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Rare Metals 2023年第12期42卷 4070-4080页

作者： Chen Liu Shuang Yuan Yang Yang xiao-xi zhao xiao Duan Bin Cao Qiang Wang School of Metallurgy Northeastern UniversityShenyang 110819China Key Laboratory for Ecological Metallurgy of Multimetallic Mineral(Ministry of Education) Northeastern UniversityShenyang 110819China Key Laboratory of Electromagnetic Processing of Materials(Ministry of Education) Northeastern UniversityShenyang 110819China Department of Design and Engineering Faculty of Science and TechnologyBournemouth UniversityPooleDorset BH125BBUK

The design of electrode materials with specific structures is considered a promising approach for improving the performance of lithium-ion batteries(LIBs).In this paper,FeO/CoO hollow nanocages coated with a N-doped carbon layer(FCO@NC)was prepared using Fe-Co-based Prussian blue analogs(PBA)as a *** the synthesis,dopamine was the carbon and nitrogen *** reducing atmosphere was assured via NH_3/Ar,which regulated the vacancies in the structure of FCO@NC as well as increased its *** used as anode materials for LIBs,the FCO@NC nanocages deliver a high reversible capacity of 774.89 mAh·g^(-1)at 0.3 A·g^(-1)after200 cycles with a capacity retention rate of 80.4%and426.76 mAh·g^(-1)after 500 cycles at a high current density of 1 A·g^(-1).It is demonstrated that the hollow nanocage structure can effectively enhance the cycle stability,and the heat treatment in NH_(3)/Ar atmosphere contributes to the oxygen vacancy content of the electrode materials,further facilitating its conductivity and electrochemical performance.

关键词： Prussian blue analogue(PBA) Oxygen vacancy Hollow nanocage Nitrogen doping Lithium ion batteries(LIBs)

Comparison of the autofluorescence bronchoscope and the white light bronchoscope in airway examination

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Chinese Journal of Cancer 2010年第12期29卷 1018-1022页

作者： Yun Li xiao Li xi-zhao Sui Liang Bu Zu-Li Zhou Fan Yang Yan-Guo Liu Hui zhao Jian-Feng Li Jun Liu Guan-Chao Jiang Jun Wang Department of Thoracic Surgery People's Hospital Peking University Beijing 100044 P. R. China

Background and Objective: The sensitivity and accuracy of white light bronchoscopy (WLB) in airway examination are low. Autofluorescence bronchoscope (AFB) can determine early lesions in bronchial mucosa more sensitively, but it has seldom performed in China. To assess the clinical value of the AFB in airway examination, we compared the sensitivity and specificity of the AFB and WLB in detecting cancer of the airway mucosa. Methods: Between September 2009 and May 2010, bronchoscope examinations using both the AFB and WLB were performed on 136 patients, 95 men and 41 women with a median age of 61.5 years (ranged from 25 to 84 years). There were 46 lesions located in the central airway, 84 in the peripheral lung parenchyma, and 6 in the mediastinal region. All patients received local and general anesthesia and were subsequently examined with the WLB and AFB in tandem. All procedures were completed safely. Abnormal visual findings were recorded, and biopsies of the affected regions were collected for pathologic examination. Results: Of 241 regions sampled for biopsy, 76 sites contained malignant lesions, whereas 165 sites contained benign lesions. The AFB detected 72 of the 76 malignant lesions, but the WLB detected only 50. The sensitivities of the AFB and WLB were 94.7% and 65.8%, respectively, and the specificities were 57.0% and 83.6%, respectively. The negative predictive values of the AFB and WLB were 95.9% and 84.1%, respectively. Conclusions: The AFB is more sensitive than the WLB in detecting cancerous lesions in the mucosa, and is an effective airway examination.

关键词：病理检查支气管气道萤光自体检测灵敏度空军基地色光

Associations between PRF1 Ala91 Val polymorphism and risk of hemophagocytic lymphohistiocytosis: a meta-analysis based on 1366 subjects

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World Journal of Pediatrics 2020年第6期16卷 598-606页

作者： Guang-Hua Zhu Li-Ping Zhang Zhi-Gang Li Ang Wei Ying Yang Yu Tian Hong-Hao Ma Dong Wang xiao-xi zhao Yun-Ze zhao Na Li Wei Liu Tian-You Wang Rui Zhang Beijing Children's Hospital.Nanlishi Road No.56 Xicheng DistrictBeijingChina

Background Perforin(PRF1)gene mutation can cause the onset of hemophagocytic lymphohistiocytosis(HLH).It has reported that PRFl Ala91 Val polymorphism was related with HLH *** the meta-analysis,we aim to evaluate the association between PRF1 Ala91 Val polymorphism and HLH *** We accomplished a meta-analysis of six published case-control studies including 391 patients with HLH and 975 *** evaluated the quality of each study through Newcastle-Ottawa Scale(NOS).Data analysis was performed with Stata *** In general,all studies were of high quality(NOS score higher than 7).There were statistically significant between the PRFl Ala91 Val polymorphism and HLH risk though the pooled analysis[for Ala/Val ***/Ala:pooled odds ratio(OR)=3.22,95%confidence interval(Cl)1.08-9.56,P=0.035,random model;for Ala/Val+Val/Val ***/Ala:pooled OR=2.96,95%Cl 1.14-7.69,P=0.025,random model].Furthermore,sensitivity analysis also revealed a relationship between PRFl Ala91Val polymorphism and HLH risk(for Ala/Val ***/Ala:pooled OR=5.236,95%Cl 2.72-10.08,P<0.000,/2=12.1%,^heterogeneity=0-332;for Ala/Val+Val/Val ***/Ala,pooled OR=4.856,95%Cl 2.66-8.85,P<0.000,/2=5.9%,Pheterogeneity=0.373).Funnel plot and Egger’s test did not indicate obvious published bias(P=0.841 for Ala/Val ***/Ala;?=0.284 for Ala/Val+Val/Val ***/Ala).Conclusion This meta-analysis indicated that PRFl Ala91 Val polymorphism affects the factor for developing HLH and future studies of PRFl Ala91 Val on the onset of HLH will be guaranteed.

关键词： Ala91Val polymorphism Hemophagocytic lymphohistiocytosis PRFl

Cells in G2/M phase increased in human nasopharyngeal carcinoma cell line by EBV-LMP1 through activation of NF-кB and AP-1

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Cell Research 2003年第3期13卷 187-194页

作者： LIN DENG,JING YANG,xiao RONG zhao,xi YUN DENG,LIANG ZENG,HUAN HUA GU,MIN TANG,YA CAOCancer Research Institute,xiangya School of Medicine,Central South University,xiangya Road 88,Chang-sha,Hunan 410078,China Cancer Research Institute Xiangya School of Medicine Central South University Changsha China

Although previous studies showed that the principal oncoprotein encoded by Epstein-Barr virus, latentmembrane protein 1 （LMP1） 5 could induce the nasopharyngeal carcinoma cells in G2/M phase increased, littleis known about the target molecules and mechanisms. The present study demonstrated that LMP1 couldinduce the accumulation of p53 protein and upregulate its transactivity in a dose dependent manner, whichresulted in the decrease of the kinase activity of cdc2/cyclin B complex and inducing arrest at G2/M phasethrough the activation of NF-κB and AP-1 signaling pathways, and the effect of NF-κB was more obviousthan that of AP-1. This study provided some significant evidence for further elucidating the molecularmechanisms that LMP1 had effects on the surveillance mechanism of cell cycle and promoting the survivalof transformed cells and tumorigenesis.

关键词： LMP1 nasopharyngeal carcinoma p53 G2/M

Clinical Research of Pulmonary Langerhans Cell Histiocytosis in Children

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Chinese Medical Journal 2018年第15期131卷 1793-1798页

作者： Dong Wang Lei Cui Zhi-Gang Li Li Zhang Hong-Yun Lian Hong-Hao Ma Yun-Ze zhao xiao-xi zhao Tian-You Wang Rui Zhang Beijing Key Laboratory of Pediatric Hematology Oncology National Key Discipline of Pediatrics (Capital Medical University) Key Laboratory of Major Diseases in Children Ministry of Education Hematology Oncology Center Beijing Children's Hospital Capital Medical University National Center for Children's Health Beijing 100045 China Hematology and Oncology Laboratory Beijing Pediatric Research Institute Beijing Children's Hospital Capital Medical University National Center for Children's Health Beijing 100045 China Dong Wang and Lei Cui contributed equally to this work

Background： Pulmonary Langerhans cell histiocytosis （PLCH） is an interstitial primary pulmonary disease, characterized by Langerhans cell proliferation. It is easily misdiagnosed in children. This study aimed to characterize the clinical manifestations and features of PLCH by retrospective analysis. Meihods： A retrospective analysis was performed in 117 PLCH patients out of 338 LCH patients who were admitted in our center from November 2006 to October 2013. Variables between two groups were compared by Mann-Whitney U-test and Chi-square test. Kaplan-Meier curves were constructed to compare the survival rates and Cox regression to evaluate the effect of risk factors. Results： The median age of PLCH group was significantly lower than that ofnon-PkCH group （ 18.63 months vs. 43.4 months, P 〈 0.001 ）. All PLCH children had other organ involvement and only 11 cases （9.4%） had respiratory symptoms. The most common radiologic finding was cystic lesions （29 cases, 24.8%）. Pulmonary thnction abnormalities were dominated by obstructive ventilatory dysfunction （63 cases, 82.9%）. The 5-year overall survival （OS） of PECH children was 93.6% ± 2.3% and the event-free survival （EFS） was 55.7% ± 5.2%. Among the 38 cases with progressed or relapsed disease, five cases （13.2%） were due to progression or recurrence of lung damage. The 5-year OS of PECH children with ＂risk organ＂ involvement was significantly lower than those without ＂risk organ＂ involvement （86.0% ± 4.9% vs. 100%,X^2 = 8.793, P= 0.003）. The difference of EFS between two groups was also significant （43.7% ± 7.7% vs. 66.3% ± 6.5%,X^2 = 5.399, P = 0.020）. The ＂＇risk organ＂ involvement had a significant impact on survival （hazard ratio = 1.9, P = 0.039）. Conclusions： PLCH mainly occurs in young children, and only a small percentage of patients have respiratory symptoms. They generally have other organ involvement. Most of PLCH children have a good prognosis and most lung lesions could have improved or stabilized. Managemen

关键词： Children Langerhans Cell Histiocytosis Lung

Central Nervous System Involvement in 179 Chinese Children with Hemophagocytic Lymphohistiocytosis

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Chinese Medical Journal 2018年第15期131卷 1786-1792页

作者： Yun-Ze zhao Qing Zhang Zhi-Gang Li Li Zhang Hong-Yun Lian Hong-Hao Ma Dong Wang xiao-xi zhao Tian-You Wang Rui Zhang Beijing Key Laboratory of Pediatric Hematology Oncology National Key Discipline of Pediatrics（Capital Medical University）Key Laboratory of Major Diseases in ChildrenMinistry of EducationHematology Oncology CenterBeijing Children＇s HospitalCapital Medical UniversityNational Center for Children＇s HealthBeijing 100045China Hematology and Oncology Laboratory Beijing Pediatric Research InstituteBeijing Children＇s HospitalCapital Medical UniversityNational Center for Children＇s HealthBeijing Key Laboratory of Pediatric Hematology OncologyKey Laboratory of Major Diseases in ChildrenMinistry of EducationNational Key Discipline of PediatricsMinistry of EducationBeijing 100045China Yun-Ze zhao and Qing Zhang contributed equally to this work

Background： Central nervous system （CNS） involvement is found in many patients with hemophagocytic lymphohistiocytosis （HLH）. In this study, we mainly analyzed neurological symptoms, imaging findings, cerebrospinal fluid （CSF）, and their relationship with outcomes of HLH children. Methods： Related data of 179 Chinese pediatric patients with HLH admitted to our center from January 2010 to December 2015 were analyzed retrospectively. Diagnosis and treatment were based on the H LH-2004 protocol. Two-tailed Chi-squared test was used to compare between different groups, and Kaplan-Meier survival curves were used to analyze the overall survival （OS） of patients with HLH. Results： In the present study, 21.2% （38/179） of total patients had neurological symptoms including seizure, irritability, somnolence, and unconsciousness. There were 80 （50.0%, excluding 19 patients without imaging data） patients with cranial imaging abnormalities. There were 14.7% （17/116, excluding 63 patients who did not accept lumbar puncture） of patients with abnormal CSF results. CNS involvement is defined as abnormalities in one or more of CNS symptoms, radiological findings, and CSF. Thus, 60.3% of them had CNS involvement, As for the prognosis, the median follow-up time was 3.2 years （17 lost to follow-up）. The probable 3-year OS of children was higher without CNS involvement （86.0% ± 4.6%） than those with CNS involvement （68.9% ± 4.9%, hazard ratio [HR] = 2.286, P = 0.019）, Among them, the probable 3-year OS of children without CNS symptoms was 76.0% ± 3.8%, higher than with CNS symptoms （59.5% ± 8.1%, HR = 2.147, P ： 0.047）. The 3-year OS of children with abnormal CSF was 64.7% ± 11.6%, compared with normal CSF （85.1% ± 3.7%, HR = 0.255, P = 0.038）. Conclusions： HLH patients with CNS involvement might have worse outcomes compared with those without CNS involvement, and CNS symptoms and CSF changes are more important to access the prognosis than imaging abnormality.

关键词： Central Nervous System Cerebrospinal Fluid Hemophagocytic Lymphohistiocytosis

A promising approach for quantifying focal stroke modeling and assessing stroke progression:optical resolution photoacoustic microscopy photothrombosis

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Neural Regeneration Research 2025年第7期20卷 2029-2037页

作者： xiao Liang xingping Quan xiaorui Geng Yujing Huang Yonghua zhao Lei xi Zhen Yuan Ping Wang Bin Liu Faculty of Health Sciences University of MacaoMacao Special Administrative RegionChina Center for Cognitive and Brain Sciences University of MacaoMacao Special Administrative RegionChina Department of Biomedical Engineering Southern University of Science and TechnologyShenzhenGuangdong ProvinceChina State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoTaipaMacao Special Administrative RegionChina Department of Emergency Zhujiang HospitalSouthern Medical UniversityGuangzhouGuangdong ProvinceChina

To investigate the mechanisms underlying the onset and progression of ischemic stroke,some methods have been proposed that can simultaneously monitor and create embolisms in the animal cerebral ***,these methods often require complex systems and the effect of age on cerebral embolism has not been adequately studied,although ischemic stroke is strongly *** this study,we propose an optical-resolution photoacoustic microscopy-based visualized photothrombosis methodology to create and monitor ischemic stroke in mice simultaneously using a 532 nm pulsed *** observed the molding process in mice of different ages and presented age-dependent vascular embolism ***,we integrated optical coherence tomography angiography to investigate age-associated trends in cerebrovascular variability following a *** imaging data and quantitative analyses underscore the differential cerebrovascular responses to stroke in mice of different ages,thereby highlighting the technique's potential for evaluating cerebrovascular health and unraveling age-related mechanisms involved in ischemic strokes.

关键词： age-dependent cerebral cortex ischemic stroke mouse model optical coherence tomography angiography photoacoustic microscopy photothrombosis vascular imaging

FUZZY NEURAL NETWORK INTEGRATED EVALUATION IN LOGISTICS FACILITY LAYOUT

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FUZZY NEURAL NETWORK INTEGRATED EVALUATION IN LOGISTICS FACI...

Smart Cellulose‑Based Janus Fabrics with Switchable Liquid Transportation for Personal Moisture and Thermal Management

第一届交通运输工程国际学术会议

作者： JIA xiao-xia and ZHOU xi-zhao School of Economic and Management Shanghai Maritime University Postcode 200135 Shanghai China

With the rapid development of logistics management, the study on the logistics facility layout has become a hot topic in logistics management domain. On the basis of the summarization of frontier theories and tools such as logistics management, system engineering, and neural network, a systematic evaluation study on fuzzy neural network integrated evaluation method for plane layout of logistics facility is carried out in order to overcome the highly subjective methods of current evaluation approaches.

关键词： logistics facility layout neural network integrated evaluation

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Nano-Micro Letters 2025年第1期17卷 333-347页

作者： Jianfeng xi Yanling Lou Liucheng Meng Chao Deng Youlu Chu zhaoyang Xu Huining xiao Weibing Wu Jiangsu Co‑Innovation Center of Efficient Processing and Utilization of Forest Resources International Innovation Center for Forest Chemicals and MaterialsJiangsu Provincial Key Lab of Sustainable Pulp and Paper Technology and Biomass MaterialsNanjing Forestry UniversityNanjing 210037People’s Republic of China College of Materials Science and Engineering Nanjing Forestry UniversityNanjing 210037People’s Republic of China Department of Chemical Engineering University of New BrunswickFrederictonNB E3B 5A3Canada Macromolecular Chemistry and Bavarian Polymer Institute University of BayreuthBayreuth 95440Germany

The Janus fabrics designed for personal moisture/thermal regulation have garnered significant attention for their potential to enhance human ***,the development of smart and dynamic fabrics capable of managing personal moisture/thermal comfort in response to changing external environments remains a ***,a smart cellulose-based Janus fabric was designed to dynamically manage personal moisture/*** cotton fabric was grafted with N-isopropylacrylamide to construct a temperature-stimulated transport ***,hydrophobic ethyl cellulose and hydrophilic cellulose nanofiber were sprayed on the bottom and top sides of the fabric to obtain wettability *** fabric exhibits anti-gravity directional liquid transportation from hydrophobic side to hydrophilic side,and can dynamically and continuously control the transportation time in a wide range of 3–66 s as the temperature increases from 10 to 40℃.This smart fabric can quickly dissipate heat at high temperatures,while at low temperatures,it can slow down the heat dissipation rate and prevent the human from becoming too *** addition,the fabric has UV shielding and photodynamic antibacterial properties through depositing graphitic carbon nitride nanosheets on the hydrophilic *** smart fabric offers an innovative approach to maximizing personal comfort in environments with significant temperature variations.

关键词： Directional water transport Cotton fabric Anti-gravity directional liquid transportation Janus wettability

1例高龄糖尿病患者合并大疱类天疱疮病例护理经验

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当代护士（下旬刊） 2017年第4期24卷 136-138页

作者：唐小飞赵锡丽重庆医科大学附属第二医院内分泌科重庆400010

报告1例高龄糖尿病合并大疱类天疱疮患者的诊治及护理过程。依托多学科会诊及专业的护理,患者20 d好转出院。

关键词：高龄糖尿病大疱类天疱疮护理