinese Academy of Sciences Beijing 100084

A novel amperometric sensor for the determination of nitric oxide was developed by coating polythionine / nation on a glassy carbon electrode. This sensor exhibited a great enhancement to the oxidation of nitric oxide. The oxidation peak currents were linear to the concentration of nitric oxide over the wide range from 3.6×10^-7 to 6.8×10^-5 mol·L^-1, and the detection limit was 7.2×10^-8 mol·L^-1. Experimental results showed that this nitric oxide sensor possessed excellent selectivity and longer stability. NO releasing from rat kidney was monitored by this sensor.

关键词： Amperometric sensor nitric oxide thionine electrochemistry.

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Individualized Chemotherapy in Advanced NSCLC Patients Based on mRNA Levels of BRCA1 and RRM1

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Chinese Journal of Cancer Research 2012年第3期24卷 226-231页

作者： Sheng-xiang Ren Ai-wu Li Song-wen Zhou Ling Zhang Yong-sheng Wang Bing Li xiao-xia chen Jie Zhan Jian-fang Xu Cai-cun Zhou Department of Medical Oncology Shanghai Pulmonary HospitalCancer InstituteTongji University Medical SchoolShanghai 200433China Department of Lung Cancer and Immunology Shanghai Pulmonary HospitalCancer InstituteTongji University Medical SchoolShanghai 200433China

Objective： Experimental evidence suggests that the overexpression of breast cancer-specific tumor suppressor protein 1 （BRCA1） gene enhances sensitivity to docetaxel and resistance to cisplatin and ribonucleotide reductase M1 （RRM1） gene overexpression enhances resistance to gemcitabine. To further examine the effect of BRCA1 and RRM1 mRNA levels on outcome in advanced non-small cell lung cancer （NSCLC）, we performed this non-randomized phase II clinical trial which tested the hypothesis that customized therapy would confer improved outcome over non-customized therapy. Methods： RNA was isolated from fresh tumor tissue. Patients received chemotherapy regimen based on their BRCA1 and RRM1 mRNA levels： both low-cisplatin plus gemcitabine （GP）; both high-vinorelbine plus cisplatin （NP）; BRCA1 low and RRM1 high-cisplatin plus docetaxel （TP）; BRCA1 high and RRM1 low-vinorelbine plus gemcitabine （GN）. Results： From Dec 2005 to Nov 2008, 94 metastatic and locally advanced NSCLC patients from our institute were enrolled in this study. The median age was 58 years old. Among them, 21 patients received GP, 30 patients received TP and 43 patients received NP chemotherapy. GP group had a higher response rate, and longer median time to progression （TTP） and median overall survival （OS） time than the other 2 groups. The response rates in the GP, TP and NP groups were 42.9%, 36.7% and 27.9%, respectively （P=0.568）. The median TTP was 5.6, 5.0, 4.8 months （P=0.975）, respectively, and the median OS time was 12.5, 11.0, 9.7 months （P=0.808）, respectively. Conclusion： Chemotherapy customized according to BRCA1 and RRM1 expression levels is associated with higher response rate and longer TTP and OS time in the GP group. This suggests that BRCA1 and RRM1 mRNA levels could be used as biomarkers in individual therapy in NSCLC.

关键词： Individualized chemotherapy Non-small cell lung cancer BRCAI RRM1

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Analysis of Reform on Badminton specialist Course

Analysis of Reform on Badminton specialist Course

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2012 2nd International Conference on Physical Education and Society Management (ICPESM 2012)

作者： Jin liang Wang xiao xia chen Hunan University of Science and Technology of Institute of Physical Education xiangtan technician institute

Employing literature reference, questionnaire, interview and logical induction, the author is to point out the problems existing and to discuss new ideas of reform in badminton specialist course teaching with methods of surveying and analyzing badminton specialist course teaching situation such as teaching objectives, curriculum provision, content of courses, course schedule, students’ basic practical competency, graduate employment direction, etc.. By doing this, it’s hoped that the pertinence and efficiency of teaching objectives will be increased in badminton specialist course, applied badminton specialists conforming to social needs will be cultivated, reference for education reform on badminton specialist course will be provided. With the vigorous development of national fitness campaign, badminton has become welcomed to most students due to its flexible organization, accommodative exercise amount, good combination of recreation and leisure, therefore more and more colleges offer badminton specialist course. Suitable supply of talents which can meet the social development needs is the starting point and goal of badminton specialist course teaching objective reform. Whether this supply suits could be directly reflected in the graduates employment rate and quantity. However, what cause the difficulty for graduates to find a job is intricate, among which the most prominent part is inappropriate talent cultivating modes causing ‘homoplasy’ and imbalance of supply and demand. Since long time ago, our badminton athletes have a considerable advantage on international stage while the general public stays ordinary in badminton sports. From survey in recent years, it can be found that social demand on badminton specialists shows more diversified and the training mode of teacher-oriented can hardly meet current social needs. How to make training objective conform to social demand is the most important problem for us. Therefore, this paper is to discuss badminton specialist course reform by exploring the situation of im

关键词： Badminton Specialist Course Education Reform Social Needs

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Observation on the quality of life before and after the injection of antiangiogenic drug in the vitreous cavity of patients with wet age-related macular degeneration

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Chinese Nursing Research 2015年第1期2卷 35-39页

作者： Dan-Dan Wang Pei-Ying Xu Tian-Yu Wang xiao-xia chen Qing Peng Department of Ophthalmology Xinhua HospitalShanghai Jiaotong University School of Medicine Shanghai Minhang Hospital Fudan University

Objective: To explore the vision-related quality of life ( VRQL) before and after the injection of antiangiogenic drug into the vitreous cavity of patients with wet age-related macular degeneration ( AMD) . Methods: The 2000 edition of the Visual Functioning Questionnaire 25 that was issued by the Na-tional Eye Institute was applied, and the VRQL evaluation was conducted on the initially diagnosed patients with wet-AMD before and after the injection of ranibizumab into the vitreous cavity. Results: Among the wet-AMD patients, patients with better distance visual acuity before the in-travitreal injection had a lower VFQ-25 score. After the vitreous cavity injection, the VFQ-25 questionnaire score was related to patient care and education from the doctors and nurses; specific-ally, the better the nursing, the higher the score. Conclusions: Before the vitreous cavity injection, the degree of distance visual acuity is an im-portant factor affecting the VRQL of wet-AMD patients. In addition, patient care and education from the doctors and nurses toward patients during the pre-, intra-and post-operation of the intrav-itreal injection are also important factors affecting the VRQL.

关键词： Age-related macular degeneration Intravitreal injection Quality of life

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Correlation of serum STMN1 and Cath-D levels with the invasive growth of cervical cancer

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Journal of Hainan Medical University 2018年第11期24卷 57-60页

作者： Chun-Lian Zhao xiao-Lan Li xiao-xia chen Ling-Ling Xie Xi Wang Jie Tian Xu-Ru Zhou Department of Gynecology the Second People's Hospital of Yichang Hubei ProvinceYichangHubei Province443000

Objective:To study the correlation of serum stathmin 1 (STMN1) and cathepsin D (Cath-D) levels with the invasive growth of cervical cancer.Methods: The patients with cervical cancer and those with uterine fibroids who underwent surgical resection in the Second People's Hospital of Yichang between January 2013 and November 2017 were selected and enrolled in the malignant group and the benign group of the study respectively;the serum was collected before operation to detect the contents of STMN1 and Cath-D;the cervical cancer lesion tissues were collected from the malignant group and the normal cervical tissues were collected from the benign group to measure the expression of STMN1, Cath-D, invasion genes and invasion signal molecules.Results:STMN1 and Cath-D contents in serum as well as STMN1 and Cath-D mRNA expression in lesion tissue of malignant group were significantly higher than those of benign group, and serum STMN1 and Cath-D contents of malignant group were positively correlated with STMN1 and Cath-D mRNA expression in lesion tissue;RACK1, Twist, MMP9, mTOR, S6K1, Wnt andβ-catenin mRNA expression in lesion tissue of malignant group were significantly higher than those of benign group whereas E-cadherin, GRIM19 and GSK-3β mRNA expression were significantly lower than those of benign group, and serum STMN1 and Cath-D contents of malignant group were positively correlated with RACK1, Twist, MMP9, mTOR, S6K1, Wnt andβ-catenin mRNA expression in lesion tissue, and negatively correlated with E-cadherin, GRIM19 and GSK-3β mRNA expression. Conclusion:The abnormally elevated STMN1 and Cath-D in serum of patients with cervical cancer can evaluate the invasive growth of the lesion.

关键词： Cervical cancer Stathmin 1 Cathepsin D Invasion Signaling pathway

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Two-stage Planning Method for Energy Router Considering Its Optimal Operation in Distribution Networks

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CSEE Journal of Power and Energy Systems 2024年第2期10卷 605-616页

作者： Meifu chen Mingchao xia Qifang chen School of Electrical Engineering Beijing Jiaotong UniversityBeijing 100044China

An energy router can effectively optimize the network loss and power quality of distribution networks. The optimal configuration of the energy router is relatively complex because issues dynamically influence each other, such as the location of the energy router, optimal number and capacity of its ports, and building new distribution lines for the ports. Presently, there has been very few research studies on the practical problems for the energy router. In this paper, a planning model of an energy router combined with the distribution network is established, which fully exploits the active and reactive power control abilities of the energy router to optimize the operation of the grid. The configuration problem is decoupled into two stages. The upper layer determines the location of the energy router and the parameters of the candidate new distribution lines for the ports. The lower layer calculates the optimal configuration of the energy router by minimizing the total annual cost. Because of the same rated bus voltage in the distribution network, the existing structure of the energy router is changed to be more applicable for the distribution network, and then the power flow model of the energy router is also modified. Due to the nonlinearity of the model, the planning model is converted into a mixed-integer second-order cone model to solve efficiently. In addition, some core factors influencing the optimal scheme of the energy router are also analyzed in this paper. Simulation results show that the optimal scheme of the energy router can significantly improve the economic deployment of the energy router, and optimize the network loss and power quality of the distribution network.

关键词： Capacity allocation distribution network energy router optimal operation

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Formalin irrigation for hemorrhagic chronic radiation proctitis

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World Journal of Gastroenterology 2015年第12期21卷 3593-3598页

作者： Teng-Hui Ma Zi-Xu Yuan Qing-Hua Zhong Huai-Ming Wang Qi-Yuan Qin xiao-xia chen Jian-Ping Wang Lei Wang Department of Colorectal Surgery The Sixth Affiliated Hospital of Sun Yat-Sen University

AIM: To assess the efficacy and safety of a modified topical formalin irrigation method in refractory hemorrhagic chronic radiation proctitis(CRP). METHODS: Patients with CRP who did not respond to previous medical treatments and presented with grade II-III rectal bleeding according to the Common Terminology Criteria for Adverse Events were enrolled. Patients with anorectal strictures, deep ulcerations, and fistulas were excluded. All patients underwent flexible endoscopic evaluation before treatment. Patient demographics and clinical data, including primary tumor, radiotherapy and previous treatment options, were collected. Patients received topical 4% formalin irrigation in a clasp-knife position under spinal epidural anesthesia in the operating room. Remission of rectal bleeding and related complications were recorded. Defecation, remission of bleeding, and other symptoms were investigated at follow-up. Endoscopic findings in patients with rectovaginal fistulas were analyzed.RESULTS: Twenty-four patients(19 female, 5 male) with a mean age of 61.5 ± 9.5 years were enrolled. The mean time from the end of radiotherapy to the onset of bleeding was 11.1 ± 9.0 mo(range: 2-24 mo). Six patients(25.0%) were blood transfusion dependent. The median preoperative Vienna Rectoscopy Score(VRS) was 3 points. Nineteen patients(79.2%) received only one course of topical formalin irrigation, and five(20.8%) required a second course. No side effects were observed. One month after treatment, bleeding cessation was complete in five patients and obvious in14; the effectiveness rate was 79.1%(19/24). For longterm efficacy, 5/16, 1/9 and 0/6 patients complained of persistent bleeding at 1, 2 and 5 years after treatment, respectively. Three rectovaginal fistulas were found at 1 mo, 3 mo and 2 years after treatment. Univariate analysis showed associations of higher endoscopic VRS and ulceration score with risk of developing rectovaginal fistula. CONCLUSION: Modified formalin irrigation is an effective and safe method for hemorrhagic CRP

关键词： Chronic radiation proctitis Efficacy Rectal bleedi

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