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Monitoring immune function after rapid corticosteroid reduction in kidney transplant recipients

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Chinese Medical Journal 2011年第5期124卷 679-682页

作者： LI Shi-hai WANG Wei HU xiao-peng YIN Hang ren Liang YANG xiao-yong LIU Hang ZHANG xiao-dong Department of Urology Beijing Chaoyang Hospital of Capital Medical University Beijing 100020 China

Background Long-term use of steroid with large dosage might cause many adverse effects in kidney transplant patients; reducing steroid dosage to a low level for maintenance is helpful in avoiding the side-effects, but meanwhile, acute rejection may rise to be a main concern. The present research monitored the immune function changes and the incidence of acute rejection and infection after rapid steroid reduction to investiclate the safety of this *** A prospective trial was conducted, using tacrolimus and mycophenolate mofetil as the basic immunosuppressive regimen, in addition to antibody induction with basiliximab. Corticosteroid dosage was rapidly reduced to 10 mg/d seven days post-transplantation in the experimental group, and the standard corticosteroid therapy was employed in the control group. Patient immunity was monitored by the Immune Cell Function Assay pre- and two weeks post-transplantation. The incidence of acute rejection and infection were compared between the experimental and control *** Comparison of intracellular adenosine triphosphate （iATP） values detected two weeks post-transplantation for the control group （（324±45） ng/ml） and the experimental group （（345±91） ng/ml） did not reveal a significant difference （P 〉0.05）. The incidence of acute rejection was analogous between groups （P 〉0.05）, while an increased incidence of infection was observed in the control group （53% （n=-16）） versus the experimental group （22% （n=-6）, P 〈0.05）. Overall, recipients in the control group had longer and more recurrent infections than those in the experimental group （P 〈0.05）. Patients in the control group had a lower immune response （（235±35） ng/ml） than those in the experimental group （（286±16） ng/ml） when infection occurred （P 〈0.05）.Conclusion Rapid reduction of steroid early after kidney transplantation does not lead to a significant rise in patient immunity. It is a safe and effective therapy for kidney transplant patients.

关键词： kidney transplantation corticosteroid reduction acute rejection immune cell function assay infection

g-C_(3)N_(4)nanosheets coupled with CoSe_(2)as co-catalyst for efficient photooxidation of xylose to xylonic acid

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Green Energy & Environment 2025年第1期10卷 231-238页

作者： Qi Hao Yijun Liu ren Zou Ge Shi Shilian Yang Linxin Zhong Wu Yang xiao Chi Yunpeng Liu Shimelis Admassie Xinwen peng State Key Laboratory of Pulp and Paper Engineering South China University of TechnologyGuangzhou510641GuangdongChina Hainan Key Laboratory of Storage&Processing of Fruits and Vegetables Agricultural Products Processing Research InstituteChinese Academy of Tropical Agricultural SciencesZhanjiangGuangdong524001China Department of Chemistry and Centre for Advanced 2D Materials(CA2DM)National University of Singapore 3 Science Drive 3 Singapore117543Singapore School of Materials Science and Hydrogen Energy Foshan UniversityFoshan528231GuangdongChina Department of Chemistry Addis Ababa UniversityPO BOX 1176Addis AbabaEthiopia

Photocatalysis has emerged as an effective approach to sustainably convert biomass into value-added ***_(2)is a promising nonprecious,efficient cocatalyst for photooxidation,which can facilitate the separation of photogenerated electron–holes,increase the reaction rates,and enhance photocatalytic *** this work,we synthesized a stable and efficient photocatalysis system of CoSe_(2)/g-C_(3)N_(4)through attaching CoSe_(2)on g-C_(3)N_(4)sheets,with a yield of 50.12%for the selective photooxidation of xylose to xylonic *** light illumination,the photogenerated electrons were prone to migrating from g-C_(3)N_(4)to CoSe_(2)due to the higher work function of CoSe_(2),resulting in the accelerated separation of photogenerated electron–holes and the promoted ***,this study reveals the unique function of CoSe_(2),which can significantly promote oxygen adsorption,work as an electron sink and accelerate the generation of ·O_(2)^(-),thereby improving the selectivity toward xylonic acid over other *** work provides useful insights into the design of selective photocatalysts by engineering g-C_(3)N_(4)for biomass high-value utilization.

关键词： Biomass photooxidation Hemicelluloses Xylose g-C_(3)N_(4) Xylonic acid

Selective serotonin reuptake inhibitors in the treatment of major depressive disorder after brain trauma:Systematic review and metaanalysis

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World Journal of Psychiatry 2025年第3期15卷 311-318页

作者： ren-Xian Gao xiao-Na Zhang peng Zhu Department of Emergency Wenzhou People's Hospital(The Third Affiliated Hospital of Shanghai University)Wenzhou 325000Zhejiang ProvinceChina Department of Orthopedics Wenzhou Central HospitalWenzhou 325000Zhejiang ProvinceChina

BACKGROUND Traumatic brain injury(TBI)poses a considerable risk to human *** TBI,individuals are susceptible to a range of psychiatric disorders,with depression being a primary *** serotonin reuptake inhibitors(SSRIs)are frequently used in the treatment of depression;however,their efficacy in addressing major depressive disorder(MDD)in adults following TBI remains *** To investigate the efficacy of SSRIs in the treatment of MDD after *** A comprehensive search across multiple databases was conducted following the guidelines outlined in the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement,encompassing studies published until May *** review focused on studies that examined the efficacy of SSRIs in the treatment of MDD following *** were assessed based sample size,treatment duration,treatment methodologies,severity of brain injury,assessment techniques,and drug response.A random-effects model was used to derive the summary effect *** Eight studies compared the reduction in depression scores in patients with MDD after TBI and SSRI *** eight studies did not exhibit heterogeneity(I^(2)=38%).The depression score for MDD after TBI in the SSRI group decreased more than that in the control group[odds ratio(OR)1.68,95%CI:1.09-2.58,P=0.02].The adverse reactions after treatment included diarrhea,dizziness,dry mouth,nausea,or *** was no difference in the incidence of adverse reactions after treatment between the two groups(OR 1.16,95%CI:0.78-1.73,P=0.46).These studies did not show significant heterogeneity(I^(2)=44%).CONCLUSION SSRIs may be effective in treating patients with MDD after *** powered,randomized,controlled trials are required to confirm these findings.

关键词： Antidepressant Meta-analysis Depression Traumatic brain injury Selective serotonin reuptake inhibitors

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糖尿病在急性心肌梗死危险评估中地位的探讨

中国危重病急救医学 2011年第6期23卷 322-328页

作者：彭晓韧赵艳芳邹大进顾萍解放军第八一医院内分泌科江苏南京210002 解放军第八一医院心脏内科江苏南京210002 第二军医大学附属长海医院内分泌科南京军区南京总医院内分泌科

目的观察血糖升高对急性心肌梗死（AMI）患者预后的影响,探讨糖尿病在AMI危险评估中的地位.方法回顾性选择解放军第八一医院2000年1月至2010年5月收治的AMI患者.将无糖尿病史、空腹血糖（FBG）≥7.0 mmol/L,而后又恢复正常定义为非糖... 详细信息

目的观察血糖升高对急性心肌梗死（AMI）患者预后的影响,探讨糖尿病在AMI危险评估中的地位.方法回顾性选择解放军第八一医院2000年1月至2010年5月收治的AMI患者.将无糖尿病史、空腹血糖（FBG）≥7.0 mmol/L,而后又恢复正常定义为非糖尿病AMI患者的应激性高血糖.根据FBG水平将糖尿病和非糖尿病患者分为〈7.0、7.0～7.9、8.0～11.0及≥11.1 mmol/L 4组,观察院内病死率、并发症发生率及降糖治疗情况;并对AMI预后危险因素进行Logistic回归分析.结果共入选AMI患者152例,糖尿病组45例,其中FBG≥8.0 mmol/L者占73.3%（33例）,FBG≥11.1 mmol/L者占46.7%（21例）;非糖尿病组107例,发生应激性高血糖者（47例,占43.9%）中有91.5%的患者（43例）FBG为7.0～11.0 mmol/L.糖尿病组院内病死率较非糖尿病组显著增高（35.6%比15.9%,P=0.007）,且两组病死率均随FBG升高呈上升趋势.多因素Logistic回归分析显示,FBG≥8.0 mmol/L糖尿病患者死亡风险是FBG〈8.0 mmol/L者的12.28倍,FBG≥7.0 mmol/L非糖尿病患者死亡风险是FBG〈7.0 mmol/L者的4.81倍.FBG是AMI死亡的独立危险因素,糖尿病组相对比值比（OR）为1.03,95%可信区间（95%CI）为1.01～1.16,P=0.012;非糖尿病组OR为1.56,95%CI为1.09～2.23,P=0.015.糖尿病组充血性心力衰竭发生率较非糖尿病组显著增高（40.0H比22.4%,P=0.027）;其中非糖尿病组FBG≥7.0 mmol/L者肺部感染、充血性心力衰竭、严重心律失常及急性脑血管事件发生率（分别为51.1%、34.0%、27.7%、14.9%）均较FBG〈7.0 mmol/L者（分别为18.3%、13.3%、10.0%、0）显著增高（P〈0.05或P〈0.01）,而在糖尿病组中未观察到该现象.糖尿病组中有80.0%（36例）的患者接受降糖治疗,其中23例（占63.9%）应用胰岛素;而非糖尿病组应激性高血糖者无一例进行降血糖治疗.结论糖尿病AMI患者及伴应激性高血糖的非糖尿病AMI患者院内病死率和并发症发生率增加,糖尿病史和血糖都是影响AMI预后的危险因素,将二者结合起来对AMI进行危险分层更为合理.

关键词：心肌梗死,急性糖尿病应激性高血糖空腹血糖预后危险分层

应激性高血糖对非糖尿病急性心肌梗死预后的影响

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中华急诊医学杂志 2011年第6期20卷 631-636页

作者：彭晓韧赵艳芳邹大进解放军第81医院内分泌科南京210002 解放军第81医院心脏科南京210002 第二军医大学附属长海医院内分泌科

目的急性心肌梗死（acute myocardial infarction，AMI）常见血糖升高，其增高的程度与疾病转归相关。现以空腹血糖定义非糖尿病AMI患者的应激性高血糖，研究应激性高血糖对非糖尿病的AMI院内预后的影响。方法研究对象为南京解放军第81... 详细信息

目的急性心肌梗死（acute myocardial infarction，AMI）常见血糖升高，其增高的程度与疾病转归相关。现以空腹血糖定义非糖尿病AMI患者的应激性高血糖，研究应激性高血糖对非糖尿病的AMI院内预后的影响。方法研究对象为南京解放军第81医院2000年1月至2010年5月收治入院的107例非糖尿病AMI患者。回顾性分析各组的院内死亡和院内并发症。排除标准：（1）年龄小于18岁；（2）有糖尿病史；（3）无糖尿病史但住院期间启动降糖治疗的患者；（4）非心血管病因的急性心肌梗死患者；（5）严重肝肾功能不全、严重肺部基础疾患、恶性肿瘤晚期患者；（6）近期使用过类固醇药物以及甲状腺机能亢进、库欣综合征等影响葡萄糖代谢疾病的患者。根据空腹血糖（fasting blood glucose，FBG）水平将其分为4组，分别是：〈7．0mmol／L，7．0～8．0mmol／L，8．0～11．1mmol／L，≥11．1mmol/L。采用Stata9．2统计软件，分别进行成组t检验、方差分析、秩和检验及确切概率法分析。对有意义的变量进行多因素logistics回归分析。结果发生应激性高血糖47例（43．9％）。FBGt〉7．0mmol／L的患者即有应激性高血糖的患者较FBG〈7．0mmol／L患者的病死率显著增高，分别是27．66％和6．67％（P=0．0063），OR=5．35（95％C／1．61～17．75，P=0．0061），肺部感染、充血性心力衰竭、严重心律失常和急性脑血管事件等院内并发症发生率也显著增高。经多因素Logistic回归分析显示FBG是AMI死亡的独立危险因素，OR=1．56（95％CI1．09～2．23）。结论有应激性高血糖的非糖尿病AMI患者死亡风险增高、院内并发症显著增多。应激性高血糖可作为判定非糖尿病AMI预后的一个较好指标。

关键词：急性心肌梗死非糖尿病应激高血糖症空腹血糖预后院内死亡院内并发症

Transforming waste particles into valuable adsorbents via amyloid-mediated molecular engineering

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Science China Chemistry 2025年第1期68卷 317-328页

作者： Qingmin Yang Jian Zhao Yujia Zhang Xingyu Zhou Hao ren Bowen Hu Zhongli Lei Lixin Chen peng Yang Key Laboratory of Applied Surface and Colloid Chemistry Ministry of EducationSchool of Chemistry and Chemical EngineeringShaanxi Normal UniversityXi’an 710119China School of Material and Chemical Engineering Bengbu UniversityBengbu 233030China Anhui Provincial Engineering Laboratory of Silicon-Based Materials Bengbu 233030China Xi’an Key Laboratory of Polymeric Soft Matter School of Chemistry and Chemical EngineeringShaanxi Normal UniversityXi’an 710119China International Joint Research Center on Functional Fiber and Soft Smart Textile School of Chemistry and Chemical EngineeringShaanxi Normal UniversityXi’an 710119China School of Chemistry and Chemical Engineering Northwestern Polytechnical UniversityXi’an 710129China

The high-value utilization of industrial solid waste using a facile and eco-friendly process is of great interest and significance in reducing environmental pollution and developing a green circular ***,we propose an amyloid-mediated molecular engineering strategy to transform particulate waste into valuable adsorbents for metal *** method has the advantage of aqueous solution fabrication under mild conditions without the use of high-temperature hydrothermal methods and toxic chemical ***-mediated molecular engineering manipulates the phase transition of bovine serum albumin(BSA)on particulate waste surfaces,resulting in a remarkable~3.1 times improvement in the adsorption capacity of fly ash,a typical industrial solid waste for gold ions after modification with the phase-transitioned BSA(PTB).The resultant adsorption ability was 69–1,980 times higher than those of conventional and emerging adsorbent materials such as ion exchange resins,activated carbon(AC),covalent organic frameworks(COFs),and metal-organic frameworks(MOFs).We further demonstrated the application of our PTB-modified materials in the recovery of precious metals from low-grade gold ore and electronic waste ***,this strategy could increase the value of waste materials nearly 27 *** addition,this method is generally extendable to other conventional industrial adsorbents such as resin,clay,and Al_(2)O_(3),and enhances their adsorption capabilities at least ***,this work provides a simple and green approach for improving the adsorption performance of solid particles,and is expected to develop into a universal strategy for transforming waste particles into high-value-added products.

关键词： amyloid-like protein aggregates surface engineering fly ash solid waste adsorption

Diagnosis and management of first branchial fistula: a study of 12 cases

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Journal of Otology 2008年第1期3卷 51-55页

作者： OU Yong-kang, XU Yao-dong, LIU Xiang, HUANG xiao-ming, peng Jie-ren, ZHENG Yi-qing Department of Otorhinolaryngology&Head-Neck Surgery, The 2nd Affiliated Hospital of Sun Yat-sen University Department of Otorhinolaryngology&Head–Neck Surgery The 2nd Affiliated Hospital of Sun Yat–sen University

Objectives To report authors’ experiences in the diagnosis and treatments of congenital first branchial fistula (congenital auriculocervical fistula). Materials and Methods Twelve cases of congenital first branchial fistula were reviewed. Of these, 8 underwent fistulectomy with facial nerve dissection and partial parotidectomy and 4 underwent simple fistulectomy. Results The inner openings (upper opening) of fistulae lay in the following sites: inferioposterior wall at the junction of cartilaginous and bony segments of the auricular canal and inferior wall of cartilaginous auricular canal. The outer openings(lower opening) lay along the anterior border of upper sternocleidomastoid muscle, at the mastoid tip and posterior to the mandibular angle. Complete fistulae resection was achieved in all but one case. Eleven cases were followed for 5 year with no recurrence. Recurrence occurred in 1 case 6 months after the primary surgery and revision surgery was performed. Conclusions Pre-operative radiography for the location and course of the fistula is crucial for successful fistula resection, especially in cases with past infections. Facial nerve dissection should be done routinely for deeply located fistulae.

关键词： Congenital Malformation First Branchia Auriculocervical Fistula Diagnosis Surgery

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生化指标对中老年人群白内障发病的影响

国际眼科杂志 2016年第12期16卷 2244-2246页

作者：周洋任鹏晓梁勇新疆医科大学第五附属医院眼科

目的：探讨生化指标对中老年人群白内障发病的影响。方法：选择2014-01/2016-01间我院诊治的132例244眼中老年白内障患者作为观察组,并选择同期我院收治的156例312眼非白内障患者作为对照组。根据所有入选者年龄的不同分为3个亚组,其中4... 详细信息

目的：探讨生化指标对中老年人群白内障发病的影响。方法：选择2014-01/2016-01间我院诊治的132例244眼中老年白内障患者作为观察组,并选择同期我院收治的156例312眼非白内障患者作为对照组。根据所有入选者年龄的不同分为3个亚组,其中40~59岁为A组,60~79岁为B组,80岁以上为C组。检测所有入选者的血液生化指标,主要包括周血白蛋白（ALB）、球蛋白（GLB）、总蛋白（TP）、葡萄糖（GLU）、尿素氮（BUN）、尿酸（UA）、肌酐（Cr）、谷丙转氨酶（ALT）、乳酸脱氢酶（LDH）、碱性磷酸酶（ALP）、总胆固醇（TC）、钙离子（Ca）、钠离子（Na）、钾离子（K）和磷离子（P）等指标,并进行相关性分析。结果：两组患者的ALP、ALT、K、P、LDH水平差异无统计学意义（P〉0.05）;而观察组患者的ALB、GLB、TP、GLU、BUN、Cr、TC、Ca、Na水平显著高于对照组,差异有统计学意义（P〈0.05）。经多因素分析发现,ALB、GLU、BUN、Cr、Ca与白内障的发生发展存在显著相关性。以年龄组为单位分析结果显示：A组中观察组患者的ALB、GLU、Na水平显著高于对照组,差异有统计学意义（P〈0.05）;B组中白内障患者的ALB、BUN、Cr、GLU、Na水平显著高于对照组,差异有统计学意义（P〈0.05）;C组中白内障患者的BUN、Cr、GLU、Na水平显著高于对照组,差异有统计学意义（P〈0.05）。结论：中老年白内障患者外周血中ALB、TP、BUN、Cr、TC、Ca水平均显著升高,这些变化可能与白内障病变存在着一定的关联性。

关键词：白内障生化指标中老年

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高血糖与急性心肌梗死患者的不良预后

中华内分泌代谢杂志 2011年第10期27卷 868-872页

作者：彭晓韧张雯赵艳芳邹大进解放军第81医院内分泌科南京210002 解放军第81医院心脏内科南京210002 第二军医大学附属长海医院内分泌科上海

高血糖在急性心肌梗死时很常见，并且不论是否有糖尿病史，急性心肌梗死预后较差都与其有关。虽然国内外已对此进行了深入的研究，但仍有很多问题有待明确。本文对近年来高血糖及其与急性心肌梗死预后的相关进展进行介绍，对存在的争议... 详细信息

高血糖在急性心肌梗死时很常见，并且不论是否有糖尿病史，急性心肌梗死预后较差都与其有关。虽然国内外已对此进行了深入的研究，但仍有很多问题有待明确。本文对近年来高血糖及其与急性心肌梗死预后的相关进展进行介绍，对存在的争议进行阐述。

关键词：高血糖急性心肌梗死死亡率预后胰岛素