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Whole exome sequencing identifies risk variants associated with intracranial epidermoid cyst deterioration:A case report

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World Journal of Clinical Oncology 2024年第11期15卷 1428-1434页

作者： Zhao-Na Song Yan Cheng Dan-Dan Wang Ming-Jun Li Xiang-Rong Zhao Fa-Wang Li Zhen Liu xiao-ru zhu xiao-Dong Jia Yu-Fang Wang Feng-Fan Liang Joint Laboratory for Translational Medicine Research Liaocheng People's HospitalLiaocheng 252000Shandong ProvinceChina Harbin Genars Technology Co. Ltd.Harbin 150060Heilongjiang ProvinceChina Department of Radiotherapy Liaocheng People's HospitalLiaocheng 252000Shandong ProvinceChina Department of Medical laboratory Qilu Hospital of Shandong University Dezhou HospitalDezhou 253600Shandong ProvinceChina

BACKGROUND Intracranial epidermoid cyst(IEC)transformation to malignant squamous cell carcinoma(SCC)is extremely rare,and its etiology is yet ***,SCC is treated by performing surgery,followed by a combination of radiotherapy and *** is crucial to identify efficient and trustworthy therapeutic targets for SCC to improve its diagnosis,prognosis,and *** SUMMARY In this study,we report the case of a 47-year-old female patient with SCC,which progressed from IEC in the left internal capsule *** patient was sought treatment at our hospital for severe diplopic vision,accompanied with speech disorder and memory *** on the clinical and postoperative pathology,this patient was finally diagnosed with *** identify disease-causing variants,whole exome sequencing(WES)was performed on the *** revealed two pathogenic missense mutations on Gap junction protein beta 2(GJB2)(c.257C>T)and Toll-like receptor 2(TLR2)(c.1039A>G),*** This study provided the first clinical evidence for demonstrating the role of GJB2 and TLR2 in IEC development and *** further confirmed WES as a robust and reliable technique for underlying rare and complex disease-related genetic factor identification.

关键词： Intracranial epidermoid cyst Squamous cell carcinoma Whole exome sequencing Variants Case report

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Efficacy of scraping therapy on blood pressure and sleep quality in stage Ⅰ and Ⅱ essential hypertension: A systematic review and meta-analysis

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Journal of Integrative Medicine 2024年第1期22卷 12-21页

作者： Zheng-gang zhu Jian-ru Wang xiao-yan Pan School of Nursing Hunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina School of Health Sciences Universiti Sains MalaysiaKubang Kerian 16150KelantanMalaysia Department of Cardiovascular Medicine the First Affiliated Hospital of Henan University of Chinese MedicineZhengzhou 450000Henan ProvinceChina

Background Scraping therapy is widely used in treating stage I and II essential hypertension in ***,there has been no systematic evaluation of the efficacy of scraping therapy on blood pressure and sleep quality in stage I and II essential *** strategy Seven electronic databases(PubMed,Scopus,Cochrane Library,Web of Science,EBSCO,China National Knowledge Infrastructure and Wanfang Data electronic databases)were searched from inception to December *** on the principle of combining subject words with text words,the search strategy was constructed around search terms for“scraping therapy,”“scraping,”“Guasha,”“Gua sha,”“hypertension,”and“high blood pressure”during the database *** criteria Randomized controlled trials(RCTs)were included if they recruited patients with stage I and II essential hypertension and included a scraping therapy *** intervention group received antihypertensive drugs and scraping therapy,while the control group only took antihypertensive *** extraction and analysis Review Manager 5.4.0 and STATA 15.1 were used to enter all the relevant outcome variables to conduct the *** quality of the selected RCTs was assessed using the PEDro *** sensitivity analysis was carried out by iteratively excluding individual studies and repeating the analysis to determine the stability of the findings and identify any studies with greater influence on the *** analysis was performed to find the source of *** plots were used to evaluate the publication bias of included *** Nine RCTs including 765 participants were ***-analysis showed that scraping therapy combined with medication had an advantage over the use of medication alone in lowering systolic blood pressure(mean difference[MD]=?5.09,95%confidence interval[CI]=?6.50 to?3.67,P<0.001)and diastolic blood pressure(MD=?2.66,95%CI=?3.17 to?2.14,P<0.001).Subgroup analysis showed tha

关键词： Scraping therapy Essential hypertension Efficacy Blood pressure Sleep quality Systematic review Meta-analysis

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Down-regulation of peroxisome proliferator-activated receptor γ coactivator-1α expression in fatty acid-induced pancreatic betacell apoptosis involves nuclear factor-κB pathway

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Chinese Medical Journal 2011年第22期124卷 3657-3663页

作者： HE Ting-ting CAO xiao-pei CHEN ru-zhu zhu xiao-nan WANG Xue-lan LI Yan-bing xiao Hai-peng Department of Endocrinology First Affiliated Hospital of Sun Yat-sen University Guangzhou Guangdong 510080 China

Background Pancreatic beta-cell apoptosis induced by lipotoxicity, to a large extent, contributes to the progression of type 2 diabetes. To investigate the mechanism of free fatty acid induced apoptosis, we aimed to study the effects of palmitic acid （PA） on the apoptosis and peroxisome proliferator-activated receptor y coactivator-1α （PGC-1α） expression in βTC3 cells as well as the possible role of nuclear factor-KB （NF-KB） in this process. Methods Hoechst 33258 was used to detect βTC3 cell apoptosis, which was induced by PA stimulation for 12 hours. PGC-1α expression was analyzed by reverse transcription polymerase chain reaction, IκB kinase β （IKKβ）, IκBα NF-KB-inducing kinase （NIK） and ReI-B expressions were analyzed by Western blotting. MGβ2 was employed to block the endogenous IκBαdegradation before PA administration, and then its effect on PA-inducing cell apoptosis and PGC-1α mRNA expression was analyzed. Results Significant increased cell apoptosis was found at the concentration of 0.5 mmol/L and 1.0 mmol/L PA administration. PA （0.5 mmol/L） could extensively reduced the expression of PGC-1α mRNA. After exposing βTC3 cells to 0.5 mmol/L PA for different time periods （0, 4, 6, 8, 10 and 12 hours）, IKKβ protein expression increased while IκBα NIK and ReI-B protein expression declined in a time-dependent manner. Pretreatment with MGβ2 to inhibit the degradation of IκBα partially prevented the down-regulation of PGC-1α mRNA expression after 12-hour PA treatment in accordance with the decrease of PA induced apoptosis. Conclusions NF-KB canonical pathway was activated in PA-mediated βTC3 cell apoptosis, whereas non-canonical pathway was inhibited. Reduced PGC-1α expression by PA in βTC3 cells could involve the activation of canonical NF-KB pathway, so as to deteriorate the PA induced apoptosis.

关键词： beta-cell apoptosis peroxisome proliferator-activated receptor 7 coactivator-1α nuclear factor-κB

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Sm-like 5 knockdown inhibits proliferation and promotes apoptosis of colon cancer cells by upregulating p53,CDKN1A and TNFRSF10B

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World Journal of Gastrointestinal Oncology 2024年第6期16卷 2716-2726页

作者： Cai-Jing Mo xiao-Yuan Deng ru-Lan Ma Kun zhu Lei Shi Kang Li Department of Surgical Oncology The First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710061Shaanxi ProvinceChina Department of Infectious Diseases The First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710061Shaanxi ProvinceChina

BACKGROUND The role of Sm-like 5(LSM5)in colon cancer has not been *** this study,we investigated the role of LSM5 in progression of colon cancer and the potential underlying mechanism *** To determine the role of LSM5 in the progression of colon cancer and the potential underlying mechanism *** The Gene Expression Profiling Interactive Analysis database and the Human Protein Atlas website were used for LSM5 expression analysis and prognosis ***-time quantitative polymerase chain reaction and Western blotting were utilized to detect the expression of mRNAs and proteins.A lentivirus targeting LSM5 was constructed and transfected into colon cancer cells to silence LSM5 *** and apoptosis assays were also conducted to evaluate the growth of the colon cancer *** GeneChip assay and bioinformatics analysis were performed to identify the potential underlying mechanism of LSM5 in colon *** LSM5 was highly expressed in tumor tissue and colon cancer cells.A high expression level of LSM5 was related to poor prognosis in patients with colon *** of LSM5 suppressed proliferation and promoted apoptosis in colon cancer *** of LSM5 also facilitates the expression of p53,cyclin-dependent kinase inhibitor 1A(CDKN1A)and tumor necrosis factor receptor superfamily 10B(TNFRSF10B).The inhibitory effect of LSM5 knockdown on the growth of colon cancer cells was associated with the upregulation of p53,CDKN1A and *** LSM5 knockdown inhibited the proliferation and facilitated the apoptosis of colon cancer cells by upregulating p53,CDKN1A and TNFRSF10B.

关键词： Sm-like 5 Colon cancer Proliferation Apoptosis Knockdown

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CdS/LaFeO_(3) heterojunctions with improved optical properties for visible-light catalytic applications

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Journal of Rare Earths 2024年第5期42卷 879-888,I0003页

作者： Jiaqi Wei Wen zhu Xuelian Xu xiao Xu Junjiang zhu Hubei Key Laboratory of Biomass Fibers and Eco-dyeing&Finishing College of Chemistry and Chemical EngineeringWuhan Textile University ChemistryWuhan430200China

Construction of heterojunctions is a normal and effective strategy to improve the photocatalytic performances of semiconductors,through which both the lifetime and the redox ability of electrons/holes can be improved,as co mpared to the respective *** this basis,we constructed Z-scheme CdS/LaFeO_(3) heterojunctions(CdS/LFO),by in-situ growing different amounts of CdS on the surface of LaFeO_(3),for photocatalytic degradation of tetracycline hydrochloride(TC)in aqueous solution at room *** crystal structure,surface morphology and optoelectronic properties of the COS/LFO heterojunctions were systemically characterized to correlate the reaction *** tests indicate that the CdS/LFO heterojunctions exhibit promising activity for TC degradation under visible light irradiation(λ≥420 nm),with 85%TC conversion obtained at reaction time of 45 min,which is 3.4 and 1.9 times higher than that of CdS and LaFeO_(3).The CdS/LFO heterojunctions are also stable in the reaction and can be reused for four cycles with no appreciable activity *** applicability of CdS/LFO to photocatalytic degradation of organic dyes,as well as the reaction mechanism,was also explored.

关键词： LaFeO_(3) CdS Photocatalytic degradation Tetracycline hydrochloride Reaction mechanism Rare earths

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Increase of β1-adrenergic receptor gene expression induced by nicotine in hippocampal slice of rat

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Acta Pharmacologica Sinica 2003年第12期24卷 107-112页

作者： WANG Yong, zhu xiao-Nan, YAN Jie YU Jian-Ping, HUANG xiao-Hui, CHEN ru-zhu Department of Pharmacology, Sun Yat-sen University of Medical Science, Guangzhou 510089, China Department of Pharmacology Sun Yat-sen University of Medical Science Guangzhou 510089 China

AIM: To investigate the effect of nicotine on β1-adrenergic receptor (β1-AR) in the hippocampal slice of rat. METHODS: Hippocampal slices (400 μm thick) were incubated in artificial cerebrospinal fluid (ACSF) previously saturated with 95％ O2and 5％ CO2at 28℃ for 120 min, and then incubated with nicotine 10 μmol/L for 30, 60, 90, and 120 min. mRNA of the β1-adrenergic receptor was examined with semiquantitative reverse transcription-polymerase chain reaction (RT-PCR), and the protein level was measured by Western blot and RIA. RESULTS: The mRNA gene expression and the protein level of β1-adrenergic receptor in hippocampal slices were increased after nicotine treatment. The peak of protein occurred later but higher than that of mRNA level. CONCLUSION: Both expression of β1-adrenergic receptor gene transcription and post-transcriptional protein level in rat hippocampus were altered by nicotine.

关键词： nicotine β-adrenergic receptors hippocampus reverse transcriptase polymerase chain reaction Western blotting radioligand assay

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Carbon emission quantification and reduction in pavement use phase:A review

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Journal of Traffic and Transportation Engineering(English Edition) 2024年第1期11卷 69-91页

作者： Linjie zhu Jin Li Feipeng xiao Key Laboratory of Road and Traffic Engineering of Ministry of Education Tongji UniversityShanghai 201804China

The carbon emissions arising from road pavement infrastructures have emerged as critical issue in recent *** life cycle of a pavement can be divided into five phases,namely raw materials and production,construction,use,maintenance and end of *** the use phase generates the highest carbon emissions throughout the pavement's life cycle,it is usually neglected in most pavement life cycle assessment(LCA)studies due to its complexity and ***,this review selected 126 relevant references,focuses on quantification methods,influential factors and reduction technologies of carbon emissions in pavement use *** the carbon accounting approached,the LCA approach,remains the most widely used for evaluating the environmental impact of ***,the primary influential factors on the use phase'carbon emission include pavement-vehicle interaction primarily affected by pavement roughness,pavement albedo and climate *** influential factors above indirectly cause changes in carbon emissions by influencing the pavement performance and subsequent vehicle ***,the review surveys carbon emission reduction technologies during pavement use phase,focusing mainly on reducing pavement rolling resistance and constructing cool *** pavements and permeable pavements are the most widely used cool pavement ***,the aspects involved in this paper hold significant promise for quantifying and reducing carbon emissions in the pavement use phase.

关键词： Pavement Carbon emission Life cycle assessment Use phase Emission reduction

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Advances of Electrochemical and Electrochemiluminescent Sensors Based on Covalent Organic Frameworks

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Nano-Micro Letters 2024年第2期16卷 395-422页

作者： Yue Cao ru Wu Yan‑Yan Gao Yang Zhou Jun‑Jie zhu Key Laboratory for Organic Electronics and Information Displays(KLOEID)and Institute of Advanced Materials(IAM) Nanjing University of Posts and Telecommunications(NJUPT)Nanjing 210023People’s Republic of China State Key Laboratory of Analytical Chemistry for Life Science School of Chemistry and Chemical EngineeringNanjing UniversityNanjing 210023People’s Republic of China

Covalent organic frameworks(COFs),a rapidly developing category of crystalline conjugated organic polymers,possess highly ordered structures,large specific surface areas,stable chemical properties,and tunable pore *** the first report of boroxine/boronate ester-linked COFs in 2005,COFs have rapidly gained popularity,showing important application prospects in various fields,such as sensing,catalysis,separation,and energy *** them,COFs-based electrochemical(EC)sensors with upgraded analytical performance are arousing extensive *** this review,therefore,we summarize the basic properties and the general synthesis methods of COFs used in the field of electroanalytical chemistry,with special emphasis on their usages in the fabrication of chemical sensors,ions sensors,immunosensors,and ***,the emerged COFs in the electrochemiluminescence(ECL)realm are thoroughly covered along with their preliminary ***,final conclusions on state-of-the-art COFs are provided in terms of EC and ECL sensors,as well as challenges and prospects for extending and improving the research and applications of COFs in electroanalytical chemistry.

关键词： Covalent organic frameworks Electrochemistry Electrochemiluminescence Sensors

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IR-YOLO: Real-Time Infrared Vehicle and Pedestrian Detection

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Computers, Materials & Continua 2024年第2期78卷 2667-2687页

作者： xiao Luo Hao zhu Zhenli Zhang Department of Electrical Engineering and Automation Jiangxi University of Science and TechnologyGanzhou341000China Jiangxi Provincial Key Laboratory of Maglev Technology Ganzhou341000China Graduate School of Information Production and SystemsWaseda UniversityKitakyushu-shiFukuoka808-0135Japan

Road traffic safety can decrease when drivers drive in a low-visibility *** application of visual perception technology to detect vehicles and pedestrians in infrared images proves to be an effective means of reducing the risk of *** tackle the challenges posed by the low recognition accuracy and the substan-tial computational burden associated with current infrared pedestrian-vehicle detection methods,an infrared pedestrian-vehicle detection method A proposal is presented,based on an enhanced version of You Only Look Once version 5(YOLOv5).First,A head specifically designed for detecting small targets has been integrated into the model to make full use of shallow feature information to enhance the accuracy in detecting small ***,the Focal Generalized Intersection over Union(GIoU)is employed as an alternative to the original loss function to address issues related to target overlap and category ***,the distribution shift convolution optimization feature extraction operator is used to alleviate the computational burden of the model without significantly compromising detection *** test results of the improved algorithm show that its average accuracy(mAP)reaches 90.1%.Specifically,the Giga Floating Point Operations Per second(GFLOPs)of the improved algorithm is only *** contrast,the improved algorithms outperformed the other algorithms on similar GFLOPs,such as YOLOv6n(11.9),YOLOv8n(8.7),YOLOv7t(13.2)and YOLOv5s(16.0).The mAPs that are 4.4%,3%,3.5%,and 1.7%greater than those of these algorithms show that the improved algorithm achieves higher accuracy in target detection tasks under similar computational resource *** the other hand,compared with other algorithms such as YOLOv8l(91.1%),YOLOv6l(89.5%),YOLOv7(90.8%),and YOLOv3(90.1%),the improved algorithm needs only 5.5%,2.3%,8.6%,and 2.3%,respectively,of the *** improved algorithm has shown significant advancements in balancing accuracy and computati

关键词： Traffic safety infrared image pedestrians and vehicles focal GIoU distributed shift convolution

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Clinical analysis of secondary penile cancer:a case series at a tertiary referral center in China

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Asian Journal of Andrology 2024年第2期26卷 225-226页

作者： xiao-Yu Li Chun-ru Xu Xing Ji Zhen-Peng zhu Zhen-Ke Guo Tian-Yu Cai Jian Lin Department of Urology Peking University First HospitalBeijing 100034China Institute of Urology Peking UniversityBeijing 100034China National Urological Cancer Center Beijing 100034China Beijing Key Laboratory of Urogenital Diseases(Male)Molecular Diagnosis and Treatment Center Beijing 100034China

Dear Editor,Secondary penile cancer is an extremely rare condition that refers to the metastasis of other malignancies to the *** are limited reports on secondary penile cancer in Asian populations,and perceptions about this disease are extremely *** reviewed and analyzed the data of patients diagnosed with secondary penile cancer based on the pathological findings at Peking University First Hospital in Beijing,China,aiming to expand the clinical reference for this rare disease.

关键词： cancer rare finding

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