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Integration of perioperative features and intragraft TCF7L2 expression to predict lipid metabolic disorder in liver transplant recipients

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Science China Life Sciences 2025年第1期 297-299页

作者： Junbin Zhou Rongli Wei Guanghan Fan Zhengxing Lian Xuanyu Zhang linsong Tang Zhetuo qi Haiyang Xie Shusen Zheng qiang Wei xiao Xu Department of Hepatobiliary and Pancreatic Surgery People's Hospital of LishuiAffiliated Lishui Hospital of Wenzhou Medical UniversityThe First Affiliated Hospital of Lishui University NHFPC Key Laboratory of Combined Multi-Organ Transplantation Key Laboratory of Integrated Oncology and Intelligent Medicine of Zhejiang Province Department of Hepatobiliary and Pancreatic SurgeryHangzhou First People's Hospital Department of Hepatobiliary and Pancreatic Surgery The First Affiliated HospitalZhejiang University School of Medicine Department of Urology The Second Affiliated HospitalZhejiang University School of Medicine Department of Hepatobiliary and Pancreatic Surgery Department of Liver TransplantationShulan (Hangzhou) Hospital Hangzhou Medical College Zhejiang University School of Medicine

Dear Editor, Liver transplantation(LT) is the only curative therapy for patients with endstage liver disease(He et al., 2023; ling et al., 2022). Post-transplant hypertriglyceridemia(PTHT), which has an incidence of up to 32.8% in 6 months after LT, is one of the major post-transplant complications(Toshima et al., 2020).

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我国中西部三省(自治区)贫困边远地区农村基层医疗机构处方医生对基本药物制度的知信行调查

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中国卫生资源 2017年第6期20卷 495-498页

作者：肖琳琪王文杰李琛方欣张欲晓崔丹傅昌毛宗福武汉大学健康学院湖北武汉430071

目的 :了解我国中西部贫困边远地区农村基层医疗机构处方医生对基本药物制度的知识、态度、行为以及基本药物标识的态度。方法 :采用自编的基本药物制度认知知识-态度-行为问卷,经信效度分析,信度系数α=0.907,效度KMO=0.854,问卷的信... 详细信息

目的 :了解我国中西部贫困边远地区农村基层医疗机构处方医生对基本药物制度的知识、态度、行为以及基本药物标识的态度。方法 :采用自编的基本药物制度认知知识-态度-行为问卷,经信效度分析,信度系数α=0.907,效度KMO=0.854,问卷的信效度良好。采用典型抽样法,按乡镇卫生院1∶3、村卫生室1∶30的比例,在湖北、广西、江西抽取73家有代表性的农村基层医疗机构(26家乡镇卫生院、47家村卫生室)。调查处方医生400人,有效问卷370份,有效率92.5%。采用基本药物使用率和添加基本药物标识率等指标进行分析。采用SAS 8.0进行描述性分析,包括均数、标准差和率等。结果 :86.5%的人对基本药物制度有较高认知,约80%的人对基本药物制度持积极态度,92.2%的人开处方时首选基本药物,70.8%的人希望增加基本药物的标识。结论 :贫困边远地区农村基层医疗机构的处方医生对基本药物制度的认知中高,虽普遍支持基本药物制度,但缺乏系统、合理的认知渠道。因此,加强基本药物制度的宣传、增加基本药物的标识对提高处方医生的基本药物制度认知度、促进合理用药有重要意义。

关键词：农村基层医疗机构处方医生基本药物制度知识-态度-行为问卷认知标识合理用药

Sulfolane‑Based Flame‑Retardant Electrolyte for High‑Voltage Sodium‑Ion Batteries

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Nano-Micro Letters 2025年第2期17卷 498-516页

作者： Xuanlong He Jie Peng qingyun lin Meng Li Weibin Chen Pei Liu Tao Huang Zhencheng Huang Yuying Liu Jiaojiao Deng Shenghua Ye Xuming Yang Xiangzhong Ren xiaoping Ouyang Jianhong Liu Biwei xiao Jiangtao Hu qianling Zhang Graphene Composite Research Center College of Chemistry and Environmental EngineeringShenzhen UniversityShenzhen 518060People’s Republic of China Center of Electron Microscopy State Key Laboratory of Silicon and Advanced Semiconductor MaterialsSchool of Materials Science and EngineeringZhejiang UniversityHangzhou 310027People’s Republic of China GRINM(Guangdong)Research Institute for Advanced Materials and Technology FoshanGuangdong 528051People’s Republic of China College of Energy Engineering Zhejiang UniversityHangzhouZhejiang 310027People’s Republic of China School of Materials Science and Engineering Xiangtan UniversityXiangtan 411105People’s Republic of China Shenzhen Eigen-Equation Graphene Technology Co.Ltd Shenzhen 518000People’s Republic of China

Sodium-ion batteries hold great promise as next-generation energy storage ***,the high instability of the electrode/electrolyte interphase during cycling has seriously hindered the development of *** particular,an unstable cathode–electrolyte interphase(CEI)leads to successive electrolyte side reactions,transition metal leaching and rapid capacity decay,which tends to be exacerbated under high-voltage ***,constructing dense and stable CEIs are crucial for high-performance *** work reports localized high-concentration electrolyte by incorporating a highly oxidation-resistant sulfolane solvent with non-solvent diluent 1H,1H,5H-octafluoropentyl-1,1,2,2-tetrafluoroethyl ether,which exhibited excellent oxidative stability and was able to form thin,dense and homogeneous *** excellent CEI enabled the O3-type layered oxide cathode NaNi_(1/3)Mn_(1/3)Fe_(1/3)O_(2)(NaNMF)to achieve stable cycling,with a capacity retention of 79.48%after 300 cycles at 1 C and 81.15%after 400 cycles at 2 C with a high charging voltage of 4.2 *** addition,its nonflammable nature enhances the safety of *** work provides a viable pathway for the application of sulfolane-based electrolytes on SIBs and the design of next-generation high-voltage electrolytes.

关键词： Sodium-ion batteries Sulfolane-based electrolyte High voltage Layered oxide cathode Flame retardant

Single-cell omics: experimental workflow, data analyses and applications

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Science China Life Sciences 2025年第1期68卷 5-102页

作者： Fengying Sun Haoyan Li Dongqing Sun Shaliu Fu Lei Gu Xin Shao qinqin Wang Xin Dong Bin Duan Feiyang Xing Jun Wu Minmin xiao Fangqing Zhao Jing-Dong J.Han qi Liu xiaohui Fan Chen Li Chenfei Wang Tieliu Shi Department of Clinical Laboratory the Affiliated Wuhu Hospital of East China Normal University (The Second People's Hospital of Wuhu City) Pharmaceutical Informatics Institute College of Pharmaceutical SciencesZhejiang University Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration (Tongji University) Ministry of EducationOrthopaedic DepartmentTongji HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Frontier Science Center for Stem Cells School of Life Sciences and TechnologyTongji University Translational Medical Center for Stem Cell Therapy and Institute for Regenerative Medicine Shanghai East HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Research Institute of Intelligent Computing Zhejiang Lab Shanghai Research Institute for Intelligent Autonomous Systems Center for Single-cell Omics School of Public HealthShanghai Jiao Tong University School of Medicine National Key Laboratory of Chinese Medicine Modernization Innovation Center of Yangtze River DeltaZhejiang University Center for Bioinformatics and Computational Biology Shanghai Key Laboratory of Regulatory Biologythe Institute of Biomedical Sciences and School of Life SciencesEast China Normal University Beijing Institutes of Life Science Chinese Academy of Sciences Peking-Tsinghua Center for Life Sciences Academy for Advanced Interdisciplinary StudiesCenter for Quantitative Biology (CQB)Peking University Zhejiang Key Laboratory of Precision Diagnosis and Therapy for Major Gynecological Diseases Women's HospitalZhejiang University School of Medicine Key Laboratory of Advanced Theory and Application in Statistics and Data Science-MOE School of StatisticsEast China Normal University

Cells are the fundamental units of biological systems and exhibit unique development trajectories and molecular features. Our exploration of how the genomes orchestrate the formation and maintenance of each cell, and control the cellular phenotypes of various organismsis, is both captivating and intricate. Since the inception of the first single-cell RNA technology, technologies related to single-cell sequencing have experienced rapid advancements in recent years. These technologies have expanded horizontally to include single-cell genome, epigenome,proteome, and metabolome, while vertically, they have progressed to integrate multiple omics data and incorporate additional information such as spatial sc RNA-seq and CRISPR screening. Single-cell omics represent a groundbreaking advancement in the biomedical field,offering profound insights into the understanding of complex diseases, including cancers. Here, we comprehensively summarize recent advances in single-cell omics technologies, with a specific focus on the methodology section. This overview aims to guide researchers in selecting appropriate methods for single-cell sequencing and related data analysis.

关键词： single-cell sequencing genome epigenome proteomics metabolomics multimodal spatial transcriptomics CRISPR screening

基于健康大数据的军队老干部全维保健模式研究

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医学研究生学报 2020年第8期33卷 855-857页

作者：曹清心朱小蔚陈飞万文辉李莹齐晓林东部战区疾病预防控制中心疾病监测科南京210005 东部战区总医院(原南京军区南京总医院)保健科南京210002 东部战区总医院(原南京军区南京总医院)信息科南京210002 东部战区总医院(原南京军区南京总医院)干部一科南京210002 东部战区总医院(原南京军区南京总医院)医学信息数据室南京210002 东部战区总医院(原南京军区南京总医院)院部南京210002

伴随物联网、云计算、区块链和人工智能等现代信息技术的广泛应用,健康大数据融合多学科关键技术,将有力推动健康事业和健康产业的发展。文章针对军队离退休老干部的现实需求,构建全员、全域、全程、全时服务的综合保健新模式。融合物... 详细信息

伴随物联网、云计算、区块链和人工智能等现代信息技术的广泛应用,健康大数据融合多学科关键技术,将有力推动健康事业和健康产业的发展。文章针对军队离退休老干部的现实需求,构建全员、全域、全程、全时服务的综合保健新模式。融合物联网、云计算、区块链和人工智能等信息科技,加强大数据技术在全维保健模式上的采集挖掘和分析利用。文章构建四种保健模式和相应的运行机制,具有较好的实用性和推广价值,能有效提升基层卫生机构预防、医疗和保健质量水平。

关键词：健康大数据军队老干部保健模式

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混合式教学法在《有机化学》课程中的实践

教育教学论坛 2017年第12期 175-176页

作者：王超强晓琪何霖俐西南科技大学材料科学与工程学院四川绵阳621010 西南科技大学教务处四川绵阳621010

混合式教学法是一种新型教学模式,此模式弥补了传统教学模式的不足,并在其基础上进行了一定的创新和突破,在发挥学生主体地位方面具有一定优势。本文根据学生专业特点,从学习需求、教学设计、评价标准等几个方面初步探讨混合式教学法在... 详细信息

混合式教学法是一种新型教学模式,此模式弥补了传统教学模式的不足,并在其基础上进行了一定的创新和突破,在发挥学生主体地位方面具有一定优势。本文根据学生专业特点,从学习需求、教学设计、评价标准等几个方面初步探讨混合式教学法在《有机化学》课程教学中的实践应用。

关键词：混合式教学法有机化学课程教学

江西省某县基层医疗卫生机构药品集中采购情况分析

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卫生软科学 2018年第8期32卷 26-31页

作者：李琛王文杰肖琳琪殷潇张欲晓崔丹武汉大学健康学院湖北武汉430071

[目的]了解江西省基层医疗卫生机构药品网上集中采购情况,为进一步完善基层医疗卫生机构药品集中采购工作提供参考。[方法]根据药品招采平台数据和访谈结果,利用Excel 2007对江西省某县基层医疗卫生机构药品网上集中采购数据进行统计、... 详细信息

[目的]了解江西省基层医疗卫生机构药品网上集中采购情况,为进一步完善基层医疗卫生机构药品集中采购工作提供参考。[方法]根据药品招采平台数据和访谈结果,利用Excel 2007对江西省某县基层医疗卫生机构药品网上集中采购数据进行统计、分析。[结果]2014-2016年,网上集中采购药品的配送率分别为93.88%、96.64%、84.09%,基本药物采购金额占比分别为99.49%、98.94%、99.15%,基本药物品种占比分别为93.92%、93.64%、94.08%,中成药采购金额占采购药物比分别为64.53%、62.42%、66.46%。基本药物短缺品种占比分别为97.78%、94.55%和100%。[结论]网上集中采购的中成药占比较高;基本药物配备状况良好;基本药物短缺现象需引起重视。

关键词：江西省药品网上集中采购乡镇卫生院采购分析药品短缺

FSD1 inhibits glioblastoma diffuse infiltration through restriction of HDAC6-mediated microtubule deacetylation

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Science China Life Sciences 2025年

作者： Dake xiao Haowen Ran Lishu Chen Yuanyuan Li Yan Cai Songyang Zhang qinghui qi Huiran Wu Cheng Zhang Shuailiang Cao Lanjuan Mi Haohao Huang Ji qi qiuying Han Haiqing Tu Huiyan Li Tao Zhou Fangye Li Ailing Li Jianghong Man Nanhu Laboratory National Center of Biomedical Analysis School of Traditional Chinese Medicine Capital Medical University Department of Neurosurgery General Hospital of Central Theater Command of Chinese PLA School of Life and Health Sciences Huzhou College Department of Neurosurgery Beijing Fengtai Hospital Department of Neurosurgery First Medical Center of PLA General Hospital

The infiltration of glioblastoma multiforme(GBM) is predominantly characterized by diffuse spread, contributing significantly to therapy resistance and recurrence of GBM. In this study, we reveal that microtubule deacetylation, mediated through the downregulation of fibronectin type III and SPRY domain-containing 1(FSD1), plays a pivotal role in promoting GBM diffuse infiltration. FSD1 directly interacts with histone deacetylase 6(HDAC6) at its second catalytic domain, thereby impeding its deacetylase activity on α-tubulin and preventing microtubule deacetylation and depolymerization. This inhibitory interaction is disrupted upon phosphorylation of FSD1 at its Ser317 and Ser324 residues by activated CDK5, leading to FSD1 dissociation from microtubules and facilitating HDAC6-mediated α-tubulin deacetylation. Furthermore, increased expression of FSD1 or interference with FSD1 phosphorylation reduces microtubule deacetylation, suppresses invasion of GBM stem cells, and ultimately mitigates tumor infiltration in orthotopic GBM xenografts. Importantly, GBM tissues exhibit diminished levels of FSD1 expression, correlating with microtubule deacetylation and unfavorable clinical outcomes in GBM patients. These findings elucidate the mechanistic involvement of microtubule deacetylation in driving GBM cell invasion and offer potential avenues for managing GBM infiltration.

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基于ANSYS的燃气管道环焊缝有限元分析

管道技术与设备 2019年第1期 55-58,62页

作者：齐晓琳王嵩梅董绍华北京市燃气集团有限责任公司北京100035 中国石油大学(北京)管道技术与安全研究中心北京102249

为分析城镇燃气管道失效原因,对发生泄漏的某燃气管道进行了有限元分析,利用ANSYS软件建立几何模型和管土相互作用模型,并进行了单元选择、管材模型建立、土弹簧计算、边界条件与载荷分析等研究工作,在分别只有内压载荷、内压与地表沉... 详细信息

为分析城镇燃气管道失效原因,对发生泄漏的某燃气管道进行了有限元分析,利用ANSYS软件建立几何模型和管土相互作用模型,并进行了单元选择、管材模型建立、土弹簧计算、边界条件与载荷分析等研究工作,在分别只有内压载荷、内压与地表沉降、内压与土体沿管道轴向移动、内压与土体水平横向移动的4种工况下对管道进行模拟,得到管道最大应力位置和导致管道失效断裂的原因。

关键词：燃气管道 ANSYS分析环焊缝管道安全