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一种适用于B3G移动通信系统下行共享信道的调度算法

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电子学报 2005年第7期33卷 1173-1176页

作者：赵新胜鞠涛尤肖虎东南大学移动通信国家重点实验室东南大学移动通信国家重点实验室江苏南京21.096

本文针对后三代(B3G)移动通信系统中的宽带无线信道特性和流媒体业务特征,分析了可用于高速下行共享信道的各种传统分组调度算法,提出面向流媒体业务能够提高系统吞吐量的基于优先级公平调度(Priority-BasedFairnessScheduling,PBFS)算... 详细信息

本文针对后三代(B3G)移动通信系统中的宽带无线信道特性和流媒体业务特征,分析了可用于高速下行共享信道的各种传统分组调度算法,提出面向流媒体业务能够提高系统吞吐量的基于优先级公平调度(Priority-BasedFairnessScheduling,PBFS)算法.该算法根据各移动用户收发信道质量和业务传输的QoS要求动态调整各用户的业务传输优先级,确定下行共享信道的调度方案.并给出该算法的简化形式S-PBFS.仿真结果表明,与传统调度算法相比,S-PBFS算法在数据包传输时延受限的条件下具有无线信道利用率高、实现复杂度低等特点.

关键词： B3G移动通信系统下行共享信道流媒体 PBFS算法 S-PBFS算法

Blockage of EGFR/AKT and mevalonate pathways synergize the antitumor effect of temozolomide by reprogramming energy metabolism in glioblastoma

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Cancer Communications 2023年第12期43卷 1326-1353页

作者： xiaoteng Cui Jixing Zhao Guanzhang Li Chao Yang Shixue Yang Qi Zhan Junhu Zhou Yunfei Wang Menglin xiao Biao Hong Kaikai Yi Fei Tong Yanli Tan Hu Wang Qixue Wang tao Jiang Chuan Fang Chunsheng Kang Laboratory of Neuro-oncology Tianjin Neurological Institute Tianjin Medical University General Hospital Tianjin P. R. China Key Laboratory of Post-Neuro Injury Neuro-repair and Regeneration in Central Nervous System Ministry of Education and Tianjin City Tianjin P. R. China Department of Neurosurgery Beijing Tiantan Hospital Capital Medical University Beijing P. R. China Chinese Glioma Genome Atlas Network (CGGA) and Asian Glioma Genome Atlas Network (AGGA) Beijing P. R. China Department of Neurosurgery The First Affiliated Hospital of Zhengzhou University Zhengzhou Henan P. R. China Tianjin Key Laboratory of Composite and Functional Materials School of Material Science and Engineering Tianjin University Tianjin P. R. China Department of Neurosurgery Affiliated Hospital of Hebei University Baoding Hebei P. R. China Hebei Key Laboratory of Precise Diagnosis and Treatment of Glioma Baoding Hebei P. R. China Department of Neuro-Oncology and Neurosurgery Tianjin Medical University Cancer Institute and Hospital Tianjin P. R. China Department of Pathology Affiliated Hospital of Hebei University Baoding Hebei P. R. China Department of Pathology Hebei University School of Basic Medical Sciences Baoding Hebei P. R. China Department of Neurosurgery Tianjin Huanhu Hospital Tianjin P. R. China Department of Molecular Neuropathology Beijing Neurosurgical Institute Capital Medical University Beijing P. R. China Research Unit of Accurate Diagnosis Treatment and Translational Medicine of Brain Tumors Chinese Academy of Medical Sciences Beijing P. R. China

Background Metabolism reprogramming plays a vital role in glioblastoma(GBM)progression and recurrence by producing enough energy for highly proliferating tumor *** addition,metabolic reprogramming is crucial for tumor growth and immune-escape *** growth factor receptor(EGFR)amplification and EGFR-vIII mutation are often detected in GBM cells,contributing to the malignant *** study aimed to investigate the functional role of the EGFR pathway on fatty acid metabolism remodeling and energy *** Clinical GBM specimens were selected for single-cell RNA sequencing and untargeted metabolomics analysis.A metabolism-associated RTK-fatty acid-gene signature was constructed and ***-2206 and MK-803 were utilized to block the RTK pathway and mevalonate pathway induced abnormal *** metabolism in GBM with activated EGFR pathway was *** antitumor effect of Osimertinib and Atorvastatin assisted by temozolomide(TMZ)was analyzed by an intracranial tumor model in *** GBM with high EGFR expression had characteristics of lipid remodeling and maintaining high cholesterol levels,supported by the single-cell RNA sequencing and metabolomics of clinical GBM *** of the EGFR/AKT and mevalonate pathways could remodel energy metabolism by repressing the tricarboxylic acid cycle and modulating ATP ***,the EGFR/AKT pathway upregulated the expressions of acyl-CoA synthetase short-chain family member 3(ACSS3),acyl-CoA synthetase long-chain family member 3(ACSL3),and long-chain fatty acid elongation-related gene ELOVL fatty acid elongase 2(ELOVL2)in an NF-κB-dependent ***,inhibition of the mevalonate pathway reduced the EGFR level on the cell membranes,thereby affecting the signal transduction of the EGFR/AKT ***,targeting the EGFR/AKT and mevalonate pathways enhanced the antitumor effect of TMZ in GBM cells and animal *** Our findings no

关键词： combinatorial therapeutic strategy EGFR energy metabolism glioblastoma

Capsule endoscopy and single-balloon enteroscopy in small bowel diseases: Competing or complementary?

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World Journal of Gastroenterology 2016年第48期22卷 10625-10630页

作者： Jing-Jing Ma Ying Wang xiao-Min Xu Jie-Wen Su Wen-Yu Jiang Jian-Xia Jiang Lin Lin Dao-Quan Zhang Jing Ding Li Chen Ting Jiang Ying-Hong Xu Gui {1. Hong-Jie Zhang Department of Gastroenterology The First Affiliated Hospital of Nanjing Medical University Department of Gastroenterology Jiangsu Provincial Hospital

AIM To evaluate diagnostic yields of capsule endoscopy(CE) and/or single-balloon enteroscopy(SBE) in patients with suspected small bowel *** Were trospectively analyzed 700 patients with suspected small bowel diseases from September 201. to March 201.. CE, SBE, or SBE with prior CE was performed in 401. 353, and 47 patients, respectively. Data from clinical and endoscopy records were collected for analysis. Indications, procedure times, diagnostic yields, and complications were summarized and *** The overall diagnostic yield for the CE group was 57.6%. The diagnostic yield of CE in patients with obscure gastroin testinal bleeding(OGIB) was significantly greater than that in patients with no bleeding(70.5% vs 43.8%, P 1.. The overall diagnostic yield of SBE was 69.7%. There was no difference in the diagnostic yield of SBE between patients with OGIB and those with no bleeding(72.5% vs 68.9%, P = 0.534). Forty-seven patients underwent CE prior to SBE. Among them, the diagnostic yield of SBE with positive findings on prior CE was 93.3%. In addition, SBE detected two cases with superficial ulcer and erosive lesions in the small bowel, which were missed by CE. However, one case with lymphoma and two with Crohn's disease were not confirmed by SBE. The rate of capsule retention was 2.0%. There were no significant complications during or after SBE *** SBE is a safe and effective technique for diagnosing small bowel diseases. SBE with prior CE seemed to improve the diagnostic yield of small bowel diseases.

关键词： Capsule endoscopy Small bowel diseases Single-balloon enteroscopy Diagnosis Balloon-assisted enteroscopy

基于赤铁矿的生物质化学链燃烧过程中氮氧化物的释放特性

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燃料化学学报 2015年第4期43卷 490-498页

作者：肖申沈来宏肖军牛欣顾海明宋涛东南大学能源热转换及其过程测控教育部重点实验室江苏南京210096

在单批次进料固定床上,基于赤铁矿载氧体,研究了还原反应阶段反应温度和水蒸气量对谷壳的氮氧化物释放特性的影响。研究表明,碳转化率随反应温度升高而增加,但随水蒸气量呈先增加后下降,并在水蒸气量为1.0 g/min时达到最大值。在实验条... 详细信息

在单批次进料固定床上,基于赤铁矿载氧体,研究了还原反应阶段反应温度和水蒸气量对谷壳的氮氧化物释放特性的影响。研究表明,碳转化率随反应温度升高而增加,但随水蒸气量呈先增加后下降,并在水蒸气量为1.0 g/min时达到最大值。在实验条件下,还原阶段未检测到NO2。随着反应温度由750℃升高到900℃,NO的生成率增加,而N2O的生成率先增加后降低,在850℃时达到最大值。水蒸气量由0.5 g/min升高到2.0 g/min,N2O和NO的生成率均增加,且NO增加速率高于N2O。在反应后的载氧体中,检测到KAl Si3O8存在,表明载氧体与生物质中的K元素发生反应。

关键词：化学链燃烧生物质赤铁矿氮氧化物

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边疆的类型划分与研究视角

地域研究与开发 2008年第3期27卷 7-10,60页

作者：金晓哲林涛北京大学城市与环境学院城市与区域规划系北京100871

边疆在整个国家空间结构中的重要性不亚于首都和核心区。但目前我国边疆研究却相对滞后,研究内容和视角也相对单一。这与目前我国以领土边疆为主的边疆观具有重要的关系。为此,作者首先对我国的边疆界定进行了评述,认为以领土边疆为主... 详细信息

边疆在整个国家空间结构中的重要性不亚于首都和核心区。但目前我国边疆研究却相对滞后,研究内容和视角也相对单一。这与目前我国以领土边疆为主的边疆观具有重要的关系。为此,作者首先对我国的边疆界定进行了评述,认为以领土边疆为主的我国边疆观无法涵盖不同时期和国家边疆概念中拓居边疆、利益边疆等的多重涵义。基于此,依据国内外边疆的多重涵义,对我国的边疆概念进行了拓展,将边疆划分为政治边疆、文化边疆和拓居边疆3种类型,并依据各自的空间涵义提出了相应的研究视角。

关键词：边疆政治边疆文化边疆拓居边疆研究视角

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棱镜单目立体视觉系统的参数最优化

东北大学学报（自然科学版） 2013年第6期34卷 802-805页

作者：赵越魏永涛崔笑宇东北大学中荷生物医学与信息工程学院辽宁沈阳110819

针对基于棱镜的单目立体视觉系统,提出了一种分析和选择系统参数的最优化方法.该方法可以使系统拍摄到的图像以最佳的位置满足立体视觉算法处理的需要.从系统的建立和参数的选择角度分析了单目立体视觉系统的组成.引入了一种计算系统成... 详细信息

针对基于棱镜的单目立体视觉系统,提出了一种分析和选择系统参数的最优化方法.该方法可以使系统拍摄到的图像以最佳的位置满足立体视觉算法处理的需要.从系统的建立和参数的选择角度分析了单目立体视觉系统的组成.引入了一种计算系统成像区域的数学方法,使用空间直线来表示光线的传播,利用光的折射定理的向量计算方法,解出光线经过棱镜折射后的直线方程,通过空间直线的关系确定系统的成像区域.通过对该系统成像区域的重新定义,将成像区域与捕获的图像联系起来,从而选择最佳系统参数配置.

关键词：单目立体视觉棱镜成像区域系统参数最优化

Buyang Huanwu Decoction(补阳还五汤)Attenuates Glial Scar by Downregulating Expression of Leukemia Inhibitory Factor in Intracerebral Hemorrhagic Rats

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Chinese Journal of Integrative Medicine 2019年第4期25卷 264-269页

作者： KANG xiao ZHOU Hua-jun YANG Jian ZHONG Jian-hua TANG {1. CUI Han-jin ZHOU Jing-hua MEI Zhi-gang Institute of Neurology China Three Gorges UniversityHubei Province(443003)China Department of Neurology The First College of Clinical Medical SciencesChina Three Gorges UniversityHubei Province(443003)China Key Laboratory of Cardiovascular and Cerebrovascular Diseases Translational Medicine China Three Gorges UniversityYichangHubei Province(443003)China Department of Intensive Care Unit The First College of Clinical Medical SciencesChina Three Gorges UniversityYichangHubei Province(443003)China Institute of Integrative Medicine Xiangya HospitalCentral South UniversityChangsha(410008)China Medical College of China Three Gorges University Hubei Province(443002)China

Objective: To evaluate the effect of Buyang Huanwu Decoction(补阳还五汤,BYHWD) on glial scar after intracerebral hemorrhage(ICH) and investigate the underlying ***: Collagenase type Ⅶ(0.5 U) was injected stereotaxically into right globus pallidus to induce ICH *** hundred and twenty SpragueDawley rats were randomly divided into 3 groups according to a random number table,including normal group(n=40),ICH model group(n=40) and BYHWD group(n=40),*** ICH,the rats in the BYHWD group were intragastrically administered with BYHWD(4.36 g/kg) once a day for 21.days,while the rats in ICH group were administered with equal volume of distilled water for 21.days,*** immunolabeling was performed for proliferating cell nuclear antigen(PCNA)+/glial ?brillary acidic protein(GFAP)+ *** expression of GFAP and leukemia inhibitory factor(LIF) was evaluated by immunohistochemistry and quantitative real-time reverse transcription-polymerase chain reaction(RT-PCR).Results: The astrocytes with hypertrophied morphology around the hematoma was observed on day 3 after *** number of GFAP positive cells and GFAP m RNA levels increased notably on day 3 and reached the peak on day 1. post-ICH(P1..PCNA+/GFAP+ nuclei were observed around the hematoma and reached the peak on day 1. post-ICH(P1..In addition,LIF-positive astrocytes and LIF m RNA level in the hemorrhagic region increased signi?cantly till day 1. post-ICH(P1..However,BYHWD not only reduced the number of PCNA+/GFAP+ nuclei,but also decreased GFAP and LIF levels(P<0.05).Conclusion:BYHWD could attenuate ICH-induced glial scar by downregulating the expression of LIF in the rats.

关键词： Buyang Huanwu Decoction intracerebral hemorrhage glial scar leukemia inhibitory factor Chinese medicine

A Novel Cinnamyl Alcohol Dehydrogenase Gene from Isatis Indigotica Fort.

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A Novel Cinnamyl Alcohol Dehydrogenase Gene from Isatis Indi...

Primary Hyperparathyroidism:A Tale of Two Cities Revisited-New York and Shanghai

第十四届全国中药和天然药物学术研讨会

作者： xiao Ying Ying-Bo Yang Wan-Sheng Chen Zheng-{1. Wang Shanghai University of Traditional Chinese Medicine

A novel Cinnamyl alcohol dehydrogenase gene,designated as liCAD(GenBank Accession ***937874)was cloned by rapid amplification of cDNA ends(RACE)from Isatis indigotica *** full-length cDNA of liCAD was 1.02 bp containing an open reading frame(ORF)of 1.83bp,encoding a polypeptide of 360 amino acids,with a predicted molecular mass of 38.91.kDa

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Bone Research 2013年第2期1卷 162-169页

作者： Jian-min Liu Natalie E. Cusano Barbara C. Silva Lin Zhao xiao-yan He Bei {1. Li-hao Sun Hong-yan Zhao Wen-wei Fan Megan E. Romano Guang Ning John P. Bilezikian Department of Endocrine and Metabolic Diseases Rui-jin HospitalShanghai Jiao-tong University School of Medicine Department of Medicine Division of EndocrinologyCollege of Physicians and surgeonsColumbia University

In the 1.70s, with the advent of biochemical multichannel screening in the United States and other western countries, the clinical presentation of primary hyperparathyroidism （PHPT） changed from a symptomatic to an asymptomatic disorder. However, in Asian countries, like China, PHPT did not show this evolution, but rather continued to be a symptomatic disease with target organ involvement. In this paper, we revisit the clinical features of PHPT in New York and Shanghai, representative United States and Chinese cites, over the past decade. The questions we address are whether the disease evolved in China to a more asymptomatic one and, whether in the United States further changes are evident. The results indicate that while PHPT con- tinues to present primarily as an asymptomatic disease in the United States, a new phenotype characterized by normal serum calcium and high parathyroid hormone levels, normocalcemic PHPT, has emerged. Data from Shanghai demonstrates a trend for PHPT to present more commonly as an asymptomatic disorder in China. However, most patients with PHPT in China still manifest classical symptoms, i.e. nephrolithiasis and fractures. A comparison of the two cohorts shows that Chinese patients with PHPT are younger, with higher serum calcium and PTH levels, and lower 25-hydroxyvitamin D levels than patients in New York. Normocalcemic PHPT has not yet been recognized in Shanghai. In summary, although the phenotypes of PHPT in both cities are evolving towards less evident disease, sharp clinical and biochemical differences are still apparent in PHPT as expressed in China and the United States.

关键词： normocalcemic primay hyperparathyroidism asymptomatic symptomatic