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Food Science and Human Wellness 2024年

作者： Huihui Xu Kai'ao zou Haipeng Huang Qinghe Zeng Xu Wang ping'er Wang Wenhua Yuan Luwei xiao Jiali Chen Peijian Tong Hongting Jin he First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine) The First College of Clinical Medicine Zhejiang Chinese Medical University Institute of Orthopaedics and Traumatology of Zhejiang Province

The study aimed to explore the efficacy and potential mechanisms of a naturally aromatic cyanogenic compound-amygdalin (AMY) in treating glucocorticoid (GC)-associated necrosis of the femoral head (GANFH). We demonstrated that GC exacerbates the oxidative stress (OS) microenvironment via promoting nicotinamide adenine dinucleotide phosphate oxidase 4 (NOX4) expression in human， rat， and mesenchymal stem cells (MSCs) samples， thus generating excessive ROS， leading to increased apoptosis and unbalanced osteolipogenic differentiation. Furthermore， computational docking results revealed that AMY could bind specifically to the predicted binding sites of NOX4. Additionally， AMY ameliorated the OS microenvironment of MSCs via decreasing NOX4 expression and inhibiting NOX4/ROS/p38MAPK signaling， thereby reversing the GC-induced apoptosis and imbalanced osteolipogenic differentiation， and ultimately alleviating GANFH. In summary， we demonstrated for the first time that AMY attenuated apoptosis and maintained osteolipogenic differentiation balance in MSCs via specifically targeting NOX4， inhibiting NOX4/ROS/p38MAPK signaling， thereby treating GANFH.

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Diagnostic Value of GDF10 for the Tumorigenesis and Immune Infiltration in Lung Squamous Cell Carcinoma

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Current Medical Science 2024年第2期44卷 309-327页

作者： xiao-jun WANG Jia-ping CHEN Xin-wei QIAO Wang-yang MENG Yang-wei WANG Yun-chong MENG Rong ZHAO Wei LIN Yong-de LIAO Han xiao Pei-yuan MEI Department of Thoracic Surgery Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Department of Thoracic Surgery Shandong Provincial Hospital Afiliated to Shandong First Medical UniversityJinan 250021China

Objective:Lung squamous cell carcinoma(LUSC)is associated with a low survival rate.Evidence suggests that bone morphogenetic proteins(BMPs)and their receptors(BMPRs)play crucial roles in tumorigenesis and progression.However,a comprehensive analysis of their role in LUSC is lacking.Our study aimed to explore the relationship between BMPs/BMPRs expression levels and the tumorigenesis and prognosis of LUSC.Methods:The“R/Limma”package was utilized to analyze the differential expression characteristics of BMPs/BMPRs in LUSC,using data from TCGA,GTEx,and GEO databases.Concurrently,the“survminer”packages were employed to investigate their prognostic value and correlation with clinical features in LUSC.The core gene associated with LUSC progression was further explored through weighted gene correlation network analysis(WGCNA).LASSO analysis was conducted to construct a prognostic risk model for LUSC.Clinical specimens were examined by immunohistochemical analysis to confirm the diagnostic value in LUSC.Furthermore,based on the tumor immune estimation resource database and tumor-immune system interaction database,the role of the core gene in the tumor microenvironment of LUSC was explored.Results:GDF10 had a significant correlation only with the pathological T stage of LUSC,and the protein expression level of GDF10 decreased with the tumorigenesis of LUSC.A prognostic risk model was constructed with GDF10 as the core gene and 5 hub genes(HRASLS,HIST1H2BH,FLRT3,CHEK2,and ALPL)for LUSC.GDF10 showed a significant positive correlation with immune cell infiltration and immune checkpoint expression.Conclusion:GDF10 might serve as a diagnostic biomarker reflecting the tumorigenesis of LUSC and regulating the tumor immune microenvironment to guide more effective treatment for LUSC.

关键词： lung squamous cell carcinoma tumorigenesis bone morphogenetic protein GDF10 tumor immune microenvironment

Preparation of Tartary Buckwheat Seed Coating Agent and Its Effect on Germination

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Phyton-International Journal of Experimental Botany 2024年第4期93卷 699-712页

作者： Xin zou Jieyu Zhang Ting Cheng Yangyang Guo xiao Han Han Liu Yuxing Qin Jie Li Dabing Xiang Key Laboratory of Coarse Cereal Processing Ministry of Agriculture and Rural AffairsCollege of Food and Biological EngineeringChengdu UniversityChengdu610106China Agricultural Service Center People’s Government of Yanglu TownYunyang CountyChongqing404512China

To mitigate the wastage of seed resources and reduce the usage of pesticides and fertilizers, seed coating agentshave gained popularity. This study employs single-factor and multi-index orthogonal experimental design methodsto investigate the seed coating formula and physical properties of Tartary buckwheat. The specific effects ofeach component on Tartary buckwheat seed germination are analyzed. The findings reveal that the seed coatingagent formulated with 1.5% polyvinyl alcohol, 0.15% sodium alginate, 0.2% op-10, 0.1% polyacrylamide, 8% colorant,3% ammonium sulfate, 1% potassium dihydrogen phosphate, and 0.15% carbendazim exhibits the mosteffective coating. It demonstrates optimal physical properties and promotes seed germination efficiently. The suspensionrate of this seed coating agent reaches 91.12%, with a mere 2.13% coating shedding rate and 2.5% coatingseed rot rate. Furthermore, it achieves a germination percentage of 99.17%, which is 20.84% higher than the lowestgroup. The germination potential and index are also significantly higher than the lowest group, with anincrease of 20.84% and 26.56%, respectively. Additionally, the vitality index is 553.08, a 15.75% increase comparedto the lowest group. The application of seed coating agents helps reduce seed resource loss, increase plant numbers,and ultimately enhance agricultural yields. This finding holds practical significance in agriculturalproduction.

关键词： Tartary buckwheat seed coating agent formula germination

Simulating the evolution of focused waves by a two-layer Boussinesq-type model

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Acta Oceanologica Sinica 2024年第5期43卷 91-99页

作者： ping Wang Zhongbo Liu Kezhao Fang Wenfeng zou Xiangke Dong Jiawen Sun State Environmental Protection Key Laboratory of Marine Ecosystem Restoration National Marine Environmental Monitoring CenterDalian 116023China College of Transportation Engineering Dalian Maritime UniversityDalian 116026China State Key Laboratory of Coastal and Offshore Engineering Dalian University of TechnologyDalian 116024China

Accurate simulation of the evolution of freak waves by the wave phase focusing method requires accurate linear and nonlinear properties,especially in deep-water conditions.In this paper,we analyze the ability to simulate deep-water focused waves of a two-layer Boussinesq-type(BT)model,which has been shown to have excellent linear and nonlinear performance.To further improve the numerical accuracy and stability,the internal wavegenerated method is introduced into the two-layer Boussinesq-type model.Firstly,the sensitivity of the numerical results to the grid resolution is analyzed to verify the convergence of the model;secondly,the focused wave propagating in two opposite directions is simulated to prove the symmetry of the numerical results and the feasibility of the internal wave-generated method;thirdly,the limiting focused wave condition is simulated to compare and analyze the wave surface and the horizontal velocity of the profile at the focusing position,which is in good agreement with the measured values.Meanwhile the simulation of focused waves in very deep waters agrees well with the measured values,which further demonstrates the capability of the two-layer BT model in simulating focused waves in deep waters.

关键词： focused waves numerical simulation Boussinesq-type model velocity profile

Global status and trends of metabolomics in diabetes: A literature visualization knowledge graph study

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World Journal of Diabetes 2024年第5期15卷 1021-1044页

作者： Hong Li Liu Li Qiu-Qing Huang Si-Yao Yang Jun-Ju zou Fan xiao Qin Xiang Xiu Liu Rong Yu College of Chinese Medicine Hunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina College of International Education Hunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina Department of Science and Technology Hunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina Hunan Key Laboratory of TCM Prescription and Syndromes Translational Medicine Hunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina College of Graduate Hunan University of Chinese MedicineHunan ChangshaHunan ProvinceChina

BACKGROUND Diabetes is a metabolic disease characterized by hyperglycemia,which has increased the global medical burden and is also the main cause of death in most countries.AIM To understand the knowledge structure of global development status,research focus,and future trend of the relationship between diabetes and metabolomics in the past 20 years.METHODS The articles about the relationship between diabetes and metabolomics in the Web of Science Core Collection were retrieved from 2002 to October 23,2023,and the relevant information was analyzed using CiteSpace6.2.2R(CiteSpace),VOSviewer6.1.18(VOSviewer),and Bibliometrix software under R language.RESULTS A total of 3123 publications were included from 2002 to 2022.In the past two decades,the number of publications and citations in this field has continued to increase.The United States,China,Germany,the United Kingdom,and other relevant funds,institutions,and authors have significantly contributed to this field.Scientific Reports and PLoS One are the journals with the most publications and the most citations.Through keyword co-occurrence and cluster analysis,the closely related keywords are"insulin resistance","risk","obesity","oxidative stress","metabolomics","metabolites"and"biomarkers".Keyword clustering included cardiovascular disease,gut microbiota,metabonomics,diabetic nephropathy,molecular docking,gestational diabetes mellitus,oxidative stress,and insulin resistance.Burst detection analysis of keyword depicted that"Gene","microbiota","validation","kidney disease","antioxidant activity","untargeted metabolomics","management",and"accumulation"are knowledge frontiers in recent years.CONCLUSION The relationship between metabolomics and diabetes is receiving extensive attention.Diabetic nephropathy,diabetic cardiovascular disease,and kidney disease are key diseases for future research in this field.Gut microbiota,molecular docking,and untargeted metabolomics are key research directions in the future.Antioxidant activity,gene,validation,mass spectrometry,manage

关键词： Diabetes Metabolomics Bibliometric CiteSpace VOSviewer

Supramolecular polymer-based gel fracturing fluid with a double network applied in ultra-deep hydraulic fracturing

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Petroleum Science 2024年第3期21卷 1875-1888页

作者： Yong-ping Huang Yong Hu Chang-Long Liu Yi-Ning Wu Chen-Wei zou Li-Yuan Zhang Ming-Wei Zhao Cai-Li Dai School of Petroleum Engineering China University of Petroleum(East China) Shandong Key Laboratory of Oilfield Chemistry China University of Petroleum(East China) SINOPEC Petroleum Exploration and Production Research Institute CNOOC China Co Ltd Tianjin Branch

A gel based on polyacrylamide, exhibiting delayed crosslinking characteristics, emerges as the preferred solution for mitigating degradation under conditions of high temperature and extended shear in ultralong wellbores. High viscosity/viscoelasticity of the fracturing fluid was required to maintain excellent proppant suspension properties before gelling. Taking into account both the cost and the potential damage to reservoirs, polymers with lower concentrations and molecular weights are generally preferred. In this work, the supramolecular action was integrated into the polymer, resulting in significant increases in the viscosity and viscoelasticity of the synthesized supramolecular polymer system.The double network gel, which is formed by the combination of the supramolecular polymer system and a small quantity of Zr-crosslinker, effectively resists temperature while minimizing permeability damage to the reservoir. The results indicate that the supramolecular polymer system with a molecular weight of(268—380) × 10～4g/mol can achieve the same viscosity and viscoelasticity at 0.4 wt% due to the supramolecular interaction between polymers, compared to the 0.6 wt% traditional polymer(hydrolyzed polyacrylamide, molecular weight of 1078 × 10～4g/mol). The supramolecular polymer system possessed excellent proppant suspension properties with a 0.55 cm/min sedimentation rate at 0.4 wt%, whereas the0.6 wt% traditional polymer had a rate of 0.57 cm/min. In comparison to the traditional gel with a Zrcrosslinker concentration of 0.6 wt% and an elastic modulus of 7.77 Pa, the double network gel with a higher elastic modulus(9.00 Pa) could be formed only at 0.1 wt% Zr-crosslinker, which greatly reduced the amount of residue of the fluid after gel-breaking. The viscosity of the double network gel was66 m Pa s after 2 h shearing, whereas the traditional gel only reached 27 m Pa s.

关键词： Ultra-deep reservoir Gel fracturing fluid Double network Supramolecular polymer system Proppant suspension property

Computed tomography radiogenomics:A potential tool for prediction of molecular subtypes in gastric stromal tumor

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World Journal of Gastrointestinal Oncology 2024年第4期16卷 1296-1308页

作者： xiao-Nan Yin Zi-Hao Wang Li zou Cai-Wei Yang Chao-Yong Shen Bai-Ke Liu Yuan Yin Xi-Jiao Liu Bo Zhang Gastric Cancer Research Center West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina Department of Paediatric Surgery West China Hospital of Sichuan UniversityChengdu 610041Sichuan ProvinceChina Department of Radiology West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina Department of Gastrointestinal Surgery Sichuan University West China HospitalChengdu 610041Sichuan ProvinceChina

BACKGROUND Preoperative knowledge of mutational status of gastrointestinal stromal tumors(GISTs)is essential to guide the individualized precision therapy.AIM To develop a combined model that integrates clinical and contrast-enhanced computed tomography(CE-CT)features to predict gastric GISTs with specific genetic mutations,namely KIT exon 11 mutations or KIT exon 11 codons 557-558 deletions.METHODS A total of 231 GIST patients with definitive genetic phenotypes were divided into a training dataset and a validation dataset in a 7:3 ratio.The models were constructed using selected clinical features,conventional CT features,and radiomics features extracted from abdominal CE-CT images.Three models were developed:ModelCT sign,modelCT sign+rad,and model CTsign+rad+clinic.The diagnostic performance of these models was evaluated using receiver operating characteristic(ROC)curve analysis and the Delong test.RESULTS The ROC analyses revealed that in the training cohort,the area under the curve(AUC)values for model_(CT sign),model_(CT sign+rad),and modelCT_(sign+rad+clinic)for predicting KIT exon 11 mutation were 0.743,0.818,and 0.915,respectively.In the validation cohort,the AUC values for the same models were 0.670,0.781,and 0.811,respectively.For predicting KIT exon 11 codons 557-558 deletions,the AUC values in the training cohort were 0.667,0.842,and 0.720 for model_(CT sign),model_(CT sign+rad),and modelCT_(sign+rad+clinic),respectively.In the validation cohort,the AUC values for the same models were 0.610,0.782,and 0.795,respectively.Based on the decision curve analysis,it was determined that the model_(CT sign+rad+clinic)had clinical significance and utility.CONCLUSION Our findings demonstrate that the combined modelCT_(sign+rad+clinic)effectively distinguishes GISTs with KIT exon 11 mutation and KIT exon 11 codons 557-558 deletions.This combined model has the potential to be valuable in assessing the genotype of GISTs.

关键词： Gastrointestinal stromal tumor Radiomics Gene mutation Computed tomography Model

Theoretical analysis of the double-differential cross-sections of neutron,proton,deuteron,^(3)He,andαfor the p+^(6) Li reaction

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Nuclear Science and Techniques 2024年第3期35卷 181-197页

作者： Fang-Lei zou xiao-Jun Sun Jing-Shang Zhang Hai-Rui Guo Yin-Lu Han Rui-Rui Xu Xi Tao Ji-Min Wang xiao-Dong Sun Yuan Tian Tao Ye Yong-Li Xu Chun-Tian Liang College of Physics Guangxi Normal University541004 GuilinChina Guangxi Key Laboratory of Nuclear Physics and Nuclear Technology 541004 GuilinChina China Institute of Atomic Energy P.O.Box 275(41)102413 BeijingChina Institute of Applied Physics and Computational Mathematics 10094 BeijingChina College of Physics and Electronic Shanxi Datong University037009 DatongChina School of Science Tianjin Chengjian University300384 TianjinChina

Based on the unified Hauser–Feshbach and exciton model,which can describe the particle emission processes between discrete energy levels with energy,angular momentum,and parity conservations,a statistical theory of light nucleus reaction(STLN)is developed to calculate the double-differential cross-sections of the outgoing neutron and light charged particles for the proton-induced^(6) Li reaction.A significant difference is observed between the p+^(6) Li and p+^(7) Li reactions owing to the discrepancies in the energy-level structures of the targets.The reaction channels,including sequential and simultaneous emission processes,are analyzed in detail.Taking the double-differential cross-sections of the outgoing proton as an example,the influence of contaminations(such as^(1) H,^(7)Li,^(12)C,and^(16)O)on the target is identified in terms of the kinetic energy of the first emitted particles.The optical potential parameters of the proton are obtained by fitting the elastic scattering differential cross-sections.The calculated total double-differential cross-sections of the outgoing proton and deuteron at E_(p)=14 MeV agree well with the experimental data for different outgoing angles.Simultaneously,the mixed double differential cross-sections of^(3) He andαare in good agreement with the measurements.The agreement between the measured data and calculated results indicates that the two-body and three-body breakup reactions need to be considered,and the pre-equilibrium reaction mechanism dominates the reaction processes.Based on the STLN model,a PLUNF code for the p+^(6) Li reaction is developed to obtain an ENDF-6-formatted file of the double-differential cross-sections of the nucleon and light composite charged particles.

关键词： Statistical theory of light nucleus reaction p+^(6)Li reaction Light composite charged particle Double-differential cross-sections Two-body breakup Three-body breakup

Remaining Useful Life Prediction Method for Multi-Component System Considering Maintenance:Subsea Christmas Tree System as A Case Study

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China Ocean Engineering 2024年第2期38卷 198-209页

作者： WU Qi-bing CAI Bao-ping FAN Hong-yan WANG Guan-nan RAO Xi GE Weifeng SHAO xiao-yan LIU Yong-hong CNOOC Safety Technology Services Co. Ltd.Tianjin 300456China College of Mechanical and Electronic Engineering China University of PetroleumQingdao 266580China CNOOC EnerTech Safety&Environmental Protection BranchTianjin 300456China

Maintenance is an important technical measure to maintain and restore the performance status of equipment and ensure the safety of the production process in industrial production,and is an indispensable part of prediction and health management.However,most of the existing remaining useful life(RUL)prediction methods assume that there is no maintenance or only perfect maintenance during the whole life cycle;thus,the predicted RUL value of the system is obviously lower than its actual operating value.The complex environment of the system further increases the difficulty of maintenance,and its maintenance nodes and maintenance degree are limited by the construction period and working conditions,which increases the difficulty of RUL prediction.An RUL prediction method for a multi-omponent system based on the Wiener process considering maintenance is proposed.The performance degradation model of components is established by a dynamic Bayesian network as the initial model,which solves the uncertainty of insufficient data problems.Based on the experience of experts,the degree of degradation is divided according to Poisson process simulation random failure,and different maintenance strategies are used to estimate a variety of condition maintenance factors.An example of a subsea tree system is given to verify the effectiveness of the proposed method.

关键词： remaining useful life Wiener process dynamic Bayesian networks maintenance subsea Christmas tree system

Development of a high-repetition-rate lumped-inductance kicker magnet prototype for the beam switchyard of SHINE

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Nuclear Science and Techniques 2024年第2期35卷 20-31页

作者： Yong-Fang Liu Rui-ping Wang Jin Tong Bo Zhang Si Chen Qi-Bing Yuan Hai-xiao Deng Ming Gu Bo Liu Shanghai Advanced Research Institute Chinese Academy of SciencesShanghai 201412People’s Republic of China

The Shanghai high-repetition-rate X-ray free-electron laser and extreme light facility(SHINE)operates at a maximum repetition rate of 1 MHz.Kicker magnets are key components that distribute electron bunches into three different undulator lines in a bunch-by-bunch mode.The kicker field width must be less than the time interval between bunches.A lumpedinductance kicker prototype was developed using a vacuum chamber with a single-turn coil.The full magnetic field strength was 0.005 T.This paper presents the requirements,design considerations,design parameters,magnetic field calculations,and measurements of the kicker magnets.The relevant experimental results are also presented.The pulse width of the magnetic field was approximately 600 ns,and the maximum operation repetition rate was 1 MHz.The developed kicker satisfies the requirements for the SHINE project.Finally,numerous recommendations for the future optimization of kicker magnets are provided.

关键词： X-ray free-electron laser Kicker magnet Beam switchyard High repetition rate Ni-Zn ferrites