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Value of multiple models of diffusion-weighted imaging to predict hepatic lymph node metastases in colorectal liver metastases patients

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World Journal of Gastroenterology 2024年第4期30卷 308-317页

作者： Hai-Bin Zhu Bo Zhao xiao-ting li xiao-Yan Zhang Qian Yao Ying-Shi Sun Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Department of RadiologyPeking University Cancer Hospital and InstituteBeijing 100142China Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Department of PathologyPeking University Cancer Hospital and InstituteBeijing 100142China

BACKGROUND About 10%-31% of colorectal liver metastases(CRLM)patients would concomitantly show hepatic lymph node metastases(LNM),which was considered as sign of poor biological behavior and a relative contraindication for liver *** to now,there’s still lack of reliable preoperative methods to assess the status of hepatic lymph nodes in patients with CRLM,except for pathology examination of lymph node after *** To compare the ability of mono-exponential,bi-exponential,and stretchedexponential diffusion-weighted imaging(DWI)models in distinguishing between benign and malignant hepatic lymph nodes in patients with CRLM who received neoadjuvant chemotherapy prior to *** In this retrospective study,97 CRLM patients with pathologically confirmed hepatic lymph node status underwent magnetic resonance imaging,including DWI with ten b values before and after *** parameters,such as the apparent diffusion coefficient from the mono-exponential model,and the true diffusion coefficient,the pseudo-diffusion coefficient,and the perfusion fraction derived from the intravoxel incoherent motion model,along with distributed diffusion coefficient(DDC)andαfrom the stretched-exponential model(SEM),were *** parameters before and after chemotherapy were compared between positive and negative hepatic lymph node groups.A nomogram was constructed to predict the hepatic lymph node *** reliability and agreement of the measurements were assessed using the coefficient of variation and intraclass correlation *** Multivariate analysis revealed that the pre-treatment DDC value and the short diameter of the largest lymph node after treatment were independent predictors of metastatic hepatic lymph nodes.A nomogram combining these two factors demonstrated excellent performance in distinguishing between benign and malignant lymph nodes in CRLM patients,with an area under the curve of ***,parameters from SEM sho

关键词： Colorectal cancer Individualized treatment Diffusion magnetic resonance imaging Intravoxel incoherent motion liver

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First-Principles Study of Ultrathin Molybdenum Sulfides Nanowires:Electronic and Catalytic Hydrogen Evolution Properties

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Chinese Journal of Chemical Physics 2019年第2期32卷 267-272,I0003页

作者： xiao-ting li Yang-yang Wan xiao-jun Wu Hefei National Laboratory of Physical Sciences at the Microscale School of Chemistry and Materi-als Sciences and CAS Key Laboratory of Materials for Energy Conversion University of Science and Technology of China Hefei 230026 China

Molybdenum sulfides nanomaterials, such as one-dimensional (1D) nanotubes, nanoribbons, and two-dimensional (2D) nanosheets, have attracted intensive research interests for their novel electronic, optical, and catalytic properties. On the basis of first-principles calculation, here, we report a new series of 1D ultrathin molybdenum sulfides nanowires, including Mo2S6、Mo3S6 and Mo6S10 nanowires. Our results demonstrate that these ultrathin nanowires are both thermal and lattices dynamically stable, confirmed with the calculated phonon spectrum and Born-Oppenheimer molecular dynamic simulation at the temperature up to 600 K. The calculated elastic constant is 21.33, 103.22, and 163.00 eV/■ for Mo2S6, Mo3S6, and Mo6S10 nanowires, respectively. Mo2S6 and Mo3S6 nanowires are semiconductors with band gap of 1.55 and 0.46 eV, while Mo6S10 nanowires is metal, implying their potential applications in electronics and optoelectronics. In particular, ultrathin molybdenum sulfides nanowires can be used as catalysts for hydrogen evolution reaction. The calculated Gibbs free energy change for hydrogen evolution is about -0.05 eV for Mo2S6 nanowire, comparable with those of Pt and H-MoS2. The prediction of these 1D molybdenum sulfides nanowires may enrich the 1D family molybdenum sulfides and make a supplement to understand the high performance of hydrogen evolution reaction in transition-metal dichalcogenides.

关键词： First-principles calculations Molybdenum sulfide nanowires Hydrogen evolution reaction

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In vitro Degradation of Pure Mg for Esophageal Stent in Artificial Saliva

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Journal of Materials Science & Technology 2016年第5期32卷 437-444页

作者： Rong-Chang Zeng xiao-ting li li-Jun liu Shuo-Qi li Fen Zhang College of Materials Science and Engineering Shandong University of Science and Technology State Key Laboratory of Mining Disaster Prevention and Control Co-founded by Shandong Province and the Ministry of Science and Technology Shandong University of Science and Technology

Magnesium and its alloys as biodegradable implant materials can be potentially used in cardiovascular and orthopedic devices. However, few studies have focused on its application in esophageal stents. In this paper, time-lapse degradation characteristics of pure Mg were analyzed by scanning electron microscopy, energy dispersive spectroscopy, X-ray diffraction, Fourier transform infrared spectroscopy, hydrogen evolution, pH and electrochemical measurements after immersion in artificial saliva for different times. Results revealed that a dense degradation product film formed on samples, which mainly consisted of two kinds of layers： one was calcium phosphate compounds with different structures; the other was thin magnesium hydrate layer close to the substrate. Less pH increase and low degradation rate were ob- served in the first 5 days of immersion, which can be ascribed to the formation of a thicker and denser layer on the sample surface with increasing immersion time. And then there was an increase in degradation rate and pH values; the deposition layer remained almost intact after immersion for 6 and 8 days. After 10 days of immersion, the degradation rate and pH value remained stable, and the calcium phosphate layer was delaminated and the inner magnesium hydrate layer was exposed. This study indicated that pure Mg exhibited desirable degradation resistance in artificial saliva, which provided magnesiumbased materials with the potential to be used as esophageal stents.

关键词： Magnesium Biomaterials Esophageal stents Degradation Artificial saliva

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A 5.12-GHz LC-based phase-locked loop for silicon pixel readouts of high-energy physics

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Nuclear Science and Techniques 2022年第7期33卷 49-59页

作者： xiao-ting li Wei Wei Ying Zhang Xiong-Bo Yan xiao-Shan Jiang Ping Yang State Key Laboratory of Particle Detection and Electronics Experimental Physics DepartmentInstitute of High Energy PhysicsChinese Academy of Sciences19B Yuquan RoadBeijing100049China School of Physical Sciences University of Chinese Academy of Sciences19A Yuquan RoadBeijing100049China PLAC Key Laboratory of Quark and Lepton Physics(MOE)Central China Normal University152 Luoyu RoadWuhan430079China

There is an urgent need for high-quality and high-frequency clock generators for high-energy physics *** transmission data rate exceeds 10 Gbps for a single channel in future readout electronics of silicon pixel ***,such as time measurement detectors,require a high time resolution based on the time-to-digital readout architecture.A phase-locked loop(PLL)is an essential and broadly used circuit in these *** study presents an application-specific integrated circuit of a low-jitter,low-power LC-tank that is PLL fabricated using 55-nm CMOS *** includes a 3rd-order frequency synthesis loop with a programmable bandwidth,a divide-by-2 pre-scaler,standard low-voltage differential signaling interfaces,and a current mode logic(CML)driver for clock *** the d-flip-flop dividers and phase-frequency detectors are protected from single-event upsets using the triple modular redundancy *** proposed VCO uses low-pass filters to suppress the noise from bias *** tested LC-PLL covers a frequency locking range between 4.74 GHz and 5.92 GHz with two *** jitter measurements of the frequency-halved clock(2.56 GHz)are less than 460 fs and 0.8 ps for the random and deterministic jitters,respectively,and a total of 7.5 ps peak-to-peak with a bit error rate of 10^(-12).The random and total jitter values for frequencies of 426 MHz and 20 MHz are less than 1.8 ps and 65 ps,*** LC-PLL consumed 27 mW for the core and 73.8 mW in *** measured results nearly coincided with the simulations and validated the analyses and tests.

关键词： LC phase-locked loop Analog electronic circuits Front-end electronics for detector readout High-energy physics experiments

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Impact of Serum Vascular Endothelial Growth Factor on Prognosis in Patients with Unresectable Hepatocellular Carcinoma after Transarterial Chemoembolization

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Chinese Journal of Cancer Research 2012年第1期24卷 36-43页

作者： Jian-hai Guo Xu Zhu xiao-ting li Ren-jie Yang Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education) Department of Interventional TherapyPeking University School of OncologyBeijing Cancer Hospital&InstituteBeijing 100142China

Objective： To investigate the expression level with unresectable hepatocellular carcinoma （HCC） and to assess the impact of serum VEGF as chemoembolization （TACE） treatments. of serum vascular endothelial growth factor （VEGF） in patients and its relationship with the c a predictive factor for HCC nicopathological characteristics, prognosis during transarterial Methods： Serum VEGF levels were measured using enzyme-linked immunosorbent assay （EliSA） in 60 random patients who underwent TACE or transarterial infusion （TAI） for unresectable HCC between May and September 2008 and 12 healthy volunteers were also involved in this study to serve as control. All patients＇ clinicopathological features were retrospectively analyzed. Serum VEGF levels were correlated with clinicopathological features of the HCC patients. The patients＇ survival rates were analyzed with Kaplan-Meier survival curves and compared by the log-rank test. The prognostic significance of serum VEGF levels and factors related to survival rate were evaluated by univariate and multivariate analysis. Results： The median serum VEGF level in the HCC patients was 285 pg/ml （range 14-1,207 pg/ml）, significantly higher than that of healthy controls （P=0.021）. The serum VEGF levels were significantly correlated with platelet counts （r=0.396, P=0.002） but not other clinicopathological features. Patients with serum VEGF level 〉285 pg/ml had worse overall survival compared with those with serum VEGF level 〈285 pg/ml （P=0.002）. By multivariate analysis, the serum VEGF level was a significant prognostic factor. Conclusion： High serum VEGF levels may predict poor prognosis of HCC after TACE. This study highlights the importance of tumor biomarker as a prognostic predictor in TACE therapy for HCC, which has an intrinsic problem of unavailability of histopathological prognostic features.

关键词： Hepatocellular carcinoma Vascular endothelial growth factor TACE EliSA

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Spectral CT imaging as a new quantitative tool? Assessment of perfusion defects of pulmonary parenchyma in patients with lung cancer

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Chinese Journal of Cancer Research 2013年第6期25卷 722-728页

作者： Ying-Shi Sun xiao-Yan Zhang Yong Cui Lei Tang xiao-ting li Ying Chen xiao-Peng Zhang Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education) Department of RadiologyPeking University Cancer Hospital & Institute

Objective： This study investigated the capability of dual-energy spectral computed tomography （CT） to quantitatively evaluate lung perfusion defects that are induced by central lung cancer. Methods： Thirty-two patients with central lung cancer underwent CT angiography using spectral imaging. A univariate general linear model was conducted to analyze the variance of iodine concentration/CT value with three factors of lung fields. A paired t-test was used to compare iodine concentrations and CT values between the distal end of lung cancer and the corresponding area in the contralateral normal lung. Results： Iodine concentrations increased progressively in the far, intermediate and near ground sides in the normal lung fields at 0.60±0.28, 0.93±0.27 and 1.25±0.38 mg/mL, respectively （P〈0.001）. The same trend was observed for the CT values [-（840.64±49.08）, -（812.66±50.85） and -（760.83±89.17） HU, P〈0.001]. The iodine concentration （0.70±0.42 mg/mL） of the lung field in the distal end of lung cancer was significantly lower than the corresponding area in the contralateral normal lung （1.19±0.62 mg/mL）（t=-7.23, P〈0.001）. However, the CT value of lung field in the distal end of lung cancer was significantly higher than the corresponding area in the contralateral normal lung [-（765.29±93.34） HU vs. -（800.07±76.18） HU, t=3.564, P=0.001]. Conclusions： Spectral CT imaging based on the spectral differentiation of iodine is feasible and can quantitatively evaluate pulmonary perfusion and identify perfusion defects that are induced by central lung cancer. Spectral CT seems to be a promising technique for the simultaneous evaluation of both morphological and functional lung information.

关键词： Spectral computed tomography (CT) quantitative analysis perfusion lung cancer

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Significantly improved photocatalysis-self-Fenton degradation performance over g-C3N4 via promoting Fe(Ⅲ)/Fe(Ⅱ)cycle

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Rare Metals 2022年第7期41卷 2429-2438页

作者： Le Chen Xin-Xia He Ze-Han Gong Jia-lian li Yang liao xiao-ting li Jun Ma College of Chemistry and Materials Science Sichuan Normal UniversityChengdu 610068China Department of Science and Technology Sichuan Normal UniversityChengdu 610068China Key Laboratory of Land Resources Evaluation and Monitoring in Southwest Ministry of EducationChengdu 610068China

Photocatalysis-self-Fenton system,i.e.,photo-catalytic H_(2)O_(2)generation and utilization in situ for OH radials production to remove organic pollutants with high-fluent degradation and mineralization performance pos-sesses such advantages as cleanliness,efficiency and ***,its degradation activity always suffers from the Fe(Ⅲ)/Fe(Ⅱ)*** this reason,graphitic carbon interface-modified g-C_(3)N_(4)(CUCN)was fabricated to remarkably improve photocatalysis-self-Fenton degra-dation *** experiment results indicated that CUCN-2%photocatalyst,in which the loading percentage of graphitic carbon was 2%,demonstrated the optimum degradation performance among all the *** mineralization degree for RhB in 3 h over CUCN-2%reached 63.77%,nearly 3.35-fold higher than the pristine g-C_(3)N_(4).The significantly improved mineralization efficiency was ascribed to the promoted Fe(Ⅲ)/Fe(Ⅱ)cycle by photogenerated electrons,which leading to the higher utilization efficiency of H_(2)O_(2)through Fenton reaction,thereby producing more hydroxyl *** is anticipated that our work could provide new insights for the design of photocatalysis-self-Fenton system with exceptional degradation performance for actual photocat-alytic applications.

关键词： g-C_(3)N_(4) Photocatalysis-self-Fenton degradation Fe(Ⅲ)/Fe(Ⅱ)cycle Interface modification Graphitic carbon

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Factors Influencing Subjective Orthodontic Treatment Need and Culture-related Differences among Chinese Natives and Foreign Inhabitants

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International Journal of Oral Science 2010年第3期2卷 149-157页

作者： xiao-ting li Yin Tang Xue-lian Huang Hua Wan Yang-xi Chen Department-of Orthodontics West China College of Stomatology Sichuan University Chengdu China Department of Operative Dentistry and Endodontics West China College of Stomatology Sichuan University Chengdu China Department of Health Statistics West China College of Public Health Sichuan University Chengdu China

Aim The aim of this survey was to compare Chinese natives and foreign inhabitants in Chengdu, China, with respect to：（1） attitudes towards dental appearance, （2） subjective orthodontic treatment need, and （3） the main factors influencing orthodontic treatment need. Methodology A total of 522 subjects, including 227 foreign inhabitants and 295 Chinese natives in Chengdu participated in the survey. A simple random sampling method was adopted and a face-to-face interview was conducted at some public sites using a questionnaire. Data was entered by two persons synchronously using Epidata 3.0, and SPSS 13.0 was used to analyze these data. Results 89.0% of foreign inhabitants were satisfied with their teeth compared to only 46.8% of Chinese natives. Females were more dissatisfied with their teeth than males. Chinese natives put improving appearance as the top priority （55.9%） for seeking orthodontic treatment; however, in foreign inhabitants, the main reason for seeking treatment was to improve masticatory function（44.1%）, followed by ＂to be pretty＂（35.2%）. The importance of well-aligned teeth and self-perception of psychosocial impact of malocclusion were the same two main factors influencing subjective orthodontic treatment need （P〈0.05） in foreign inhabitants and Chinese natives. Sub- jective orthodontic treatment need between the two target groups was significantly different （P〈0.05）. Conclusion （1） It was very common that Chinese natives were dissatisfied with their dental appearance, and their subjective orthodontic treatment needs were high. （2） There were some differences in orthodontic treatment motives between the two target groups. （3） There were differences in subjective orthodontic treatment needs between foreign inhabitants and Chinese natives. However, the prominent influential factors were almost the same. There may be benefit to understanding subjective orthodontic needs of different races.

关键词： orthodontic treatment motives subjective needs,comparative study

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Primary extra-pancreatic pancreatic-type acinar cell carcinoma in the right perinephric space: A case report and review of literature

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World Journal of Clinical Cases 2021年第20期9卷 5637-5646页

作者： Yi-Yuan Wei Ying li Yan-Jie Shi xiao-ting li Ying-Shi Sun Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education) Department of RadiologyPeking University Cancer Hospital&InstituteBeijing 100142China

BACKGROUND Primary extra-pancreatic pancreatic-type acinar cell carcinoma(ACC)is a rare malignancy,and has only been reported in the gastrointestinal tract,liver,and lymph nodes until ***-pancreatic pancreatic-type ACC in the perinephric space has not been ***,we report the first case of ACC in the perinephric space and describe its clinical and imaging features,which should be considered when differentiating perinephric space *** SUMMARY A 48-year-old man with a 5-year history of hypertension was incidentally found to have an asymptomatic right retroperitoneal mass during a routine health *** tests were *** computed tomography and magnetic resonance imaging showed an oval hypervascular mass with a central scar and enhanced capsule in the right perinephric *** surgical resection of the neoplasm,the diagnosis was primary extra-pancreatic pancreatic-type *** patient was alive without recurrence or metastasis during a 15-mo *** This is the first report of an extra-pancreatic ACC in right perinephric space,which should be considered as a possible diagnosis in perinephric tumors.

关键词： Acinar cell carcinoma Retroperitoneal space Tomography X-ray Magnetic resonance imaging Case report

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Fused monochromatic imaging acquired by single source dual energy CT in hepatocellular carcinoma during arterial phase: an initial experience

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Chinese Journal of Cancer Research 2014年第4期26卷 437-443页

作者： Shun-Yu Gao xiao-Peng Zhang Yong Cui Ying-Shi Sun Lei Tang xiao-ting li xiao-Yan Zhang Jun Shan Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education) Department of RadiologyPeking University Cancer Hospital& Institute

Objective： To explore whether single and fused monochromatic images can improve liver tumor detection and delineation by single source dual energy CT （ssDECT） in patients with hepatocellular carcinoma （HCC） during arterial phase. Methods： Fifty-seven patients with HCC who underwent ssDECT scanning at Beijing Cancer Hospital were enrolled retrospectively. Twenty-one sets of monochromatic images from 40 to 140 keV were reconstructed at 5 keV intervals in arterial phase. The optimal contrast-noise ratio （CNR） monochromatic images of the liver tumor and the lowest-noise monochromatic images were selected for image fusion. We evaluated the image quality of the optimal-CNR monochromatic images, the lowest-noise monochromatic images and the fused monochromatic images, respectively. The evaluation indicators included the spatial resolution of the anatomical structure, the noise level, the contrast and CNR of the tumor. Results： In arterial phase, the anatomical structure of the liver can be displayed most clearly in the 65-keV monochromatic images, with the lowest image noise. The optimal-CNR monochromatic images of HCC tumor were 50-keV monochromatic images in which the internal structural features of the liver tumors were displayed most clearly and meticulously. For tumor detection, the fused monochromatic images and the 50-keV monochromatic images had similar performances, and were more sensitive than 65-keV monochromatic images. Conclusions： We achieved good arterial phase images by fusing the optimal-CNR monochromatic images of the HCC tumor and the lowest-noise monochromatic images. The fused images displayed liver tumors and anatomical structures more clearly, which is potentially helpful for identifying more and smaller HCC tumors.

关键词： Computed tomography (CT) dual energy hepatocellular carcinoma (HCC) image postprocessing comparative study

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