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A 3-channel CCD photometer at the Xinglong Observatory

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Research in Astronomy and Astrophysics 2013年第2期13卷 239-252页

作者： Yong-Na Mao xiao-meng lu Jian-Feng Wang xiao-Jun Jiang National Astronomical Observatories Chinese Academy of Sciences Graduate University of Chinese Academy of Sciences Key Laboratory of Optical Astronomy National Astronomical ObservatoriesChinese Academy of Sciences

We describe the design and construction of a new rapid 3-channel CCD photometer, dedicated to simultaneous multicolor photometric observations of rapidly variable objects. This photometer is equipped on the 1-meter telescope at the Xinglong Observatory. It allows simultaneous imaging within fields of view of 18.81′×18.8′, 18.2′×17.6′ and 9.2′×9.2′ in the Sloan Digital Sky Survey＇s g′, r′ and i′ bands, respectively. The results of its calibration and performance are reported.

关键词： instrumentation photometers-- techniques photometric-- stars novae

Evaluation of a scientific CMOS camera for astronomical observations

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Research in Astronomy and Astrophysics 2013年第5期13卷 615-628页

作者： Peng Qiu Yong-Na Mao xiao-meng lu E Xiang xiao-Jun Jiang Xinjiang Astronomical Observatories Chinese Academy of Sciences National Astronomical Observatories Chinese Academy of Sciences University of Chinese Academy of Sciences Key Laboratory of Optical Astronomy National Astronomical Observatories Chinese Academy of Sciences

We evaluate the performance of the first generation scientific CMOS （sC- MOS） camera used for astronomical observations. The sCMOS camera was attached to a 25 cm telescope at Xinglong Observatory, in order to estimate its photometric capabilities. We further compared the capabilities of the sCMOS camera with that of full-frame and electron multiplying CCD cameras in laboratory tests and observations. The results indicate the sCMOS camera is capable of performing photometry of bright sources, especially when high spatial resolution or temporal resolution is desired.

关键词： instrumentation detectors sCMOS CCD

Degradation of Hydrogenated Nitrile-butadiene Rubber in Aqueous Solutions of H2S or HCI

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Chemical Research in Chinese Universities 2013年第4期29卷 806-810页

作者： CONG Chuan-bo CUI Can-can meng xiao-yu lu Shao-jie ZHOU Qiong Department of Material Science and Engineering Beijing Key Laboratory of Failure Corrosion and Protection of Oil~Gas Facilities China University of Petroleum(Beijing) Beijing 102249 P. R. China

The degradation of hydrogenated nitrile-butadiene rubber（HNBR） soaped in aqueous solutions of HzS and HC1 was investigated, The samples unexposed and exposed to different solutions were characterized by 13C nuclear magnetic resonance（~3C NMR）, X-ray photoelectron and infrared spectroscopies. In contrast to those of unexposed samples and samples soaped in HCI solution, the mechanical properties of samples exposed to H2S solution signifi- cantly deteriorated, in which the new groups of C（=O）--NH2, C--S--C and C=S emerged. The mechanism of C=S and C--S--C formation was speculated, except for that of the formation of group C（=O）--NH2, which was widely discussed in acidic condition such as HC1 solution. The formation of C--S--C was due to radical reaction in- itiated by mercapto radical and that of C=S was due to nucleophilic reaction initiated by mercapto cations. This finding is helpful to understanding the seal failure of HNBR in working cnvironment containing H2S.

关键词： Hydrogenated nitrile-butadiene rubbcr(HNBR) Degradation mechanism H2S corrosion

A GRB Follow-up System at the Xinglong Observatory and Detection of the High-Redshift GRB 060927

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Chinese Journal of Astronomy and Astrophysics 2008年第6期8卷 693-699页

作者： Wei-Kang Zheng Jin-Song Deng meng Zhai Li-Ping Xin Yu-Lei Qiu Jing Wang xiao-meng lu Jian-Yan Wei Jing-Yao Hu National Astronomical Observatories Chinese Academy of Sciences Beijing 100012 China Graduate School of Chinese Academy of Sciences Beijing 100049 China

A gamma-ray burst （GRB） optical photometric follow-up system at the Xinglong Observatory of National Astronomical Observatories of China （NAOC） has been constructed. It uses the 0.8-m Tsinghua-NAOC Telescope （TNT） and the 1-m EST telescope, and can au- tomatically respond to GRB Coordinates Network （GCN） alerts. Both telescopes slew relatively fast, being able to point to a new target field within - 1 min upon a request. Whenever available, the 2.16-m NAOC telescope is also used. In 2006 the system responded to 15 GRBs and detected seven early afterglows. In 2007 six GRBs have been detected among 18 follow- up observations. TNT observations of the second most distant GRB 060927 （z = 5.5） are shown, which started as early as 91 s after the GRB trigger. The afterglow was detected in the combined image of the first 19 × 20 s unfiltered exposures. This GRB follow-up system has joined the East-Asia GRB Follow-up Observation Network （EAFON）.

关键词： gamma-rays: bursts gamma-rays: observations telescopes

Genetic Testing of the mucin I gene-Variable Number Tandem Repeat Single Cytosine Insertion Mutation in a Chinese Family with Medullary Cystic Kidney Disease

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Chinese Medical Journal 2017年第20期130卷 2459-2464页

作者： Nuo Si Ke Zheng Jie Ma xiao-lu meng Xue-Mei Li Xue Zhang McKusick-Zhang Center for Genetic Medicine State Key Laboratory of Medical Molecular Biology Institute of Basic Medical Sciences Chinese Academy of Medical Sciences School of Basic Medicine Peking Union Medical College Beijing 100005 China Department of Nephrology Peking Union Medical College Hospital Chinese Academy of Medical Science and Peking Union Medical College Beijing 100073 China

Background： Medullary cystic kidney disease （MCKD） is clinically indistinguishable from several other autosomal-dominant renal diseases： thus, molecular genetic testing is needed to establish a definitive diagnosis. A specific type of single cytosine insertion in the variable number tandem repeat （VNTR） of the mucin 1 （MUC1） gene is the only known cause of MCKD1; however, genetic analysis of this mutation is difficult and not yet offered routinely. To identify the causative mutation/s and establish a definitive diagnosis in a Chinese family with chronic kidney disease, clinical assessments and genetic analysis were performed, including using a modified genotyping method to identify the MUC1-VNTR single cytosine insertion. Methods： Clinical data from three patients in a Chinese family with chronic kidney disease were collected and evaluated. Linkage analysis was used to map the causative locus. Mutation analysis of uromodulin （UMOD） gene was performed using polymerase chain reaction （PCR） and direct sequencing. For MUC1 genotyping, the mutant repeat units were enriched by Mwol restriction, and then were amplified and introduced into pMD-18T vectors. The 192 clones per transformant were picked up and tested by colony PCR and second round of Mwol digestion. Finally, Sanger sequencing was used to confirm the MUC1 mutation. Results： Clinical findings and laboratory results were consistent with a tubulointerstitial lesion. Linkage analysis indicated that the family was compatible with the MCKDI locus. No mutations were found in UMOD gene. Using the modified MUC1 genotyping method, we detected the MUC1-VNTR single cytosine insertion events in three patients of the family; and mutation-containing clones were 12/192, 14/192, and 5/96, respectively, in the three patients. Conclusions： Clinical and genetic findings could support the MCKDI diagnosis. The modified strategy has been demonstrated to be a practical way to detect MUCI mutation.

关键词： Autosomal Dominant Tubulointerstitial Kidney Diseases Genotyping Medullary Cystic Kidney Disease MUC1 Gene Variable Number Tandem Repeat

De novo synthesis of atropisomeric benzofurans via Cu/SPDO complex catalyzed asymmetric formal [3 + 2] annulation

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Science China Chemistry 2025年第1期68卷 174-180页

作者： Fan-xiao meng Xing-Yu Wang Ka lu Ju-Song Yang Fu-Min Zhang Ai-Jun Ma Bao Du Yong-Qiang Tu State Key Laboratory of Applied Organic Chemistry College of Chemistry and Chemical Engineering Lanzhou University School of Chemistry and Chemical Engineering Shanghai Jiao Tong University School of Biotechnology and Health Sciences Wuyi University

Herein, the de novo synthesis of atropisomeric benzofurans through the Cu/spirocyclic-pyrrolidine-oxazoline(SPDO) complex catalyze asymmetric formal [3 + 2] cycloaddition between quinones and ynamides is explored, producing a range of structurally diverse axially chiral benzofurans in satisfactory yields with good to excellent enantioselectivities. Furthermore, density functional theory calculations were applied to explain the possible reaction mechanism.

关键词： benzofuran atropisomers novel de novo synthetic strategy asymmetric formal [3 + 2] cycladdition Cu/SPDO complex DFT calculations

A model of depression in tree shrews:learned helplessness

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A model of depression in tree shrews:learned helplessness

演绎归纳的二分与结合——略论西方逻辑与印度因明之差异

中国神经科学学会第十届全国学术会议

作者： xiao-lu meng Ning ZHU Chun-lu LI Nan SUI Key Laboratory of Mental Health Institute of PsychologyChinese Academy of Sciences University of Chinese Academy of Sciences

Objective We are developing a model of depression in tree shrews,a newly recognized nonhuman primate,using learned helplessness *** helplessness（LH） is widely used for screening new treat targets and the pathophysiological mechanism as an animal model of *** present study was to test the face and predict validity of this *** Male tree shrews were subjected to 40 footshocks for 7 days,uncontrollable and inescapable（UI） or controllable and escapable（CE）.Then fluoxetine（15 mg/kg） was orally administrated for 2 *** the day after stress and the day after drug treatment,depression-like behaviors were determined,including escape latency,escape failure and the breakpoint for 5%sucrose under a progressive-ratio（PR） *** One third of tree shrews subjected to UI footshocks showed increase number of escape failure,prolonged escape latency and reduced breakpoint for 5%*** treatment reduced the number of escape failure and shortened the escape latency,but didn’t affect the breakpoint for *** The learned helplessness in tree shrews shows some depression-like behaviors with individual difference,some of which reversed by a typical *** it requires further validation,the learned helplessness model in tree shrews is a promising primate model for research on the etiology and pathophysiology of depression.

关键词： tree shrews learned helplessness face validity predictive validity

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河北大学学报（哲学社会科学版） 2005年第3期30卷 42-45页

作者：孟晓路徐红欣河北大学政法学院河北保定071002

逻辑与因明有着诸多差异。在逻辑中演绎与归纳是二分的,而演绎体系所要求的普遍必然性的第一原理,归纳并不能提供,这终令西学走入穷途。因明中演绎与归纳完美地于每一论式之中,而佛教认为并不存在普遍必然的因果规律,故因明并不存在西... 详细信息

逻辑与因明有着诸多差异。在逻辑中演绎与归纳是二分的,而演绎体系所要求的普遍必然性的第一原理,归纳并不能提供,这终令西学走入穷途。因明中演绎与归纳完美地于每一论式之中,而佛教认为并不存在普遍必然的因果规律,故因明并不存在西学的尴尬局面。此外逻辑与因明在各自认识方法中的地位及为自为他上亦有不同。

关键词：演绎归纳目明逻辑

Recent Strategies and Advances in Hydrogel‑Based Delivery Platforms for Bone Regeneration

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Nano-Micro Letters 2025年第3期17卷 389-439页

作者： xiao Wang Jia Zeng Donglin Gan Kun Ling Mingfang He Jianshu Li Yongping lu Scientific and Technological Innovation Center for Biomedical Materials and Clinical Research Guangyuan Key Laboratory of Multifunctional Medical HydrogelGuangyuan Central HospitalGuangyuan 628000People’s Republic of China Jiangsu Collaborative Innovation Center of Biomedical Functional Materials Jiangsu Key Laboratory of Bio‑Functional MaterialsSchool of Chemistry and Materials ScienceNanjing Normal UniversityNanjing 210023People’s Republic of China College of Polymer Science and Engineering State Key Laboratory of Polymer Materials EngineeringSichuan UniversityChengdu 610065People’s Republic of China

Bioactive molecules have shown great promise for effectively regulating various bone formation processes,rendering them attractive therapeutics for bone ***,the widespread application of bioactive molecules is limited by their low accumulation and short half-lives in *** have emerged as ideal carriers to address these challenges,offering the potential to prolong retention times at lesion sites,extend half-lives in vivo and mitigate side effects,avoid burst release,and promote adsorption under physiological *** review systematically summarizes the recent advances in the development of bioactive molecule-loaded hydrogels for bone regeneration,encompassing applications in cranial defect repair,femoral defect repair,periodontal bone regeneration,and bone regeneration with underlying ***,this review discusses the current strategies aimed at improving the release profiles of bioactive molecules through stimuli-responsive delivery,carrier-assisted delivery,and sequential ***,this review elucidates the existing challenges and future directions of hydrogel encapsulated bioactive molecules in the field of bone regeneration.

关键词： Hydrogel Bone regeneration Bioactive molecules Drug delivery Nano-/microscale carriers