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Whole exome sequencing identifies risk variants associated with intracranial epidermoid cyst deterioration:A case report

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World Journal of Clinical Oncology 2024年第11期15卷 1428-1434页

作者： Zhao-Na Song Yan Cheng Dan-Dan wang Ming-Jun Li Xiang-Rong Zhao Fa-wang Li Zhen Liu xiao-ru Zhu xiao-Dong Jia Yu-Fang wang Feng-Fan Liang Joint Laboratory for Translational Medicine Research Liaocheng People's HospitalLiaocheng 252000Shandong ProvinceChina Harbin Genars Technology Co. Ltd.Harbin 150060Heilongjiang ProvinceChina Department of Radiotherapy Liaocheng People's HospitalLiaocheng 252000Shandong ProvinceChina Department of Medical laboratory Qilu Hospital of Shandong University Dezhou HospitalDezhou 253600Shandong ProvinceChina

BACKGROUND Intracranial epidermoid cyst(IEC)transformation to malignant squamous cell carcinoma(SCC)is extremely rare,and its etiology is yet ***,SCC is treated by performing surgery,followed by a combination of radiotherapy and *** is crucial to identify efficient and trustworthy therapeutic targets for SCC to improve its diagnosis,prognosis,and *** SUMMARY In this study,we report the case of a 47-year-old female patient with SCC,which progressed from IEC in the left internal capsule *** patient was sought treatment at our hospital for severe diplopic vision,accompanied with speech disorder and memory *** on the clinical and postoperative pathology,this patient was finally diagnosed with *** identify disease-causing variants,whole exome sequencing(WES)was performed on the *** revealed two pathogenic missense mutations on Gap junction protein beta 2(GJB2)(c.257C>T)and Toll-like receptor 2(TLR2)(c.1039A>G),*** This study provided the first clinical evidence for demonstrating the role of GJB2 and TLR2 in IEC development and *** further confirmed WES as a robust and reliable technique for underlying rare and complex disease-related genetic factor identification.

关键词： Intracranial epidermoid cyst Squamous cell carcinoma Whole exome sequencing Variants Case report

Effect of Plastic Deformation on Microstructure and Properties of Cu-(1 wt%-6 wt%) Ag Alloy

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Journal of Wuhan University of Technology(Materials Science) 2024年第3期39卷 747-753页

作者：茹亚东 ZHANG Zhongyuan 高召顺 ZHANG Ling ZUO Tingting XUE Jiangli TANG Zhixiang DA Bo LIU Yongsheng xiao Liye Institute of Electrical Engineering Chinese Academy of SciencesBeijing 100190China Department of Physics Shanghai University of Electric PowerShanghai 201306China University of Chinese Academy of Sciences Beijing 100190China International Joint Labora-tory for Light Alloys(MOE) College of Materials Science and EngineeringChongqing UniversityChongqing 400044China Research and Services Division of Materials Data and Integrated System National Institute for Materials ScienceTsukuba 305-0047Japan

In the present study,the Cu-(1 wt%-6 wt%)Ag alloys were prepared by melting,forging and wire *** effects of plastic deformation on microstructure evolution and properties of the alloys were *** results show that non-equilibrium eutectic colonies exist in the Cu-(3 wt%-6 wt%)Ag alloy and no eutectic colonies in the 1 wt%-2 wt%Ag containing *** eutectic colonies are aligned along the drawing direction and refined with the increase of draw *** to the refinement of eutectic colonies,the Cu-Ag alloy exhibits higher strength with the increase of draw *** Cu-6Ag alloy exhibits excellent comprehensive properties with a strength of 930 MPa and a conductivity of 82%IACS when the draw ratio reaches 5.7.

关键词： Cu-Ag alloy high strength and high conductivity microstructure eutectic structure strengthening mechanism

GMA改性磷酸腺苷的制备及其对棉织物的阻燃整理

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精细化工 2024年第1期41卷 185-194页

作者：杨琪王晓刘雨铜陈茹李佥大连工业大学纺织与材料工程学院辽宁大连116034 大连工业大学生物工程学院辽宁大连116034

采用甲基丙烯酸缩水甘油酯(GMA)分别对一磷酸腺苷(AMP)、二磷酸腺苷(ADP)、三磷酸腺苷(ATP)进行改性,制得了3种带有不饱和双键的阻燃单体AMP-m-GMA、ADP-m-GMA、ATP-m-GMA;然后通过紫外光接枝法将3种阻燃单体分别接枝到棉织物上,制备了... 详细信息

采用甲基丙烯酸缩水甘油酯(GMA)分别对一磷酸腺苷(AMP)、二磷酸腺苷(ADP)、三磷酸腺苷(ATP)进行改性,制得了3种带有不饱和双键的阻燃单体AMP-m-GMA、ADP-m-GMA、ATP-m-GMA;然后通过紫外光接枝法将3种阻燃单体分别接枝到棉织物上,制备了光接枝AMP-m-GMA、ADP-m-GMA和ATP-m-GMA阻燃棉织物;对3种阻燃单体进行了结构表征和热稳定性分析,并探究了3种阻燃单体光接枝阻燃棉织物的热稳定性、阻燃性能、燃烧行为和残炭结构。结果表明,3种磷酸腺苷通过GMA环氧基开环引入不饱和双键,且具有良好的热稳定性。相比于原棉织物,3种阻燃棉织物的最大热降解速率分别降低了60.0%、52.0%、60.0%,极限氧指数由16.1%分别提升到25.4%、27.4%、26.4%,织物热释放速率(HRR)分别下降了15.09%、60.47%、37.82%,说明3种磷酸腺苷阻燃单体均有助于棉织物形成致密炭层,阻止热量扩散,获得良好的阻燃效果。其中,光接枝ADP-m-GMA阻燃棉织物的增重率可达22.4%,燃烧后损毁长度缩短至14.2 cm,表现出更优异的阻燃性能。

关键词：磷酸腺苷甲基丙烯酸缩水甘油酯结构表征阻燃性能纺织染整助剂

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半乳糖凝集素-3、可溶性基质溶素-2检测对心力衰竭诊断的相关性研究

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中国循环杂志 2016年第9期31卷 866-869页

作者：徐晓晓贾如意王涛刘强甄臻泰山医学院济南市第四人民医院心血管一科山东省济南市250031

目的:探讨半乳糖凝集素-3和可溶性基质溶素-2(ST2)与慢性心力衰竭分级、传统心力衰竭指标的相关性。方法:选择2014-02至2015-10间在我院心血管内科就诊的慢性心力衰竭患者(慢性心力衰竭组)142例和健康体检人群(正常对照组)85例。按纽约... 详细信息

目的:探讨半乳糖凝集素-3和可溶性基质溶素-2(ST2)与慢性心力衰竭分级、传统心力衰竭指标的相关性。方法:选择2014-02至2015-10间在我院心血管内科就诊的慢性心力衰竭患者(慢性心力衰竭组)142例和健康体检人群(正常对照组)85例。按纽约心脏协会(NYHA)心功能分级标准将患者分为Ⅱ级、Ⅲ级、Ⅳ级。入院后完善N末端B型利钠肽原(NT-pro BNP)、高敏C反应蛋白(hs-CRP)、超声形态学等检查,并采用酶联免疫吸附法检测半乳糖凝集素-3、可溶性ST2的表达水平。结果:心力衰竭NYHA心功能Ⅲ级、Ⅳ级患者半乳糖凝集素-3、可溶性ST2明显升高。半乳糖凝集素-3、可溶性ST2与hs-CRP、NT-pro BNP呈正相关,与左心室射血分数呈负相关;可溶性ST2与左心室舒张末期内径(LVEDD)也呈正相关。Logistic分析显示,半乳糖凝集素-3和可溶性ST2与心力衰竭患者近期死亡存在相关性(P<0.05)。半乳糖凝集素-3、可溶性ST2诊断心力衰竭的受试者工作特征曲线(ROC曲线)下面积分别为0.738和0.771,差异有统计学意义(P<0.01)。结论:半乳糖凝集素-3、可溶性ST2与传统心力衰竭指标具有相关性,可用于慢性心力衰竭的诊断。

关键词：心力衰竭半乳糖凝集素-3 可溶性基质溶素-2 N末端B型利钠肽原诊断

Asymptotic Property for the Estimator of Nonparametric Regression Models Under Negatively Orthant Dependent Errors

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Chinese Quarterly Journal of Mathematics 2015年第2期30卷 300-307页

作者： PENG Zhi-qing ZHENG Lu-lu LIU Yah-fang xiao ru wang Xue-jun School of Mathematical Sciences Anhui University Hefei 230601 China

In this paper, by using some inequalities of negatively orthant dependent(NOD,in short) random variables and the truncated method of random variables, we investigate the nonparametric regression model. The complete co... 详细信息

关键词： negatively orthant dependent random variables nonparametric regression model complete consistency

Plerixafor-based mobilization and mononuclear cell counts in graft increased the risk of engraftment syndrome after autologous hematopoietic stem cell transplantation

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Blood Science 2024年第3期6卷 48-54页

作者： Le-Qing Cao Qi Wen Bo-Ning Liu Zhen-Yu Zhao xiao-Hui Zhang Lan-Ping Xu Huan Chen Yu wang Lu Yu Feng-Rong wang xiao-Jun Huang xiao-Dong Mo Peking University People’s Hospital Peking University Institute of HematologyNational Clinical Research Center for Hematologic DiseaseBeijing Key Laboratory of Hematopoietic Stem Cell TransplantationBeijingChina Hainan General Hospital Hainan Affiliated Hospital of Hainan Medical UniversityHaikouChina Peking-Tsinghua Center for Life Sciences Academy for Advanced Interdisciplinary StudiesPeking UniversityBeijingChina Research Unit of Key Technique for Diagnosis and Treatments of Hematologic Malignancies Chinese Academy of Medical SciencesBeijing 2019RU029China

Engraftment syndrome(ES)is one of the most common complications in the early phase after autologous hematopoietic stem cell transplantation(ASCT),and we aimed to evaluate the incidence and risk factors for ES patients receiving ASCT in the era of plerixafor-based mobilization.A total of 294 were enrolled,and 16.0%(n=47)experienced ES after *** main clinical manifestations were fever(100%),diarrhea(78.7%),skin rash(23.4%),and hypoxemia/pulmonary edema(12.8%).Plerixafor-based mobilization was associated with higher counts of CD3^(+)cells,CD4^(+)cells,and CD8^(+)cells in *** univariate analysis of the total cohort,age≥60 years,receiving ASCT at complete remission(CR),higher number of mononuclear cell(MNC),CD3^(+)cell counts,CD4^(+)cells as well as CD8^(+)cells transfused and plerixafor-based mobilization were associated with ES after *** analysis showed that age≥60 years(P=0.0014),receiving ASCT at CR(P=0.002),and higher number of MNC transfused(P=0.026)were associated with ES in total *** plasma cell disease subgroup,age≥60 years(P=0.013),plerixafor-based mobilization(P=0.036),and receiving ASCT at CR(P=0.002)were associated with *** with more risk factors had a higher risk of *** 1-year probabilities of relapse,non-relapse mortality,and survival were comparable between patients with and without ***,plerixafor-based mobilization may influence the composition of T lymphocytes in grafts and increase the risk of ES,particularly in patients with plasma cell disease.

关键词： Autologous stem cell transplantation Engraftment syndrome Plerixafor Risk factors

Effect of SARS-CoV-2 infection on semen parameters in sperm bank volunteers with normal sperm concentration

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Asian Journal of Andrology 2024年第3期26卷 328-332页

作者： Li wang Wen-Kai Han xiao-Hui Song Qi-Lin Zhang An-Quan Guan Yuan Gao Jin-Long Ma Center for Reproductive Medicine Shandong UniversityJinan 250001China State Key Laboratory of Reproductive Medicine and Offspring Health ShandongUniversityJinan 250001China Key Laboratory of Reproductive Endocrinology of Ministry of Education Shandong UniversityJinan 250001China Shandong KeyLaboratory of Reproductive Medicine Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinan 250001China Shandong Provincial Clinical Research Center for Reproductive Health Jinan 250001China Shandong Technology Innovation Center for Reproductive Health Jinan 250001China NationalResearch Center for Assisted Reproductive Technology and Reproductive Genetics Shandong UniversityJinan 250001China Research Unit of Gametogenesis andHealth of ART-Offspring Chinese Academy of Medical Sciences(No.2021RU001)Jinan 250001China

In this study,we aimed to assess the effect of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection on *** study comprised 110 sperm volunteers who self-reported SARS-CoV-2 infection from the Human Sperm Bank ofthe Center for Reproductive Medicine,Shandong University(Jinan,China).The volunteers had normal sperm concentration *** volunteer provided semen samples before and after *** selected 90 days after infection as the cutoff *** parameters within 90 days after infection of 109 volunteers(group A)were compared with semen parameters before ***,semen parameters on or after 90 days after infection of 36 volunteers(group B)were compared with semen parameters ***,based on whether the volunteers had completed the three-dose SARS-CoV-2 vaccination booster,volunteersin group A and B were further divided into two subgroups *** parameters were compared before and after infection ineach *** results showed that in this cohort population,the semen quality in volunteers with normal sperm concentrationsbefore infection decreased after SARS-CoV-2 infection within 90 days,while the semen quality returned to preinfection levels after *** completion of a three-dose SARS-CoV-2 vaccination booster may exert a protective effect on semen quality after infection.

关键词： SARS-CoV-2 SARS-CoV-2 vaccination semen quality sperm donation sperm parameters

Sintilimab(anti-PD-1 antibody)plus chidamide(histone deacetylase inhibitor)in relapsed or refractory extranodal natural killer T-cell lymphoma(SCENT):a phase Ⅰb/Ⅱ study

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Signal Transduction and Targeted Therapy 2024年第6期9卷 2765-2773页

作者： Yan Gao Haixia He Xueping Li Liling Zhang Wei Xu ru Feng Wenyu Li Yin xiao Xinxiu Liu Yu Chen xiaoxiao wang Bing Bai Huijing Wu Qingqing Cai Zhiming Li Jibin Li Suxia Lin Yanxia He Liqin Ping Cheng Huang Jiaying Mao Xiujin Chen Baitian Zhao Huiqiang Huang State Key Laboratory of Oncology in South China&Collaborative Innovation Center of Cancer Medicine Guangdong Provincial Clinical Research Center for CancerSun Yat-sen University Cancer CenterGuangzhouChina Department of Medical Oncology Sun Yat-sen University Cancer CenterGuangzhouChina Department of Radiation Oncology Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhouChina Department of Hematology Sun Yat-sen University Cancer CenterGuangzhouChina Cancer Center Union Hospital affiliated to Tongji Medical College of Huazhong University of Science and TechnologyWuhanChina Department of Hematology The First Affiliated Hospital of Nanjing Medical UniversityJiangsu Province HospitalNanjingChina Department of Hematology Nanfang HospitalSouthern Medical UniversityGuangzhouChina Department of Lymphoma Guangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangzhouChina Department of pathology Guangdong General HospitalGuangdong Academy of Medical SciencesGuangzhouChina Department of Medical Oncology Hubei Cancer CenterWuhanChina Department of Clinical Research Sun Yat-sen University Cancer CenterGuanzhouChina Department of Pathology Sun Yat-sen University Cancer CenterGuangzhouChina

Anti-PD-1 antibodies are a favorable treatment for relapsed or refractory extranodal natural killer T cell lymphoma(RR-ENKTL),however,the complete response(CR)rate and the duration of response(DOR)need to be *** phase 1b/2 study investigated the safety and efficacy of sintilimab,a fully human anti-PD-1 antibody,plus chidamide,an oral subtype-selective histone deacetylase inhibitor in 38 patients with *** objective response rate(ORR)of combination treatment was 80%.Patients received escalating doses of chidamide,administered concomitantly with fixed-dose sintilimab in 21-days cycles up to 12 *** dose-limiting events were observed,RP2D of chidamide was 30 mg twice a ***-nine patients were enrolled in phase *** the intention-to-treat population(n=37),overall response rate was 59.5% with a complete remission rate of 48.6%.The median DOR,progression-free survival(PFS),and overall survival(OS)were 25.3,23.2,and 32.9 months,*** most common grade 3 or higher treatment-emergent adverse events(AEs)were neutropenia(28.9%)and thrombocytopenia(10.5%),immune-related AEs were reported in 18(47.3%)*** biomarker assessment suggested that a combination of dynamic plasma ctDNA and EBV-DNA played a vital prognostic ***3 mutation shows an unfavorable *** outcome of anticipate ORR was not achieved,sintilimab plus chidamide was shown to have a manageable safety profile and yielded encouraging CR rate and DOR in RR-ENKTL for the first *** is a promising therapeutic option for this population.

关键词： killer lymphoma doses

Frontiers in high entropy alloys and high entropy functional materials

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Rare Metals 2024年第10期43卷 4639-4776页

作者： Wen-Tao Zhang Wen Huang Fu-Jie Yu Qi Zhao Xin-Dong Zhu Tao Feng Yao Jiang xiao-Ming Li Xue-Fei Miao He Zhu Si Lan Xue-Qian wang Bao-Long Shen Zhe Jia Feng-Qi Zhang Wei wang Qi Liu Yang Ren Xun-Li wang xiao-Ya Cui xiao-Yang wang Ya-Nan Chen Bing-Bing Fan Meng-ru Li Qi-Long Gao Jia-Ming Guo Zeng-Bao Jiao Zhi-Min Guo Yu-Ping Zhao Qian Yu rui Huang Ling-Kun Zhang Yi-Ping Lu Xu-Bo Li Huai-Jun Lin Yan Ma Wei-Ming Yang Zhi-Hua Shen Hai-Yan He Yong-Gang Sun Yong-Jiang Huang De-Zhuang wang Qing-Feng Liu Fei-Yang wang Hui Liu Hong-Hui Wu Li-Qiang wang Yang Lu Nan wang Tian-Li wang Wei-Bing Liao Yi-Han wang Yuan Wu Yu-Zhen Yin Jie Pan Yi Zhang Qing wang Jian-Yang Zhang Tao Yang Yasir Sohail Jin-Yu Zhang Hua Ji Qiang Li Wei-Di Liu Zhi-Gang Chen Xiong-Jun Liu Wen Ma Liang Mao Zhen-Duo Wu School of Materials Science and Engineering Nanjing University of Science and Technology Jiangsu Key Laboratory for Advanced Metallic Materials School of Materials Science and Engineering Southeast University Department of Physics City University of Hong Kong School of Materials Science and Engineering Tianjin University School of Physics and Microelectronics Zhengzhou University Department of Mechanical Engineering Research Institute for Advanced Manufacturing The Hong Kong Polytechnic University Center of Electron Microscopy and State Key Laboratory of Silicon Materials School of Materials Science and Engineering Zhejiang University Key Laboratory of Solidification Control and Digital Preparation Technology (Liaoning Province) School of Materials Science and Engineering Dalian University of Technology Institute of Advanced Wear & Corrosion Resistance and Functional Materials Jinan University School of Mechanics and Civil Engineering China University of Mining and Technology School of Physical Sciences Great Bay University School of Materials Science andEngineering Harbin Institute of Technology State Key Laboratory of Materials-Oriented Chemical Engineering College of Chemical Engineering Nanjing Tech University Beijing Advanced Innovation Center for Materials Genome Engineering Research Institute for Carbon Neutrality University of Science and Technology Beijing Department of Mechanical Engineering The University of Hong Kong School of Computing Macquarie University Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province College of Physics and Optoelectronic Engineering Shenzhen University State Key Laboratory for Advanced Metals and Materials University of Science and Technology Beijing State Key Laboratory of Materials Processing and Die & Mould Technology School of Materials Science and Engineering Huazhong University of Science and Technology Institute of materials Shanghai University Department of Materials Science and Engineering C

Owing to their exceptional properties, high-entropy alloys(HEAs) and high-entropy materials have emerged as promising research areas and shown diverse applications. Here,the recent advances in the field are comprehensively reviewed,organized into five sections. The first section introduces the background of HEAs, covering their definition, significance,application prospects, basic properties, design principles, and microstructure. The subsequent section focuses on cutting-edge high-entropy structural materials, highlighting developments such as nanostructured alloys, grain boundary engineering,eutectic systems, cryogenic alloys, thin films, micro-nano-lattice structures, additive manufacturing, high entropy metallic glasses, nano-precipitate strengthened alloys, composition modulation, alloy fibers, and refractory systems. In the following section, the emphasis shifts to functional materials, exploring HEAs as catalysts, magneto-caloric materials, corrosion-resistant alloys, radiation-resistant alloys, hydrogen storage systems, and materials for biomedicine. Additionally, the review encompasses functional high-entropy materials outside the realm of alloys, including thermoelectric, quantum dots, nanooxide catalysts, energy storage materials, negative thermal expansion ceramics,and high-entropy wave absorption materials. The paper concludes with an outlook, discussing future directions and potential growth areas in the field. Through this comprehensive review,researchers, engineers, and scientists may gain valuable insights into the recent progress and opportunities for further exploration in the exciting domains of high-entropy alloys and functional materials.

关键词： Cutting-edge structural materials Cutting-edgefunctional materials High entropy alloys