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Plasma Homocysteine and Gene Polymorphisms Associated with the Risk of Hyperlipidemia in Northern Chinese Subjects

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Biomedical and Environmental Sciences 2008年第6期21卷 514-520页

作者： LEI HUANG xiao-MING song wen-LI ZHU YONG LI Department of Nutrition and Food Hygiene School of Public Health Peking University Beijing 100083 China

Objective To examine the relationship between occurrence of hyperlipidemia, plasma homocysteine and polymorphisms of methylenetetra hydrofolate reductase （MTHFR） gene and methionine synthase （MS） gene. Methods A total of 192 hyperlipidemia patients were selected and divided into hypercholesterolemia group, hypertriglyceridemia group, and combined hyperlipidemia group. Another 208 normal individuals were selected as control. Total plasma homocysteine （tHcy） concentration was measured by high-performance liquid chromatography （HPLC）. Lipid profiles were measured for all subjects The polymorphisms of MTHFR gene C677T and MS gene A2756G were analyzed by PCR-RFLP. Results The tHcy concentration in the combined hyperlipidemia patients was significantly higher than that in the control （15.95μmol/L vs 13.43 μmol/L, P〈0.05）. The prevalence of hyperhomocysteinemia （HHcy） in the combined hyperlipidemia group was significantly higher than that in the control （42.2% vs 23.0%, P=0.015）, with the odds ratio （OR） of 3.339 （95%CI： 1.260-8.849）. The hyperlipidemia patients with HHcy had a higher concentration of total cholesterol （TC） than that in the normal tHcy patients （5.67±0.95 mmol/L vs 5.47±0.92 retool/L, P=0.034）. There was no significant difference in genotype or allele frequencies of MTHFR C677T between the hyperlipidemic and control groups. The hyperlipidemia patients with MTHFR CT/TT genotype had a higher concentration of triglyceride （TG） than those with CC genotype （2.24±1.75 mmol/L vs 1.87±0.95 mmol/L, P〈0.05）. Individuals with CT/TT genotype had a higher concentration of tHcy than those with 677CC genotype both in the hyperlipidemia group （12.61±1.24μmol/L vs 11.20±1.37 μmol/L, P〈0.05） and in the control group （14.04±1.48 μmol/L vs 12.61±1.24 μmol/L, P〈0.05）. The percentage of MS 2756 GG/AG genotype in the combined hyperlipidemia group was significantly higher than that in the control （26.7% vs 13.0%, P=0.012）, with the OR of 3.121 （95%C1： 1.288-7.65/）. The hyperlipid

关键词： Methylenetetra hydrofolate reductase Methionine synthase Gene polymorphism Homocysteine Hyperlipidemia

Characterization and functional analysis of hsp18.3 gene in the red flour beetle, Tribolium castaneum

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Insect Science 2019年第2期26卷 263-273页

作者： Jia Xie Xing-Xing Hu Meng-Fan Zhai xiao-Juan Yu xiao-wen song Shan-Shan Gao Wei Wu Bin Li Jiangsu Key Laboratory for Biodiversity and Biotechnology College of Life Sciences Nanjing Normal University Nanjing China

Small heat shock proteins (sHSPs) are diverse and mainly function as molecular chaperones to protect organisms and cells from various stresses. In this study, hsp 18.3, one Tribolium castaneum species-specific shsp、has been identified. Quantitative real-time polymerase chain reaction illustrated that Tchsp 18.3 is expressed in all developmental stages, and is highly expressed at early pupal and late adult stages, while it is highly expressed in ovary and fat body at the adult period. Moreover, it was up-regulated 4532 ± 396-fold in response to enhanced heat stress but not to cold stress;meanwhile the lifespan of adults in ds-Tchsp 18.3 group reduced by 15.8% from control group under starvation. Laval RNA interference (RNAi) of Tchsp 18.3 caused 86.1%±4.5% arrested pupal eclosion and revealed that Tchsp 18.3 played an important role in insect development. In addition, parental RNAi of Tchsp 18.3 reduced the oviposition amount by 94.7%. These results suggest that Tchsp 18.3 is not only essential for the resistance to heat and starvation stress, but also is critical for normal development and reproduction in T. castaneum.

关键词： development reproduction stress Tchspl8.3 Tribolium castaneum

Original article Predictive value of RIFLE classification on prognosis of critically ill patients with acute kidney injury treated with continuous renal replacement therapy

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Chinese Medical Journal 2009年第9期 1020-1025页

作者： LI wen-xiong CHEN Hui-de WANG xiao-wen ZHAO song CHEN Xiu-kai ZHENG Yue song Yang Department of Surgical Intensive Care Unit Beijing Chaoyang Hospital Capital Medical University Beijing 100020 China

Background The optimal timing to start continuous renal replacement therapy （CRRT） for acute kidney injury （AKI） patients has not been accurately established. The recently proposed risk, injury, failure, loss, end-stage kidney disease （RIFLE） criteria for diagnosis and classification of AKI may provide a method for clinicians to decide the ＂optimal timing＂ for starting CRRT under uniform guidelines. The present study aimed：（1） to analyze the correlation between RIFLE stage at the start of CRRT and 90-day survival rate after CRRT start, （2） to further investigate the correlation of RIFLE stage with the malignant kidney outcome in the 90-day survivors, and （3） to determine the influence of the timing of CRRT defined by RIFLE classification on the 90-day survival and malignant kidney outcome in 90-day survivors.Methods A retrospective cohort analysis was performed on the data of 106 critically ill patients with AKI, treated with CRRT during a 6-year period in a university affiliated surgical intensive care unit （SICU）. Information such as sex, age, RIFLE stage, sepsis, sepsis-related organ failure assessment （SOFA） score, number of organ failures before CRRT, CRRT time during SICU, survival, and kidney outcome conditions at 90 days after CRRT start was collected. According to their baseline severity of AKI at the start of CRRT, the patients were assigned to three groups according to the increasing severity of RIFLE stages： RIFLE-R （risk of renal dysfunction, R）, RIFLE-I （injury to the kidney, I） and RIFLE-F （failure of kidney function, F） using RIFLE criteria. The malignant kidney outcome was classified as RIFLE-L （loss of kidney function L） or RIFLE-E （end-stage kidney disease, E） using RIFLE criteria. The correlation between RIFLE stage and 90-day survival rate was analyzed among these three RIFLE-categorized groups. Additionally, the association between RIFLE stage and the malignant kidney outcome （RIFLE-L＋RIFLF-E） in the 90-day survivors was *** Fif

关键词： RIFLE classification renal replacement therapy acute kidney injury prognosis

Skin friction reduction characteristics of variable ovoid non-smooth surfaces

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2017年第1期18卷 59-66页

作者： xiao-wen song Peng-zhe LIN Rui LIU Pei ZHOU State Key Laboratory of Fluid Power and Mechatronic Systems Zhejiang University Hangzhou 310027 China

The use of bionic non-smooth surfaces is a popular approach for saving energy because of their drag reduction property. Conventional non-smooth structures include riblets and dimples. Inspired by sand dunes, a novel variable ovoid non-smooth structure is proposed in this study. The body of the variable ovoid dimple was designed based on three size parameters, the radius, semimajor, and depth, and a 3D model was created based on UG software. The constructed variable dimples were placed in a rectangular array on the bottom of a square tube model. Following ANSYS meshing, the grid model was imported into FLUENT, where the flow characteristics were calculated. Results of skin friction reduction were achieved and the effect of the design parameters on different variable ovoid dimples was obtained by orthogonal testing. Various aspects of the skin friction reduction mechanism were discussed including the distribution of velocity vectors, variation in boundary layer thickness, and pressure distribution.

关键词： Variable ovoid dimple Non-smooth surface Numerical simulation Skin friction reduction

Characterization of a sigma class GST (GSTS6) required for cellular detoxification and embryogenesis in Tribolium castaneum

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Insect Science 2022年第1期29卷 215-229页

作者： xiao-wen song Qi-Sheng Zhong Yan-Hao Ji Yue-Mei Zhang Jing Tang Fan Feng Jing-Xiu Bi Jia Xie Bin Li Jiangsu Key Laboratory for Biodiversity and Biotechnology College of Life SciencesNanjing Normal UniversityNanjing210046China

The sigma glutathione S-transferases (GSTSs) are a class of cytosolic glutathione S transferases (GSTs) that play important roles in antioxidant defense in insects, but the mechanisms by which GSTSs contribute to antioxidant activity remain unclear. Here, we isolated a GSTS (GSTS6) from Tribolium castaneum and explored its function. Homology and phylogenetic analysis revealed that TcGSTS6 shared high identity with other evolutionarily conserved GSTSs. The recombinant TcGSTS6 protein had strong activity toward cumene hydroperoxide and 4-hydroxynonenal but low activity toward the universal substrate 1-chloro-2,4-dinitrobenzene. Exposure to various types of oxidative stress, including heat, cold, UV and pathogenic microbes, significantly induced TcGSTs6 expression, which indicates that it is involved in antioxidant defense. Knockdown TcGSTs6 by using RNA interference (RNAi) caused reduced antioxidant capacity, which was accomplished by cooperating with other antioxidant genes. Moreover, treatment with various insecticides such as phoxim, lambda-cyhalothrin, dichlorvos and carbofuran revealed that TcGSTS6 plays an important role in insecticide detoxification. The RNAi results showed that TcGSTS6 is essential for embryogenesis in T. castaneum. Our study elucidates the mechanism by which a GSTS contributes to antioxidant activity and enhances our understanding of the functional diversity of GSTSs in insects.

关键词： antioxidant enzyme embryogenesis glutathione S-transferase insecticide resistance RNAi Tribolium castaneum

A Low Complexity VCS Method for PAPR Reduction in Multicarrier Code Division Multiple Access

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Journal of Electronic Science and Technology of China 2007年第2期5卷 102-106页

作者： Si-Si Liu Yue xiao Qing-song wen Shao-Qian Li National Key Lab of Communications University of Electronic Science and Technology of China （UESTC） Chengdu 610054 China

This paper investigates a peak to average power ratio （PAPR） reduction method in multicarrier code division multiple access （MC-CDMA） system. Variable code sets （VCS）, a spreading codes selection scheme, can improve the PAPR property of the MC-CDMA signals, but this technique requires an exhaustive search over the combinations of spreading code sets. It is observed that when the number of active users increases, the search complexity will increase exponentially. Based on this fact, we propose a low complexity VCS （LC-VCS） method to reduce the computational complexity. The basic idea of LC-VCS is to derive new signals using the relationship between candidature signals. Simulation results show that the proposed approach can reduce PAPR with lower comtational pucomplexity. In addition, it can be blindly received without any side information.

关键词： Low complexity variable code sets,multicarrier code division multiple access (MC-CDMA),peak to average power ratio variable code sets.

Electrochemical conversion of methane to bridge the gap in the artificial carbon cycle

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Journal of Energy Chemistry 2025年第1期100卷 286-308页

作者： Yuhao Peng Yuefeng song Ihar Razanau Juanxiu xiao Wei xiao Di Hu Guoxiong Wang College of Chemistry and Molecular Sciences Hubei Key Laboratory of Electrochemical Power Sources Wuhan University State Key Laboratory of Catalysis Dalian National Laboratory for Clean Energy iChEM (Collaborative Innovation Center of Chemistry for Energy Materials) Dalian Institute of Chemical Physics Chinese Academy of Sciences Laboratory of Physical-Chemical Technologies SSPA Scientific and Practical Materials Research Centre of NAS of Belarus State Key Laboratory of Marine Resources Utilization in South China Sea Collaborative Innovation Center of Marine Science and Technology School of Marine Science and Engineering Hainan University Department of Chemical and Environmental Engineering University of Nottingham Ningbo China

Methane, an abundant one-carbon（C1） resource, is extensively used in the industrial production of vital fuels and value-added chemicals. However, current industrial methane conversion technologies are energy-and carbon-intensive, mainly due to the high activation energy required to break the inert C–H bond, low selectivity, and problematic side reactions, including CO2emissions and coke deposition. Electrochemical conversion of methane（ECM） using intermittent renewable energy offers an attractive solution, due to its modular reactor design and operational flexibility across a broad spectrum of temperatures and pressures. This review emphasizes conversion pathways of methane in various reaction systems, highlighting the significance and advantages of ECM in facilitating a sustainable artificial carbon cycle. This work provides a comprehensive overview of conventional methane activation mechanisms and delineates the complete pathways of methane conversion in electrolysis contexts. Based on surface/interface chemistry, this work systematically analyzes proposed reaction pathways and corresponding strategies to enhance ECM efficiency towards various target products, including syngas, hydrocarbons, oxygenates, and advanced carbon materials. The discussion also encompasses opportunities and challenges for the ECM process, including insights into ECM pathways, rational electrocatalyst design, establishment of benchmarking protocols, electrolyte engineering, enhancement of CH4conversion rates, and minimization of CO2emission.

关键词： Activation energy

持久性有机污染物机械化学无害化处理的研究进展

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矿冶工程 2006年第2期26卷 53-56页

作者：肖松文肖骁长沙矿冶研究院湖南长沙410012 中南大学冶金科学与工程学院湖南长沙410083

机械化学处理方法是目前最有商业化应用前景的持久性有机污染物(POPs)无害化处理技术之一,尤其适宜于发展中国家的偏远地区使用。详细介绍了POPs机械化学处理研究起源与现状,分析了工艺原理及优点,提出下一步研究工作的重点是强化POPs... 详细信息

机械化学处理方法是目前最有商业化应用前景的持久性有机污染物(POPs)无害化处理技术之一,尤其适宜于发展中国家的偏远地区使用。详细介绍了POPs机械化学处理研究起源与现状,分析了工艺原理及优点,提出下一步研究工作的重点是强化POPs机械化学反应机理及产物结构的研究,明确中间及最终产物的结构形态,确认工艺安全性与有效性,消除疑虑,推动工艺的商业化应用。

关键词：持久性有机污染物(POPs) 机械化学球磨脱卤

An efficient quantum proactive incremental learning algorithm

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 49-57页

作者： Lingxiao Li Jing Li Yanqi song Sujuan Qin Qiaoyan wen Fei Gao State Key Laboratory of Networking and Switching Technology Beijing University of Posts and Telecommunications School of Cyberspace Security Beijing University of Posts and Telecommunications

In scenarios where a large amount of data needs to be learned, incremental learning can make full use of old knowledge, significantly reduce the computational cost of the overall learning process, and maintain high performance. In this paper, taking the MaxCut problem as our example, we introduce the idea of incremental learning into quantum computing, and propose a Quantum Proactive Incremental Learning algorithm(QPIL). Instead of a one-off training of quantum circuit, QPIL contains a multi-phase training on gradually-increased subgraphs of all vertices, proactively reducing large-scale problems to smaller ones to solve in steps, providing an efficient solution for MaxCut. Specifically, some vertices and corresponding edges are randomly selected for training to obtain optimized parameters of the quantum circuit at first. Then, in each incremental phase, the remaining vertices and corresponding edges are gradually added and the parameters obtained from the previous phase are reused in the parameter initialization of the current phase. We perform experiments on 120 different small-scale graphs, and it shows that QPIL performs superior to prevalent quantum and classical baselines in terms of approximation ratio(AR), time cost, anti-forgetting, and solving stability. In particular, QPIL's AR surpasses 20% of mainstream quantum baselines, and the time cost is less than 1/5 of them. The idea of QPIL is expected to inspire efficient and high-quality solutions in large-scale Max Cut and other combinatorial optimization problems.

关键词： variational quantum algorithm incremental learning multi-phase training MaxCut quantum computing