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Influence of in situ formed spinel in bonding phase on mechanical properties and air permeability of magnesia-chrome porous purging materials

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Journal of Iron and Steel Research International 2024年第6期31卷 1459-1472页

作者： Yi An Hao Liu Zhou-fu wang Yan Ma Xi-tang wang The State Key Laboratory of Refractories and Metallurgy Wuhan University of Science and TechnologyWuhan 430081HubeiChina

Magnesia-chrome porous purging plugs are crucial functional components to remove inclusions and stabilize the flow field during iron and steel ***,practical applications of magnesia-chrome porous purging materials are stil hampered by the poor scouring resistance to molten steel and unstable air permeability owing to their low mechanical properties and uncontrollable pore ***,the particle-packing type magnesiachrome porous purging materials reinforced by in situ formed spinel were prepared using fused magnesia-chrome particles and Al powders as major raw *** results show that in situ formed spinel solid solutions in bonding phase led to the decreased median pore size and increased pore surface fractal dimension from the reactions between Al powders and magnesia-chrome particles and along with high-temperature sintering,bonding between magnesia-chrome particles and the resultant mechanical properties of materials were greatly ***,the results of air permeability tests and polynomial ftting indicated that the formation of spinel solid solutions was the main contributing factor for controllable air permeability,and pressure drop of porous purging materials was positively correlated with surface fractal dimension of ***,the as-prepared porous purging materials added with 6 wt.%Al powders obtained the maximum cold crushing strength(54.2 MPa)and hot modulus of rupture(12.9 MPa)with median pore size of 24.06μm and ftting non-Darcian permeability coefficient of 0.97×10^(-6)m.

关键词： Magnesia Chrome porous purging material Metallic Al-Spinel Mechanical strength Air permeability

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Preparing lipid nanoparticles with tunable drug loading capacity and morphology via improved sequential nanoprecipitation

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Science China Chemistry 2024年第5期67卷 1373-1374页

作者： Haoran wang Ben Zhong tang Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction Department of Chemistry.Institute of Molecular Functional MaterialsState Key Laboratory of NeuroscienceDivision of Biomedical Engineering and Division of Life ScienceThe Hong Kong University of Science and TechnologyHong Kong 999077China School of Science and Engineering Shenzhen Institute of Aggregate Science and Technology The Chinese University of Hong KongShenzhen(CUHK-Shenzhen)Shenzhen 518172China

Nanotechnology hailed as a revolutionary new technology of the 21st century, has ignited a wave of innovation across diverse fields spanning chemistry, physics, materials science,medicine, engineering, and electronics. In 2016, Nature published an article titled “The nanolight revolution is coming”, underscoring that “virus-sized particles that emit light in every color could transform applications ranging from television displays to cancer treatment”.

关键词： sized loading treatment

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Preparation of three-dimensional nanoporous copper foil with high specific surface area

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Rare Metals 2024年第7期43卷 3430-3437页

作者： Ning Song Li-Juan wang Jun-Feng wang Juan Liao Jian Huang Peng-Kang Du Yun-Zhi tang Yu-Hui Tan xiao-Wei Fan Jiangxi Provincial Key Laboratory of Functional Molecular Materials Chemistry School of Chemistry and Chemical EngineeringJiangxi University of Science and TechnologyGanzhou 341000China

The porous copper foil material has the advantages of ultralight and ultra-thin,and can prevent dangers such as thermal runaway and battery fire,which could be regarded as a prospective material for lithium battery **... 详细信息

关键词： copper porous dimensional

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Microglial autophagy in neurogenesis:a new player in Alzheimer's disease

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Neural Regeneration Research 2024年第12期19卷 2573-2574页

作者： Xin tang Aarti Nagayach Chenran wang Department of Cancer Biology University of Cincinnati College of MedicineCincinnatiOHUSA

While extensive studies have illuminated the impact of Alzheimer's disease(AD) on neuronal survival,there is growing evidence that abnormal postnatal neurogenesis in early AD brains contributes to disease *** neurogenesis serves as a mechanism to replace dead or damaged *** neurons generated from neural stem cells(NSCs) in the subgranular zone(SGZ) of the dentate gyrus integrate into the existing hippocampal circuit.

关键词： Alzheimer replace integrate

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Full-domain collaborative deployment method of multiple interference sources and evaluation of its deployment effect

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Defence Technology（防务技术） 2024年第2期32卷 572-595页

作者： Yue wang Fuping Sun Xian wang Jinming Hao Kai xiao School of Geospatial Information The PLA Information Engineering UniversityZhengzhou 450001HenanChina

This paper realizes the full-domain collaborative deployment of multiple interference sources of the global satellite navigation system(GNSS)and evaluates the deployment effect to enhance the ability to disturb the attacker and the capability to defend the GNSS during navigation *** evaluation indicators for the jamming effect of GNSS suppressive and deceptive jamming sources are first created,their evaluation models are built,and their detection procedures are sorted out,as the basis for determining the deployment *** principles for collaboratively deploying multi-jamming sources are developed to obtain the deployment structures(including the required number,structures in demand,and corresponding positions)of three single interference sources required by collaboratively ***,simulation and hardware-in-loop testing results are presented to determine a rational configuration of the collaborative deployment of multi-jamming sources in the set situation and further realize the full-domain deployment of an interference network from ground,air to *** evaluation indices for the deployment effect are finally developed to evaluate the deployment effect of the proposed configuration and further verify its reliability and rationality.

关键词： Jamming effect Multiple interference sources Collaborative deployment Effect evaluation Defense capability

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Predictive value of bilirubin and serum γ-glutamyltranspeptidase levels in type-2 diabetes mellitus patients with acute coronary syndrome

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World Journal of Diabetes 2024年第1期15卷 34-42页

作者： Jie Chen Wan-Chao Zhang xiao-Qiang tang Ruo-Han Yin Tao wang xiao-Yu Wei Chang-Jie Pan Radiology Department The Affiliated Changzhou No.2 People's Hospital of Nanjing Medical UniversityChangzhou 213164Jiangsu ProvinceChina Radiology Department The People’s Hospital of WuQia CountyWuqia 845450Xinjiang Uygur Autonomous RegionChina

BACKGROUND Cardiovascular disease is a major complication of diabetes mellitus(DM).Type-2 DM(T2DM)is associated with an increased risk of cardiovascular events and mortality,while serum biomarkers may facilitate the prediction of these *** differential diagnosis of T2DM complicated with acute coronary syndrome(ACS)plays an important role in controlling disease progression and improving *** To investigate the correlation of serum bilirubin andγ-glutamyltranspeptidase(γ-GGT)with major adverse cardiovascular events(MACEs)in T2DM patients with *** The clinical data of inpatients from January 2022 to December 2022 were analyzed *** to different conditions,they were divided into the T2DM complicated with ACS group(T2DM+ACS,n=96),simple T2DM group(T2DM,n=85),and simple ACS group(ACS,n=90).The clinical data and laboratory indices were compared among the three groups,and the correlations of serum total bilirubin(TBIL)levels and serumγ-GGT levels with other indices were discussed.T2DM+ACS patients received a 90-day follow-up after discharge and were divided into event(n=15)and nonevent(n=81)groups according to the occurrence of MACEs;Univariate and multivariate analyses were further used to screen the independent influencing factors of MACEs in *** The T2DM+ACS group showed higherγ-GGT,total cholesterol,low-density lipoprotein cholesterol(LDL-C)and glycosylated hemoglobin(HbA1c)and lower TBIL and high-density lipoprotein cholesterol levels than the T2DM and ACS groups(P<0.05).Based on univariate analysis,the event and nonevent groups were significantly different in age(t=3.3612,P=0.0011),TBIL level(t=3.0742,P=0.0028),γ-GGT level(t=2.6887,P=0.0085),LDL-C level(t=2.0816,P=0.0401),HbA1c level(t=2.7862,P=0.0065)and left ventricular ejection fraction(LEVF)levels(t=3.2047,P=0.0018).Multivariate logistic regression analysis further identified that TBIL level and LEVF level were protective factor for MACEs,and age andγ-GGT

关键词： Acute coronary syndrome Type-2 diabetes mellitus Total bilirubin Major adverse cardiovascular events

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Control of fine particulate nitrate during severe winter haze in“2+26”cities

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Journal of Environmental Sciences 2024年第2期136卷 261-269页

作者： Chuang Qin xiao Fu Tao wang Jian Gao Jiaqi wang Institute of Environment and Ecology Tsinghua Shenzhen International Graduate SchoolTsinghua UniversityShenzhen 518055China Department of Civil and Environmental Engineering Hong Kong Polytechnic UniversityHong Kong 99907China State Key Laboratory of Environmental Criteria and Risk Assessment Chinese Research Academy of Environmental SciencesBeijing 10084China

The“2+26”cities,suffering the most severe winter haze pollution,have been the key region for air quality improvement in *** prominent nitrate pollution is one of the most challenging environmental issues in this region,necessitating development of an effective control ***,we use observations,and state-of-the-art model simulations with scenario analysis and process analysis to quantify the effectiveness of the future SO_(2)-NO_(X)-VOC-NH_(3) emission control on nitrate pollution mitigation in“2+26”*** on a serious winter haze episode,we find that limited NO_(X)emission reduction alone in the short-term period is a less effective choice than VOC or NH_3emission reduction alone to decrease nitrate concentrations,due to the accelerated NO_(X)-HNO_(3)conversion by atmospheric oxidants and the enhanced HNO_(3)to NO_(3)^(-)partition by ammonia,although deep NO_(X)emission reduction is essential in the long-term *** synergistic NH_(3) and VOC emission control is strongly recommended,which can counteract the adverse effects of nonlinear photochemistry and aerosol chemical feedback to decrease nitrate *** extra benefits will be reduced if the synergistic NH_(3) and VOC reduction is delayed,and thus reducing emission of multiple precursors is urgently required for the effective control of increasingly severe winter nitrate pollution in“2+26”cities.

关键词： Nitrate Winter haze pollution Emission reduction “2+26”cities

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A deep Koopman operator-based modelling approach for long-term prediction of dynamics with pixel-level measurements

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CAAI Transactions on Intelligence Technology 2024年第1期9卷 178-196页

作者： Yongqian xiao Zixin tang Xin Xu Xinglong Zhang Yifei Shi College of Intelligence Science and Technology National University of Defense TechnologyChangshaChina

Although previous studies have made some clear leap in learning latent dynamics from high-dimensional representations,the performances in terms of accuracy and inference time of long-term model prediction still need to be *** this study,a deep convolutional network based on the Koopman operator(CKNet)is proposed to model non-linear systems with pixel-level measurements for long-term *** adopts an autoencoder network architecture,consisting of an encoder to generate latent states and a linear dynamical model(i.e.,the Koopman operator)which evolves in the latent state space spanned by the *** decoder is used to recover images from latent *** to a multi-step ahead prediction loss function,the system matrices for approximating the Koopman operator are trained synchronously with the autoencoder in a mini-batch *** this manner,gradients can be synchronously transmitted to both the system matrices and the autoencoder to help the encoder self-adaptively tune the latent state space in the training process,and the resulting model is time-invariant in the latent ***,the proposed CKNet has the advantages of less inference time and high accuracy for long-term *** are per-formed on OpenAI Gym and Mujoco environments,including two and four non-linear forced dynamical systems with continuous action *** experimental results show that CKNet has strong long-term prediction capabilities with sufficient precision.

关键词： deep neural networks image motion analysis image sequences sequential estimation

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A novel cabazitaxel liposomes modified with ginsenoside Rk1 for cancer targeted therapy

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Acupuncture and Herbal Medicine 2024年第1期4卷 113-121页

作者： Dandan Huang Zhongjie tang xiao Pu Tianqi wang Feiyan Gao Chong Li Medical Research Institute College of Pharmaceutical SciencesSouthwest UniversityChongqingChina Department of Pharmacy National University of SingaporeSingapore 117545Singapore

Objective:In this study,we aim to enhance the anti-prostate cancer efficacy of cabazitaxel(CTX)and reduce its immunosuppression and systemic toxicity by developing CTX-loaded liposomes modified with ginsenoside Rk1(Rk1/CTX-Lip).Methods:Physical and chemical properties of Rk1/CTX-Lip were *** evaluated the biological functions of Rk1/CTXLip,both in vitro and in vivo.A subcutaneous prostate cancer(RM-1)-bearing mouse model was established to study the efficacy of Rk1/CTX-Lip inhibition in ***,a Candida albicans infection model was established in tumor-bearing mice to study the infection-relieving efficacy of Rk1/***,biocompatibility and in vivo safety of Rk1/CTX-Lip were ***:We successfully prepared Rk1/CTX-Lip,achieving high CTX encapsulation efficiency(97.24±0.75)%and physical ***1/CTX-Lip demonstrated evasion of macrophage phagocytosis,effective tumor tissue targeting,and a significant reduction(>50%)in average tumor volume compared with Chol/***,it relieved the concurrent infection burden and effectively regulated immune organs and cells,demonstrating superior ***:Rk1/CTX-Lip presents a promising new therapy for prostate cancer and holds potential for relieving concurrent fungal infections in cancer patients with low immunity.

关键词： Cabazitaxel Fungal infection Ginsenoside Rk1 Liposome-drug delivery system Prostate cancer

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Preparation of tungsten-particle-reinforced Zr-based bulk metallic glass composites by two-step spark plasma sintering:microstructure evolution,densification mechanism and mechanical properties

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Rare Metals 2024年第4期43卷 1793-1808页

作者： Yun-Fei Ma Pan Gong Mao Zhang Hui-EHu Zhen Peng xiao Xu Xin wang Mehdi Malekan Xue-Feng tang Lei Deng Jun-Song Jin Xin-Yun wang State Key Laboratory of Materials Processing and Die and Mould Technology School of Materials Science and EngineeringHuazhong University of Science and TechnologyWuhan430074China Research Institute of Huazhong University of Science and Technology in Shenzhen Shenzhen518057China Department of Chemistry and Materials Naval University of EngineeringWuhan430032China School of Materials Science and Engineering Jiangsu UniversityZhenjiang212013China College of Machine Shanghai Dianji UniversityShanghai201306China School of Metallurgy and Materials Engineering College of EngineeringUniversity of TehranTehran 11155-4563Iran

A new two-step spark plasma sintering(TSS)process with low-temperature pre-sintering and high-temperature final sintering has been successfully applied to prepare the tungsten-particle(Wp)-reinforced bulk metallic glass composites(Wp/BMGCs).Compared to normal spark plasma sintering(NS),the densification rate and relative density of Wp/BMGCs can be improved by selecting TSS with appropriate sintering pressure in the low temperature pre-sintering ***,the compressive strength and plastic strain of 30%Wp/BMGCs prepared by TSS are both higher than those of the samples prepared by *** TSS process can significantly enhance the compressive strength of 30%Wp/BMGCs by 12%and remarkably increase the plastic strain by 50%,while the trend is completely opposite for 50%Wp/***-in situ experiments and finite element simulations reveal that uneven temperature distribution among particles during low-temperature pre-sintering causes local overheating at contact points between particles,accelerating formation of sintering neck between particles and plastic deformation of *** the volume fraction of Wp is low,TSS can improve the interface bonding between particles by increasing the number of sintering *** makes the fracture mode of Wp/BMGCs being predominantly transgranular ***,as the volume fraction of Wp increases,the adverse effects of Wp plastic deformation are becoming more and more *** aggregated Wp tends to form a solid"cage structure"that hinders the bonding between particles at the interface;correspondingly,the fracture behavior of Wp/BMGCs is mainly dominated by intergranular ***,reducing the sintering pressure during the low-temperature pre-sintering stage of TSS has been shown to effectively decrease plastic deformation in Wp,resulting in a higher degree of densification and better mechanical properties.

关键词： Bulk metallic glass composites Tungsten particle Two-step spark plasma sintering Densification mechanism Mechanical properties

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