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Fluorescence microscopic morphology and inhibition ratestudies on apoptosis of osteosarcoma cells induced by ^(153)Sm

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Nuclear Science and Techniques 2000年第4期11卷 263-266页

作者： ZHU Shou-peng, xiao Dong, han xiao-Feng (Suzhou Medical College, Sizhou 215007) 苏州医学院江苏苏州 215007

The apoptosis of osteosarcoma cells treated with irradiation by 153Sm-EDTMP was studied. The morphological changes in osteosarcoma cells were observed by fluorescence microscopy. It was found that osteosarcoma cells exposed with 153Sm-EDTMP displayed significant nuclear fragmentation and marked pyknosis. With the prolongation of observing period, the membrane bound apoptotic bodies formation was observed. It should be noted, that with the lengthening of irradiation time by 153Sm-EDTMP, the inhibition rate of proliferation of osteosarcoma cells increased progressively.

关键词：钐153 ^153Sm-EDTMP 放射性核素标记荧光显微镜胃肉瘤肿瘤细胞细胞凋亡

Electron microscopic observations and DNA chain fragmentation studies on apoptosis in bone tumor cells induced by ^(153)Sm-EDTMP

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Nuclear Science and Techniques 1997年第3期8卷 163-165页

作者： Zhu Shou peng, xiao Dong and han xiao Feng ( Suzhou Medical College, Suzhou 215007)

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关键词： DNA 胃癌细胞 153Sm-EDTMP

High-entropy oxide-supported platinum nanoparticles for efficient hydrogen evolution reaction

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Rare Metals 2024年第4期43卷 1537-1546页

作者： Ming-Yu Fan Jia-Jun Wang Jun Zhao Hong Zhang Tian-Yi Ma xiao-peng han Wen-Bin Hu School of Materials Science and Engineering Tianjin Key Laboratory of Composite and Functional Materials Key Laboratory of Advanced Ceramics and Machining TechnologyTianjin UniversityTianjin300350China Joint School of National University of Singapore and Tianjin University International Campus of Tianjin UniversityFuzhou350207China School of Science RMIT UniversityMelbourneVIC3000Australia

High-entropy oxides(HEOs)are a new class of single-phase structures with unique electronic and catalytic properties;therefore,it is worthwhile to explore their applications in *** this study,a Pt/(FeCoNiCrAl)_(3)O_(4)nanohybrid using HEO as a support was developed as an efficient catalyst for the hydrogen evolution reaction(HER).Pt/(FeCoNiCrAl)_(3)O_(4)exhibited high HER activity with a low overpotential of 22 mV at10 mA·cm^(-2),outperforming other binary,ternary,and quaternary *** HER activity of Pt/(FeCoNiCrAl)_(3)O_(4)was higher than that of a commercial Pt/C with a significantly lower Pt *** catalyst exhibited good activity and long-term stability(60 h)in an electrolytic water-splitting *** good activity can be attributed to the fact that the introduction of Pt effectively facilitates electronic interactions between Pt and the *** addition,the HEO substrate was more favorable for dispersing Pt particles,optimizing the electrochemical specific surface area,and significantly reducing the charge resistance of the *** study extends the application of HEOs in electrocatalysis and demonstrates the promising prospects of HEOs as supports for electrocatalysts.

关键词： High-entropy oxides Hydrogen evolution reaction Nanohybrid Water electrolysis

Improving Li reversibility in Li metal batteries through uniform dispersion of Ag nanoparticles on graphene

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Rare Metals 2022年第10期41卷 3391-3400页

作者： Yu Gao Bing-Feng Cui Jia-Jun Wang Zhao-Yong Sun Qiang Chen Yi-Da Deng xiao-peng han Wen-Bin Hu School of Materials Science and Engineering Tianjin Key Laboratory of Composite and Functional Materials Key Laboratory of Advanced Ceramics and Machining TechnologyTianjin UniversityTianjin300350China Joint School of National University of Singapore and Tianjin University International Campus of Tianjin UniversityFuzhou350207China China Energy Lithium Co. LtdTianjin300072China State Key Laboratory of Marine Resource Utilization in South China Sea School of Materials Science and EngineeringHainan UniversityHaikou570228China

Li metal is the most attractive and promising anode material for next-generation high-energy ***,uncontrolled Li dendrite growth during cycling remains a highly challenging *** solve this problem,silver-coated graphene(Ag/GH)was prepared via a simple liquid-phase reduction *** effect of Ag/GH on Li deposition behavior was investigated by adjusting the dispersion of Ag nanoparticles(Ag NPs).Subsequently,a composite electrode was fabricated via uniform deposition of metallic Li on Ag/*** was used as a lithiophilic nucleating agent to ensure uniform deposition of Li and inhibit the growth of Li dendrites on the *** prepared composite anode showed a significantly improved performance compared to the unmodified *** symmetric cell comprising this composite electrode exhibited a stable cycling performance with a low hysteresis of~40 mV and a lifetime of>2000 h at a current density of 0.5 mA·cm^(-2).Meanwhile,the discharge capacity reached 0.5 mAh·cm^(-2).In addition,Ag/GH was found to be amenable to large-scale ***,the composite Ag/GH anode exhibited improved performance and the preparation method showed significant potential for application in the manufacture of Li metal batteries.

关键词： Ag/graphene composite Uniform Li deposition Li anodes Li metal batteries

Size-controllable synthesis and high-performance formic acid oxidation of polycrystalline Pd nanoparticles

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Rare Metals 2019年第2期38卷 115-121页

作者： Hui-Hui Wang Jin-Feng Zhang Ze-Lin Chen Meng-Meng Zhang xiao-peng han Cheng Zhong Yi-Da Deng Wen-Bin Hu Tianjin Key Laboratory of Composites and Functional Materials and Key Laboratory of Advanced Ceramics and Machining Technology (Ministry of Education) Tianjin University

A facile approach was developed for the synthesis of polycrystalline palladium nanoparticles(Pd NPs)by using tannic acid(TA) as green reagent and stabilizer in a 30 ℃ water bath. The size of Pd NPs can be tuned in a range of 10–60 nm simply by adjusting the concentration of Pd precursor. The catalytic activity and stability of the as-obtained Pd NPs toward formic acid oxidation were analyzed. It is found that these Pd NPs with different sizes exhibit size-dependent and enhanced formic acid oxidation performance compared to the commercial Pd black catalyst. It should be noted that the Pd catalysts with an average size of 24 nm demonstrate the best catalytic activity and stability among the other prepared Pd NPs, which can be ascribed to its larger electrochemical surface area(ECSA)and polycrystalline structure with defects.

关键词： Polycrystalline palladium nanoparticle Size controllable Tannic acid: Room temperature Formic acid oxidation

Polymorphism of Exon 2 of FSHβ Gene and Its Relationship with Reproduction Performance in Two Goat Breeds

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Agricultural Sciences in China 2010年第6期9卷 880-886页

作者： AN xiao-peng han Dan HOU Jin-xing LI Guang WANG Ya-na LI Ling ZHU Guang-qin WANG Jian-gang SONG Yu-xuan CAO Bin-yun College of Animal Science and Technology Northwest Agriculture and Forestry University Yangling 712100 P..R.China

The objectives of the present study were to detect the polymorphism in follicle stimulating hormone beta （FSHβ） gene and investigate the relationship between FSHβ gene and high prolificacy in *** to the sequence of ovine FSHβ gene,two pairs of primers were designed to detect single nucleotide polymorphism of exon 2 of FSHβ gene in two goat breeds,Xinong Saanen dairy goat and Boer goat,by *** least square mean and genetic variance of different genotypes at polymorphic locus were analyzed,and the selection reaction was forecasted by genetic correlation between marker locus and genetic variance of litter size *** was one polymorphic locus occurring in exon 2 （P2） with three genotypes （EE,EF and FF）.In Xinong Saanen dairy goat,EE genotype had significantly higher （P 〈 0.05） litter size than EF and FF genotype in the first to fourth parity and average parity;EF genotype had significantly higher （P 〈 0.05） litter size than FF genotype in the second and average *** Boer goat,EE genotype had significantly higher （P 〈 0.01） litter size than EF and FF genotype in the second to fourth parity and average parity;EF genotype had significantly higher （P 〈 0.05） litter size than FF genotype in average *** Xinong Saanen dairy and Boer goat,the heredity of litter size was mainly influenced by genetic additive effect and the EE genotype is a favorable marker genotype for litter size in these two breeds.

关键词： goat FSHβ polymorphism litter size

Tungsten disulfide-based nanomaterials for energy conversion and storage

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Tungsten 2020年第2期2卷 109-133页

作者： Chang‑Bin Sun Yu‑Wei Zhong Wen‑Jie Fu Ze‑Quan Zhao Jie Liu Jia Ding xiao‑peng han Yi‑Da Deng Wen‑Bin Hu Cheng Zhong School of Materials Science and Engineering Tianjin UniversityTianjin 300072China Joint School of National University of Singapore and Tianjin University International Campus of Tianjin UniversityFuzhou 350207China

Energy and environmental issues received widespread attentions due to the fast growth of world population and rapid development of social *** a transition metal dichalcogenide,tungsten disulfide(WS_(2))nanomaterials make important research progress in the field of energy conversion and *** view of the versatile and rich microstructure of these mate-rials,the modification and controllable synthesis of WS_(2) nanomaterials also inspire a research *** review mainly focuses on WS_(2)-based nanomaterials in the application of energy conversion and storage as well as discusses some basic characteristics and modification strategies of ***,the research progress of WS_(2)-based nanomaterials is reviewed and some prospects for future research directions are *** review is expected to be beneficial to the future study of WS_(2) nanomaterials used in the field of energy conversion and storage.

关键词： Nanomaterials Tungsten disulfide Controlled synthesis Energy conversion Energy storage

Effects of Bifidobacterium lactis BLa80 on fecal and mucosal flora and stem cell factor/c-kit signaling pathway in simulated microgravity rats

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World Journal of Gastroenterology 2025年第1期31卷 93-109页

作者： Ping Zhang Ying Zhu Pu Chen Tong Zhou Zhe-Yi han Jun xiao Jian-Feng Ma Wen Ma peng Zang Ying Chen Graduate School Hebei North UniversityZhangjiakou 075000Hebei ProvinceChina Key Laboratory of Aerospace Nutrition and Food Engineering China Astronaut Research and Training CenterBeijing 100094China Department of Gastroenterology The Air Force Medical CenterBeijing 100142China Department of Blood Transfusion Air Force Medical CenterBeijing 100142China

BACKGROUND Simulated microgravity environment can lead to gastrointestinal motility *** pathogenesis of gastrointestinal motility disorders is closely related to the stem cell factor(SCF)/c-kit signaling pathway associated with intestinal flora and Cajal stromal ***,intestinal flora can also affect the regulation of SCF/c-kit signaling pathway,thus affecting the expression of Cajal stromal *** cells are the pacemakers of gastrointestinal *** To investigate the effects of Bifidobacterium lactis(***)BLa80 on the intestinal flora of rats in simulated microgravity and on the gastrointestinal motility-related SCF/c-kit *** The internationally recognized tail suspension animal model was used to simulate the microgravity environment,and 30 rats were randomly divided into control group,tail suspension group and drug administration tail suspension group with 10 rats in each group for a total of 28 *** tail group was given *** BLa80 by intragastric administration,and the other two groups were given water intragastric administration,the concentration of intragastric administration was 0.1 g/mL,and each rat was 1 mL/***&eosin staining was used to observe the histopathological changes in each segment of the intestine of each group,and the expression levels of SCF,c-kit,extracellular signal-regulated kinase(ERK)and p-ERK in the gastric antrum of each group were detected by Western blotting and *** fecal flora and mucosal flora of rats in each group were detected by 16S *** Simulated microgravity resulted in severe exfoliation of villi of duodenum,jejunum and ileum in rats,marked damage,increased space between villi,loose arrangement,shortened columnar epithelium of colon,less folds,narrower mucosal thickness,reduced goblet cell number and crypts,and significant improvement after probiotic *** microgravity reduced the expressions of SCF and c-kit,and increased the express

关键词： Simulated microgravity Rat Intestinal flora Gastrointestinal motility Stem cell factor/c-kit signaling pathway

Interleukin-17A facilitates tumor progression via upregulating programmed death ligand-1 expression in hepatocellular carcinoma

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 176-198页

作者： Zhong-Xia Yang Li-Ting Zhang xiao-Jun Liu Xue-Bin peng xiao-Rong Mao The First School of Clinical Medicine Lanzhou UniversityLanzhou 730000Gansu ProvinceChina Department of Infectious Diseases The First Hospital of Lanzhou UniversityLanzhou 730000Gansu ProvinceChina Department of Radiotherapy Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina

BACKGROUND Hepatocellular carcinoma(HCC)is an inflammation-associated tumor with a dismal *** has become an important treatment strategy for HCC,as immunity is closely related to inflammation in the tumor *** regulates the expression of programmed death ligand-1(PD-L1)in the immunosuppressive tumor microenvironment and affects im-munotherapy ***-17A(IL-17A)is involved in the remodeling of the tumor microenvironment and plays a protumor or antitumor role in different *** hypothesized that IL-17A participates in tumor progression by affe-cting the level of immune checkpoint molecules in *** upregulation of PD-L1 expression in HCC cells by IL-17A was assessed by reverse transcription PCR,western blotting,and flow *** studies were conducted with gene knockout models and pathway *** function of IL-17A in immune evasion was explored through coculture of T cells and HCC *** effects of IL-17A on the malignant biological behaviors of HCC cells were evaluated in vitro,and the antitumor effects of an IL-17A inhibitor and its synergistic effects with a PD-L1 inhibitor were studied in *** IL-17A upregulated PD-L1 expression in HCC cells in a dose-dependent manner,whereas IL-17A receptor knockout or treatment with a small mothers against decapentaplegic 2 inhibitor diminished the PD-L1 expression induced by ***-17A enhanced the survival of HCC cells in the coculture ***-17A increased the viability,G2/M ratio,and migration of HCC cells and decreased the apoptotic *** D1,VEGF,MMP9,and Bcl-1 expression increased after IL-17A treatment,whereas BAX expression *** combination of IL-17A and PD-L1 inhibitors showed synergistic antitumor efficacy and increased cluster of differentiation 8+T lymphocyte infiltration in an HCC mouse *** IL-17A upregulates PD-L1 expression via the IL-17A receptor/phosphorylation-small mothers against

关键词： Interleukin-17A Programmed death ligand-1 Interleukin-17A receptor Small mothers against decapentaplegic 2 Hepatocellular carcinoma Immunotherapy