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The emerging role of nitric oxide in the synaptic dysfunction of vascular dementia

Neural Regeneration Research 2025年第2期20卷 402-415页

作者： xiaorong Zhang Zhiying Chen Yinyi Xiong qin Zhou Ling-Qiang Zhu Dan Liu Department of Pathology Affiliated Hospital of Jiujiang UniversityJiujiangJiangxi ProvinceChina Jiujiang Clinical Precision Medicine Research Center JiujiangJiangxi ProvinceChina Center for Cognitive Science and Transdisciplinary Studies Jiujiang UniversityJiangxi ProvinceChina Department of Neurology Affiliated Hospital of Jiujiang UniversityJiujiangJiangxi ProvinceChina Department of Rehabilitation Affiliated Hospital of Jiujiang UniversityJiujiangJiangxi ProvinceChina Department of Pathophysiology School of Basic MedicineTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina

With an increase in global aging,the number of people affected by cerebrovascular diseases is also increasing,and the incidence of vascular dementia-closely related to cerebrovascular risk-is increasing at an epidemic ***,few therapeutic options exist that can markedly improve the cognitive impairment and prognosis of vascular dementia *** in Alzheimer’s disease and other neurological disorders,synaptic dysfunction is recognized as the main reason for cognitive *** oxide is one of the ubiquitous gaseous cellular messengers involved in multiple physiological and pathological processes of the central nervous ***,nitric oxide has been implicated in regulating synaptic plasticity and plays an important role in the pathogenesis of vascular *** review introduces in detail the emerging role of nitric oxide in physiological and pathological states of vascular dementia and summarizes the diverse effects of nitric oxide on different aspects of synaptic dysfunction,neuroinflammation,oxidative stress,and blood-brain barrier dysfunction that underlie the progress of vascular ***,we propose that targeting the nitric oxide-sGC-cGMP pathway using certain specific approaches may provide a novel therapeutic strategy for vascular dementia.

关键词： endoplasmic reticulum stress endothelial nitric oxide synthase gene therapy nitric oxide NO-sGC-cGMP pathway synaptic dysfunction vascular dementia

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Nano high-entropy oxide cathode with enhanced stability for direct borohydride fuel cells

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Journal of Energy Chemistry 2025年第1期100卷 309-316页

作者： Lei Zhang Lingfeng Kuang Lianke Zhang Wen Chu Haiying qin Jing Zhang Junjing He Hualiang Ni Hongzhong Chi New Energy Materials Research Center College of Materials and Environmental EngineeringHangzhou Dianzi UniversityHangzhou 310018ZhejiangChina School of Materials Science and Engineering Zhejiang UniversityHangzhou 310027ZhejiangChina Key Laboratory of MEMS of Ministry of Education School of Integrated CircuitsSoutheast UniversityNanjing 210096JiangsuChina

High-entropy materials have become high-activity electrocatalysis owing to their high-entropy effect and multiple active ***,we synthesize a series of carbon-supported nano high-entropy oxides(HEOs/C),specifically (PtFeCoNiCu)O/C,using a carbothermal shock (CTS) method for application as a cathode catalyst in direct borohydride fuel cells (DBFCs).The microstructure of the prepared catalysts was characterized by X-ray photoelectron spectroscopy,X-ray absorption fine structure,and transmission electron *** prepared (PtFeCoNiCu)O/C,with particle sizes ranging from 2 to 4 nm,demonstrates 3.94 transferred electrons towards the oxygen reduction reaction in an alkaline environment,resulting in a minimal H_(2)O_(2)yield of 2.6%.Additionally,it exhibits a Tafel slope of 61 mV dec-1,surpassing that of commercial Pt/C (82 mV dec-1).furthermore,after 40,000 cycles of cyclic voltammetry(CV) testing,the half-wave potential of (PtFeCoNiCu)O/C shows a positive shift of 3 mV,with no notable decline in the limiting current *** (PtFeCoNiCu)O/C is used as a cathode catalyst in DBFCs,the DBFC achieves a maximum power density of 441 mW cm^(-2)at 60°C and sustains a cell voltage of approximately 0.73 V after 52 h at 30°*** findings confirm that HEO/C is a promising cathode catalyst for DBFCs.

关键词： High-entropy oxides Oxygen reduction reaction Carbothermal shock Stability Direct borohydride fuel cells

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Isothermal reduction kinetics and reduction prediction for iron ore pellets

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Journal of Iron and Steel Research International 2025年第1期32卷 64-72页

作者： Fei Meng Hao Liu Yue-lin qin Huang-jie Hua Yin Deng Ze-zheng Sun Long-hai Liu School of Metallurgy and Materials Engineering Chongqing University of Science and TechnologyChongqing401331China CISDI Group Co. Ltd.Chongqing401122China College of Materials Science and Engineering Chongqing UniversityChongqing400044China Sichuan Desheng Group Vanadium&Titanium Co. Ltd.Leshan614000SichuanChina

Iron ore pellets,as one of the main charges of blast furnaces,have a greater impact on the CO_(2)emission reduction and stable operation of blast *** isothermal reduction behavior of the pellets obtained from a Chinese steel plant was studied in the gas mixtures of CO and N_(2).The results showed the reduction process is divided into two *** reduction in the initial stage(time t≤40 min)is cooperatively controlled by internal diffusion and interface chemical reactions with the activation energy of 30.19 and 16.67 kJ/mol,*** controlling step of the reduction in the final stage(t>40 min)is internal diffusion with the activation energy of 34.60 kJ/*** reduction process can be described by two equations obtained from kinetic *** reduction degree can be predicted under different temperatures and time,and the predicted results showed an excellent correlation with the experimental *** reduction mechanisms were confirmed by the analysis of the scanning electron microscope equipped with an energy dispersive spectrometer and optical microscope.

关键词： Pellet Reduction behavior Kinetics Mechanism Reduction prediction

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下伏溶洞顶板厚度对桩基承载特性影响模型试验研究

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岩石力学与工程学报 2025年第1期44卷 236-247页

作者：杨柏肖世国覃超杨源浩石青叶西南交通大学地球科学与工程学院四川成都610031 桂林电子科技大学建筑与交通工程学院广西桂林541004 西南交通大学土木工程学院四川成都610031

为研究下伏溶洞顶板厚度对嵌岩桩承载特性的影响,开展不同顶板厚度(1D~5D,D为试桩桩径)条件下模型桩载荷试验,揭示溶洞顶板破坏模式、荷载-位移曲线、桩身轴力和阻力分布特征、极限承载力随顶板厚度变化的规律,并建立溶洞顶板极限承载... 详细信息

为研究下伏溶洞顶板厚度对嵌岩桩承载特性的影响,开展不同顶板厚度(1D~5D,D为试桩桩径)条件下模型桩载荷试验,揭示溶洞顶板破坏模式、荷载-位移曲线、桩身轴力和阻力分布特征、极限承载力随顶板厚度变化的规律,并建立溶洞顶板极限承载力计算模型,基于顶板破坏模式和H-B准则提出计算式,得出下伏溶洞桩基极限承载力计算方法。研究结果表明:(1)顶板厚度为1D,2D时,顶板破坏形式为冲切破坏;顶板厚度为3D,4D时,为弯拉-冲切组合破坏;顶板厚度为5D时,为弯拉破坏;下伏溶洞顶板临界厚度为5.9D。(2)试桩荷载-位移曲线呈陡变型,陡变点出现前,荷载-位移关系呈线性形态,荷载-位移曲线陡变点对应桩顶位移为(0.215~0.3)D,规范取0.05D位移对应荷载作为桩基极限承载力偏于保守。(3)顶板厚度每增加1D,试桩极限承载力显著提升,但增幅由158%逐步降低至35%;当顶板厚度超过2D,试桩桩端承载比例超过90%。(4)所建立的下伏溶洞桩基极限承载力计算方法,与试验结果的误差范围为3.29%~15.62%,吻合较好。

关键词：桩基工程嵌岩桩溶洞顶板厚度承载特性模型试验

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The Impacts of Climate Change on the Environment and Human Health in China:A Call for more Ambitious Action

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Biomedical and Environmental Sciences 2025年第2期38卷 127-143页

作者： Shilu Tong Yu Wang Yonglong Lu Cunde xiao Qiyong Liu Qi Zhao Cunrui Huang Jiayu Xu Ning Kang Tong Zhu Dahe qin Ying Xu Buda Su xiaoming Shi National Institute of Environmental Health Chinese Center for Disease Control and PreventionBeijing 100021China School of Public Health and Social Work Queensland University of TechnologyBrisbane 4001Australia State Key Laboratory of Marine Environmental Science and International Institute for Sustainability Science College of the Environment and EcologyXiamen UniversityXiamen 361102FujianChina State Key Laboratory of Earth Surface Processes and Resource Ecology Beijing Normal UniversityBeijing 100875China National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases National Institute for Communicable Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing 102206China School of Public Health Shandong UniversityJinan 250012ShandongChina Vanke School of Public Health Tsinghua UniversityBeijing 100084China Institute of Reproductive and Child Health/National Health Commission Key Laboratory of Reproductive Health and Department of Epidemiology and Biostatistics/Ministryof Education Key Laboratory of Epidemiology of Major Diseases(PKU) School of Public HealthPeking University Health Science CentreBeijing 100191China SKL-ESPC&SEPKL-AERM Department of Environmental HealthCollege of Environmental Sciences and Engineering&Center for Environment and HealthPeking UniversityBeijing 100871China China Meteorological Administration Beijing 100081China National Climate Centre China Meteorological AdministrationBeijing 100081China Nanjing University of Information Science and Technology Nanjing 210044JiangsuChina Chinese Center for Disease Control and Prevention Beijing 102206China

As global greenhouse gases continue rising,the urgency of more ambitious action is clearer than ever *** is the world’s biggest emitter of greenhouse gases and one of the countries affected most by climate *** evidence about the impacts of climate change on the environment and human health may encourage China to take more decisive action to mitigate greenhouse gas emissions and adapt to climate impacts.

关键词： change. greenhouse climate

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Improved reference-frame-independent quantum key distribution with intensity fluctuations

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Chinese Physics B 2025年第2期34卷 48-52页

作者： Zi-Qi Chen Hao-Bing Sun Ming-Shuo Sun qin Wang Institute of Quantum Information and Technology Nanjing University of Posts and TelecommunicationsNanjing 210003China Broadband Wireless Communication and Sensor Network Technology Key Laboratory of Ministry of EducationNanjing University of Posts and TelecommunicationsNanjing 210003China

Reference-frame-independent quantum key distribution(RFI-QKD) can avoid real-time calibration operation of reference frames and improve the efficiency of the communication process. However, due to imperfections of optical devices,there will inevitably exist intensity fluctuations in the source side of the QKD system, which will affect the final secure key rate. To reduce the influence of intensity fluctuations, an improved 3-intensity RFI-QKD scheme is proposed in this *** considering statistical fluctuations and implementing global parameter optimization, we conduct corresponding simulation analysis. The results show that our present work can present both higher key rate and a farther transmission distance than the standard method.

关键词： quantum key distribution intensity fluctuations decoy-state method

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Territorial Ecological Restoration with a High-carbon Storage Focus in the Beibu Gulf Urban Agglomeration of China:Insights from Carbon Metabolism Spatial Security Patterns

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Chinese Geographical Science 2025年第1期35卷 73-91页

作者： qin Menglin LIU Yuting TAN Qianxi ZHU Ziming WU Xinyu JIANG Hongbo LI Hang SHI Qianqian School of Civil Engineering and Architecture Guangxi UniversityNanning 530004China School of Forestry Guangxi UniversityNanning 530004China Ecosystem Science and Management Program University of Northern British ColumbiaPrince George V2N 4Z9Canada Zhuhai Institute of Planning and Design Zhuhai 519000China

This study focuses on urgent research on restoring and enhancing carbon storage capacity in the Beibu Gulf Urban Agglomer-ation of China,a key area in the‘Belt and Road’Initiative,which aligns with carbon peaking and neutrality *** research ana-lyzes the spatial characteristics of carbon metabolism from 2000 to 2020 and uses models to identify stable carbon sink areas,positive carbon flow corridors,and carbon sequestration *** goal is to construct a carbon metabolism spatial security pattern(CMSSP)and propose territorial ecological restoration strategies under different development demand *** results show the following:1)in 2020,the study area’s carbon sink decreased by 8.29×10^(4) t C/yr compared with that in 2010 and by 10.83×10^(4) t C/yr compared with that in ***-carbon sinks were found mainly in mountainous areas,whereas low-carbon sinks are concentrated in urban con-struction land,rural residential areas,and land margins.2)From 2000 to 2020,the spatial security pattern of carbon metabolism tended to be‘high in the middle of the east and west and low in the gulf.’In 2000,2010,and 2020,16 stable carbon sinks were *** carbon energy flow density in Guangxi was greater than that in Guangdong and Hainan,with positive carbon flow corridors located primarily in Guangxi and *** number of carbon sequestration nodes remained stable at approximately 15,mainly in Guangxi and Hainan.3)Scenario simulations revealed that under the Nature-based mild restoration scenario,the carbon sink rate will reach 611.85×10^(4) t C/yr by 2030 and increase to 612.45×10^(4) t C/yr by 2060,with stable carbon sinks increasing to *** the restora-tion scenario based on Anti-globalization,the carbon sink will decrease from 610.24×10^(4) t C/yr in 2030 to 605.19×10^(4) t C/yr in 2060,with the disappearance of some positive carbon flow corridors and stable carbon *** the Human-based sustainable restoration scenario,the carbon sink area wil

关键词： carbon metabolism spatial security pattern(CMSSP) territorial ecological restoration carbon sink carbon storage capacity Beibu Gulf Urban Agglomeration,China

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Polyvinyl alcohol fiber with enhanced strength and modulus and intense cyan fluorescence based on covalently functionalized graphene quantum dots

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Chinese Chemical Letters 2025年第2期36卷 250-255页

作者： Manman Ou Yunjian Zhu Jiahao Liu Zhaoxuan Liu Jianjun Wang Jun Sun Chuanxiang qin Lixing Dai College of Chemistry Chemical Engineering and Materials Science Soochow University

In this study, we proposed a novel and efficient way to strengthen polyvinyl alcohol(PVA) fiber using graphene quantum dots(GQDs). PVA molecular chains were grafted onto the surface of GQDs through Friedel-Crafts alkylation reaction to obtain functionalized GQDs(f-GQDs), and PVA/f-GQDs composite fiber was successfully prepared by wet spinning and post-treatment. The tensile strength and Young's modulus of the composite fiber reached up to 1229.24 MPa and 35.36 GPa which were approximately twice and 4 times those of the pure PVA fiber, respectively. Moreover, the composite fiber was demonstrated excellent resistance to solvents. In addition, the PVA/f-GQDs composite fiber showed intense and uniform cyan fluorescence, meanwhile, it could maintain stable solid-state fluorescence in acid and alkali solutions and particularly after long-term immersion in water(1 month). This study proposes a promising route for obtaining high-performance conventional fibers with some new functions.

关键词： Enhancement Fluorescence Graphene quantum dots Polyvinyl alcohol fiber

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基于电子鼻和HS-GC-MS技术结合气味活度值法分析梅花鹿茸炮制前后腥臭气成分差异

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中国中药杂志 2025年第2期50卷 421-429页

作者：姚晓煜申柯吴迪孙晓菲毛春芹付莉王小燕谢辉陆兔林南京中医药大学药学院江苏南京210023 吉林敖东延边药业股份有限公司吉林敦化133700

炮制去腥在动物药中多有应用,该研究利用Heracles Neo超快速气相色谱电子鼻技术结合化学计量学分析梅花鹿茸炮制前后整体性气味差异,结果表明梅花鹿茸炮制前后气味差异较大,电子鼻可对梅花鹿茸药材及饮片进行有效区分。采用HS-GC-MS技... 详细信息

炮制去腥在动物药中多有应用,该研究利用Heracles Neo超快速气相色谱电子鼻技术结合化学计量学分析梅花鹿茸炮制前后整体性气味差异,结果表明梅花鹿茸炮制前后气味差异较大,电子鼻可对梅花鹿茸药材及饮片进行有效区分。采用HS-GC-MS技术对梅花鹿茸药材及饮片中挥发性成分进行鉴定与相对定量,在梅花鹿茸药材与饮片中分别检测出35、37种挥发性成分,其中28种为药材与饮片的共有气味成分。基于气味嗅觉阈值和相对百分含量计算各挥发性成分气味活度值(OAV),结果表明梅花鹿茸药材与饮片中共含异戊醛、2-甲基丁醛、异丁醛、正己醛、甲硫醇等17种关键性气味物质,是梅花鹿茸产生腥臭气的主要来源。通过PCA及OPLS-DA对炮制前后挥发性成分进行差异性分析,结果显示梅花鹿茸药材与饮片的挥发性成分有明显差异,基于P1的原则筛选了21种差异挥发性气味成分,其中异戊醇、异戊醛、2-甲基丁醛、壬醛、二甲胺是关键性气味差异物质。梅花鹿茸加酒炮制后腥臭气成分种类及相对百分含量有所减少,并且产生酯类等一些香味物质,是梅花鹿茸炮制后腥臭气味减淡的主要原因。

关键词：梅花鹿茸炮制腥臭成分电子鼻顶空进样-气质联用技术气味活度值

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Transcriptome Analysis of Derris fordii and Derris elliptica to Identify Potential Genes Involved in Rotenoid Biosynthesis

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Phyton-International Journal of Experimental Botany 2025年第1期94卷 123-136页

作者： Yanlin Pan Yibin Zhang Xingui Wang Hongbo qin Lunfa Guo Guangxi Institute of Botany Guangxi Zhuangzu Autonomous Region and the Chinese Academy of SciencesGuilin541006China Guangxi Key Laboratory of Plant Conservation and Restoration Ecology in Karst Terrain Guangxi Institute of BotanyGuangxi Zhuangzu Autonomous Region and the Chinese Academy of SciencesGuilin541006China

Derris fordii and Derris elliptica belong to the Derris genus of the Fabaceae family, distinguished by their high isoflavonoid content, particularly rotenoids, which hold significance in pharmaceuticals and agriculture. Rotenone, as a prominent rotenoid, has a longstanding history of use in pesticides, veterinary applications, medicine, and medical research. The accumulation of rotenoids within Derris plants adheres to species-specific and tissue-specific patterns and is also influenced by environmental factors. Current research predominantly addresses extraction techniques, pharmacological applications, and pesticide formulations, whereas investigations into the biosynthesis pathway and regulatory mechanism of rotenoids remain relatively scarce. In this study, we observed notable differences in rotenone content across the roots, stems, and leaves of D. fordii, as well as within the roots of D. elliptica. Utilizing RNA sequencing (RNA-seq), we analyzed the transcriptomes and expression profiles of unigenes from these four tissues, identifying a total of 121,576 unigenes. Differentially expressed genes (DEGs) across four comparison groups demonstrated significant enrichment in the phenylpropanoid and flavonoid biosynthesis pathways. Key unigenes implicated in the rotenoid biosynthesis pathway were identified, with PAL, C4H, CHS, CHI, IFS, and HI4OMT playing critical roles in D. fordii, while IFS and HI4OMT were determined to be essential for rotenoid biosynthesis in D. elliptica. These findings enhance our understanding of the biosynthesis mechanism of rotenoids in Derris species. The unigenes identified in this study represent promising candidates for future investigations aimed at validating their roles in rotenoid biosynthesis.

关键词： Derris fordii Derris elliptica RNA-seq rotenoid comparative transcriptomic analysis

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