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Unraveling the efficacy network: A network meta-analysis of adjuvant external beam radiation therapy methods after hepatectomy

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World Journal of Gastrointestinal surgery 2024年第1期16卷 205-214页

作者： Gao-Yuan Yang Zhi-Wei He Yong-Chang Tang Feng Yuan Ming-Bo Cao Yu-Peng Ren Yu-Xuan Li xiao-rui su Zhi-Cheng Yao Mei-Hai Deng Department of Hepatobiliary surgery The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510630Guangdong ProvinceChina Department of General surgery Qilu HospitalShandong UniversityJinan 250012Shandong ProvinceChina Department of General surgery The First Affiliated HospitalGuangzhou Medical UniversityGuangzhou 511436Guangdong ProvinceChina Department of Hepatobiliary and Pancreatic surgery The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510630Guangdong ProvinceChina

BACKGROUND Primary liver cancer is a malignant tumor with a high recurrence rate that significantly affects patient *** adjuvant external radiation therapy(RT)has been shown to effectively prevent recurrence after liver cancer ***,there are multiple RT techniques available,and the differ-ential effects of these techniques in preventing postoperative liver cancer re-currence require further *** To assess the advantages and disadvantages of various adjuvant external RT methods after liver resection based on overall survival(OS)and disease-free survival(DFS)and to determine the optimal *** This study involved network meta-analyses and followed the PRISMA *** data of qualified studies published before July 10,2023,were collected from PubMed,Embase,the Web of Science,and the Cochrane *** included relevant studies on postoperative external beam RT after liver resection that had OS and DFS as the primary *** magnitudes of the effects were determined using risk ratios with 95%confidential *** results were analyzed using R software and STATA *** A total of 12 studies,including 1265 patients with hepatocellular carcinoma(HCC)after liver resection,were included in this *** was no significant heterogeneity in the direct paired comparisons,and there were no significant differences in the inclusion or exclusion criteria,intervention measures,or outcome indicators,meeting the assumptions of heterogeneity and *** analysis revealed that patients who underwent stereotactic body radiotherapy(SBRT)after resection had longer OS than those who underwent intensity modulated radiotherapy(IMRT)or 3-dimensional conformal RT(3D-CRT).DFS analysis revealed that patients who underwent 3D-CRT after resection had the longest *** who underwent IMRT after resection had longer OS than those who underwent 3D-CRT and longer DFS than those who underwent ***

关键词： Primary liver cancer Hepatocellular carcinoma Network meta-analysis External beam radiation therapy Stereotactic body radiotherapy Intensity modulated radiotherapy

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Reduced mesencephalic astrocyte-derived neurotrophic factor expression by mutant androgen receptor contributes to neurodegeneration in a model of spinal and bulbar muscular atrophy pathology

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Neural Regeneration Research 2025年第9期20卷 2655-2666页

作者： Yiyang Qin Wenzhen Zhu Tingting Guo Yiran Zhang Tingting Xing Peng Yin Shihua Li xiao-Jiang Li su Yang Guangdong Key Laboratory of Non-human Primate Research Key Laboratory of CNS Regeneration(Ministry of Education)Guangdong–HongKong–Macao Institute of CNS RegenerationJinan UniversityGuangzhouGuangdong ProvinceChina

Spinal and bulbar muscular atrophy is a neurodegenerative disease caused by extended CAG trinucleotide repeats in the androgen receptor gene,which encodes a ligand-dependent transcription facto *** mutant androgen receptor protein,characterized by polyglutamine expansion,is prone to misfolding and forms aggregates in both the nucleus and cytoplasm in the brain in spinal and bulbar muscular atrophy *** aggregates alter protein-protein interactions and compromise transcriptional *** this study,we reported that in both cultured N2a cells and mouse brain,mutant androgen receptor with polyglutamine expansion causes reduced expression of mesencephalic astrocyte-de rived neurotrophic *** n of mesencephalic astrocyte-derived neurotrophic factor amelio rated the neurotoxicity of mutant androgen receptor through the inhibition of mutant androgen receptor *** down endogenous mesencephalic astrocyte-derived neurotrophic factor in the mouse brain exacerbated neuronal damage and mutant androgen receptor *** findings suggest that inhibition of mesencephalic astrocyte-derived neurotrophic factor expression by mutant androgen receptor is a potential mechanism underlying neurodegeneration in spinal and bulbar muscular atrophy.

关键词： androgen receptor mesencephalic astrocyte-derived neurotrophic factor mouse model neurodegeneration neuronal loss neurotrophic factor polyglutamine disease protein misfolding spinal and bulbar muscular atrophy transcription factor

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Rock fracture mechanism of buffer blasting with cushion layer at the borehole bottom

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 325-334页

作者： Xinguang Zhu Chenxi Ding Zhe sui Hong su Xu Guo School of Civil and Resources Engineering University of Science and Technology BeijingBeijing 100083China Key Laboratory for Mechanics in Fluid Solid Coupling Systems Institute of MechanicsChinese Academy of SciencesBeijing 100190China School of Mechanics and Civil Engineering China University of Mining and Technology(Beijing)Beijing 100083China School of Chemical and Blasting Engineering Anhui University of Science and TechnologyHuainan 232001China

This study primarily investigates the rock fracture mechanism of bottom cushion layer blasting and explores the effects of the bottom cushion layer on rock *** involves analyses of the evolution patterns of blasting stress,characteristics of crack distribution,and rock fracture features in the ***,blasting model experiments were carried out using the dynamic caustics principle to investigate the influence of bottom cushion layers and initiation methods on the integrity of the bottom rock *** experimental results indicate that the combined use of bottom cushion layers and inverse initiation effectively protects the integrity of the bottom rock ***,the process of stress wave propagation and dynamic crack propagation in rocks was simulated using the continuum-discontinuum element method(CDEM)and the Landau explosion source model,with varying thicknesses of bottom cushion *** numerical simulation results indicate that with increasing cushion thickness,the absorption of energy generated by the explosion becomes more pronounced,resulting in fewer cracks in the bottom rock *** illustrates the positive role of the cushion layer in protecting the integrity of the bottom rock mass.

关键词： bottom cushion layer blasting crack propagation continuum-discontinuum element method dynamic stress intensity factor

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Glucocorticoid receptor signaling in the brain and its involvement in cognitive function

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Neural Regeneration Research 2025年第9期20卷 2520-2537页

作者： Chonglin su Taiqi Huang Meiyu Zhang Yanyu Zhang Yan Zeng Xingxing Chen Brain Science and Advanced Technology Institute Hubei Province Key Laboratory of Occupational Hazard Identification and ControlSchool of MedicineWuhan University of Science and TechnologyWuhanHubei ProvinceChina

The hypothalamic-pituitary-adrenal axis regulates the secretion of glucoco rticoids in response to environmental *** the brain,a nuclear receptor transcription fa ctor,the glucocorticoid recepto r,is an important component of the hypothalamicpituitary-a d renal axis's negative feedback loop and plays a key role in regulating cognitive equilibrium and *** glucoco rticoid receptor influences cognitive processes,including glutamate neurotransmission,calcium signaling,and the activation of brain-derived neurotrophic factor-mediated pathways,through a combination of genomic and non-genomic *** interactions within the central nervous system can alter the expression and activity of the glucocorticoid receptor,there by affecting the hypothalamic-pituitary-a d renal axis and stress-related cognitive *** appropriate level of glucocorticoid receptor expression can improve cognitive function,while excessive glucocorticoid receptors or long-term exposure to glucoco rticoids may lead to cognitive *** with cognitive impairment-associated diseases,such as Alzheimer's disease,aging,depression,Parkinson's disease,Huntington's disease,stroke,and addiction,often present with dysregulation of the hypothalamic-pituitary-adrenal axis and glucocorticoid receptor *** review provides a comprehensive overview of the functions of the glucoco rticoid receptor in the hypothalamic-pituitary-a d renal axis and cognitive *** emphasizes that appropriate glucocorticoid receptor signaling fa cilitates learning and memory,while its dysregulation can lead to cognitive *** provides clues about how glucocorticoid receptor signaling can be targeted to ove rcome cognitive disability-related disorders.

关键词： brain-derived neurotrophic factor calcium signaling glucocorticoid receptor glucocorticoid glutamate transmission hypothalamic-pituitary-adrenal axis long-term potentiation neurocognitive disorders neuroplasticity stress

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Single-cell and spatial omics:exploring hypothalamic heterogeneity

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Neural Regeneration Research 2025年第6期20卷 1525-1540页

作者： Muhammad Junaid Eun Jeong Lee su Bin Lim Department of Biochemistry&Molecular Biology Ajou University School of MedicineSuwonSouth Korea Department of Biomedical Sciences Graduate School of Ajou UniversitySuwonSouth Korea Department of Brain Science Ajou University School of MedicineSuwonSouth Korea

Elucidating the complex dynamic cellular organization in the hypothalamus is critical for understanding its role in coordinating fundamental body functions. Over the past decade, single-cell and spatial omics technologies have significantly evolved, overcoming initial technical challenges in capturing and analyzing individual cells. These high-throughput omics technologies now offer a remarkable opportunity to comprehend the complex spatiotemporal patterns of transcriptional diversity and cell-type characteristics across the entire hypothalamus. Current single-cell and single-nucleus RNA sequencing methods comprehensively quantify gene expression by exploring distinct phenotypes across various subregions of the hypothalamus. However, single-cell/single-nucleus RNA sequencing requires isolating the cell/nuclei from the tissue, potentially resulting in the loss of spatial information concerning neuronal networks. Spatial transcriptomics methods, by bypassing the cell dissociation, can elucidate the intricate spatial organization of neural networks through their imaging and sequencing technologies. In this review, we highlight the applicative value of single-cell and spatial transcriptomics in exploring the complex molecular-genetic diversity of hypothalamic cell types, driven by recent high-throughput achievements.

关键词： cellular diversity hypothalamus multi-omics single-cell transcriptomics spatial transcriptomics

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Challenges and Perspectives in Target Identification and Mechanism Illustration for Chinese Medicine

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Chinese Journal of Integrative Medicine 2023年第7期29卷 644-654页

作者： GUO xiao-xi AN su BAO Fan XU Tian-rui Faculty of Life Science and Technology Kunming University of Science and TechnologyKunming650500China The First People’s Hospital of Yunnan Province Kunming650032China

Chinese medicine(CM)is an important resource for human life understanding and discovery of ***,due to the unclear pharmacological mechanism caused by unclear target,research and international promotion of many active components have made little progress in the past decades of *** is mainly composed of multi-ingredients with *** identification of targets of multiple active components and the weight analysis of multiple targets in a specific pathological environment,that is,the determination of the most important target is the main obstacle to the mechanism clarification and thus hinders its *** this review,the main approach to target identification and network pharmacology were *** BIBm(Bayesian inference modeling),a powerful method for drug target identification and key pathway determination was *** aim to provide a new scientific basis and ideas for the development and international promotion of new drugs based on CM.

关键词： Chinese medicine target identification network pharmacology Bayesian inference modeling

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Neurocircuit regeneration by extracellular matrix reprogramming

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Neural Regeneration Research 2025年第8期20卷 2300-2301页

作者： Shengzhang su Ian N.Levasseur Kimberly M.Alonge Department of Medicinal Chemistry University of WashingtonSeattleWAUSA Department of Chemistry University of WashingtonSeattleWAUSA Department of Medicine University of Washington Medicine Diabetes InstituteSeattleWAUSA

The brain's extracellular matrix(ECM),which is comprised of protein and glycosaminoglycan(GAG)scaffolds,constitutes 20%-40% of the human brain and is considered one of the largest influencers on brain cell functioning(Soles et al.,2023).Synthesized by neural and glial cells,the brain's ECM regulates a myriad of homeostatic cellular processes,including neuronal plasticity and firing(Miyata et al.,2012),cation buffering(Moraws ki et al.,2015),and glia-neuron interactions(Anderson et al.,2016).Considering the diversity of functions,dynamic remodeling of the brain's ECM indicates that this understudied medium is an active participant in both normal physiology and neurological diseases.

关键词： matrix programming

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Experimental investigation of the thermal insulation performance of Ce/Si/Ti oxide heat-reflective coating

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2023年第10期24卷 912-924页

作者： rui su Yue LV Qian su Yanfei PEI School of Civil Engineering Southwest Jiaotong UniversityChengdu 610031China

To solve the problem of deformation and cracking of ballastless track slab under temperature load,a composite oxide and a series of heat-reflective coating samples were *** the microscopic level,the elemental composition and optical properties of the materials prepared were analyzed by Fourier transform infrared spectroscopy and ultraviolet-visible spectroscopy,and the feasibility of Ce/Si/Ti oxide as functional fillers for heat-reflective coatings of track slabs was *** the macro level,by designing and assembling an indoor sunlight simulation test device,the surface and internal temperatures of the coated and uncoated concrete specimens were analyzed and studied,and the macroscopic cooling effect of the coatings was ***,to study the engineering application effect of the track slab thermal insulation reflective coating,COMSOL was used to build a 3D calculation model of the heat transfer deformation of the ballastless track slab *** research results showed that:Ce/Si/Ti oxide has strong reflectivity and can reflect 95%of infrared light;it has good ultraviolet(UV)shielding ability and can absorb more than 65%of the UV *** TiO2 coating can reduce the temperature of the concrete surface by 6–11℃and that of the inside of the concrete by 10–14℃;the cooling effect decreases evenly with the increase of air *** Ce/Si/Ti oxide coating can reduce the surface temperature of the concrete by 16℃and that of the inside of the concrete by 15℃.In addition,the cooling effect is basically not affected by the air temperature,and it changes non-linearly with the increase of the Ce/Si/Ti oxide *** calculation shows that the heat reflective coating can reduce the surface temperature and internal temperature difference of the track slab by 11.54–21.31℃,and the vertical displacement of the track slab can be reduced by about 35%–70%.Considering the cooling effect,the adhesion strength,and the engineering application effe

关键词： Track slab Solar radiation Thermochromic coating Cooling performance

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Agmatine Prevents Adaptation of the Hippocampal Glutamate System in Chronic Morphine-Treated Rats

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Neuroscience Bulletin 2016年第6期32卷 523-530页

作者： xiao-Fei Wang Tai-Yun Zhao rui-Bin su Ning Wu Jin Li State Key Laboratory of Toxicology and Medical Countermeasures Beijing Key Laboratory of NeuropsychopharmacologyBeijing Institute of Pharmacology and Toxicology

Abstract Chronic exposure to opioids induces adaptation of glutamate neurotransmission, which plays a crucial role in addiction. Our previous studies revealed that agmatine attenuates opioid addiction and prevents the adaptation of glutamate neurotransmission in the nucleus accumbens of chronic morphine-treated rats. The hippocampus is important for drug addiction; however, whether adaptation of glutamate neurotransmission is modulated by agmatine in the hippocampus remains unknown. Here, we found that continuous pretreatment of rats with ascending doses of morphine for 5 days resulted in an increase in the hip- pocampal extracellular glutamate level induced by nalox- one （2 mg/kg, i.p.） precipitation. Agmatine （20 mg/kg, s.c.） administered concurrently with morphine for 5 days attenuated the elevation of extracellular glutamate levels induced by naloxone precipitation. Furthermore, in the hippocampal synaptosome model, agmatine decreased the release and increased the uptake of glutamate in synapto- somes from chronic morphine-treated rats, which might contribute to the reduced elevation of glutamate levels induced by agrnatine. We also found that expression of the hippocampal NR2B subunit, rather than the NR1 subunit, of N-methyl-D-aspartate receptors （NMDARs） was down-regulated after chronic morphine treatment, and agmatine inhibited this reduction. Taken together, agmatine pre- vented the adaptation of the hippocampal glutamate system caused by chronic exposure to morphine, including mod- ulating extracellular glutamate concentration and NMDAR expression, which might be one of the mechanisms underlying the attenuation of opioid addiction by agmatine.

关键词： Agmatine Opioid addiction HippocampusExtracellular glutamate NMDA receptors

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Parity-dependent skin effects and topological properties in the multilayer nonreciprocal su−Schrieffer−Heeger structures

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Frontiers of physics 2024年第3期19卷 115-133页

作者： Jia-rui Li Cui Jiang Han su Di Qi Lian-Lian Zhang Wei-Jiang Gong College of Sciences Northeastern UniversityShenyang 110819China Basic Department Shenyang Institute of EngineeringShenyang 110136China

We concentrate on the skin effects and topological properties in the multilayer non-Hermitian su−Schrieffer−Heeger (SSH) structure, by taking into account the nonreciprocal couplings between the different sublattices in the unit cells. Following the detailed demonstration of the theoretical method, we find that in this system, the skin effects and topological phase transitions induced by nonreciprocal couplings display the apparent parity effect, following the increase of the layer number of this SSH structure. On the one hand, the skin effect is determined by the parity of the layer number of this SSH system, as well as the parity of the band index of the bulk states. On the other hand, for the topological edge modes, such an interesting parity effect can also be observed clearly. Next, when the parameter disorders are taken into account, the zero-energy edge modes in the odd-layer structures tend to be more robust, whereas the other edge modes are easy to be destroyed. In view of these results, it can be ascertained that the findings in this work promote to understand the influences of nonreciprocal couplings on the skin effects and topological properties in the multilayer SSH lattices.

关键词： multilayer SSH lattice nonreciprocal couplings band structure skin effect

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