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Comparison of the retinal modulation transfer function between amblyopes successfully corrected and normal subjects

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International Journal of Ophthalmology(English edition) 2011年第3期4卷 284-285页

作者： xiao-ming huang, Guo-Xing Xu Optometry and Ophthalmology Hospital Affiliated to Wenzhou Medical College Wenzhou 325027 Zhejiang Province China The First Hospital Affiliated to Fujian Medical University Fuzhou 350005 Fujian Province China

AIM:To analyze the retinal modulation transfer function between amblyopes whose visual acuity was corrected to 5.0 and normal subjects at the same age. METHODS: RM-800 used to detect contrast sensitivity was adopted to measure MTF of 96 amblyopes (96 eyes) whose visual acuity was corrected to 5.0 and 80 normal controls (80 eyes) at the same age under six interference fringes (IVA=0.06, 0.1, 0.2, 0.4, 0.6, 0.8). RESULTS: The functional values of amblyopes were significantly lower than those of normal subjects in every fringe (P<0.01), especially in medium and high frequency. CONCLUSION: For amblyopes, MTF was still abnormal after stopping the treatments.

关键词： modulation transfer function amblyope Interference Fringe Visual Acuity

Crystal Structure of Sar1[H79G]-GDP Which Provides Insight into the Coat-controlled GTP Hydrolysis in the Disassembly of COP Ⅱ

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Chinese Journal of Structural Chemistry 2006年第7期25卷 854-860页

作者： RAO Yi-Jian YUAN Cai BIAN Chuan-Bing HOU xiao-Min LI Yong-Dong ZHAO Geng-Xiang YE xiao-ming huang Zi-Xiang huang ming-Dong State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of Matter The Chinese Academy of Sciences Fuzhou Fujian 350002 China

Sarl is a small GTPase involved in COPⅡ vesicle transport. Previous studies showed that H79G mutation of Sarl can lock Sarl in its GTP-bound active conformation, stabilize coat assembly, and prevent the disassembly of COP Ⅱ vesicle coats by reducing Sec23/24 GAP- stimulated hydrolysis. We show here that the replacement of His79 by glycine induces a large conformation change in switch Ⅱ and results in the lost of hydrogen bond between His79 and its associated nucleophilic water molecule that was hypothesized to reduce the GAP-stimulated hydrolysis during the COP Ⅱ assembly and disassembly. These results confirm that the switch Ⅱ conformation is important for COP Ⅱ disassembly through coat-controlled GTP hydrolysis.

关键词： Sarl switch Ⅱ COP Ⅱ disassembly crystal structure

Physical properties and device applications of graphene oxide

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Frontiers of physics 2020年第3期15卷 27-96页

作者： xiao-ming huang Li-Zhao Liu Si Zhou Ji-Jun Zhao School of Ocean Science and Technology Dalian University of TechnologyPanjin124221China School of Mathematical and Physical Sciences Dalian University of TechnologyPanjin124221China Key Laboratory of Materials Modification by Laser Ion and Electron BeamsDalian University of TechnologyMinistry of EducationDalian116024China

Graphene oxide(GO),the functionalized graphene with oxygenated groups(mainly epoxy and hydroxyl),has attracted resurgent interests in the past decade owing to its large surface area,superior physical and chemical properties,and easy composition with other materials via surface functional ***,GO is used as an important raw material for mass production of graphene via ***,under different conditions,the coverage,types,and arrangements of oxygen-containing groups in GO can be varied,which give rise to excellent and controllable physical properties,such as tunable electronic and mechanical properties depending closely on oxidation degree,suppressed thermal conductivity,optical transparency and fluorescence,and nonlinear optical *** on these outstanding properties,many electronic,optical,optoelectronic,and thermoelectric devices with high performance can be achieved on the basis of *** we present a comprehensive review on recent progress of GO,focusing on the atomic structures,fundamental physical properties,and related device applications,including transparent and flexible conductors,field-effect transistors,electrical and optical sensors,fluorescence quenchers,optical limiters and absorbers,surface enhanced Raman scattering detectors,solar cells,light-emitting diodes,and thermal rectifiers.

关键词： graphene oxide mechanics electronics thermal properties nonlinear optics

An 11-gene signature for the prediction of systemic recurrences in colon adenocarcinoma

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Gastroenterology Report 2021年第5期9卷 451-460,I0002,I0003页

作者： Jia-Wei Cai xiao-ming huang xiao-Lan Li Si Qin Yu-ming Rong Xi Chen Jing-Rong Weng Yi-Feng Zou Xu-Tao Lin Department of Colorectal Surgery The Sixth Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdongP.R.China Guangdong Institute of Gastroenterology Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor DiseasesThe Sixth Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdongP.R.China Department of Hepatobiliary Surgery The Sixth Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdongP.R.China Department of Reproductive Medicine The Sixth Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdongP.R.China Department of Medical Ultrasonics The Sixth Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdongP.R.China Department of VIP Region Sun Yat-sen University Cancer CenterGuangzhouGuangdongP.R.China Department of Gastrointestinal Endoscopy The Sixth Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdongP.R.China

Background Prognosis varies among patients within the same colon adenocarcinoma(COAD)stage,indicating the need for reliable molecular markers to enable individualized *** study aimed to investigate gene signatures that can be used for better prognostic prediction of *** Gene-expression profiles of COAD patients were obtained from the Gene Expression Omnibus database(n=332)and The Cancer Genome Atlas database(n=431).The relationship between gene signature and relapse-free survival was analysed in the training set(n=93)and validated in the internal validation set(n=94)and external validation sets(n=145 and 431).Results Overall,11 genes(N-myc downstream regulated gene 1[NDRG1],fms-like tyrosine kinase 1[FLT1],lipopolysaccharide binding protein[LBP],fatty acid binding protein 4[FABP4],adiponectin gene[ADIPOQ],angiotensinogen gene[AGT],activin A receptor,type II-like kinase 1[ACVRL1],CC chemokine ligand 11[CCL11],cell division cycle 42[CDC42],T-cell receptor alpha variable 9_2[TRAV9_2],and proopiomelanocortin[POMC])were identified by univariable and least absolute shrinkage and selection operator(LASSO)Cox regression *** on the risk-score model,the patients were grouped into the high-risk or low-risk groups using the median risk score as the *** area under the curve(AUC)values for 1-,3-,and 5-year recurrence were 0.970,0.849,and 0.859,*** in the high-risk group had significantly poorer relapsefree survival than did those in the low-risk *** predictive accuracy of the 11-gene signature was proven in the validation *** gene signature showed better predictive performance for 1-,3-,and 5-year recurrence than did the other four *** The 11-gene signature showed good performance in predicting recurrence in *** accuracy of the signature for prognostic classification requires further confirmation.

关键词： colon cancer gene signature recurrence prognosis

GenomeSyn:a bioinformatics tool for visualizing genome synteny and structural variations

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Journal of Genetics and Genomics 2022年第12期49卷 1174-1176页

作者： Zu-Wen Zhou Zhi-Guang Yu xiao-ming huang Jin-Shen Liu Yi-Xiong Guo Ling-Ling Chen Jia-ming Song State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources College of Life Science and TechnologyGuangxi UniversityNanningGuangxi 530004China College of Stomatology Guangxi Medical UniversityNanningGuangxi 530021China National Key Laboratory of Crop Genetic Improvement Huazhong Agricultural UniversityWuhanHubei 430070China

Advances in the next-generation and long-read sequencing technologies have promoted the development of genome-wide comparative genomics analysis,and constructing pangenomes and identifying structural variations(SVs)are becoming the frontier of *** genomics is of critical importance for determining the gene function and the evolutionary basis of traits.

关键词： traits Genome structural

Antitumor immunity of low-dose cyclophosphamide:changes in T cells and cytokines TGF-beta and IL-10 in mice with colon-cancer liver metastasis

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Gastroenterology Report 2020年第1期8卷 56-65,I0002页

作者： xiao-ming huang Nan-Rong Zhang Xu-Tao Lin Cai-Yan Zhu Yi-Feng Zou xiao-Jian Wu xiao-Sheng He xiao-Wen He Yun-Le Wan Ping Lan Department of Hepatobiliary Surgery The Sixth Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdongP.R.China Guangdong Institute of Gastroenterology Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor DiseasesThe Sixth Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdongP.R.China Department of Anesthesiology The Sixth Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdongP.R.China Department of Gastrointestinal Endoscopy Department of Colorectal SurgeryThe Sixth Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdongP.R.China Department of Pharmacy The Sixth Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdongP.R.China Department of Colorectal Surgery The Sixth Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdongP.R.China

Background:The tumor immune microenvironment is one of the most important prognostic factors in liver metastasis from colorectal ***-dose cyclophosphamide(CTX)is widely believed to be involved in the modulation of the immune ***,the underlying mechanism of low-dose CTX remains *** study aimed to investigate the antitumor immunity of low-dose CTX in the treatment of colon-cancer liver ***:Thirty mice were randomly divided into five *** liver metastasis was established in colon-cancer models,mice in the treatment groups were injected with low-dose CTX(20 mg/kg)at different time *** and spleen tissues were examined for T-cell markers via flow ***(IL)-10 and transforming growth factor(TGF)-b1 expression levels in liver tissues were analysed by *** interferon(IFN)-c and IL-10 levels were detected by enzyme-linked immunosorbent *** additional 20 mice were randomly allocated into two groups and the survival times were ***:The expression levels of CD4^(+)T cells,CD8^(+)T cells,and IFN-c were down-regulated,whereas those of IL-10 and TGF-b1 were up-regulated in liver metastasis from colon cancer in ***,the local and systemic microenvironments of the liver were altered,which led to reduced antitumor immune responses and subsequently liver ***,treatment with low-dose CTX reversed these *** survival times of mice treated with low-dose CTX were significantly longer than those of the other ***:Low-dose CTX exerts its antitumor activity by changing the systemic and local immune microenvironments and enhancing immune regulation *** could be used as a drug to prevent and treat livermetastasis from colon cancer.

关键词： colon cancer liver metastasis cyclophosphamide immune microenvironment

Solar broadband metamaterial perfect absorber based on dielectric resonant structure of Ge cone array and InAs film

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Chinese Physics B 2021年第11期30卷 325-330页

作者： Kuang-Ling Guo Hou-Hong Chen xiao-ming huang Tian-Hui Hu Hai-Ying Liu Guangdong Provincial Key Laboratory of Nanophotonic Functional Materials and Devices School for Information and Optoelectronic Science and EngineeringSouth China Normal UniversityGuangzhou 510006China

The broadband metamaterial perfect absorber has been extensively studied due to its excellent characteristics and promising application *** this work a solar broadband metamaterial perfect absorber is proposed based on the structure of the germanium(Ge)cone array and the indium arsenide(InAs)dielectric film on the gold(Au)*** results show that the absorption covers the whole ultraviolet-visible and near-infrared *** the case of A>99%,the absorption bandwidth reaches up to 1230 nm with a wavelength range varied from 200 nm to 1430 *** proposed absorber is able to absorb more than 98.7%of the solar energy in a solar spectrum from 200 nm to 3000 *** electromagnetic dipole resonance and the high-order modes of the Ge cone couple strongly to the incident optical field,which introduces a strong coupling with the solar radiation and produces an ultra-broadband *** absorption spectrum can be feasibly manipulated via tuning the structural parameters,and the polarization insensitivity performance is particularly *** proposed absorber can possess wide applications in active photoelectric effects,thermion modulators,and photoelectric detectors.

关键词： metamaterial electromagnetic resonance perfect absorber solar broadband absorption`

A first-principle assisted framework for designing high elastocaloric Ni-Mn-based magnetic shape memory alloy

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Journal of Materials Science & Technology 2023年第3期134卷 151-162页

作者： xiao-ming huang Ying Zhao Hai-Le Yan Shuai Tang Yiqiao Yang Nan Jia Bo Yang Zongbin Li Yudong Zhang Claude Esling Xiang Zhao Liang Zuo Key Laboratory for Anisotropy and Texture of Materials(Ministry of Education) School of Material Science and EngineeringNortheastern UniversityShenyang110819China State Key Laboratory of Rolling and Automation Northeastern UniversityShenyang110819China Analytical and Testing Center Northeastern UniversityShenyang110819China Laboratoire d’Étude des Microstructures et de Mécanique des Matériaux(LEM3) CNRS UMR 7239Universitéde Lorraine57045 MetzFrance

A large adiabatic temperature change(△T_(ad))is a prerequisite for the application of elastocaloric ***,a large volume change ratio(△V/V_(0))during martensitic transformation is favorable to enhance△T_(ad).However,the design or prediction of△V/V_(0)in experiments is a complex task because the structure of martensite changes simultaneously when the lattice parameter of austenite is tuned by mod-ifying chemical *** far,the solid strategy to tailor△V/V_(0)is still urgently *** this work,a first-principles-based method was proposed to estimate△V/V_(0)for Ni-Mn-based *** this method,the substitution of Ga for In is found to be an effective method to increase the value of△V/V_(0)for Ni-Mn-In *** with the strategies of reducing the negative contribution of magnetic en-tropy change(via the substitution of Cu for Mn)and introducing strong crystallographic texture(through directional solidification),an outstanding elastocaloric prototype alloy of Ni_(50)(Mn_(28.5)Cu_(4.5))(In_(14)Ga_(3))was fabricated *** room temperature,a huge△T_(ad)of-19 K and a large specific adiabatic temperature change of 67.8 K/GPa are *** proposed first-principle-assisted framework opens up the possibility of efficiently tailoring△V/V_(0)to promote the design of advanced elastocaloric refrigerants.

关键词： Magnetic shape memory alloy Elastocaloric effect First-principles calculation Martensitic transformation Volume change ratio

Overexpression of G protein-coupled receptor 31 as a poor prognosticator in human colorectal cancer

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World Journal of Gastroenterology 2018年第41期24卷 4679-4690页

作者： Yu-ming Rong xiao-ming huang De-Jun Fan Xu-Tao Lin Feng Zhang Jian-Cong Hu Ying-Xin Tan Xi Chen Yi-Feng Zou Ping Lan VIP Region Sun Yat-sen University Cancer CenterGuangzhou 510060Guangdong ProvinceChina Department of Hepatobiliary Surgery the Sixth Affiliated HospitalSun Yat-sen UniversityGuangzhou 510655Guangdong ProvinceChina Department of Gastrointestinal Endoscopy the Sixth Affiliated HospitalSun Yat-sen UniversityGuangzhou 510655Guangdong ProvinceChina Department of Rheumatology the Sixth Affiliated HospitalSun Yat-sen UniversityGuangzhou 510655Guangdong ProvinceChina Department of Colorectal Surgery the Sixth Affiliated HospitalSun Yat-sen UniversityGuangzhou 510655Guangdong ProvinceChina Guangdong Institute of Gastroenterology Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases the Sixth Affiliated HospitalSun Yat-sen UniversityGuangzhou 510655Guangdong ProvinceChina

AIM To investigate the expression of G protein-coupled receptor 31 (GPR31) and its clinical significance in human colorectal cancer (CRC).METHODS To determine the association between the GPR31 expression and the prognosis of patients, we obtained paraffin-embedded pathological specimens from 466 CRC patients who underwent initial resection. A total of 321 patients from the First Affiliated Hospital of Sun Yat-sen University from January 1996 to December 2008 were included as a training cohort, whereas 145 patients from the Sixth Affiliated Hospital of Sun Yat-sen University from January 2007 to November 2008 were included as a validation cohort. We examined GPR31 expression levels in CRC tissues from two independent cohorts via immunohistochemical staining. All patients were categorized into either a GPR31 low expression group or a GPR31 high expression group. The clinicopathological factors and the prognosis of patients in the GPR31 low expression group and GPR31 high expression group were *** We compared the clinicopathological factors and the prognosis of patients in the GPR31 low expression group and GPR31 high expression group. Significant differences were observed in the number of patients in pM classification between patients in the GPR31 low expression group and GPR31 high expression group (P = 0.007). The five-year survival and tumor-free survival rates of patients were 84.3% and 82.2% in the GPR31 low expression group, respectively, and both rates were 59.7% in the GPR31 high expression group (P < 0.05). Results of the Cox proportional hazard regression model revealed that GPR31 upregulation was associated with shorter overall survival and tumor-free survival of patients with CRC (P < 0.05). Multivariate analysis identified GPR31 expression in colorectal cancer as an independent predictive factor of CRC patient survival (P < 0.05).CONCLUSION High GPR31 expression levels were found to be correlated with pM classification of CRC and to serve as

关键词： G protein-coupled receptor 31 Colorectal cancer Predictive factor Metastasis Clinical significance