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Chinese Chemical Letters 2004年第12期15卷 1407-1410页

作者： Feng SHI Hong Yang LI xiao Jun PENG Rong ZHANG xiao qiang CHEN Jiang Li FAN Li Cheng SUN State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116012 State Key Lab. of Fine Chemicals Dalian University of Technology Dalian 116012 China

As photosensitizer for solar cell, a new ruthenium (Ⅱ) complex with four ester groups hadbeen synthesized, in which a phenol substituted by {[(2-hydroxy-5-tert-butylbenzyl)(pyridyl-2-methyl)amino]methyl} is covalently linked to ruthenium (Ⅱ) tris-bipyridine. The structures ofthe new compounds were confirmed by NMR and ESI-MS spectra. The electrochemical andphotochemical properties were also studied.

关键词： Photosensitizer ruthenium complex phenolate ligand nanocryatalline TiO_2, solar cell.

Effect of transcutaneous electrical acupoint stimulation combined with palonosetron on chemotherapy-induced nausea and vomiting: a ***,randomized, controlled trial

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Chinese Journal of Cancer 2017年第5期36卷 213-221页

作者： Jing Xie Lei-Hua Chen Zhou-Yu Ning Chen-Yue Zhang Hao Chen Zhen Chen Zhi-qiang Meng xiao-Yan Zhu Department of Integrative Oncology Fudan University Shanghai Cancer Center 270 Dong’An Road Shanghai 200032 P. R. China Department of Oncology Shanghai Medical College Fudan University 270 Dong’An RoadShanghai 200032 P. R. China

Background: Chemotherapy?induced nausea and vomiting adversely affects the quality of life of patients who receive chemotherapy via intravenous infusion or transcatheter arterial chemoembolization(TACE). This study aimed to investigate the clinical effects of transcutaneous electrical acupoint stimulation(TEAS) on nausea and vomiting after ***: A total of 142 patients who received TACE with cisplatin for primary or metastatic liver cancer were assigned to the active?acupuncture(n = 72) or placebo?acupuncture(n Hegu(LI4), Neiguan(P6), an= 70) groups using a covariate?adaptive randomization at a ratio of 1:1. The acupointsd Zusanli(ST36) were stimulated twice daily for 6 days. The effects of TEAS on nausea and vomiting were assessed by using occurrence rate and severity of these symptoms. Anorexia scale and M. D. Anderson Symptom Inventory(MDASI) scores were secondary endpoints and were used to assess the effect of TEAS on patient appetite and quality of life. The safety of the treatments was also ***: Between the two groups, the differences in occurrence rates and severities of nausea and vomiting after TACE were not significant(all P > 0.05). From the second day after TACE, anorexia scores were significantly lower in the active?acupuncture group than in the placebo?acupuncture group and continued to decrease over time with treat?ment(all P values less than 0.01). On days 0, 1, and 2, the mean MDASI scores for the active?acupuncture group were slightly lower than those for the placebo?acupuncture group, but the differences were not statistically significant(all P > 0.05). No significant differences were found between the two groups in the occurrence rate of any adverse event(P > 0.05).Conclusion: TEAS appears to be a safe and effective therapy to relieve patients' gastrointestinal discomfort after chemotherapy.

关键词： Acupuncture Electro-acupuncture Transcutaneous electrical acupoint stimulation Nausea Vomiting Anorexia

Atmospheric HULIS and its ability to mediate the reactive oxygen species (ROS)： A review

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Journal of Environmental Sciences 2018年第9期30卷 13-31页

作者： Myat Sandar Win Zhengyang tian Hui Zhao Kai xiao Jiaxian Peng Yu Shang Minghong Wu Guangli Xiu Senlin Lu Shinich Yonemochi Qingyue Wang School of Environmental and Chemical Engineering Shanghai University Shanghai 200444 China East China University of Science and Technology (ECUST) Shanghai 200237 China Centers for Environmental Science in Saitama Saitama 374-0115 Japan School of Science and Engineering Saitama University Saitama 338-8570 Japan

Atmospheric humic-like substances （HULIS） are not only an unresolved mixture of macro- organic compounds but also powerful chelating agents in atmospheric particulate matters （PMs）; impacting on both the properties of aerosol particles and health effects by generating reactive oxygen spedes （ROS）. Currently, the interests of HULIS are intensively shifting to the investigations of HULIS-metal synergic effects and kinetics modeling studies, as well as the development of HULIS quantification, findings of possible HULIS sources and generation of ROS from HULIS. In light of HULIS studies, we comprehensively review the current knowledge of isolation and physicochemical characterization of HULIS from atmospheric samples as well as HULIS properties （hygroscopic, surface activity, and colloidal） and possible sources of HULIS. This review mainly highlights the generation of reactive oxygen species （ROS） from PMs, HULIS and transition metals, especially iron. This review also summarized the mechanism of iron-organic complexation and recent findings of OH formation from HULIS-metal complexes. This review will be helpful to carry out the modeling studies that concern with HULIS-transition metals and for further studies in the generation of ROS from HULIS-metal complexes,

关键词： Atmospheric HULIS Reactive oxygen species (ROS) Transition metals Characterization methods

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菰黑粉菌细胞核和线粒体的荧光标记菌株构建

农业生物技术学报 2024年第5期32卷 1188-1197页

作者：汤近天杨芙容章蕾蕾李钰康张雅芬傅慧兰夏文强崔海峰叶子弘中国计量大学生命科学学院/浙江省生物计量与检验检疫技术重点实验室

菰(Zizania latifolia)的茎部膨大形成可食用的茭白，与菰黑粉菌(Ustilago esculenta)的侵染有关，而侵染与否取决于菰黑粉菌的二型态转换。在二型态转换过程中，细胞核与线粒体的变化动态仍然未知。本研究将定位于细胞核的组蛋白H1编... 详细信息

菰(Zizania latifolia)的茎部膨大形成可食用的茭白，与菰黑粉菌(Ustilago esculenta)的侵染有关，而侵染与否取决于菰黑粉菌的二型态转换。在二型态转换过程中，细胞核与线粒体的变化动态仍然未知。本研究将定位于细胞核的组蛋白H1编码基因和线粒体定位信号(mitochondrial targeting signa, MTS)编码序列，分别连接GFP和mCherry荧光蛋白基因后，构建细胞核和线粒体荧光标记载体。采用根癌农杆菌介导遗传转化法(Agrobacterium tumefaciens-mediated transformation, ATMT)，以菰黑粉菌野生型菌株UeT14和UeT55为出发菌株来进行遗传转化，得到细胞核或线粒体中稳定表达红、绿色荧光蛋白的重组菌株：UeT55-H1-GFP、UeT14-H1-mCherry、UeT55-MTS-GFP和UeT14-MTS-mCherry。在UeT55-H1-GFP和UeT14-H1-mCherry菌株中，孢子中央有明亮的荧光点，与DAPI染色所形成的蓝色荧光共定位。在UeT55-MTS-GFP、UeT14-MTS-mCherry菌株中，孢子内可见小点状荧光，且绿色荧光与MitoTracker形成的红色荧光共定位。本研究获得了细胞核及线粒体能稳定表达荧光蛋白标记的菰黑粉菌，为研究菰黑粉菌生长发育、融合和侵染的分子机制提供了重要的参考和材料。

关键词：菰黑粉菌菰细胞核线粒体荧光蛋白标记

面向产漂流性卵鱼类的三峡水库生态调度效果评价

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水生态学杂志 2024年第1期45卷 58-66页

作者：张迪徐薇吴凡林俊强侯轶群朱博然彭期冬靳甜甜中国水利水电科学研究院北京100038 水利部中国科学院水工程生态研究所湖北武汉430079 国家发展和改革委员会一带一路建设促进中心北京100038

构建生态调度效果评估指标体系,评估三峡水库历年生态调度的效果并提出生态调度方案的优化建议,为三峡水库生态调度提供参考。从生态环境效益和社会经济效益2个维度出发,构建的面向产漂流性卵鱼类繁殖的水库生态调度效果评价体系包含目... 详细信息

构建生态调度效果评估指标体系,评估三峡水库历年生态调度的效果并提出生态调度方案的优化建议,为三峡水库生态调度提供参考。从生态环境效益和社会经济效益2个维度出发,构建的面向产漂流性卵鱼类繁殖的水库生态调度效果评价体系包含目标层、准则层和6个一级指标、10个二级指标,提出了各指标的计算方法和赋分标准,并采用层次分析法根据指标相对重要度,计算了各指标的权重系数。2012-2022年三峡水库生态调度效果各年度存在明显差异,涨水持续时间、初始流量、流量日上涨率和洪峰流量、水温等水文水环境指标满足鱼类最适繁殖需求的生态调度,鱼类繁殖响应良好;开展2次生态调度年份的效果好于开展1次调度的年份。三峡水库生态调度尽可能控制在水温20℃以上起调,水库出流过程尽可能接近鱼类适宜的水文需求阈值区间,同时在水库运行条件合适的前提下,年内尽可能开展2次生态调度实践,泄放较大脉冲的洪峰过程,促进鱼类繁殖。

关键词：产漂流性卵鱼类四大家鱼生态调度效果评价三峡水库

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Phase-field crystal simulation of evolution of liquid pools in grain boundary pre-melting regions

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Transactions of Nonferrous Metals Society of China 2021年第4期31卷 1175-1188页

作者： xiao-lin tian Yu-hong ZHAO Dun-wei PENG Qing-wei GUO Zhen GUO Hua HOU School of Materials Science and Engineering North University of ChinaTaiyuan 030051China

Pre-melting is a phenomenon that below the melting point the liquid-like structure appears at the grainboundary while the grain interior remains a crystal structure. The phase-field crystal method was employed to investigate the early evolution of the liquid pools in pre-melting regions, mainly involving four structural transformations: solid-solid state → small droplet → large liquid pool → homogeneous liquid melting. The microscopic morphology and free energy variation with different average atomic densities demonstrate that the average atomic density is sensitive to the morphological characteristics of liquid pools. Both two-dimensional and three-dimensional simulation results show that the amplitude reduction of order parameters can promote the order-disorder transition of grain boundaries, causing pre-melting in the edge dislocation aggregation. The relationship between the average atomic density and the width of the liquid pools is verified from thermodynamics, which provides a prerequisite for the application of high-temperature strain in the later stage to some extent.

关键词： phase-field crystal method pre-melting edge dislocations liquid pools

Evaluation of a novel hybrid bioartificial liver based on a multi-layer flat-plate bioreactor

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World Journal of Gastroenterology 2012年第28期18卷 3752-3760页

作者： xiao-Lei Shi Yue Zhang Xue-Hui Chu Bing Han Jin-Yang Gu Jiang-qiang xiao Jia-Jun Tan Zhong-Ze Gu Hao-Zhen Ren Xian-Wen Yuan Yi-Tao Ding Department of Hepatobiliary Surgery Jiangsu Province's Key Medical Center for Hepatobiliary Disease The Affiliated Drum Tower Hospital of Nanjing University Medical School Nanjing 210008 Jiangsu Province China State Key Laboratory of Bioelectronics Southeast University Nanjing 210008 Jiangsu Province China

AIM: To evaluate the efficacy and safety of a hybrid bioartificial liver (HBAL) system in the treatment of acute liver failure. METHODS: Canine models with acute liver failure were introduced with intravenous administration of D-galactosamine. The animals were divided into: the HBAL treatment group (n = 8), in which the canines received a 3-h treatment of HBAL; the bioartificial liver (BAL) treatment group (n = 8), in which the canines received a 3-h treatment of BAL; the non-bioartificial liver (NBAL) treatment group (n = 8), in which the canines received a 3-h treatment of NBAL; the control group (n = 8), in which the canines received no additional treatment. Biochemical parameters and survival time were determined. Levels of xenoantibodies, RNA of porcine endogenous retrovirus (PERV) and reverse transcriptase (RT) activity in the plasma were detected. RESULTS: Biochemical parameters were significantly decreased in all treatment groups. The TBIL level in the HBAL group was lower than that in other groups (2.19 ± 0.55 mmol/L vs 24.2 ± 6.45 mmol/L, 12.47 ± 3.62 mmol/L, 3.77 ± 1.83 mmol/L, P < 0.05). The prothrombin time (PT) in the BAL and HBAL groups was significantly shorter than the NBAL and control groups (18.47 ± 4.41 s, 15.5 ± 1.56 s vs 28.67 ± 5.71 s, 21.71 ± 3.4 s, P < 0.05), and the PT in the HBAL group was shortest of all the groups. The albumin in the BAL and HBAL groups significantly increased and a significantly higher level was observed in the HBAL group compared with the BAL group (27.7 ± 1.7 g/L vs 25.24 ± 1.93 g/L). In the HBAL group, the ammonia levels significantly decreased from 54.37 ± 6.86 to 37.75 ± 6.09 after treatment (P < 0.05); there were significant difference in ammonia levels between other the groups (P < 0.05). The levels of antibodies were similar before and after treatment. The PERV RNA and the RT activity in the canine plasma were all negative. CONCLUSION: The HBAL showed great efficiency and safety in the treatment of acute liver f

关键词： Hybrid bioartificial liver Acute liver failure Flat plate bioreactor Co-culture Nanofiber scaffold

Gold self-relay catalysis for accessing functionalized cyclopentenones bearing an allcarbon quaternary stereocenter

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Organic Chemistry Frontiers 2022年第1期9卷 140-146页

作者： Fan-Tao Meng Jing-Long Chen xiao-Yan Qin tian-Shu Zhang Shu-Jiang Tu Bo Jiang Wen-Juan Hao School of Chemistry&Materials Science Jiangsu Normal UniversityXuzhou221116P.R.China School of Materials and Chemical Engineering Xuzhou University of TechnologyXuzhou 221018P.R.China

A new gold(I)self-relay catalysis consisting of a 3,3-rearrangement,Nazarov cyclization and Michael addition cascade of 1,3-enyne acetates with aurones and their derived azadienes is reported,and used to produce a series of densely functionalized cyclopentenones bearing a cyclic quaternary stereocenter in moderate to good yields under mild *** tandem protocol demonstrates high regioselectivity,broad substrate flexibility and good functional group tolerance of substrates without inert atmosphere protection,providing a catalytic and convergent approach for creating all-carbon stereoscopic centers.

关键词： catalysis quaternary functional

Effects of vitamin D supplementation on glucose and lipid metabolism in patients with type 2 diabetes mellitus and risk factors for insulin resistance

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World Journal of Diabetes 2023年第10期14卷 1514-1523页

作者： Li-Jie Sun Ji-Xuan Lu Xin-Yu Li tian-Sheng Zheng xiao-Rong Zhan Department of Endocrinology First Affiliated Hospital of Harbin Medical UniversityHarbin 150001Heilongjiang ProvinceChina Department of Endocrinology Southern University of Science and Technology HospitalShenzhen 518071Guangdong ProvinceChina

BACKGROUND Type 2 diabetes mellitus(T2DM)is a chronic metabolic disease featured by insulin resistance(IR)and decreased insulin ***,vitamin D deficiency is found in most patients with T2DM,but the relationship between vitamin D and IR in T2DM patients requires further *** To explore the risk factors of IR and the effects of vitamin D supplementation on glucose and lipid metabolism in patients with *** Clinical data of 162 T2DM patients treated in First Affiliated Hospital of Harbin Medical University between January 2019 and February 2022 were retrospectively *** on the diagnostic criteria of IR,the patients were divided into a resistance group(n=100)and a non-resistance group(n=62).Subsequently,patients in the resistance group were subdivided to a conventional group(n=44)or a joint group(n=56)according to the treatment *** regression was carried out to analyze the risk factors of IR in T2DM *** changes in glucose and lipid metabolism indexes in T2DM patients with vitamin D deficiency were evaluated after the *** Notable differences were observed in age and body mass index(BMI)between the resistance group and the non-resistance group(both P<0.05).The resistance group exhibited a lower 25-hydroxyvitamin D_(3)(25(OH)D_(3))level,as well as notably higher levels of 2-h postprandial blood glucose(2hPG),fasting blood glucose(FBG),and glycosylated hemoglobin(HbA1c)than the non-resistance group(all P<0.0001).Additionally,the resistance group demonstrated a higher triglyceride(TG)level but a lower high-density lipoprotein-cholesterol(HDL-C)level than the non-resistance group(all P<0.0001).The BMI,TG,HDL-C,25(OH)D_(3),2hPG,and HbA1c were found to be risk factors of ***,the posttreatment changes in levels of 25(OH)D_(3),2hPG,FBG and HbA1c,as well as TG,total cholesterol,and HDL-C in the joint group were more significant than those in the conventional group(all P<0.05).CONCLUSION Pati

关键词： Vitamin D Type 2 diabetes mellitus Glucose and lipid metabolism Insulin resistance Risk factors

LncRNA CUST-40243和CUST-47163在慢性苯中毒患者中的表达及其诊断价值

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毒理学杂志 2024年第2期38卷 141-145页

作者：刘晓东高冉巴合提努尔·肖克拉提田薇新疆医科大学公共卫生学院新疆乌鲁木齐830011

目的通过检测慢性苯中毒患者和健康对照人群中LncRNA CUST-40243和CUST-47163的表达水平,判断两者在慢性苯中毒中的诊断价值。方法采用实时荧光定量PCR对慢性苯中毒患者及健康对照组人群外周静脉血中LncRNA CUST-40243和CUST-47163表达... 详细信息

目的通过检测慢性苯中毒患者和健康对照人群中LncRNA CUST-40243和CUST-47163的表达水平,判断两者在慢性苯中毒中的诊断价值。方法采用实时荧光定量PCR对慢性苯中毒患者及健康对照组人群外周静脉血中LncRNA CUST-40243和CUST-47163表达水平进行检测,采用胞质分裂阻滞微核试验(CBMN)对2组人群淋巴细胞微核率进行检测,应用ROC曲线分析其诊断意义。结果慢性苯中毒组LncRNA CUST-40243表达水平高于健康对照组(Z=3.440,P<0.01);LncRNA CUST-47163表达水平低于健康对照组(Z=-6.962,P<0.01);淋巴细胞微核率明显高于对照组(Z=3.919,P<0.01)。ROC曲线分析结果显示:慢性苯中毒组lncRNA CUST-40243的曲线下面积(area under curve,AUC)为0.697,95%置信区间(confidence interval,CI)为0.590~0.805;lncRNA CUST-47163的AUC为0.898,95%CI为0.835~0.964;血浆淋巴细胞微核率的AUC为0.724,95%CI为0.624~0.823;慢性苯中毒组患者联合诊断的AUC为0.962,95%CI为0.921~0.980。结论LncRNA在慢性苯中毒患者中异常表达,联合淋巴细胞微核率检测有助于提高诊断效率,因此可作为慢性苯中毒筛检及诊断过程中的参考指标。

关键词：苯中毒长链非编码RNA 微核