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Density of Na2O-Li2O-SiO2-B2O3 Molten Slag at 1 803-1 873K

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Journal of Iron and Steel Research International 2004年第4期11卷 15-18页

作者： xiao Feng FANG liang Chongqing Institute of Technology

The structural changes and reduction degree of chromite ore in blast furnace were studied by optical micrograph analysis, scanning electron microscope (SEM) and energy dispersive X-ray analysis (EDXA). The smelting re... 详细信息

关键词： smelting reduction chromite ore mechanism blast furnace

N-6甲基腺苷调节蛋白在胶质瘤中的研究进展

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中华神经外科疾病研究杂志 2025年第1期19卷 99-104页

作者：肖海奕李阳梁冬海南医科大学第一临床医学院海南海口570100 三亚中心医院(海南省第三人民医院) 海南三亚572000

N-6甲基腺苷(m6A)是真核生物中RNA分子上的一种常见化学修饰,这种修饰对RNA的稳定性、翻译和转录等多种生物过程有重要影响。m6A修饰在所有腺苷酸中所占的比例虽然很小(0.1%-0.4%),但它是真核生物mRNA中最丰富的表观遗传修饰之一,在干... 详细信息

N-6甲基腺苷(m6A)是真核生物中RNA分子上的一种常见化学修饰,这种修饰对RNA的稳定性、翻译和转录等多种生物过程有重要影响。m6A修饰在所有腺苷酸中所占的比例虽然很小(0.1%-0.4%),但它是真核生物mRNA中最丰富的表观遗传修饰之一,在干细胞的更新、分化、转录、翻译、降解等过程中都扮演着重要角色,并可能在特定基因的表达或失活中起决定性作用。m6A修饰是一个动态可逆的过程,由甲基化酶、去甲基化酶及阅读蛋白共同调控,甲基化酶复合物的核心成员包括METTL3、METTL14和WTAP,而FTO和ALKBH5则是已知的去甲基化酶。YTH基因家族中的蛋白,即m6A阅读蛋白,能够识别并结合带有m6A修饰的RNA,从而调节RNA的代谢过程并参与不同的生理活动。研究显示m6A阅读蛋白YTH家族在胶质瘤形成和发展中起关键作用,本文旨在综述m6A及相关蛋白与胶质瘤的关系。

关键词： N-6甲基腺苷 YTH家族 RNA修饰胶质瘤

Effect of Long-Term Fertilization on Organic Nitrogen Forms in a Calcareous Alluvial Soil on the North China Plain

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Pedosphere 2006年第2期16卷 224-229页

作者： JU xiao-Tang LIU Xue-Jun ZHANG Fu-suo P. CHRISTIE Key Laboratory of Plant-Soil Interactions Ministry of Education College of Agricultural Resources and Environmental Sciences China Agricultural University Beijing 100094 （China） Agricultural and Environmental Science Department The Queen＇s University of Belfast Belfast BT9 5PX （UK）

In order to illustrate the change of nitrogen （N） supply capacity after long-term application of manure and chemical fertilizer, as well as to properly manage soil fertility through fertilizer application under the soil-climatic conditions of the North China Plain, organic N forms were quantified in the topsoil with different manure and chemical fertilizer treatments in a 15-year fertilizer experiment in a Chinese calcareous alluvial soil. Soil total N （TN） and various organic N forms were significantly influenced by long-term application of chemical fertilizer and manure. TN, total hydrolysable N, acid-lnsoluble N, amino acid N and ammonium N in the soil increased significantly （P 〈 0.05） with increasing manure and fertilizer N rates, but were not influenced by increasing P rates. Also, application of manure or N fertilizer or P fertilizer did not significantly influence either the quantity of amino sugar N or its proportion of TN. Application of manure significantly increased （P 〈 0.05） hydrolysable unknown N, but adding N or P did not. In addition, application of manure or N fertilizer or P fertilizer did not significantly influence the proportions of different soil organic N forms.

关键词： chemical fertilizer long-term fertilization manure North China Plain soil organic nitrogen forms

Mixed-mode fracture behavior in deep shale reservoirs under different loading rates and temperatures

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Petroleum Science 2023年第5期20卷 3037-3047页

作者： Yu suo Yan-Jie Zhao xiao-Fei Fu Wen-Yuan He Zhe-Jun Pan School of Petroleum Engineering Northeast Petroleum UniversityDaqing163318HeilongjiangChina Postdoctoral Resource Center Daqing Oilfield Company LimitedDaqing163458HeilongjiangChina Key Laboratory of Continental Shale Hydrocarbon Accumulation and Efficient Development(Northeast Petroleum University) Ministry of EducationDaqing163318HeilongjiangChina Heilongjiang Province Key Laboratory of Oil and Gas Reservoir Fracturing and Evaluation Daqing163318HeilongjiangChina PetroChina International Exploration and Development Company Limited Corporation Beijing100034China

In the last years,shale gas has gradually substituted oil and coal as the main sources of energy in the *** with shallow shale gas reservoirs,deep shale is characterized by low permeability,low porosity,strong heterogeneity,and strong *** the process of multi-cluster fracturing of horizontal wells,the whole deformation process and destruction modes are significantly influenced by loading *** this investigation,the servo press was used to carry out semi-circular bend(SCB)mixedmode fracture experiments in deep shales(130,160,190℃)with prefabricated fractures under different loading rates(0.02,0.05,0.1,0.2 mm/min).The fracture propagation process was monitored using acoustic *** deformation characteristics,displacementeload curve,and acoustic emission parameters of shale under different loading rates were studied during the mixed-mode fracture *** results showed that during the deformation and fracture of the specimen,the acoustic emission energy and charge significantly increased near the stress peak,showing at this point the most intense acoustic emission *** the increase in loading rate,the fracture peak load of the deep shale specimen also ***,the maximum displacement decreased to different *** the increase in temperature,the effective fracture toughness of the deep shale gradually ***,the maximum displacement *** different loading rates,the deformation of the prefabricated cracks showed a nonlinear slow growthelinear growth *** slope of the linear growth stage increased with the increase in loading *** addition,as the loading rate increased,an increase in tension failure and a decrease in shear failure were ***,the control chart showing the relationship between tension and the shear failure under different temperatures and loading rates was determined.

关键词： Deep shale Mixed-mode fracture toughness Loading rate Deformation characteristics

Effects of Mitochondrial Dysfunction via AMPK/PGC-1α Signal Pathway on Pathogenic Mechanism of Diabetic Peripheral Neuropathy and the Protective Effects of Chinese Medicine

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Chinese Journal of Integrative Medicine 2019年第5期25卷 386-394页

作者： ZHANG Qian liang xiao-chun Department of Traditional Chinese Medicine Translational Medicine CenterPeking Union Medical College HospitalChinese Academy of Medical SciencesBeijing(100730)China

Diabetic peripheral neuropathy(DPN) is a progressive neurodegenerative disease of peripheral nervous system with high energy requirement. The adenosine monophosphate-activated protein kinase(AMPK)/peroxisome proliferator-activated receptor-γ coactivator 1α(PGC-1α) axis plays a key role in regulating mitochondrial energy metabolism. Increasing preclinical evidences have shown that inhibition of AMPK/PGC-1α pathway leading to mitochondrial dysfunction in neurons or Schwann cells contributes to neuron apoptosis, distal axonopathy and nerve demyelination in DPN. Some Chinese medicine formulae or extracts from herbs may have potential neuroprotective effects on DPN via activating AMPK/PGC-1α pathway and improving mitochondrial function.

关键词： monophosphate-activated protein kinase peroxisome proliferator-activated receptor-γ coactivator 1α sirtuins diabetic peripheral neuropathy Chinese medicine

Effect of trace Ce on high-temperature oxidation behavior of an Al-Sicoated Ni-based single crystal superalloy

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Journal of Iron and Steel Research International 2019年第1期26卷 78-83页

作者： xiao-juan Pang Shu-suo Li Lu Qin Yan-ling Pei Sheng-kai Gong School of Materials Science and Engineering Beihang UniversityBeijing 100191China

Ni-based single crystal superalloy IC21 with different Ce con tents was prepared by screw selection method,and Al-Si coatings were prepared by pack *** oxidation and transient oxidation were carried out at 1150℃ to investigate the effect of Ce on the high-temperature oxidation behavior of Al-Si *** cyclic oxidation at 1150℃,the addition of trace Ce decreased the mass gain of the Al-Si-coated samples and effectively improved oxidation perform a nee and spallation *** specimens without Ce doping,microstructure examinatio n revealed that bulkyγ-Ni3Al precipitated in oxidized coating because of high Al con sumption,and this finding suggests that Ce inhibits the consumption of Al in the coating during *** slows down the Ininsformation of O-Al2O3 to oc-Al2O3 and improves the adhesion of the oxide scale.

关键词： Single crystal superalloy Trace Ce Al-Si coating Oxidation behavior AlO3

Strategies and Research Progress of Chinese Medicine in Prevention and Treatment of Diabetic Peripheral Neuropathy

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Chinese Journal of Integrative Medicine 2018年第10期24卷 794-800页

作者： YANG Dan liang xiao-chun Department of Traditional Chinese Medicine Peking Union Medical College Hospital Peking Union Medical CollegeTranslational Medicine Center Chinese Academy of Medical Sciences

Diabetic peripheral neuropathy （DPN） seriously affects the quality of life in patients with type 2 diabetes mellitus. This paper reviews the role of Chinese medicine in the main treatment goal of DPN, including protecting pancreatic β-cells, in the use of antioxidation therapy to delay disease progression, and in the endpoint of neural repair and regeneration. We propose that protecting the body from injury caused by high glucose and oxidative stress, and promoting repair and regeneration of nerves should be the research direction for the prevention and treatment of DPN.

关键词： diabetic peripheral neuropathy pancreatic β-cell anti-oxidative stress neural repair and regeneration Chinese medicine

QoS-aware scheduling algorithm in relay-assisted LTE-A system

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The Journal of China Universities of Posts and Telecommunications 2013年第5期20卷 16-21页

作者： CHUAI Gang YU xiao-liang School of Information and Communication Engineering Beijing University of Posts and Telecommunications Key Laboratory of Universal Wireless Communications Ministry of EducationBeijing University of Posts and Telecommunications

This paper details on the uplink scheduling algorithm for long term evolution advanced （LTE-A） system with relays. While emulating quality of service （QoS）-aware services with different bit-rate and delay budget requirements for the upstream direction, a new QoS-aware scheduling algorithm for in-band relays is proposed. In this work, an improved scheduling metric calculation method and bit-rate guarantee scheme is applied. Moreover, this algorithm proposes an efficient scheme for the backhaul link allocation which allows information of the most backlogged users to be transmitted first. Finally, this paper concludes with simulation results to demonstrate how the proposed resource allocation strategy improves the performance of the system.

关键词： relay station scheduling algorithm guaranteed bit rate (GBR) backhaul link access link

Iterative methods for a forward-backward heat equation in two-dimension

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Applied Mathematics(A Journal of Chinese Universities) 2010年第1期25卷 101-111页

作者： SUN Jie CHENG xiao-liang School of Mathematics and Statistics Zhejiang University of Finance and Economics Hangzhou310018 China Department of Mathematics Zhejiang University Hangzhou 310027 China

A finite difference method is introduced to solve the forward-backward heat equation in two space dimensions. In this procedure, the backward and forward difference scheme in two subdomains and a coarse-mesh second-order central difference scheme at the middle interface are used. Maximum norm error estimate for the procedure is derived. Then an iterative method based on domain decomposition is presented for the numerical scheme and the convergence of the given method is established. Then numerical experiments are presented to support the theoretical analysis.

关键词： Forward-backward heat equation coarse mesh iterative method.