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Effect of flapping‑meridians combined with thunder‑fire moxibustion on upper limb dysfunction after stroke

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Journal of Integrative Nursing 2020年第3期2卷 123-128页

作者： Feng‑Guang GUAN Qiu‑Lu JI Yue‑qing JIANG Zhuo‑Mei ZHUANG xiao‑qin lian Department of Nursing The Second People’s Hospital Affiliated to Fujian University of Traditional Chinese MedicineFuzhouChina School of Nursing Fujian University of Traditional Chinese MedicineFuzhouChina

Objective:The objective of the study is to explore the effect of flapping‑meridians combined with thunder‑fire moxibustion in the treatment of upper limb dysfunction after *** and Methods:This randomized,single‑blind,controlled trial included 140 patients with *** to the random number table,the patients were divided into four groups:the control group(receiving conventional nursing alone),the intervention group 1(receiving conventional nursing combined with flapping‑meridians),the intervention group 2(receiving conventional nursing combined with thunder‑fire moxibustion),and the intervention group 3(receiving conventional nursing,flapping‑meridians,and thunder‑fire moxibustion).All four groups were intervened 4 weeks,6 days a *** outcome indicators(Fugl‑Meyer Assessment of the upper extremity and body mass index of shoulder abduction,elbow extension,and wrist flexion)were assessed at the beginning and the end of ***:The effect of the intervention group 3 was better than that of the intervention group 2,intervention group 1,and control group(P<0.05).Conclusion:The flapping‑meridians combined with thunder‑fire moxibustion can significantly improve the upper limb motor function and muscle strength of stroke patients with hemiplegia,and its effect is better than that of single treatment.

关键词： Flapping‑meridians hemiplegia stroke thunder‑fire moxibustion

GPS: graph contrastive learning via multi-scale augmented views from adversarial pooling

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Science China(Information Sciences) 2025年第1期68卷 145-158页

作者： Wei JU Yiyang GU Zhengyang MAO Ziyue QIAO Yifang qin xiao LUO Hui XIONG Ming ZHANG School of Computer Science National Key Laboratory for Multimedia Information ProcessingPeking University Artificial Intelligence Thrust The Hong Kong University of Science and Technology Department of Computer Science University of California

Self-supervised graph representation learning has recently shown considerable promise in a range of fields, including bioinformatics and social networks. A large number of graph contrastive learning approaches have shown promising performance for representation learning on graphs, which train models by maximizing agreement between original graphs and their augmented views(i.e., positive views). Unfortunately, these methods usually involve pre-defined augmentation strategies based on the knowledge of human experts. Moreover, these strategies may fail to generate challenging positive views to provide sufficient supervision signals. In this paper, we present a novel approach named graph pooling contrast(GPS) to address these *** by the fact that graph pooling can adaptively coarsen the graph with the removal of redundancy, we rethink graph pooling and leverage it to automatically generate multi-scale positive views with varying emphasis on providing challenging positives and preserving semantics, i.e., strongly-augmented view and weakly-augmented view. Then, we incorporate both views into a joint contrastive learning framework with similarity learning and consistency learning, where our pooling module is adversarially trained with respect to the encoder for adversarial robustness. Experiments on twelve datasets on both graph classification and transfer learning tasks verify the superiority of the proposed method over its counterparts.

关键词： graph representation learning graph neural networks graph contrastive learning graph augmentations graph pooling

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高校科研档案法制化管理探析

黑龙江省政法管理干部学院学报 2006年第3期 127-128页

作者：肖连勤黑龙江大学档案馆黑龙江哈尔滨150080

《中华人民共和国档案法》的颁布,使档案事业的发展有了法律依据和保障,标志着我国档案事业进入了法制建设轨道。但是在档案法制建设的初级阶段,某些领域还存在盲区,诸如高校科研档案中科研成果、知识产权、技术转让等的利用问题。对此... 详细信息

《中华人民共和国档案法》的颁布,使档案事业的发展有了法律依据和保障,标志着我国档案事业进入了法制建设轨道。但是在档案法制建设的初级阶段,某些领域还存在盲区,诸如高校科研档案中科研成果、知识产权、技术转让等的利用问题。对此,应进一步强化科研档案管理,完善档案借阅制度;加大执法监督力度;增强知识产权保护意识。

关键词：档案法制化科研成果知识产权保护

Reduced mesencephalic astrocyte-derived neurotrophic factor expression by mutant androgen receptor contributes to neurodegeneration in a model of spinal and bulbar muscular atrophy pathology

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Neural Regeneration Research 2025年第9期20卷 2655-2666页

作者： Yiyang qin Wenzhen Zhu Tingting Guo Yiran Zhang Tingting Xing Peng Yin Shihua Li xiao-Jiang Li Su Yang Guangdong Key Laboratory of Non-human Primate Research Key Laboratory of CNS Regeneration(Ministry of Education)Guangdong–HongKong–Macao Institute of CNS RegenerationJinan UniversityGuangzhouGuangdong ProvinceChina

Spinal and bulbar muscular atrophy is a neurodegenerative disease caused by extended CAG trinucleotide repeats in the androgen receptor gene,which encodes a ligand-dependent transcription facto *** mutant androgen receptor protein,characterized by polyglutamine expansion,is prone to misfolding and forms aggregates in both the nucleus and cytoplasm in the brain in spinal and bulbar muscular atrophy *** aggregates alter protein-protein interactions and compromise transcriptional *** this study,we reported that in both cultured N2a cells and mouse brain,mutant androgen receptor with polyglutamine expansion causes reduced expression of mesencephalic astrocyte-de rived neurotrophic *** n of mesencephalic astrocyte-derived neurotrophic factor amelio rated the neurotoxicity of mutant androgen receptor through the inhibition of mutant androgen receptor *** down endogenous mesencephalic astrocyte-derived neurotrophic factor in the mouse brain exacerbated neuronal damage and mutant androgen receptor *** findings suggest that inhibition of mesencephalic astrocyte-derived neurotrophic factor expression by mutant androgen receptor is a potential mechanism underlying neurodegeneration in spinal and bulbar muscular atrophy.

关键词： androgen receptor mesencephalic astrocyte-derived neurotrophic factor mouse model neurodegeneration neuronal loss neurotrophic factor polyglutamine disease protein misfolding spinal and bulbar muscular atrophy transcription factor

Integration of perioperative features and intragraft TCF7L2 expression to predict lipid metabolic disorder in liver transplant recipients

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Science China Life Sciences 2025年第1期68卷 297-299页

作者： Junbin Zhou Rongli Wei Guanghan Fan Zhengxing lian Xuanyu Zhang Linsong Tang Zhetuo Qi Haiyang Xie Shusen Zheng Qiang Wei xiao Xu Department of Hepatobiliary and Pancreatic Surgery People's Hospital of LishuiAffiliated Lishui Hospital of Wenzhou Medical UniversityThe First Affiliated Hospital of Lishui University NHFPC Key Laboratory of Combined Multi-Organ Transplantation Key Laboratory of Integrated Oncology and Intelligent Medicine of Zhejiang Province Department of Hepatobiliary and Pancreatic SurgeryHangzhou First People's Hospital Department of Hepatobiliary and Pancreatic Surgery The First Affiliated HospitalZhejiang University School of Medicine Department of Urology The Second Affiliated HospitalZhejiang University School of Medicine Department of Hepatobiliary and Pancreatic Surgery Department of Liver TransplantationShulan (Hangzhou) Hospital Hangzhou Medical College Zhejiang University School of Medicine

Dear Editor, Liver transplantation(LT) is the only curative therapy for patients with endstage liver disease(He et al., 2023; Ling et al., 2022). Post-transplant hypertriglyceridemia(PTHT), which has an incidence of up to 32.8% in 6 months after LT, is one of the major post-transplant complications(Toshima et al., 2020).

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Effects of Ti-and Nb-based transition element from single to multiple compound oxides and carbon-based composite additives on Mg-MgH2 hydrogen storage material

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Tungsten 2025年第1期7卷 32-49页

作者： Li-Rong xiao Chen Chen Shuo Wang Zi-Yin Dai Hideo Kimura Cui Ni Chuan-Xin Hou Xue-qin Sun Si-Jie Guo Wei Du Xiu-Bo Xie School of Environmental and Material Engineering Yantai University Bosch HUAYU Steering Systems (Yantai) Co. Ltd.Ytp/MFE University of Tennessee Knoxville Shandong Key Laboratory of Eco-Environmental Science for the Yellow River Delta Shandong University of Aeronautics

MgH2is considered as a promising hydrogen storage material for its high hydrogen storage capacity,low cost and abundant resource ***,the low kinetics and high enthalpy formation of MgH2limit its wide *** the perspective of adding catalysts to enhance the hydrogen storage properties of Mg-MgH2,this article elaborated the main catalysts based on Ti and Nb transition elements,including single oxide catalysts,binary oxides catalysts（combined with Ni,Na,Sr,V,etc.）,multiple catalysts bound to carbon,and composite catalysts with Ti and Nb elements combined with MXene ***,the main pathways of various catalysts to reduce the reaction activity and broaden the hydrogen desorption channel were also *** Ti-based catalysts can enhance the reactive sites of the matrix by forming multivalent states,while Nb-based catalysts broaden the hydrogen reaction channels by forming tiny *** improving the size structure and enhancing the grain size stability,combined with carbon materials should be the future considerations.

关键词： Catalysts Mg-based hydrogen storage alloys Solid hydrogen storage Transition metal elements

静息B细胞体外诱导同种T细胞低反应的实验研究

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上海免疫学杂志 2001年第2期21卷 80-82页

作者：杨小丽秦慧莲何球藻复旦大学医学院免疫学教研室上海200032

本文采用体外同种混合淋巴细胞实验系统观察了静息B细胞 (restingBcell)诱导的同种免疫低应答反应。C5 7BL/6小鼠脾细胞经贴壁去除巨噬细胞后 ,用抗Thy 1抗体加补体和Percoll非连续密度梯度离心法分离 ,获得纯化的静息B细胞 ,经FACS检... 详细信息

本文采用体外同种混合淋巴细胞实验系统观察了静息B细胞 (restingBcell)诱导的同种免疫低应答反应。C5 7BL/6小鼠脾细胞经贴壁去除巨噬细胞后 ,用抗Thy 1抗体加补体和Percoll非连续密度梯度离心法分离 ,获得纯化的静息B细胞 ,经FACS检测其表面高表达SmIg (94 88% )和处于细胞分裂的G0 期 (95 79% ) ,并表达H 2Kb(99 5 % )和H 2I Ab(82 42 % ) ,但低表达CD80 /CD86 (分别为 4 2 6 %和 4 16 % )。C5 7BL/6小鼠静息B细胞刺激同种BALB/c小鼠T细胞 (初次MLR)只呈现微弱增殖反应 ,明显低于用LPS活化B细胞或全脾细胞刺激时的反应值。作再次MLR实验时 ,经初次MLR处理的T细胞对C5 7BL/6小鼠脾细胞表现为很弱的应答反应 ,但对无关的第三品系AKR鼠脾细胞却呈现强应答 ,说明这种应答低下具有相对特异性。上述结果提示 ,静息B细胞在MLR系统中不能诱导同种T细胞的充分活化而表现为同种免疫应答的低下。这在同种移植中诱导受体对移植物耐受提供有益的启示。

关键词：静息B细胞同种免疫低应答性辅助刺激分子混合淋巴细胞反应实验研究移植免疫

A dry-electrode enabled ECG-on-Chip with arrhythmia-aware data transmission

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Science China(Information Sciences) 2025年

作者： Xinzi XU Yanxing SUO Yang ZHAO Peiyi ZHOU xiao HAN Qiao CAI Min WANG Jiajun YUAN Liebin ZHAO Yongfu LI Guoxing WANG Yong lian Department of Micro-Nano Electronics and MoE Key Lab of Artificial Intelligence Shanghai Jiao Tong University Pediatric AI Clinical Application and Research Center Shanghai Engineering Research Center of Intelligence Pediatrics (SERCIP) Child Health Advocacy Institute Shanghai Children's Medical Center School of MedicineShanghai Jiao Tong University Shanghai Engineering Research Center of Intelligence Pediatrics (SERCIP) Xin Hua Hospital Affiliate to Shanghai Jiao Tong University School of Medicine

Early detection and treatment of cardiovascular diseases (CVDs) can be significantly enhanced through the use of flexible wearable electrocardiogram (ECG) sensors, potentially reducing CVD-related mortality. This paper introduces an ECG-on-Chip (EoC) solution tailored for flexible ECG sensors, incorporating novel features to address common challenges in wearable ECG technology. The EoC integrates a chopper-stabilized capacitively-coupled instrumentation amplifier (CS-CCIA),ensuring a high common-mode rejection ratio (CMRR) and low noise performance. Performance is further boosted via a positive feedback loop (PFL) and a programmable gain amplifier (PGA) with shared on-chip calibration logic, which enhances input impedance and minimizes gain variability to ensure consistent algorithm performance. Additionally, a secondary chopping technique is employed to further reduce noise, achieving an input-referred noise level of 454 nVrms. The embedded algorithm within the EoC is designed to extract clinically meaningful features, facilitating robust real-time arrhythmia analysis. Fabricated using a 0.18μm CMOS process, the EoC consumes 14.9μW with a supply voltage of 1.2 V. The algorithm’s efficacy has been validated over 0.4 million heartbeats, demonstrating a sensitivity of over 99.7%for R-peak detection and 98.3%for arrhythmia analysis. To demonstrate practical application, the EoC has been integrated with a commercial Bluetooth low energy (BLE)transceiver, forming a wireless arrhythmia monitoring sensor equipped with dry electrodes. This system consumes 292.04μW in arrhythmia-aware transmission mode, supporting 13 days of operation with a 30 mAh thin-film battery.

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2013年玉林市新生儿疾病筛查情况分析

中国儿童保健杂志 2015年第1期23卷 84-86页

作者：秦小莲黎秋波张宁广西壮族自治区玉林市妇幼保健院广西玉林537000

目的了解玉林市新生儿先天性甲状腺功能低下症、苯丙酮尿症、G6PD缺乏症和听力筛查等四项筛查状况。方法对2013年玉林市新生儿病筛查结果进行统计分析。结果 2013年玉林市先天性甲状腺功能减低下症筛查数110 650例,初筛阳性1 381例,筛... 详细信息

目的了解玉林市新生儿先天性甲状腺功能低下症、苯丙酮尿症、G6PD缺乏症和听力筛查等四项筛查状况。方法对2013年玉林市新生儿病筛查结果进行统计分析。结果 2013年玉林市先天性甲状腺功能减低下症筛查数110 650例,初筛阳性1 381例,筛查阳性率为1.25%,各县市区差异有统计学意义(P<0.01);苯丙酮尿症筛查110 650例,初筛阳性387例,阳性率为0.35%,各县市区差异有统计学意义(P<0.01);G6PD缺乏症筛查88 748例,初筛阳性4 143例,阳性率为4.67%,各县市区差异有统计学意义(P<0.01);听力筛查56 113例,初筛阳性4 053例,阳性率为7.22%,各县市区差异有统计学意义(P<0.01)。结论全面开展新生儿疾病筛查可早发现新生儿疾病,为新生儿早期干预提供有价值的医学依据,是提高总体人口素质的重要措施。

关键词：先天性甲状腺功能低下症新生儿苯丙酮尿症 G6PD 听力筛查