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Clinical application of a shape-preserving rapid corneal donor dehydrater

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International Journal of Ophthalmology(English edition) 2022年第5期15卷 736-740页

作者： Yu Sun xiao-lin qi xiao lin xiao-Yu Zhang Li Gao Hua Gao Shandong First Medical University&Shandong Academy of Medical Sciences JinanShandong ProvinceChina Eye Hospital of Shandong First Medical University Shandong Eye Hospital JinanShandong ProvinceChina State Key Laboratory Cultivation Base Shandong Provincial Key Laboratory of OphthalmologyShandong Eye InstituteShandong First Medical University&Shandong Academy of Medical SciencesSchool of OphthalmologyShandong First Medical UniversityJinanShandong ProvinceChina Eye Hospital Affiliated to Shandong University of Chinese Medicine JinanShandong ProvinceChina

AIM:To describe the design and clinical application of a corneal donor dehydrator which can quickly dehydrate corneas and keep its original ***:The corneal donor material is placed on stainless steel beads with different diameters in the dehydrating box to make the cornea the same shape as the steel ***,the cornea is placed inside the dehydrater for rapid dehydrating using the internal cleaning and ventilation *** 83 eyes underwent deep anterior lamellar keratoplasty(DALK)using corneal donor tissue preserved with corneal dehydrater,and 60 patients(60 eyes)received DALK by the same surgeon using corneal donor tissue preserved with glycerol were included in the control *** best corrected visual acuity(BCVA),the thickness and transparency of the corneal buttons were ***:After the completion of dehydrating,all the donor corneas maintained a normal shape without any shrinkage or distortion,and the average intraoperative rehydration time was 43.3±12.1 s during *** mean BCVA of the dehydrater group was 0.30±0.18 at 1 wk and 0.32±0.16 at 1 mo,which were statistically better than that of the control group(P<0.001).The score of corneal buttons transparency were lower than that of the control group with statistical difference(P<0.001).The thickness of corneal buttons at 1 wk and at 1 mo in the dehydrater group was significantly better than that of the control group respectively(P<0.001).One week after operation,no corneal button turbidity or edema was observed in both ***:The dehydrater can quickly dehydrate the corneal material in a clean and airtight environment and maintain the original shape of the corneal donor during the dehydrating *** dehydrater is recommended for long-term high-quality preservation in areas where corneal materials cannot be used within a reasonable time period.

关键词： keratoplasty corneal donor dehydration organ culture storage eye bank

A surgical alternative of fusiform penetrating keratoplasty for the management of severe infectious keratitis

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International Journal of Ophthalmology(English edition) 2024年第8期17卷 1431-1436页

作者： xiao-lin qi Li-Chao Wang Miao-lin Wang Hua Gao Eye Hospital of Shandong First Medical University State Key Laboratory Cultivation BaseShandong Provincial Key Laboratory of OphthalmologyShandong Eye InstituteShandong First Medical University&Shandong Academy of Medical SciencesJinan 250021Shandong ProvinceChina

AIM:To describe the surgical procedure of fusiform penetrating keratoplasty(FPK)using multiple trephines of different sizes for treating patients with severe infectious ***:Fourteen eyes underwent FPK,and 15 eyes received conventional penetrating keratoplasty(PK)were included in the *** best-corrected visual acuity(BCVA),refractive outcomes,endothelial cell density,and postoperative complications were ***:The FPK group was followed for an average of 15.3±2.1mo,whereas the PK group was followed for 16.1±*** corneal ulcers were elliptical-shaped in all 14 eyes in the FPK *** mean BCVA(logMAR,0.26±0.13)showed no statistically significant differences from that in the PK group(logMAR,0.21±0.12,P>0.05)at 1y after *** the mean curvature,mean astigmatism,and mean spherical equivalent in the FPK group were lower than those in the PK group(P<0.05).Peripheral anterior synechia was observed in one patient in the FPK group,whereas 6 patients in the PK *** loosening and neovascularization were observed in 4 and 5 eyes in the PK group,*** graft immune rejection or elevation of intraocular pressure was observed in the two ***:For patients with elliptical-shaped corneas or corneal ulcers,FPK can avoid disrupting of corneal limbus,reduce the risk of postoperative complications,and can result in satisfactory visual quality.

关键词： fusiform penetrating keratoplasty multiple trephines infectious keratitis cornea

Increased cGAS/STING signaling components in patients with Mooren's ulcer

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International Journal of Ophthalmology(English edition) 2021年第11期14卷 1660-1665页

作者： Ya-Ni Zhang Yan-ling Dong Wen-Pei Hao xiao-Fei Bai Xia qi Ting Liu xiao-Tong Sun Chao Wei xiao-lin qi Xi'an Children's Hospital Xi'an 710004Shaanxi ProvinceChina Shandong Eye Institute Shandong First Medical University&Shandong Academy of Medical SciencesQingdao 266071Shandong ProvinceChina qingdao Eye Hospital of Shandong First Medical University Qingdao 266071Shandong ProvinceChina State Key Laboratory Cultivation Base Shandong Provincial Key Laboratory of OphthalmologyShandong Eye InstituteShandong First Medical University&Shandong Academy of Medical SciencesQingdao 266071Shandong ProvinceChina Eye Hospital of Shandong First Medical University Jinan 250021Shandong ProvinceChina

AIM:To explore the expression of cGAS/STING signaling components in Mooren’s ulcer(MU).METHODS:Samples were obtained from ten MU patients,and eight residual corneal-scleral rings of healthy donor corneas for *** corneal epithelial cells(HCECs)were used to evaluate the effect of cGAS/STING signaling *** y(IHC)and Western blot were used to examine the expression of cGAS,STING,and phosphorylated interferon regulatory factor 3(p-IRF3)in MU *** expression of interferon-β(IFN-β)and interferon-stimulated genes(ISGs)was quantified by real-time polymerase chain reaction(PCR)and enzymelinked immunosorbent assay(ELISA).RESULTS:The protein levels of cGAS and STING in MU samples were significantly elevated when compared with the healthy controls by Western blot and *** stimulation with cGAMP,real-time PCR and ELISA showed a dramatic increase of IFN-βand ISGs(containing CXCL10,IFIT1,and IL-6)in ***,HCECs treated with cGAMP was characterized by increased phosphorylation and more nuclear translocation of ***,increased p-IRF3 was observed in MU samples via IHC and Western ***:The pronounced expression of cGAS/STING signaling components in the patients with MU and probably contribute to the onset and development of MU.

关键词： cGAS/STING signaling interferon regulatory factor 3 Mooren’s ulcer interferon-β

Modified ulcer debridement in the treatment of the superficial fungal infection of the cornea

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International Journal of Ophthalmology(English edition) 2018年第2期11卷 223-229页

作者： Jun-Yi Wang Dian-qiang Wang xiao-lin qi Jun Cheng Li-Xin Xie Department of Comea Qingdao Eye HospitalShandong Eye InstituteShandong Academy of Medical SciencesQingdao 266071Shandong ProvinceChina

AIM： To evaluate the efficacy of modified corneal ulcer debridement in superficial fungal keratitis unresponsive to ***： A total of 209 patients（209 eyes） with fungal keratitis, involving no more than 50% of the stromal depth and not responding to antifungal agents for 2 wk, were recruited in this retrospective, noncomparative study. The patients were treated with modified corneal ulcer debridement. All visible corneal infiltrates were removed under an operating microscope to obtain a clean stromal bed and smooth incised edges. Antifungal drugs were used immediately after surgery. Healing time of the ulcers was recorded. Fungal recurrence, visual acuity, corneal thickness and risk factors for treatment failure were ***： The follow-up was 13.6±5.8m o. The corneal ulcers healed in 195 of 209 eyes（93.3%）, with a mean healing time of 8.4±6.8 d. The other 14 eyes were further treated by penetrating keratoplasty（PK）（1 eye）, anterior lamellar keratoplasty（LK）（7 eyes）, conjunctival flap covering（4 eyes） or amniotic membrane transplantation（2 eyes）. The best corrected visual acuity（BCVA） was ≥20/70 in 80.3% of the eyes, ≥20/40 in 56.9% of the eyes, and ≥20/25 in 27.3% of the eyes. The corneas at the lesions became thinner, but all in the safe range. No fungal recurrence or corneal ectasis developed during the follow-up. The risk of treatment failure was higher in patients with preoperative hypopyon（P=0.036） and ever using steroid（P=0.025）.CONCLUSION： Modified surgical debridement is a simple and effective method for the treatment of superficial fungal infection of the cornea, with improved visual acuity and no recurrence. Such an intervention in time can rapidly control fungal infection and largely shorten corneal ulcer healing time.

关键词： fungal keratitis superficial fungal infection debridement cornea ulcer corneal scraping

Individualized treatment of breast cancer with chronic renal failure: A case report and review of literature

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World Journal of Clinical Cases 2021年第33期9卷 10345-10354页

作者： Jie-Hui Cai Jie-Hua Zheng xiao-qi lin Wei-Xun lin Juan Zou Yao-Kun Chen Zhi-Yang Li Ye-Xi Chen Department of General Surgery The Second Affiliated Hospital of Shantou University Medical CollegeShantou 515041Guangdong ProvinceChina Breast Disease Research Center The Medical Research Institute of Shantou Doctoral AssociationShantou 515041Guangdong ProvinceChina

BACKGROUND Studies have shown that patients with chronic renal failure(CRF)are more likely to suffer from breast cancer and other malignant *** our knowledge,CRF can reduce drug excretion,thereby increase drug exposure and lead to increased toxicity,which will limit drug treatment and lead to tumor ***,there are few successful reports on the combination of docetaxel,trastuzumab,and pertuzumab(THP)as a neoadjuvant treatment regimen for breast cancer patients with *** SUMMARY We report a breast cancer(cT2N2M0,Her-2+/HR-)patient with *** was a clinical stage IIIA tumor on the left *** patient had suffered from uremia for 2 years,and her heart function was *** on the pathological type,molecular type,and clinical stage of breast cancer,and the patient’s renal function,the clinician analyzed the pharmacological and pharmacokinetic characteristics of the antitumor drugs after consulting the relevant literature,and prescribed the neoadjuvant regimen of THP(docetaxel 80 mg/m²,trastuzumab 8 mg/kg for the first dose,and 6 mg/kg for the maintenance dose with pertuzumab 840 mg for the first dose and 420 mg for the maintenance dose),once every 3 wk,for a total of 6 *** neoadjuvant treatment had a good effect,and the patient then underwent surgery which was *** CRF is not a contraindication for systemic treatment and surgery of breast *** THP regimen without dose adjustment may be a safe and effective neoadjuvant treatment for HER-2 positive breast cancer patients with CRF.

关键词： Breast cancer Chronic renal failure Neoadjuvant treatment Dose adjustment Pertuzumab Case report

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可循环使用表面增强拉曼散射基底研究进展

光谱学与光谱分析 2017年第11期37卷 3435-3440页

作者：傅小奇章国林江苏大学化学化工学院江苏镇江212013

表面增强拉曼散射(SERS)技术克服了拉曼光谱灵敏度低的缺点,可以获得常规拉曼光谱不易得到的分子结构信息,成为分子甚至单一分子痕量检测的一个重要手段,在生命科学、分析化学等领域得到了广泛的应用。SERS基底是SERS检测中的核心部件,... 详细信息

表面增强拉曼散射(SERS)技术克服了拉曼光谱灵敏度低的缺点,可以获得常规拉曼光谱不易得到的分子结构信息,成为分子甚至单一分子痕量检测的一个重要手段,在生命科学、分析化学等领域得到了广泛的应用。SERS基底是SERS检测中的核心部件,只有少量特殊处理的贵金属才具有较强SERS效应,同时这些传统SERS基底一般都是一次性使用,这给实际使用造成资源的浪费。在简要介绍SERS光谱发展的基础上,重点介绍了近期在可循环SERS基底的制备和应用作一述评,并对可循环SERS基底的研究和发展做了展望。

关键词：表面增强拉曼散射基底可循环检测

抗日战争时期中共军队无线通信系统的危机与应对

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史林 2021年第4期 135-148,221页

作者：齐小林中共中央党校(国家行政学院) 100091

抗日战争初期,中共利用多种手段建构起一个复杂而庞大的信息传递系统,无线通信在其中居于至关重要的地位,几乎全部的战略信息和部分重要的战役信息,都是通过无线通信传递的。百团大战之后,由于遭受日军和国民党方面强大的压力,中共军队... 详细信息

抗日战争初期,中共利用多种手段建构起一个复杂而庞大的信息传递系统,无线通信在其中居于至关重要的地位,几乎全部的战略信息和部分重要的战役信息,都是通过无线通信传递的。百团大战之后,由于遭受日军和国民党方面强大的压力,中共军队无线通信系统在安全和效率方面的挑战日益严峻。中共中央采取一系列措施,缓解了这场危机,其应用无线通信技术的能力日益成熟。

关键词：中央军委无线通信系统危机调适

职责与顾虑:华北解放区参军动员中的村干部心态

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河北学刊 2015年第4期35卷 181-186页

作者：齐小林中共中央党校党史教研部北京100091

华北解放区的村干部,既是中共基层政权的代表,也是生活在血缘、地缘环境中的普通农民。在动员农民参军的过程中,村干部的种种角色和心态因场域不同而异,既有对政治动员的困惑,也有对上级要求带头参军的怨气,还有担忧劳动力锐减导致优抗... 详细信息

华北解放区的村干部,既是中共基层政权的代表,也是生活在血缘、地缘环境中的普通农民。在动员农民参军的过程中,村干部的种种角色和心态因场域不同而异,既有对政治动员的困惑,也有对上级要求带头参军的怨气,还有担忧劳动力锐减导致优抗工作烦难,更怕因动员他人参军而遭到村民报复。村干部的种种复杂心态对华北解放区的参军动员工作产生了深刻的影响。

关键词：华北解放区参军动员村干部心态职责与顾虑

全面抗战时期中共军队无线通信系统的结构性扩张

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河北学刊 2021年第5期41卷 32-41页

作者：齐小林中共中央党校〔国家行政学院〕中共党史教研部北京100091

全面抗战时期,中共军队无线通信系统迅速发展,呈结构性扩张态势,其支撑因素是报务、机要人员的增加以及制度的完善。在此过程中,新晋的无线通信使用者、报务和机要人员、制度之间存在的张力,使中共军队无线通信系统面临安全和效率的问题... 详细信息

全面抗战时期,中共军队无线通信系统迅速发展,呈结构性扩张态势,其支撑因素是报务、机要人员的增加以及制度的完善。在此过程中,新晋的无线通信使用者、报务和机要人员、制度之间存在的张力,使中共军队无线通信系统面临安全和效率的问题,在外在压力增强的情况下,问题逐渐演变成危机。

关键词：无线通信结构性扩张人员制度