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Chinese Chemical Letters 2024年第2期35卷 370-373页

作者： Tangxin xiao Xiuxiu li liangliang Zhang Kai Diao Zheng-Yi li xiao-qiang Sun Leyong Wang Jiangsu Key Laboratory of Advanced Catalytic Materials and Technology School of Petrochemical EngineeringChangzhou UniversityChangzhou 213164China Jiangsu Key Laboratory of Advanced Organic Materials School of Chemistry and Chemical EngineeringNanjing UniversityNanjing 210023China

Stepwise energy transfer is ubiquitous in natural photosynthesis,which greatly promotes the widespread use of solar ***,we constructed a supramolecular light harvesting system based on sequential energy transfer through the hierarchical self-assembly of M,which contains a cyanostilbene core flanked by two ureidopyrimidinone motifs,endowing itself with both aggregation-induced emission behavior and quadruple hydrogen bonding *** monomer M can self-assemble into hydrogen bonded polymers and then form supramolecular polymeric nanoparticles in water through a mini-emulsion *** nanoparticles were further utilized to encapsulate the relay acceptor ESY and the final acceptor NDI to form a two-step FRET *** fluorescence including a white-light emission was successfully *** work not only shows a desirable way for the fabrication of efficient two-step light harvesting systems,but also shows great potential in tunable photoluminescent nanomaterials.

关键词： light harvesting system Supramolecular polymer Quadruple hydrogen bonding AIE Self-assembly

Combined therapy with methylprednisolone and ulinastatin in experimental autoimmune encephalomyelitis

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Chinese Medical Journal 2013年第18期126卷 3439-3445页

作者： SHU Ya-qing YANG Yu WANG Yu-ge DAI Yong-qiang xiao li QIU Wei LU Zheng-qi WU Ai-ming RUAN Heng-fang HU Xue-qiang Multiple Sclerosis Center Department of Neurology the Third Affiliated Hospital Sun Yat-sen University Guangzhou Guangdong 510630 China

Background Our previous study had demonstrated that ulinastatin （UTI） had a neuroprotective effect in experimental autoimmune encephalomyelitis （EAE）. Methylprednisolone has been recommended to be a standard drug in multiple sclerosis （MS） therapies. The present study was to investigate the protective effects of UTI combined methylprednisolone in EAE. Methods Mice were divided into a UTI treatment group, a methylprednisolone treatment group, a combined treatment group with UTI and methylprednisolone, a normal saline treatment group, and a normal control group. EAE mice were induced in groups receiving different combined treatments, or respective monotherapies. Demyelination was evaluated by Solochrome cyanin staining. 2＇,3＇-cyclic nucleotide 3＇- phosphodiesterase （CNP）/myelin basic protein （MBP）/the precursor form of nerve growth factor （proNGF）/p75/inducible nitric oxide synthase （iNOS） proteins in cerebral cortex of EAE were detected by Western blotting. Results The combined treatment group had a lower clinical score （0.61±0.06） and demyelinating score （1.33±0.33） than the groups with normal saline （clinical score： 1.39±0.08, P 〈0.001; demyelinating score： 2.75±0.49, P 〈0.05） or monotheraphies. Compared with the saline treated EAE group, UTI combined methylprednisolone significantly increased expressions of CNP （1.14±0.06 vs. 0.65±0.04, P 〈0.001）, MBP （1.28±0.14 vs. 0.44±0.17, P 〈0.001）, and decreased expressions of proNGF （1.08±0.10 vs. 2.32±0.12, P 〈0.001）, p75 （1.13±0.13 vs. 2.33±0.17, P 〈0.001）, and iNOS （1.05±0.31 vs. 2.17±0.13, P 〈0.001） proteins in EAE. Furthermore, UTI combined methylprednisolone could significantly upregulate MBP （1.28±0.14 vs. 1.01±0.15, P 〈0.05） expression and downregulate iNOS （1.05±0.31 vs. 1.35±0.14, P 〈0.05） expression compared to methylprednisolone treatment EAE group. And proNGF expression was significantly lower in combined treatment （1.08±0.10） than that in UTI （1.51±0.24, P 〈0.05） or methylprednisolone （1.31±0.04, P 〈0.05） trea

关键词： ulinastatin methylprednisolone combined therapy experimental autoimmune encephalomyelitis neuroprotection

Copper-catalyzed C(sp)-H aryl amination enables modular synthesis of quinolines and 2-quinolinones

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Science China Chemistry 2024年第2期67卷 595-603页

作者： Yang Gao Haixia li Simin Yang Yanping Huo Qian Chen Xianwei li Zhe Wang xiao-qiang Hu School of Chemical Engineering and light Industry Guangdong University of TechnologyGuangzhou510006China Jieyang Branch of Chemistry and Chemical Engineering Guangdong Laboratory Jieyang515200China Key Laboratory of Catalysis and Energy Materials Chemistry of Ministry of Education&Hubei Key Laboratory of Catalysis and Materials Science School of Chemistry and Materials ScienceSouth-Central University for NationalitiesWuhan430074China

Herein,we disclose a novel copper-catalyzed C(sp)-H aryl amination of terminal alkynes with anthranils,enabling the rapid generation of highly reactive secondary N-aryl ynamines for the modular synthesis of structurally diverse C2-substituted quinolines and *** in-situ formed carbonyl-ynamines are prone to tautomerize to carbonyl-ketenimines,which can efficiently react with a series of nucleophiles,including amines,alcohols,phenols,thiols,thiophenols,active-methylene compounds,and even water to produce various quinoline derivatives with the generation of H_(2)O as a sole and green *** method also unlocks a practical route to create various quinoline-fused heterocycles and can be successfully applied to the late-stage modification of complex molecules and the concise synthesis of bioactive *** studies reveal a coppercatalyzed inner-sphere nitrene transfer process by using anthranils as novel aryl nitrene precursors.

关键词： copper catalysis anthranils C(sp)-H aryl amination carbonyl-ketenimines quinolines

Achieving high carrier mobility and low lattice thermal conductivity in GeTe-based alloys by cationic/anionic co-doping

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Rare Metals 2024年第6期43卷 2784-2795页

作者： xiao-qiang Wang xiao-Quan Hu Jun-Yan lin Chu-Bin li xiao-Tong Yu Qi-Yong Chen li-li Xi Qi-Shuo Yang Han li Ji-Ye Zhang Shuan-Kui li Kai Guo School of Physics and Materials Science Guangzhou UniversityGuangzhou 510006China Research Center for Advanced Information Materials(CAIM) Huangpu Research&Graduate School of Guangzhou UniversitySino-Singapore Guangzhou Knowledge CityGuangzhou510555China School of Materials Science and Engineering Shanghai UniversityShanghai 200444China Materials Genome Institute Shanghai UniversityShanghai 200444China School of Mechanical and Mining Engineering University of QueenslandBrisbaneQLD 4072Australia Key Laboratory of Si-Based Information Materials&Devices and Integrated Circuits Design Department of Education of Guangdong ProvinceGuangzhou 510006China

TheⅣ-Ⅵcompound GeTe is considered as a promising alternative to the toxic PbTe for high-efficiency mid-temperature thermoelectric ***,pristine GeTe suffers from a high concentration of Ge vacancies,resulting in an excessively high hole concentration(>1×10^(21)cm^(-3)),which greatly limits its thermoelectric *** address this issue,CuBiTe_(2)alloying is introduced to increase the formation energy of Ge vacancies in GeTe,thereby inhibiting the high carrier *** carrier scattering caused by the electronegativity difference between different elements is suppressed due to the similar electronegativity of Cu and Ge atoms.A relatively high hole mobility is obtained,which ultimately leads to a high power ***,by introducing Se as an alloying element at the anionic site in GeTe,dense point defects with mass/strainfield fluctuations are *** contributes to the strengthening of phonon scattering,thereby reducing the lattice thermal conductivity from 1.44 W·m^(-1)·K^(-1)for pristine GeTe to 0.28 W·m^(-1)·K^(-1)for Ge_(0.95)Cu_(0.05)Bi_(0.05)Te_(0.9)Se_(0.15)compound at 623 K.

关键词： GeTe Carrier mobility CuBiTe_(2)alloying Lattice thermal conductivity Thermoelectric properties

Pathological diagnosis and immunohistochemical analysis of minute pulmonary meningothelial-like nodules:A case report

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World Journal of Clinical Cases 2023年第33期11卷 8022-8029页

作者： Xin Ruan liu-Sheng Wu Zheng-Yang Fan Qi liu Jun Yan xiao-qiang li Department of Thoracic Surgery Peking University Shenzhen HospitalShenzhen 518036Guangdong ProvinceChina School of Medicine Shantou UniversityShantou 515041Guangdong ProvinceChina School of Medicine Tsinghua UniversityBeijing 100084China Department of Graduate School Xinjiang Medical UniversityUrumchi 830011Xinjiang Uygur Autonomous RegionChina

BACKGROUND Minute Pulmonary Meningothelial-like Nodules(MPMNs)are rare benign pulmonary nodules,which are more common in elderly women and have a higher detection rate in lung tissues of patients with lung malignant *** origin is not yet *** present,there are few reports on the diagnostic methods such as imaging and pathological manifestations of *** article reports a 70-year-old female patient with pulmonary adenocarcinoma combined with MPMNs and reviews of the relevant *** SUMMARY A 70-year-old women was admitted to our institution with feeling sour in her back and occasional cough for more than 2 *** electronic scanning scan and 3D reconstruction images in our institution showed there were multiple ground-glass nodules in both of her two *** biggest one was in the apicoposterior segment of left upper lobe,about 2.5 mm×9 mm in *** performed thoracoscopic resection of the left upper lung apicoposterior segment of the patient,and the final pathological report was minimally invasive ***-examination of high resolution computed tomography 21 mo after surgery showed multiple ground-glass nodules in both lungs,and a new groundglass nodule was found in the superior segment of the right lower *** took pathological biopsy of the right upper lung and right lower lung nodules for the patient under *** histomorphology of the right lower lobe nodule showed multiple lesions in the lung tissue,and the small foci in the alveolar septum were distributed in mild form of the aggregation of short spindle *** immunohistochemistry showed that the lesion was epithelial membrane antigen(EMA)(+),somatostatin receptor 2a(SSTR2a)(+),S-100(-),chromogranin A(-),Syn(-),cytokeratin(-)and HMB-45(-).The final diagnosis was minimally invasive adenocarcinoma,accompanied by *** recommend that patients continue to receive treatment after surgery and to do regular follow-up *** The imagi

关键词： Lung Pathology Immunohistochemistry Multiple pulmonary nodules Minute pulmonary meningothelial-like nodules Case report

Prospective Randomized Study of Sarpogrelate Versus Clopidogrel-based Dual Antiplatelet Therapies in Patients Undergoing Femoropopliteal Arterial Endovascular Interventions： Preliminary Results

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Chinese Medical Journal 2015年第12期128卷 1563-1566页

作者： Yue-Xin Chen Wen-Da Wang xiao-Jun Song Yong-Quan Gu Hong-Yan Tian He-Jie Hu Ji-Chun Zhao xiao-qiang li Chang-Wei liu Department of Vascular Surgery Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100068 China Department of Vascular Surgery Peking XuanWu Hospital Beijing 100053 China Department of Vascular Surgery The First Affiliated Hospital of Xi'an Jiaotong University Xi'an Shaanxi 710061 China Department of Vascular Surgery Anhui Provincial Hospital Hefei Anhui 230001 China Department of Vascular Surgery West China Hospital Chengdu Sichuan 510100 China Department of Vascular Surgery The Second Affiliated Hospital of Soochow University Suzhou Jiangsu 215006 China

Background：Sarpogrelate is a selective 5-hydroxytryptamine （5-HT） receptor subtype 2A antagonist which blocks 5-HT induced platelet aggregation and proliferation of vascular smooth muscle *** compared the efficacy of sarpogrelate-based dual antiplatelet therapies for the prevention of restenosis and target lesion revascularization （TLR） rates comparing with that of clopidogrel after percutaneous endovascular interventions （EVIs） of femoropopliteal （FP） arterial ***：This prospective,multicenter,randomized clinical trial recruited a total of 120 patients with successful EVI of FP lesions at seven centers across China between January 2011 and June *** were randomized to receive either sarpogrelate （100 mg trice daily for 6 months,n =63） or clopidogrel （75 mg once daily for 6 months,n =57）.All patients also received oral aspirin （100 mg once daily for 12 months）.Clinical follow-up was conducted up to 12 months ***：There was no significant difference between the two groups in basic demographic *** restenosis rate was higher in the clopidogrel group （22.80%） than in sarpogrelate group （17.50%）,but there was no significant difference between these two groups （P =0.465）.The TLR rate,ipsilateral amputation rate,mortality in all-cause and bleeding rate were also similar in the two groups （P 〉 0.05）.Conclusions：Aspirin plus sarpogrelate is a comparable antithrombotic regimen to aspirin plus clopidogrel after EVI of FP arterial *** antiplatelet therapies might play an important role in preventing restenosis after successful EVI of FP lesions.

关键词： Clopidogrel Femoropopliteal Artery Percutaneous Endovascular Interventions Restenosis Sarpogrelate

Construction of the tissue engineering seed cells(HaCaT-EGF) and analysis of its biological characteristics

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Asian Pacific Journal of Tropical Medicine 2013年第11期6卷 893-896页

作者： Ke Tao xiao-Zhi Bai Zhan-Feng Zhang Ji-Hong Shi xiao-qiang li Chao-Wu Tang Da-Hai Hu Jun-Tao Han Burn Center of PLA Xijing Hospitalthe Fourth Military Medical University

Objective:To construct the tissue engineering seed cell(HaCaT cell line) with stable expression of the human epidermal growth factor(EGF),and analyze the changes of its biological ***:PCDNA3.1-EGF eukaryotic expression vector was transferred into HaCaT cell,and G418 was utilized to select the HaCaT-EGF cell *** an inverted microscope,PCR,EliSA method to detect the changes of the cell morphology,the expression of the ECF gene and protein,and the mRNA expression levels of apoptosis related molecule Caspase-3,the cell cycle related protein cyclin ***:The mRNA expression levels of the obtained HaCaT-ECF cell were more than 100 times higher than the level of ordinary HaCaT *** colony of the HaCaT-EGF cells was more focused and tight compared to the empty vector transfected HaCaT cells and normal HaCaT *** expression levels of apoptotic factor Caspase-3 and cyclin Dt in HaCaT-EGF cell were significantly higher than those in the empty vector HaCaT- pcDNA3.1 cell,and the differences were statistically significant(P0.05).Conclusions: HaCaT-EGF cell can continuously secrete ECF,and the biological characteristic is *** can be used for tissue engineering experiment and is an ideal seed cell for constructing tissue engineered skin.

关键词： Tissue engineering HaCaT Gene transfection Biological characteristics

Neuroprotective Effect and Mechanism of Tanreqing Injection on Ischemic Stroke:Insights from Network Pharmacology and in vivo Experiments

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Chinese Journal of Integrative Medicine 2024年第8期30卷 713-720页

作者： li Zhong-hao PU xiao-qi li Sha-sha DONG xiao-ke ZHANG Guo-qiang WANG Yu liU Jin-min Department of Emergency China-Japan Friendship HospitalBeijing100029China Department of Neurology Beijing University of Chinese Medicine Dongfang HospitalBeijing100078China Department of Radiology China-Japan Friendship HospitalBeijing100029China Graduate School Beijing University of Chinese MedicineBeijing100029China

Objective To explore the neuroprotective effects and mechanism of Tanreqing Injection(TRQ)on treating ischemic stroke based on network pharmacology and in vivo experimental *** The chemical compounds of TRQ were retrieved based on published data,with targets retrieved from PubChem,Therapeutic Target Database and *** visualization and analysis were performed using Cytoscape,with protein-protein interaction networks derived from the STRING *** analysis was performed using Kyoto Encyclopedia of Genes Genomes pathway and Gene Ontology *** in vivo experiments,the middle cerebral artery occlusion(MCAO)model was *** volume was determined by 2,3,5-triphenyltetrazolium hydrochloride staining and protein expressions were analyzed by Western *** docking was performed to predict ligand-receptor *** We screened 81 chemical compounds in TRQ and retrieved their therapeutic *** the targets,116 were therapeutic targets for *** enrichment analysis showed that the apelin signaling pathway was a key pathway for ischemic ***,in in vivo experiment we found that administering with intraperitoneal injection of 2.5 mL/kg TRQ every 6 h could significantly reduce the infarct volume of MCAO rats(Plin receptor(APJ)/phosphatidylinositol 3-kinase(PI3K)/protein kinase B(AKT)pathway were increased by TRQ(Pling ***,further studies are needed to confirm the findings.

关键词： Tanreqing Injection Chinese medicine ischemic stroke middle cerebral artery occlusion quantitative estimate of drug-likeness

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基于深度学习的禽流感病毒溢出风险预测研究

广州大学学报（自然科学版） 2024年第2期23卷 48-56页

作者：刘耀华范馨月徐雪健王娜寇铮强小利广州大学计算科技研究院广东广州510006 广州大学计算机科学与网络工程学院广东广州510006

禽流感病毒基因组由8个长短不一的基因节段组成,全长约为14~16 kb。由于病毒本身特殊的分子遗传机制,病毒通过基因点突变和基因组重排快速变异,引发病毒感染宿主范围的改变,持续威胁人类健康,因此,自然界禽流感病毒溢出风险预测具有重... 详细信息

禽流感病毒基因组由8个长短不一的基因节段组成,全长约为14~16 kb。由于病毒本身特殊的分子遗传机制,病毒通过基因点突变和基因组重排快速变异,引发病毒感染宿主范围的改变,持续威胁人类健康,因此,自然界禽流感病毒溢出风险预测具有重要公共卫生意义。文章联合使用卷积神经网络和循环神经网络表征病毒基因组序列,分别在特定类群数据集和全类群数据集上进行训练和测试,并对模型的迁移预测能力进行评估。实验结果显示:①特定类群模型对各自数据集的预测性能良好,AUROC值和AUPR值分别达到0.966和0.876以上,但泛化能力较差;②除H9N2类群外,全局模型性能良好,AUROC值和AUPR值均达到1.000;③基于消融实验,发现注意力机制和Embedding层对模型性能影响较大;④进一步测试模型的泛化能力,迁移预测的AUROC值和AUPR值分别可达0.984和0.941以上;⑤可视化注意力权重系数矩阵,为模型提供生物学可解释性。性能良好的深度学习预测模型可用于禽流感病毒跨种感染的早期预警。

关键词：禽流感病毒深度学习溢出风险基因组

Embeddings Among Quantum Affine sl_(n)

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Acta Mathematica Sinica,English Series 2024年第3期40卷 792-805页

作者： Yi qiang li Department of Mathematics University at BuffaloThe State University of New YorkBuffaloNY 14260USA

We establish an explicit embedding of a quantum affine sl_(n) into a quantum affine sl_(n)+*** embedding serves as a common generalization of two natural,but seemingly unrelated,embed-dings,one on the quantum affine Schur algebra level and the other on the non-quantum *** embedding on the quantum affine Schur algebras is used extensively in the analysis of canonical bases of quantum affine sln and gl_(n).The embedding on the non-quantum level is used crucially in a work of Riche and Williamson on the study of modular representation theory of general linear groups over a finite *** same embedding is also used in a work of Maksimau on the categorical representations of affine general linear *** further provide a more natural compatibility statement of the em-bedding on the idempotent version with that on the quantum affine Schur algebra level.A gl_(n)-variant of the embedding is also established.

关键词： Quantum affine sl_(n) embeddings