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Effects of Hydrogen Charging Time and Pressure on the Hydrogen Embrittlement Susceptibility of X52 Pipeline Steel Material

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Acta Metallurgica Sinica(English Letters) 2024年第2期37卷 293-307页

作者： Hong-Jiang Wan xiao-qi wu Hong-Liang Ming Jian-qiu Wang En-Hou Han School of Materials Science and Engineering University of Science and Technology of ChinaShenyang110016China CAS Key Laboratory of Nuclear Materials and Safety Assessment Institute of Metal ResearchChinese Academy of SciencesShenyang110016China School of Materials Science and Engineering Northeastern UniversityShenyang110819China Institute of Corrosion Science and Technology Guangzhou510530China

The effects of hydrogen charging time and pressure on the hydrogen embrittlement(HE)susceptibility of X52 pipeline steel material are studied by slow strain rate tensile *** fracture morphologies of the specimens are observed by scanning electron *** HE susceptibility of the X52 pipeline steel material increases with an increase in both hydrogen charging time and hydrogen *** a charging time of 96 h,the HE susceptibility index reaches 45.86%,approximately 3.6 times that at a charging time of 0 ***,a charging pressure of 4 MPa results in a HE susceptibility index of 31.61%,approximately 2.5 times higher than that at a charging pressure of 0.3 MPa.

关键词： Hydrogen embrittlement X52 pipeline steel material Tubular specimen Hydrogen charging time Hydrogen charging pressure

Role of Pittsburgh Modified TNM Criteria in prognosis prediction of liver transplantation for hepatocellular carcinoma

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Chinese Medical Journal 2007年第24期120卷 2200-2203页

作者： CHEN Jun XU xiao LING qi wu Jian ZHENG Shu-sen Division of Hepatobiliary and Pancreatic Surgery Department ofSurgery First Affiliated Hospital Zhejiang University School ofMedicine Hangzhou 310003 China

Background Pittsburgh modified TNM criteria is one of the prognostic models of orthotopic liver transplantation （OLT） for hepatocellular carcinoma （HCC）. In this study, we applied this prognostic system in a series of HCC patients receiving OLT to verify its reliability in the clinical prognostic prediction. Methods The clinical record and follow-up data of 102 patients with HCC underwent OLT was collected. The patients were classified by 3 staging systems： the Pittsburgh Modified TNM Criteria, International Union Against Cancer （UICC） pTNM Staging System, and Milan Criteria. Survival rates of the patients were analyzed using the Kaplan-Meier method and the Log-Rank test, and then the prognostic values of the 3 staging systems were compared. Results Among the 3 staging systems, the Pittsburgh Modified TNM Criteria showed the best stratification of patients with different prognosis. The overall survival rates of the patients at the Pittsburgh modified TNM stage Ⅰ, Ⅱ, Ⅲ, and Ⅳ were 94.4%, 83.3%, 58.2%, and 36.8% at 1 year, and 79.4%, 62.5%, 26.2%, and 10.5% at 3 years, respectively. For those patients exceeding the Milan Criteria, the patients at Pittsburgh stages I and II had a significant higher survival rate than those at Pittsburgh stages III and IV （P〈0.001）. Conclusions The Pittsburgh Modified TNM Criteria is a more reliable postoperative staging system than the UICC pTNM staging system for HCC patients receiving OLT. As providing more accurate prognostic classification, it could be reasonable to combine the Milan Criteria for recipient selection.

关键词： Pittsburgh Modified TNM Criteria hepatocellular carcinoma liver transplantation

Chloroquine enhances the cytotoxicity of topotecan by inhibiting autophagy in lung cancer cells

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Chinese Journal of Cancer 2011年第10期30卷 690-700页

作者： Yao Wang Rui-qing Peng Dan-Dan Li Ya Ding xiao-qi wu Yi-Xin Zeng xiao-Feng Zhu xiao-Shi Zhang State Key Laboratory of Oncology in South China Guangzhou Guangdong 510060 P. R. China Biotherapy Center Department of Experimental Research Sun Yat-sen University Cancer Center Guangzhou Guangdong 510060 P. R. China Department of Chemotherapy Zhongshan People＇s Hospital Zhongshan Guangdong 528403 P. R. China

Although the anti-malaria drug chloroquine(CQ) has been shown to enhance chemotherapy and radiation sensitivity in clinical trials,the potential mechanisms underlying this enhancement are still ***,we examined the relevant mechanisms by which the multipotent CQ enhanced the cytotoxicity of topotecan(TPT).The lung cancer cell line A549 was treated with TPT alone or TPT combined with CQ at non-cytotoxic *** viability was assessed using the MTT *** percentage of apoptotic cells and the presence of a side population of cells were both determined by flow *** and the expression of Bcl-2 family proteins were examined by Western *** accumulation of YFP-LC3 dots and the formation of acidic vesicular organelles were examined by confocal *** sensitized A549 cells to TPT and enhanced TPT-induced apoptosis in a Bcl-2 family protein-independent *** inhibited TPT-induced autophagy,which modified the cytotoxicity of ***,CQ failed to modify the transfer of TPT across the cytoplasmic membrane and did not increase lysosomal *** study showed that CQ at non-cytotoxic concentrations potentiated the cytotoxicity of TPT by interfering with autophagy,implying that CQ has significant potential as a chemotherapeutic enhancer.

关键词：细胞毒作用肺癌细胞自噬拓扑氯喹细胞毒性共聚焦显微镜 A549细胞

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多跨简支梁桥低频噪声预测及空间分布研究

工程力学 2017年第3期34卷 22-28页

作者：宋晓东李奇吴定俊东南大学桥梁工程系南京210096 同济大学桥梁工程系上海200092

现有的桥梁噪声预测方法大多仅考虑一跨桥梁的噪声辐射而忽略了相邻跨桥梁的影响。提出了预测多跨桥梁低频噪声的方法:首先,通过车辆-轨道-桥梁动力相互作用分析计算了列车通过多跨桥时的桥梁响应;然后,采用2.5维边界元方法获得多跨桥... 详细信息

现有的桥梁噪声预测方法大多仅考虑一跨桥梁的噪声辐射而忽略了相邻跨桥梁的影响。提出了预测多跨桥梁低频噪声的方法:首先,通过车辆-轨道-桥梁动力相互作用分析计算了列车通过多跨桥时的桥梁响应;然后,采用2.5维边界元方法获得多跨桥梁的声模态传递向量;最后结合桥梁动力响应和声模态传递向量求得多跨桥梁的总辐射噪声。以某轨道交通U梁为研究对象,对比了采用多跨桥梁模型、单跨桥梁模型的计算声压结果的异同,并与实测值进行比较,明确了在预测远场噪声时必须采用多跨桥梁计算模型。研究表明,多跨桥梁的辐射噪声沿桥梁纵向分布较为均匀,在现场实测时可选取任意横断面位置进行噪声测试。

关键词：轨道交通多跨桥梁低频噪声远场噪声 2.5维方法

Gut microbiota shifts in hepatitis B-related portal hypertension after transjugular intrahepatic portosystemic shunt:Mechanistic and clinical implications

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World Journal of Gastroenterology 2025年第3期31卷 134-137页

作者： qi-Rong Jiang Da-wu Zeng Department of Hepatology Hepatology Research InstituteThe First Affiliated HospitalFujian Medical UniversityFuzhou 350005Fujian ProvinceChina Department of Infectious Diseases The First Affiliated Hospital of Fujian Medical UniversityFuzhou 350004Fujian ProvinceChina

In this article,we provide commentary on the recent article by Zhao et *** focus on the shifts in the gut microbiota of patients with hepatitis B virus(HBV)-associated cirrhosis/portal hypertension(PH)following transjugular intrahepatic portosystemic shunt(TIPS)and the implications for understanding the mechanisms,diagnosis,and *** comparing the gut microbiota composition and dynamic changes before and after TIPS in patients with and without hepatic encephalopathy,the authors found an increase in non-probiotic bacteria in those who developed hepatic encephalopathy post-TIPS,with Morganella species present only in the hepatic encephalopathy *** gut microbiota changes post-TIPS among patients without the occurrence of hepatic encephalopathy suggest potential therapeutic benefits through prophylactic microbiome ***,the specific gut microbiota alterations may hold promise to predict the risk of hepatic encephalopathy in individuals undergoing TIPS for HBVrelated *** these promising findings,future studies are needed to address limitations,including a small sample size,a relatively short evaluation period for gut microbiota alterations,the absence of data on dynamic alterations in gut microbiota post-TIPS and their correlation with blood ammonia levels,and the lack of validation in animal *** conclusion,Zhao et al's study has shed new light on the link of gut microbiota with post-TIPS hepatic encephalopathy,potentially through the intricate gut-liver axis,and has important clinical implications for improving the management of patients with HBV-related PH.

关键词： Hepatitis B virus Cirrhosis Portal hypertension Hepatic encephalopathy Transjugular intrahepatic portosystemic shunt Gut microbiota

Characteristics of gut microbiota dysbiosis in patients with colorectal polyps

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 13-21页

作者： Xian-Rong wu xiao-Hong He Yong-Fang Xie School of Life Health Information Science and Engineering Chongqing Post and Communications UniversityChongqing 400065China

This editorial,inspired by a recent study published in the World Journal of Gastrointestinal Oncology,covers the research findings on microbiota changes in various *** recurrent colorectal polyps,the abundances of Klebsiella,Parvimonas,and Clostridium increase,while those of Bifidobacterium and Lactoba-cillus *** dysbiosis may promote the formation and recurrence of *** microbial changes have also been observed in colorectal cancer,inflammatory bowel disease,autism spectrum disorder,and metabolic syndrome,indicating the role of increased pathogens and decreased probiotics in these *** the gut microbiota,particularly by increasing probiotic levels,may help prevent polyp recurrence and promote gut *** microbial intervention strategy holds promise as an adjunctive treatment for patients with colorectal polyps.

关键词： Recurrent colorectal polyps Gut microbiota dysbiosis Klebsiella Probiotics Intestinal inflammation Microbial intervention strategy

Feedback loops blockade potentiates antitumor activity of a novel AKT1 inhibitor DC120 in human liver cancer cells and nude mice xenografts

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Feedback loops blockade potentiates antitumor activity of a ...

倍半萜类化合物Hirsutanol激活ROS诱导肝癌细胞自噬性死亡(英文)

2013医学前沿论坛暨第十三届全国肿瘤药理与化疗学术会议

作者： Fen Yang Rong Deng Shao-Hua Chang xiao-Jun qian xiao-qi wu Juan qin Ting Sun Gong-Kan Feng Ke Ding xiao-Feng Zhu State Key Laboratory of Oncology in South China Sun Yat-sen University Cancer Center Key Laboratory of Human Functional Genomics of Jiangsu Province Department of Biochemistry and Molecular BiologyNanjing Medical University Key Laboratory of Regenerative Biology and Institute of Chemical Biology Guangzhou Institutes of Biomedicine and HealthChinese Academy of Sciences Graduate School Chinese Academy of Sciences

The serine/threonine kinase AKT is generally accepted as a promising anticancer therapeutic ***,relief of feedback inhibition and enhancement of other survival pathways often attenuate anticancer effects of AKT *** this study,we found a novel 2-pyrimidyl-5-amidothiazole compound,DC120,as an ATP competitive AKT1 kinase inhibitor, suppressed proliferation and induced apoptosis in liver cancer both in vitro and in *** 120 also blocked phosphorylation of downstream molecules in the AKT signal pathway,such as

关键词： mTOR complexes MAPK pathway PI3K/AKT pathway AKT inhibitor Apoptosis

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Chinese Journal of Cancer 2010年第7期29卷 655-660页

作者：杨芬高幼衡吴克伟 State Key Laboratory of Oncology in South China Research Department Sun Yat-sen University Cancer Center School of Chinese Material Medica Guangzhou University of Traditional Chinese Medicine

Background and Objective:Hirsutanol A is a novel sesquiterpene compound purified from fungus chondrostereum sp in Sarcophyton *** pharmacologic effect has not been reported *** study aimed to investigate cytotoxic effect of Hirsutanol A on hepatocellular carcinoma(HCC) cells and its *** hods:Hep3B cells were treated with different concentrations of Hirsutanol *** proliferation was detected by MTT *** protein expression of LC3 was determined by Western *** generation of reactive oxygen species(ROS) was monitored by flow *** s:Hirsutanol A significantly inhibited proliferation of Hep3B cells with 50% inhibition concentrations(IC50) of 14.54,6.71,and 3.59 μmol/L when exposed to Hirsutanol A for 24,48,and 72 h,*** of Hep3B cells with Hirsutanol A markedly increased the level of ROS and the autophagy marker MAP-LC3 conversion from type I to type ***-incubation with an antioxidant N-acetyl cystein(NAC) decreased the level of ROS,and reduced MAPLC3 I-II conversion,and suppressed cell *** autophagy with a specific autophagy inhibitor 3-methyladenine(3MA),the cytotoxic effect of this compound was ***:Hirsutanol A has potent cytotoxic effect,and can induce autophagic cell death via increasing ROS production.

关键词：人肝癌细胞细胞死亡活性氧倍半萜诱导细胞毒作用细胞增殖抑制浓度

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伏牛山区宝天曼自然保护区公益林的效益评价

河南林业科技 2015年第4期35卷 32-35页

作者：肖武奇河南省林业产业发展中心河南郑州450003

通过对宝天曼自然保护区国家重点公益林的涵养水源、固碳释氧、营养物质积累、生物多样性保育、净化大气、土壤保育、森林游憩等功能的实物量进行了监测。依据市场价值法、工程替代法、影子工程法等方法,采用森林生态系统服务功能评估... 详细信息

通过对宝天曼自然保护区国家重点公益林的涵养水源、固碳释氧、营养物质积累、生物多样性保育、净化大气、土壤保育、森林游憩等功能的实物量进行了监测。依据市场价值法、工程替代法、影子工程法等方法,采用森林生态系统服务功能评估标准中的评估公式,选取涵养水源、固碳释氧、营养物质积累、物种保育、保育土壤、净化大气、森林游憩等七项指标,计算出宝天曼自然保护区森林生态系统服务功能效益价值量。该监测的特色在于分不同的林龄对生态系统服务功能的价值量测度,反映了生态公益林的结构和功能的变化,对更好的开展生态公益林的管理提供了参考和借鉴。

关键词：宝天曼公益林效益评价