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Features and therapeutic potential of T-cell receptors in high-grade glioma

Chinese Medical Journal 2019年第12期132卷 1435-1440页

作者： Jie-Lin Zhang xiao-song zhong Shou-Bo Yang Xun Kang Yan Li Jian-Xin Chen Wen-Bin Li General Department of Neuro-oncology Beijing Tiantan HospitalCapital Medical UniversityBeijing 100070China The Clinical Center of Gene and Cell Engineering Beijing Shijitan HospitalCapital Medical UniversityBeijing 100038China Department of Glioma Beijing Shijitan HospitalCapital Medical UniversityBeijing 100038China

Background: Previous studies have shown that endogenous T cells play an important role in the prolonged survival time of highgrade glioma (HGG) patients. Our objectives were to investigate the features of T-cell receptor (TCR) repertoires in HGG patients and to elucidate any potential therapeutic value. Methods: During November 2011 and December 2018, tumor tissues and blood samples of 35 patients with HGG who underwent surgery at Beijing Tiantan Hospital or Beijing Shijitan Hospital were selected after surgery. After isolating DNA from samples, multiple rounds of PCR were performed to establish a DNA immune repertoire (IR). Then, the sequences and frequencies of the complementarity-determining 3 (CDR3) region in TCR beta chain (TRB) were identified by high-throughput sequencing and IR analysis. A survival follow-up was conducted monthly thereafter until December 2018. Finally, the t test and Mann-Whitney test were used to compare statistical differences between two sets of data. Results: The Shannon diversity index (SHDI) of TRB sequences of HGG patients was significantly lower than that of healthy individuals (7.34 vs. 8.45, P = 0.001). The SHDI of TRB sequences of glioblastoma (GBM) patients with more than 16 months survival time was much higher than that of GBM patients with shorter survival times in both tumor tissues (3.48 ± 0.31 vs. 6.21 ± 0.33, t =-5.49, P = 0.002) and blood cells (6.02 ± 0.66 vs. 7.44 ± 0.32, t =-2.20, P = 0.036). In addition, patients achieved a distinctly higher proportion compared to that of healthy individuals in the proportion of TRBV9 and TRBV5 functional regions (9.83% vs. 6.83%, P = 0.001). Surgical tissue from patients who survived more than 16 months yielded a much higher proportion of TRBV4 and TRBV9 regions (7.14% vs. 3.28%, t = 3.18, P = 0.019). In surgical tissues from two GBM patients who survived for longer than 46 months, we found a potentially therapeutic TCR sequence. Conclusions: HGG patients have less species diversity

关键词： Glioma T-cell receptor Immunotherapy Survival Therapeutics

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An Efficient Multi-objective Approach Based on Golden Jackal Search for Dynamic Economic Emission Dispatch

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Journal of Bionic Engineering 2024年第3期21卷 1541-1566页

作者： Keyu zhong Fen xiao Xieping Gao Key Laboratory of Computing and Stochastic Mathematics of Ministry of Education Hunan Normal UniversityChangsha410081China School of Mathematics and Statistics Hunan Normal UniversityChangsha410081China School of Computer Science Xiangtan UniversityXiangtan411105China Hunan Provincial Key Laboratory of Intelligent Computing and Language Information Processing Hunan Normal UniversityChangsha410081China

Dynamic Economic Emission Dispatch(DEED)aims to optimize control over fuel cost and pollution emission,two conflicting objectives,by scheduling the output power of various units at specific *** many methods well-performed on the DEED problem,most of them fail to achieve expected results in practice due to a lack of effective trade-off mechanisms between the convergence and diversity of non-dominated optimal dispatching *** address this issue,a new multi-objective solver called Multi-Objective Golden Jackal Optimization(MOGJO)algorithm is proposed to cope with the DEED *** proposed algorithm first stores non-dominated optimal solutions found so far into an ***,it chooses the best dispatching solution from the archive as the leader through a selection mechanism designed based on elite selection strategy and Euclidean distance index *** mechanism can guide the algorithm to search for better dispatching solutions in the direction of reducing fuel costs and pollutant ***,the basic golden jackal optimization algorithm has the drawback of insufficient search,which hinders its ability to effectively discover more Pareto *** this end,a non-linear control parameter based on the cosine function is introduced to enhance global exploration of the dispatching space,thus improving the efficiency of finding the optimal dispatching *** proposed MOGJO is evaluated on the latest CEC benchmark test functions,and its superiority over the state-of-the-art multi-objective optimizers is highlighted by performance ***,empirical results on 5-unit,10-unit,IEEE 30-bus,and 30-unit systems show that the MOGJO can provide competitive compromise scheduling solutions compared to published DEED ***,in the analysis of the Pareto dominance relationship and the Euclidean distance index,the optimal dispatching solutions provided by MOGJO are the closest to the ideal solutions for minimizing fuel costs

关键词： Dynamic economic emission dispatch Multi-objective optimization Golden jackal Euclidean distance index

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APFA:Ameliorated Pathfinder Algorithm for Engineering Applications

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Journal of Bionic Engineering 2024年第3期21卷 1592-1616页

Pathfinder algorithm(PFA)is a swarm intelligent optimization algorithm inspired by the collective activity behavior of swarm animals,imitating the leader in the population to guide followers in finding the best food *** algorithm has the characteristics of a simple structure and high ***,PFA faces challenges such as insufficient population diversity and susceptibility to local optima due to its inability to effectively balance the exploration and exploitation *** paper proposes an Ameliorated Pathfinder Algorithm called APFA to solve complex engineering optimization ***,a guidance mechanism based on multiple elite individuals is presented to enhance the global search capability of the ***,to improve the exploration efficiency of the algorithm,the Logistic chaos mapping is introduced to help the algorithm find more high-quality potential solutions while avoiding the worst ***,a comprehensive following strategy is designed to avoid the algorithm falling into local optima and further improve the convergence *** three strategies achieve an effective balance between exploration and exploitation overall,thus improving the optimization performance of the *** performance evaluation,APFA is validated by the CEC2022 benchmark test set and five engineering optimization problems,and compared with the state-of-the-art metaheuristic *** numerical experimental results demonstrated the superiority of APFA.

关键词： Pathfinder algorithm Swarm intelligent Metaheuristic Engineering problems

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Chiral multiple-resonance thermally activated delayed fluorescence materials based on chiral spiro-axis skeleton for efficient circularly polarized electroluminescence

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Science China Chemistry 2024年第7期67卷 2257-2264页

作者： Shi-Quan song xiao Han zhong-zhong Huo Ching-Fai Yip Xian-Fang Hong Meng-Ning Ding You-Xuan Zheng State Key Laboratory of Coordination Chemistry Jiangsu Key Laboratory of Advanced Organic MaterialsSchool of Chemistry and Chemical EngineeringNanjing UniversityNanjing 210023China Key Laboratory of Mesoscopic Chemistry of Ministry of Education School of Chemistry and Chemical EngineeringNanjing UniversityNanjing 210023China

Chiral luminescence materials have potential applications in the field of three-dimensional displays due to their circularly polarized luminescence(CPL)***,the further development of circularly polarized organic light-emitting diodes(CP-OLEDs)needs to meet the requirements of high efficiency,high color purity,low cost,and high dissymmetry factor(gPLor gEL),chiral multiple resonance thermally activated delayed fluorescence(MR-TADF)materials are considered as candidates in these ***,based on a pair of chiral spirofluorene precursors,two pairs of high-performance chiral MR-TADF emitters((R/S)-p-Spiro-DtBuCzB and(R/S)-m-Spiro-DtBuCzB)are developed,which exhibit strong emissions peaking at 491 and 502 nm in toluene with full-width at half-maximum values of 25 and 33 nm,*** addition,small singlet–triplet energy gaps of 0.15 and 0.10 eV with high absolute photoluminescence efficiencies of 95.0%and 96.7%are observed for p-Spiro-DtBuCzB and m-Spiro-DtBuCzB molecules,*** based on p-Spiro-DtBuCzB and m-Spiro-DtBuCzB display high maximum external quantum efficiencies of 29.6%and 33.8%,*** importantly,CP-OLEDs present symmetric circularly polarized electroluminescence spectra with|gEL|factors of 3.36×10^(-4)and 7.66×10^(-4)for devices based on(R/S)-p-Spiro-DtBuCzB and(R/S)-m-Spiro-DtBuCzB enantiomers,respectively.

关键词： chiral spiro-axis skeleton-based material multiple resonance thermally activated delayed fluorescence circularly polarized electroluminescence dissymmetry factor external quantum efficiency

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NeurstrucEnergy:A bi-directional GNN model for energy prediction of neural networks in IoT

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Digital Communications and Networks 2024年第2期10卷 439-449页

作者： Chaopeng Guo Zhaojin zhong Zexin Zhang Jie song Software Campus Northeastern UniversityShenyang110000LiaoningChina

A significant demand rises for energy-efficient deep neural networks to support power-limited embedding devices with successful deep learning applications in IoT and edge computing *** accurate energy prediction approach is critical to provide measurement and lead optimization ***,the current energy prediction approaches lack accuracy and generalization ability due to the lack of research on the neural network structure and the excessive reliance on customized training *** paper presents a novel energy prediction model,*** treats neural networks as directed graphs and applies a bi-directional graph neural network training on a randomly generated dataset to extract structural features for energy *** has advantages over linear approaches because the bi-directional graph neural network collects structural features from each layer's parents and *** results show that NeurstrucEnergy establishes state-of-the-art results with mean absolute percentage error of 2.60%.We also evaluate NeurstrucEnergy in a randomly generated dataset,achieving the mean absolute percentage error of 4.83%over 10 typical convolutional neural networks in recent years and 7 efficient convolutional neural networks created by neural architecture *** code is available at https://***/NEUSoftGreenAI/***.

关键词： Internet of things Neural network energy prediction Graph neural networks Graph structure embedding Multi-head attention

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Monocular Distance Estimated Based on PTZ Camera

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Computers, Materials & Continua 2024年第5期79卷 3417-3433页

作者： Qirui zhong xiaogang Cheng Yuxin song Han Wang Bell Honors School Nanjing University of Posts and Telecommunications Nanjing210003China College of Telecommunications and Information Engineering Nanjing University of Posts and TelecommunicationsNanjing210003China College of Automation and College of Artificial Intelligence Nanjing University of Posts and TelecommunicationsNanjing210003China

This paper introduces an intelligent computational approach for extracting salient objects fromimages and estimatingtheir distance information with PTZ (Pan-Tilt-Zoom) cameras. PTZ cameras have found wide applications innumerous public places, serving various purposes such as public securitymanagement, natural disastermonitoring,and crisis alarms, particularly with the rapid development of Artificial Intelligence and global infrastructuralprojects. In this paper, we combine Gauss optical principles with the PTZ camera’s capabilities of horizontal andpitch rotation, as well as optical zoom, to estimate the distance of the *** present a novel monocular objectdistance estimation model based on the Focal Length-Target Pixel Size (FLTPS) relationship, achieving an accuracyrate of over 95% for objects within a 5 km range. The salient object extraction is achieved through a simplifiedconvolution kernel and the utilization of the object’s RGB features, which offer significantly faster computingspeeds compared to Convolutional Neural Networks (CNNs). Additionally, we introduce the dark channel beforethe fog removal algorithm, resulting in a 20 dB increase in image definition, which significantly benefits distanceestimation. Our system offers the advantages of stability and low device load, making it an asset for public securityaffairs and providing a reference point for future developments in surveillance hardware.

关键词： Public security location information PTZ camera image processing

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A Possible X-ray Quasi-periodic Oscillation in the Narrow-line Seyfert 1 Galaxy Mrk 142

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Research in Astronomy and Astrophysics 2024年第6期24卷 191-200页

作者： xiao-Gu zhong Jian-Cheng Wang Yong-Yun Chen xiao-Ling Yu College of Physics and Electronic Engineering Qujing Normal UniversityQujing 655011China Yunnan Observatories Chinese Academy of SciencesKunming 650216China

A possible quasi-periodic oscillation(QPO) at frequency 7.045 × 10^(-5) Hz is found in the narrow-line Seyfert 1galaxy Mrk 142 in the data of XMM-Newton collected on 2020 April *** find that the QPO signal is statistically significantly larger than the 5σ level and highly coherent with quality factor Q > 5 at the 0.3–10 keV band by using the method of the Lomb–Scargle Periodogram,the Weighted Wavelet Z-transform and the *** analyze the data in 0.3–0.6 keV,0.6–1 keV,1–3 keV and 3–10 keV energy bands,and find obvious QPO signals at 0.3–0.6 keV and 1–3 keV *** then analyze the time-average spectra and time variability at the QPO frequency of 7.045 × 10^(-5) Hz,and use a model to fit *** find that the QPO signal mainly comes from the X-ray hot corona.

关键词： X-rays:galaxies galaxies:Seyfert accretion accretion disks radiation mechanisms:general

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Relationship Between Individuals’Epidemic Risk Perception Within Living Space and Subjective Well-Being:Empirical Evidence from China after the First Wave of COVID-19

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Chinese Geographical Science 2024年第2期34卷 369-382页

作者： song Jiangyu ZHOU Suhong KWAN Mei-Po ZHENG zhong School of Geography and Planning Sun Yat-sen UniversityGuangzhou 510006China Guangdong Provincial Engineering Research Center for Public Security and Disaster Guangzhou 510275China Institute of Space and Earth Information Science the Chinese University of Hong KongHong Kong 999077China Department of Geography and Resource Management the Chinese University of Hong KongHong Kong 999077China Institute of Future Cities the Chinese University of Hong KongHong Kong 999077China Center for Territorial Spatial Planning and Real Estate Studies Beijing Normal UniversityZhuhai 519000China

It is common to observe the epidemic risk perception(ERP)and a decline in subjective well-being(SWB)in the context of public health events,such as Corona Virus Disease 2019(COVID-19).However,there have been few studies exploring the impact of individuals’ERP within living space on their SWB,especially from a geographical and daily activity perspective after the resumption of work and other activities following a wave of the *** this paper,we conducted a study with 789 participants in urban China,measuring their ERP within living space and examining its influence on their SWB using path *** results indicated that individuals’ERP within their living space had a significant negative effect on their *** density of certain types of facilities within their living space,such as bus stops,subway stations,restaurants,fast food shops,convenience shops,hospitals,and public toilets,had a significantly negative impact on their SWB,mediated by their ERP within living ***,participation in out-of-home work and other activities not only increased individuals’ERP within living space,but also strengthened its negative effect on their SWB.

关键词： subjective well-being epidemic risk perception living space the density of facilities out-of-home activities

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Energy consumption optimization for edge computing-supported cellular networks based on optimal transport theory

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Science China(Information Sciences) 2024年第2期67卷 201-218页

作者： Xiangyu LV xiaohu GE Yi zhong Qiang LI Yong xiao School of Electronic Information and Communications Huazhong University of Science and Technology

With advancements in mobile communication technologies, there have been multiple user device(UD) connections to cellular networks. Because of changes in the spatial distribution of UDs and application requirements, the traditional offloading mechanism based on the nearest distance will result in heavy loads for some base stations(BSs). Because there is a high-order relationship between the energy consumption of the BS processing tasks and the number of computing tasks, the traditional offloading mechanism will result in high energy consumption, and UD’s offloading decision must be dynamically adjusted. The offloading decision of UDs is optimized based on detailed information about various parameters associated with a network from the standpoint of distribution. This information includes details regarding the spatial distribution of UDs,application requirements, and the offloading period of computing tasks. Based on optimal transport theory,an energy consumption optimization algorithm is suggested to lower the total amount of energy consumed by the offloading process of UDs’ computing tasks by reasonably planning the offloading BSs of the UDs in the networks. The simulation results show that the proposed offloading mechanism based on energy consumption optimization reduces the total energy consumption of the offloading process by 28.09% when compared to the traditional offloading mechanism, and the traffic managed by each BS is balanced.

关键词： optimal transport theory edge computing energy consumption reduction dynamic voltage frequency scaling

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台湾地区终身学习认证述评

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教育学术月刊 2011年第1期 10-12页

作者：宋孝忠华北水利水电学院学报社科版

建立终身学习认证制度,是实践终身学习社会的重要手段,也是落实终身学习政策的关键。近年来终身学习受到台湾社会各界的普遍重视。终身学习认证的理论研究十分深入,终身学习认证的法律和政策逐步出台,终身学习认证活动开展得丰富多彩,... 详细信息

建立终身学习认证制度,是实践终身学习社会的重要手段,也是落实终身学习政策的关键。近年来终身学习受到台湾社会各界的普遍重视。终身学习认证的理论研究十分深入,终身学习认证的法律和政策逐步出台,终身学习认证活动开展得丰富多彩,积累了许多有益的经验,对构建我国大陆地区终身学习认证制度有较强的启示与借鉴价值。

关键词：终身学习认证制度台湾地区

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