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中药缓解原发性肝癌患者经动脉栓塞化疗术后副作用的系统综述和meta分析

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中西医结合学报 2012年第12期10卷 1341-1362页

作者：李霄茜凌昌全第二军医大学长海医院中医科上海200433

背景:原发性肝癌是临床上最常见的恶性肿瘤之一。以经动脉栓塞化疗(transarterial chemo-embolization,TACE)为代表的局部治疗是肝癌治疗中的中流砥柱。与系统性全身化疗相比,TACE的副作用较小,大部分副作用由栓塞后综合征引起,如恶心... 详细信息

背景:原发性肝癌是临床上最常见的恶性肿瘤之一。以经动脉栓塞化疗(transarterial chemo-embolization,TACE)为代表的局部治疗是肝癌治疗中的中流砥柱。与系统性全身化疗相比,TACE的副作用较小,大部分副作用由栓塞后综合征引起,如恶心呕吐、腹痛、发热、食欲减退等。目的:系统评价中草药对原发性肝癌病人TACE治疗所引起的不良反应和毒副作用的疗效,并进行meta分析。检索策略:外文数据库检索Cochrane肝胆组对照试验注册库、Cochrane图书馆对照试验注册中心、MEDliNE(OvidSP)、EMBASE(OvidSP)、Science Citation Index Expanded。中文数据库检索中国知网数据库、重庆维普中文科技期刊数据库和万方数据库。纳入标准:纳入研究中草药对原发性肝癌病人TACE术后所引起的不良反应和毒副作用疗效的随机对照试验,无论其是否使用盲法,不限定语言和发表形式。资料提取与分析:根据Cochrane系统评价员手册中的衡量偏倚风险的标准等方法对纳入的研究进行偏倚风险评估。使用Review Manager5.1统计学软件对数据进行整合。二分类结局指标表示为风险比及95%可信区间(confidence interval,CI),连续型结局指标表示为均数差和95%CI。如果没有明显的异质性存在,则报告使用固定效应模型的分析结果;如果存在异质性,则只使用随机效应模型报告分析结果;如果异质性十分明显,则对这些试验只进行描述性定性分析。对于异质性很高无法进行meta分析的结局指标,进一步进行异质性分析以确定异质性产生的原因。结果:通过对电子检索和手工检索获得的文献进行筛选,共纳入研究47篇,其中中文46篇,英文1篇;期刊文章43篇,学位论文4篇;所有作者全部来自中国大陆,所有研究均在中国大陆进行。对纳入的研究进行偏倚风险评估,大部分的研究存在各种不确定的偏倚风险或较高的偏倚风险,研究质量较低。对干预措施(中草药)的治疗效应进行系统评价和meta分析,提示中草药在提高患者1年生存率,提高患者生活质量,减少TACE各种副作用如恶心呕吐、发热、肝区疼痛、骨髓抑制等,改善肝功能各项指标,改善免疫学指标,以及提高瘤体客观疗效方面均有积极意义。然而,很多指标由于在所纳入的研究的报告中存在明显的异质性,只能进行描述性分析。异质性分析显示,产生异质性的原因主要是各研究的治疗方案、中药方剂的组成和剂型、给药时间、疗程等方面存在明显差异。结论:中药配合TACE治疗肝癌患者对于提高患者生存期,提高患者生活质量,缓解TACE术中及术后的副作用有一定疗效。然而,由于纳入本研究的文献质量普遍偏低,且各研究之间存在较大的异质性,所以很多指标未能进行meta分析。

关键词：肝肿瘤中草药栓塞治疗性副作用随机对照试验 meta分析

Epigenetic regulation of the inflammatory response in stroke

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Neural Regeneration Research 2025年第11期20卷 3045-3062页

作者： Jingyi liang Fei Yang Zixiao li qian li School of Basic Medical Sciences Capital Medical UniversityBeijingChina Department of Neurobiology School of Basic Medical SciencesCapital Medical UniversityBeijingChina Laboratory for Clinical Medicine Beijing Key Laboratory of Neural Regeneration and RepairCapital Medical UniversityBeijingChina Department of Neurology Beijing Tiantan HospitalCapital Medical UniversityBeijingChina China National Clinical Research Center for Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina National Center for Healthcare Quality Management in Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Chinese Institute for Brain Research BeijingChina Research Unit of Artificial Intelligence in Cerebrovascular Disease Chinese Academy of Medical SciencesBeijingChina Beijing Engineering Research Center of Digital Healthcare for Neurological Diseases BeijingChina Department of Biochemistry and Molecular Biology School of Basic Medical SciencesCapital Medical UniversityBeijingChina Beijing Key Laboratory of Cancer Invasion and Metastasis Research Capital Medical UniversityBeijingChina

Stroke is classified as ischemic or hemorrhagic,and there are few effective treatments for either *** mechanisms play a critical role in secondary brain injury following a stroke,which manifests as cytokine release,blood–brain barrier disruption,neuronal cell death,and ultimately behavioral *** the inflammatory response has been shown to mitigate this cascade of events in experimental stroke ***,in clinical trials of anti-inflammatory agents,longterm immunosuppression has not demonstrated significant clinical benefits for *** may be attributable to the dichotomous roles of inflammation in both tissue injury and repair,as well as the complex pathophysiologic inflammatory processes in *** acute harmful inflammatory responses or inducing a phenotypic shift from a pro-inflammatory to an anti-inflammatory state at specific time points after a stroke are alternative and promising therapeutic *** agents that can modulate inflammation requires a detailed understanding of the inflammatory processes of ***,epigenetic reprogramming plays a crucial role in modulating post-stroke inflammation and can potentially be exploited for stroke *** this review,we summarize current findings on the epigenetic regulation of the inflammatory response in stroke,focusing on key signaling pathways including nuclear factor-kappa B,Janus kinase/signal transducer and activator of transcription,and mitogen-activated protein kinase as well as inflammasome *** also discuss promising molecular targets for stroke *** evidence to date indicates that therapeutic targeting of the epigenetic regulation of inflammation can shift the balance from inflammation-induced tissue injury to repair following stroke,leading to improved post-stroke outcomes.

关键词： DNA methylation histone modification intracerebral hemorrhage ischemic stroke neuroinflammation neuroprotection non-coding RNA RNA methylation subarachnoid hemorrhage treatment

Simplified pulmonary embolism severity index is associated with recurrent venous thromboembolism in patients with pulmonary embolism

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Chinese Medical Journal 2021年第3期134卷 359-361页

作者： Jia-Rui Zhang Chen Zhou Hai-Xia Zhou xiao-qian li Yue-Hong Hu Mao-Yun Wang Yong-Jiang Tang Qun Yi Department of Respiratory and Critical Care Medicine West China HospitalSichuan UniversityChengduSichuan 610041China West China School of Medicine Sichuan UniversityChengduSichuan 610041China

Pulmonary embolism(PE)patients have a high recurrence rate of venous thromboembolism(VTE)and recurrences are more often *** can be effectively prevented by prolonged anticoagulation treatment,but the risk of bleeding also ***,risk assessment of VTE recurrence is important in PE patients,as high-risk patients will benefit from long-term anticoagulation treatment,whereas low-risk patients will unnecessarily be exposed to an increased bleeding *** risk factors for VTE recurrence have been identified in non-Asian populations,including male gender,advanced age,thrombophilia,obesity,persistent elevation of D-dimer one month after discontinuation of anticoagulation and residual ***,risk factors for VTE recurrence have not been clearly evaluated in Chinese and Asian populations.A recent study found that the European Society of Cardiology(ESC)risk stratification for PE patients(2008 version),which is used to assess the disease severity of acute PE patients,was associated with VTE recurrence.[1]The simplified pulmonary embolism severity index(sPESI)is also widely validated for the assessment of disease severity of PE,has good prognostic value for early and even long-term *** is less clear whether the model predicts VTE *** aim of this prospective study was to investigate the short-term and long-term incidence of recurrent VTE after a first episode of acute PE and associated risk factors of recurrent *** association between VTE recurrence and disease severity assessed by sPESI was also evaluated.

关键词： patients severity embolism

Synergistically enhanced ORR and HER performance on Co-N-C coupled in-situ generated PtCo intermetallic

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Journal of Energy Chemistry 2025年第1期100卷 721-729页

作者： Guanyu Luo Min Song Lulu An xiao Huang qian Zhang Chenhao Zhang Tao Shen Shuang Wang Deli Wang Key Laboratory of Material Chemistry for Energy Conversion and Storage (Huazhong University of Science and Technology) Ministry of Education School of Chemistry and Chemical Engineering Huazhong University of Science and Technology

Integrating multi-scale sites in a composite catalyst is vital to realize efficient ***,a synergistic composite catalyst consisting of Co atomic sites and in-situ generated PtCo intermetallic compounds （IMCs）(o-PtCo@CoNC) is proposed through Co pre-anchoring and subsequent impregnation-reduction *** loading of Co atoms provides a chance for in-situ generating PtCo ordered intermetallic *** remaining Co single atoms and PtCo IMCs construct synergistic electrocatalytic *** from the ordered structure,synergistic effect of Pt Co IMCs and Co single atoms,o-PtCo@CoNC exhibits excellent electrocatalytic performance for oxygen reduction reaction （ORR） and hydrogen evolution reaction （HER） with mass activity of 1.21 A mgPt-1（at 0.9 V） and5.70 A mgPt-1（at an overpotential of 100 mV）,***,o-PtCo@CoNC delivers negligible loss of half-wave potential and overpotential during long-term stability test in acid solutions,with 13 mV decay after 50,000 potential cycles for ORR and a 2.7 mV decay after 20,000 potential cycles for *** integration strategy of single-atomic sites coupled IMCs paves the way for enhancing the activity and durability of Pt-based electrocatalysts.

关键词： Electrolytic reduction

Catalyst–Support Interaction in Polyaniline‑Supported Ni_(3)Fe Oxide to Boost Oxygen Evolution Activities for Rechargeable Zn‑Air Batteries

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Nano-Micro Letters 2025年第1期17卷 176-190页

作者： xiaohong Zou qian Lu Mingcong Tang Jie Wu Kouer Zhang Wenzhi li Yunxia Hu xiaomin Xu xiao Zhang Zongping Shao liang An Department of Mechanical Engineering The Hong Kong Polytechnic UniversityHung HomKowloonHong Kong SARPeople’s Republic of China Jiangsu Key Laboratory of Atmospheric Environment Monitoring and Pollution Control Jiangsu Collaborative Innovation Center of Atmospheric Environment and Equipment TechnologySchool of Environmental Science and TechnologyNanjing University of Information Science and TechnologyNanjing 210044People’s Republic of China Department of Chemistry The Chinese University of Hong KongMa Lin BuildingShatinHong Kong SAR 999077People’s Republic of China WA School of Mines:Minerals Energy and Chemical Engineering(WASM‑MECE)Curtin UniversityPerthWA 6102Australia Research Institute for Advanced Manufacturing The Hong Kong Polytechnic UniversityHung HomKowloonHong Kong SARPeople’s Republic of China Research Institute for Smart Energy The Hong Kong Polytechnic UniversityHung HomKowloonHong Kong SARPeople’s Republic of China

Catalyst–support interaction plays a crucial role in improving the catalytic activity of oxygen evolution reaction(OER).Here we modulate the catalyst–support interaction in polyaniline-supported Ni_(3)Fe oxide(Ni_(3)Fe oxide/PANI)with a robust hetero-interface,which significantly improves oxygen evolution activities with an overpotential of 270 mV at 10 mA cm^(-2)and specific activity of 2.08 mA cm_(ECSA)^(-2)at overpotential of 300 mV,3.84-fold that of Ni_(3)Fe *** is revealed that the catalyst–support interaction between Ni_(3)Fe oxide and PANI support enhances the Ni–O covalency via the interfacial Ni–N bond,thus promoting the charge and mass transfer on Ni_(3)Fe *** the excellent activity and stability,rechargeable Zn-air batteries with optimum Ni_(3)Fe oxide/PANI are assembled,delivering a low charge voltage of 1.95 V to cycle for 400 h at 10 mA cm^(-2).The regulation of the effect of catalyst–support interaction on catalytic activity provides new possibilities for the future design of highly efficient OER catalysts.

关键词： Catalyst-support interaction Supported catalysts Heterointerface Oxygen evolution reaction Zn-air batteries

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竖向载荷作用下单桩接触面性能分析

辽宁工程技术大学学报（自然科学版） 2007年第1期26卷 59-61页

作者：钱晓丽陶龙光刘波黑龙江科技学院建筑工程学院黑龙江哈尔滨150027 中国矿业大学力学与建筑工程学院北京100083

在桩与土界面处设置Goodman接触单元来模拟桩与土的滑移变形和开裂,建立了单桩在竖向载荷作用下接触面应力和位移的关系公式。用三维有限元的方法,考虑了土体的非线性(Drucker-Prager模型)力学性能,对模型桩进行了模拟计算分析,详细讨... 详细信息

在桩与土界面处设置Goodman接触单元来模拟桩与土的滑移变形和开裂,建立了单桩在竖向载荷作用下接触面应力和位移的关系公式。用三维有限元的方法,考虑了土体的非线性(Drucker-Prager模型)力学性能,对模型桩进行了模拟计算分析,详细讨论了双曲线接触面本构关系的初始切向、法向刚度对桩顶位移及地表沉降的影响。对理论分析桩的载荷沉降提供了一种有益的参考。

关键词： Goodman 接触面单元非线性切向刚度法向刚度

Overview of in-situ oxygen production technologies for lunar resources

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 233-255页

作者： Youpeng Xu Sheng Pang liangwei Cong Guoyu qian Dong Wang Laishi li Yusheng Wu Zhi Wang College of Materials Science and Engineering Shenyang University of TechnologyShenyang 110870China CAS Key Laboratory of Green Process and Engineering National Engineering Research Center for Green Recycling of Strategic Metal ResourcesInstitute of Process EngineeringChinese Academy of SciencesBeijing 100190China Innovation Academy for Green Manufacture Chinese Academy of SciencesBeijing 100190China School of Chemical Engineering University of Chinese Academy of SciencesBeijing 100049China

The rich resources and unique environment of the Moon make it an ideal location for human expansion and the utilization of extraterrestrial ***,crucial for supporting human life on the Moon,can be extracted from lunar regolith,which is highly rich in oxygen and contains polymetallic *** oxygen and metal extraction can be achieved using existing metallurgical ***,the ample reserves of water ice on the Moon offer another means for oxygen *** paper offers a detailed overview of the leading technologies for achieving oxygen production on the Moon,drawing from an analysis of lunar resources and environmental *** delves into the principles,processes,advantages,and drawbacks of water-ice electrolysis,two-step oxygen production from lunar regolith,and one-step oxygen production from lunar *** two-step methods involve hydrogen reduction,carbothermal reduction,and hydrometallurgy,while the one-step methods encompass fluorination/chlorination,high-temperature decomposition,molten salt electrolysis,and molten regolith electrolysis(MOE).Following a thorough comparison of raw materials,equipment,technology,and economic viability,MOE is identified as the most promising approach for future in-situ oxygen production on the *** the corrosion characteristics of molten lunar regolith at high temperatures,along with the Moon's low-gravity environment,the development of inexpensive and stable inert anodes and electrolysis devices that can easily collect oxygen is critical for promoting MOE technology on the *** review significantly contributes to our understanding of in-situ oxygen production technologies on the Moon and supports upcoming lunar exploration initiatives.

关键词： lunar resources in-situ oxygen production space metallurgy molten lunar regolith electrolysis

Increased excitatory amino acid transporter 2 levels in basolateral amygdala astrocytes mediate chronic stress–induced anxiety-like behavior

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Neural Regeneration Research 2025年第6期20卷 1721-1734页

作者： Xirong Xu Shoumin Xuan Shuai Chen Dan liu qian xiao Jie Tu Shenzhen Key Laboratory of Neuroimmunomodulation for Neurological Diseases Shenzhen-Hong Kong Institute of Brain ScienceShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong ProvinceChina CAS Key Laboratory of Brain Connectome and Manipulation Brain Cognition and Brain Disease Institute(BCBDI)Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong ProvinceChina Guangdong Provincial Key Laboratory of Brain Connectome and Behavior the Brain Cognition and Brain Disease Institute(BCBDI)Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong ProvinceChina University of Chinese of Academy of Sciences BeijingChina Faculty of life and Health Sciences Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong ProvinceChina

The conventional perception of astrocytes as mere supportive cells within the brain has recently been called into question by empirical evidence, which has revealed their active involvement in regulating brain function and encoding behaviors associated with ***, astrocytes in the basolateral amygdala have been found to play a role in the modulation of anxiety-like behaviors triggered by chronic stress. Nevertheless, the precise molecular mechanisms by which basolateral amygdala astrocytes regulate chronic stress–induced anxiety-like behaviors remain to be fully elucidated. In this study, we found that in a mouse model of anxiety triggered by unpredictable chronic mild stress, the expression of excitatory amino acid transporter 2 was upregulated in the basolateral amygdala. Interestingly, our findings indicate that the targeted knockdown of excitatory amino acid transporter 2 specifically within the basolateral amygdala astrocytes was able to rescue the anxiety-like behavior in mice subjected to stress. Furthermore, we found that the overexpression of excitatory amino acid transporter 2 in the basolateral amygdala, whether achieved through intracranial administration of excitatory amino acid transporter 2agonists or through injection of excitatory amino acid transporter 2-overexpressing viruses with GfaABC1D promoters, evoked anxiety-like behavior in mice. Our single-nucleus RNA sequencing analysis further confirmed that chronic stress induced an upregulation of excitatory amino acid transporter 2 specifically in astrocytes in the basolateral amygdala. Moreover, through in vivo calcium signal recordings, we found that the frequency of calcium activity in the basolateral amygdala of mice subjected to chronic stress was higher compared with normal *** knocking down the expression of excitatory amino acid transporter 2 in the basolateral amygdala, the frequency of calcium activity was not significantly increased, and anxiety-like behavior was ob

关键词： anxiety astrocytes basolateral amygdala behavior dihydrokainic acid excitatory amino acid transporter 2 fiber photometry glutamate LDN-212320 transporter

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《乞力马扎罗山的雪》的生态批评解读

河北联合大学学报（社会科学版） 2013年第6期13卷 214-216页

作者：钱小丽六盘水师范学院外国语言文学系贵州六盘水553001

厄内斯特·海明威是"迷惘的一代"作家的主要人物,其作品《乞力马扎罗山的雪》被普遍认为是其短篇小说中的上乘佳作。在小说中,海明威通过运用意识流手法生动地描写了战后人们的精神生态状况。从生态批评的角度对该短篇小说进行解读,探... 详细信息

厄内斯特·海明威是"迷惘的一代"作家的主要人物,其作品《乞力马扎罗山的雪》被普遍认为是其短篇小说中的上乘佳作。在小说中,海明威通过运用意识流手法生动地描写了战后人们的精神生态状况。从生态批评的角度对该短篇小说进行解读,探讨文本中所蕴含的自然生态、社会生态和精神生态观,并阐释其中所隐含的丰富的生态主义思想及作者在生态问题上的思想冲突和内心困惑。

关键词：《乞力马扎罗山的雪》生态批评自然生态社会生态精神生态