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Chinese Chemical Letters 2024年第3期35卷 419-422页

作者： Cheng Wu Yixuan Liu Chunsheng xiao Chenyang hu Xuan Pang Xuesi Chen Key Laboratory of Polymer Ecomaterials Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China School of Applied Chemistry and Engineering University of Science and Technology of ChinaHefei 230026China

A new strategy for the metal-free coordination–insertion ring-opening polymerization of tetrahydrofuran by the central metalloid Boron has been first ***(pentafluorophenyl)(phenoxy)borane was used as a catalyst for the polymerization reaction *** polytetrahydrofuran with high molecular weight and narrow molecular weight distribution could be *** proposed mechanism was studied by MALDI-TOF,ESI-MS and O-18 isotope labeling analyses as a metal-free coordination insertion mechanism.

关键词： Metal-free catalyst Bis(pentafluorophenyl)(phenoxy)borane Coordination–insertion mechanism Ring-opening polymerization Polytetrahydrofuran

Advanced oxidation via the synergy of C-defective/C-O band modified ultrathin porous g-C3N4 and PMS for efficient photothermal degradation of bisphenol pollutants and lignin derivatives

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Green Energy & Environment 2024年第7期9卷 1159-1170页

作者： Liquan Jing meng Xie Yuanguo Xu Chun Tong Xia Du Heng Zhao Na Zhong huaming Li Jinguang hu School of Chemistry and Chemical Engineering Jiangsu University Department of Chemical and Petroleum Engineering University of Calgary School of Pharmacy Jiangsu University School of Material Science & Chemical Engineering Harbin University of Science and Technology Institute for Energy Research Jiangsu University

This work uses thermal polymerization of urea nitrate, oxyacetic acid and urea as the raw material to prepare ultra-thin porous carbon nitride with carbon defects and C-O band（OA-UN-CN）. Density functional theory（DFT） calculations showed OA-UN-CN had narrower band gap,faster electron transport and a new internal construction electric field. Additionally, the prepared OA-UN-CN significantly enhanced photocatalytic activation of peroxymonosulfate（PMS） due to enhanced light absorption performance and faster electron overflow. As the result, the OA-UN-CN/PMS could entirely degrade bisphenol A（BPA） within 30 min, where the photodegradation rate was 81.8 and 7.9 times higher than that of g-C3N4and OA-UN-CN, respectively. Beyond, the OA-UN-CN/PMS could likewise degrade other bisphenol pollutants and sodium lignosulfonate efficiently. We suggested possible photocatalytic degradation pathways accordingly and explored the toxicity of its degradation products. This work provides a new idea on the development of advanced photocatalytic oxidation processes for the treatment of bisphenol pollutants and lignin derivatives, via a metal-free photothermal-catalyst.

关键词： Photothermal-catalytic G-C 3 N 4 Peroxymonosulfate Bisphenol Sodium lignosulfonate

The preparation and performance analysis of zirconium-modified aluminum phosphate-based high-temperature(RT-1500℃)resistant adhesive for joining alumina in extreme environment

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Journal of Advanced Ceramics 2024年第7期13卷 911-932页

作者： Jingxuan Liu Yange Wan Bo xiao Jiancun Li Zhanming hu Ruoyu Zhang xiaoxia hu Jiachen Liu Guoshuai Cai Hongli Liu Mingchao Wang College of Science Civil Aviation University of ChinaTianjin 300300China Department of Safety Engineering Civil Aviation University of ChinaTianjin 300300China Binzhou Beicheng Construction Engineering Materials Testing Co. Ltd.Binzhou 256602China Department of Aviation Engineering Civil Aviation University of ChinaTianjin 300300China School of Materials and Engineering Key Lab of Advanced Ceramics and Machining Technology of Ministry of EducationTianjin UniversityTianjin 300072China

High-temperature-resistant adhesives are critical materials in the aerospace *** zirconium-modified aluminum phosphate-based adhesives developed in this work had the advantage of adjustable thermal expansibility,achieving a high matching of coefficient of thermal expansion(CTE)with *** introduction of zirconium can significantly improve the thermal stability of the adhesive matrix,and the Zr/Al ratio substantially affects the various reaction processes inside the adhesive,especially the types of zirconium-containing *** of the zirconium-containing compounds in the A7Z3 adhesive were ZrO_(2) only when the mass ratio of zirconium hydroxide to aluminum hydroxide was 3:7,which was the key reason why it had the highest *** room-temperature bonding strength of A7Z3 after heat treatment at 1500℃reached 67.2 *** pretreatment at 1500℃,the high-temperature bonding strength of A7Z3 was greater than 50 MPa in the range of(room temperature)RT-1000℃.After 40 thermal cycles between RT and 1500℃,the bonding strength still reached 10 *** bonding occurred at temperatures below 1000℃,while chemical bonding dominated above 1000℃based on the generation of Al5BO9 and mullite at the interfaces.

关键词： high-temperature-resistant adhesive thermal expansion property zirconium-modified aluminum phosphate bonding performance thermal cycling bonding mechanism

Is reactive oxygen species the only way for cancer inhibition over single atom nanomedicine?Autophagy regulation also works

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Chinese Chemical Letters 2024年第6期35卷 474-479页

作者： Yuanyi Zhou Ke Ma Jinfeng Liu Zirun Zheng Bo hu Yu meng Zhizhong Li Mingshan Zhu Postdoctoral Innovation Practice Base The First and Fifth Affiliated Hospital of Jinan UniversityGuangzhou 510632China Guangdong Provincial Key Laboratory of Spine and Spinal Cord Reconstruction The Fifth Affiliated Hospital of Jinan University(Heyuan Shenhe People’s Hospital)Heyuan 517465China School of Environment Jinan UniversityGuangzhou 511443China Department of Nephrology The First Affiliated Hospital of Jinan UniversityGuangzhou 510632China

Exploring the therapeutic effect of single atom catalysts beyond reactive oxygen species(ROS)modulation would boost the prosperity of nanomedicine in cancer *** as a vital therapy target offers new options for the control of renal cell carcinoma(RCC)***,Fe single atom-decorated graphene oxide(Fe_(1)-GO)nanosheet is developed to be a feasible autophagy inducer in RCC *** the well-dispersed O-Fe_(1)-O active sites,Fe_(1)-GO kills ACHN cells effectively but maintains acceptable cytotoxicity to the normal podocyte and HK2 ***-depth analyses ascribe the inhibition of ACHN cells to the upregulated autophagy instead of the commonly known catalytic ROS *** in vivo therapeutic effect of Fe_(1)-GO nanomedicine is also validated by the RCC-bearing BALB/c mice model,realizing an 89% reduction of tumor weight and good *** work provides new insights into the design of autophagy regulators as well as potential therapeutic strategies for RCC treatment.

关键词： Fe single atom Autophagy Renal cell carcinoma Graphene oxide Cancer therapy

Identification of candidate genes for early-maturity traits by combining BSA-seq and QTL mapping in upland cotton(Gossypium hirsutum L.)

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Journal of Integrative Agriculture 2024年第10期23卷 3472-3486页

作者： Liang Ma Tingli hu meng Kang xiaokang Fu Pengyun Chen Fei Wei Hongliang Jian xiaoyan Lü meng Zhang Yonglin Yang State Key Laboratory of Cotton Bio-breeding and Integrated Utilization/Institute of Cotton Research Chinese Academy ofAgricultural SciencesAnyang 455000China School of Agriculture Henan Institute of Science and TechnologyXinxiang 453003China Shihezi Academy of Agricultural Sciences Shihezi 832099China

Cotton breeding for the development of early-maturing varieties is an effective way to improve multiple cropping indexes and alleviate the conflict between grains and cotton in the cultivated fields in *** the present study,we aimed to identify upland cotton quantitative trait loci(QTLs)and candidate genes related to early-maturity traits,including whole growth period(WGP),flowering timing(FT),node of the first fruiting branch(NFFB),height of the node of the first fruiting branch(HNFFB),and plant height(PH).An early-maturing variety,CCRI50,and a latematuring variety,Guoxinmian 11,were crossed to obtain biparental *** populations were used to map QTLs for the early-maturity traits for two years(2020 and 2021).With BSA-seq analysis based on the data of population 2020,the candidate regions related to early maturity were found to be located on chromosome *** then developed 22 polymorphic insertions or deletions(InDel)markers to further narrow down the candidate regions,resulting in the detection of five and four QTLs in the 2020 and 2021 populations,*** to the results of QTL mapping,two candidate regions(InDel_G286-InDel_G144 and InDel_G24-InDel_G43)were *** these regions,three genes(GH_D03G0451,GH_D03G0649,and GH_D03G1180)have nonsynonymous mutations in their exons and one gene(GH_D03G0450)has SNP variations in the upstream sequence between CCRI50 and Guoxinmian *** four genes also showed dominant expression in the floral *** expression levels of GH_D03G0451,GH_D03G0649 and GH_D03G1180 were significantly higher in CCRI50 than in Guoxinmian 11 during the bud differentiation stages,while GH_D03G0450 showed the opposite *** functional verification of GH_D03G0451 indicated that the GH_D03G0451-silenced plants showed a delay in the flowering *** results suggest that these are the candidate genes for cotton early maturity,and they may be used for breeding early-maturity cotton varieties.

关键词： cotton genomics early-maturity traits BSA-seq QTL mapping molecular breeding

Double-Doped Carbon-Based Electrodes with Nitrogen and Oxygen to Boost the Areal Capacity of Zinc-Bromine Flow Batteries

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Transactions of Tianjin University 2024年第1期30卷 74-89页

作者： xiaoyun Sun Deren Wang Haochen hu Xin Wei Lin meng Zhongshan Ren Sensen Li Institute for Advanced Materials and Technology University of Science and TechnologyBeijing 100083China School of Physics and Materials Engineering Hefei Normal UniversityHefei 230601China Jiangsu Heng’an Energy Storage Technology Co. Ltd.Beijing 100176China

Ensuring a stable power output from renewable energy sources,such as wind and solar energy,depends on the development of large-scale and long-duration energy storage ***–bromine fl ow batteries(ZBFBs)have emerged as cost-eff ective and high-energy-density solutions,replacing expensive all-vanadium fl ow ***,uneven Zn deposition during charging results in the formation of problematic Zn dendrites,leading to mass transport polarization and *** Zn plating and stripping are essential for the successful operation of high-areal-capacity *** this study,we successfully synthesized nitrogen and oxygen co-doped functional carbon felt(NOCF4)electrode through the oxidative polymerization of dopamine,followed by calcination under ambient *** NOCF4 electrode eff ectively facilitates effi cient“shuttle deposition”of Zn during charging,signifi cantly enhancing the areal capacity of the ***,ZBFBs utilizing NOCF4 as the anode material exhibited stable cycling performance for 40 cycles(approximately 240 h)at an areal capacity of 60 mA h/cm^(2).Even at a high areal capacity of 130 mA h/cm^(2),an impressive energy effi ciency of 76.98%was *** fi ndings provide a promising pathway for the development of high-areal-capacity ZBFBs for advanced energy storage systems.

关键词： Zinc-bromine fl ow batteries N,O co-doping Areal capacity Shuttle deposition Zinc dendrite

Functionalized lipid nanoparticles modulate the blood-brain barrier and eliminate α-synuclein to repair dopamine neurons

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Asian Journal of Pharmaceutical Sciences 2024年第2期19卷 120-135页

作者： xiaomei Wu Renxiang Yuan Yichong Xu Kai Wang Hong Yuan Tingting meng Fuqiang hu Department of Pharmacy Ruijin HospitalSchool of MedicineShanghai Jiaotong UniversityShanghai 200000China College of Pharmaceutical Science Zhejiang UniversityHangzhou 310058China Jinhua Institute of Zhejiang University Jinhua 321299China

The challenge in the clinical treatment of Parkinson's disease lies in the lack of disease-modifying therapies that can halt or slow down the progression. Peptide drugs, such as exenatide (Exe), with potential disease-modifying efficacy, have difficulty in crossing the blood-brain barrier (BBB) due to their large molecular weight. Herein, we fabricate multi-functionalized lipid nanoparticles (LNP) Lpc-BoSA/CSO with BBB targeting, permeability-increasing and responsive release functions. Borneol is chemically bonded with stearic acid and, as one of the components of Lpc-BoSA/CSO, is used to increase BBB permeability. Immunofluorescence results of brain tissue of 15-month-old C57BL/6 mice show that Lpc-BoSA/CSO disperses across the BBB into brain parenchyma, and the amount is 4.21 times greater than that of conventional LNP. Motor symptoms of mice in Lpc-BoSA/CSO-Exe group are significantly improved, and the content of dopamine is 1.85 times (substantia nigra compacta) and 1.49 times (striatum) that of PD mice. α-Synuclein expression and Lewy bodies deposition are reduced to 51.85% and 44.72% of PD mice, respectively. Immunohistochemical mechanism studies show AKT expression in Lpc-BoSA/CSO-Exe is 4.23 times that of PD mice and GSK-3β expression is reduced to 18.41%. Lpc-BoSA/CSO-Exe could reduce the production of α-synuclein and Lewy bodies through AKT/GSK-3β pathway, and effectively prevent the progressive deterioration of Parkinson's disease. In summary, Lpc-BoSA/CSO-Exe increases the entry of exenatide into brain and promotes its clinical application for Parkinson's disease therapy.

关键词： Blood-brain barrier Lipid nanoparticles Brain delivery facilitation α-Symuclein Parkinson's disease

Facile preparation of a SiC@SiO_(2)nanowire-toughened ZrB_(2)-SiC/SiC bilayer coating with good interfacial bonding,high toughness,and excellent cyclic ablation resistance on C/CA composites

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Journal of Advanced Ceramics 2024年第4期13卷 486-495页

作者： meng Yan Chenglong hu Jian Li Shengyang Pang Bohui Sun Rida Zhao Bin Liang Rui Luo Sufang Tang Shi-Changxu Innovation Center for Advanced Materials Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China School of Materials Science and Engineering University of Science and Technology of ChinaShenyang 110016China

Preparing antioxidant coatings to address the inherent oxidation sensitivity of carbon fiber-reinforced carbon aerogel(C/CA)composites is a feasible way to promote their application in oxidizing environments as thermal insulation ***,preparing the coatings with excellent oxidation and ablation resistance while avoiding evident damage to the C/CA substrate still remains a ***,a SiC@SiO_(2)nanowire-toughened ZrB2–SiC/SiC bilayer coating with a large thickness of 500μm was prepared on C/CA using a one-step low-temperature reaction sintering method,which simultaneously formed a sintered outer layer with even-distributed nanowires and a siliconized gradient inner *** courtesy of the synergic thermal response of the layers and the crack deflection induced by the nanowires,the resulting coating has moderate residual compressive stress of 0.08–1.22 GPa in the interface,high interfacial bonding strength of 6.02 MPa,and good fracture toughness of 4.36 MPa·m^(1/2).Benefited from the optimum components and improved structure,the coating shows excellent cyclic ablation resistance with linear ablation rates of 0.1μm/s at 1650℃for 1500 s(300 s×5 cycles)and 0.4μm/s at 1850℃for 900 s(300 s×3 cycles).The one-step preparation strategy contributes to little damage to the substrate,thus showing the well-preserved mechanical and thermal insulation properties.

关键词： coating carbon fiber reinforced carbon aerogel(C/CA)composites toughness interface residual stress

Studies of an event-building algorithm of the readout system for the twin TPCs in HFRS

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Nuclear Science and Techniques 2024年第4期35卷 82-95页

作者： Jing Tian Zhi-Peng Sun Song-Bo Chang Yi Qian Hong-Yun Zhao Zheng-Guo hu Xi-meng Chen Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China School of Nuclear Science and Technology University of LanzhouLanzhou 730000China School of Nuclear Science and Technology University of Chinese Academy of SciencesBeijing 100049China Advanced Energy Science and Technology Guangdong LaboratoryHuizhou 516000China

The High-energy Fragment Separator(HFRS),which is currently under construction,is a leading international radioactive beam *** sets of position-sensitive twin time projection chamber(TPC)detectors are distributed on HFRS for particle identification and beam *** twin TPCs'readout electronics system operates in a trigger-less mode due to its high counting rate,leading to a challenge of handling large amounts of *** address this problem,we introduced an event-building *** algorithm employs a hierarchical processing strategy to compress data during transmission and *** addition,it reconstructs twin TPCs'events online and stores only the reconstructed particle information,which significantly reduces the burden on data transmission and storage *** studies demonstrated that the algorithm accurately matches twin TPCs'events and reduces more than 98%of the data volume at a counting rate of 500 kHz/channel.

关键词： High counting rate Twin TPCs Trigger-less Readout electronics Event building Hierarchical data processing

Insights into the role of RNA m^(6)A modification in the metabolic process and related diseases

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Genes & Diseases 2024年第4期11卷 270-295页

作者： Haiming hu Zhibin Li Xia Xie Qiushi Liao Yiyang hu Chunli Gong Nannan Gao huan Yang Yufeng xiao Yang Chen Department of Gastroenterology Xinqiao HospitalArmy Medical UniversityChongqing 400037China

According to the latest consensus,many traditional diseases are considered meta-bolic diseases,such as cancer,type 2 diabetes,obesity,and cardiovascular ***,metabolic diseases are increasingly prevalent because of the ever-improving living standards and have become the leading threat to human *** therapy methods have been applied to treat these diseases,which improves the quality of life of many patients,but the overall effect is still ***,intensive research on the metabolic process and the pathogenesis of metabolic diseases is imperative.N6-methyladenosine(m^(6)A)is an important modification of eukaryotic *** is a critical regulator of gene expression that is involved in different cellular functions and physiological *** studies have indi-cated that m^(6)A modification regulates the development of many metabolic processes and metabolic *** this review,we summarized recent studies on the role of m^(6)A modifica-tion in different metabolic processes and metabolic ***,we highlighted the potential m^(6)A-targeted therapy for metabolic diseases,expecting to facilitate m^(6)A-targeted strategies in the treatment of metabolic diseases.

关键词： Cancer mm^(6)A-targeted therapy Metabolic disease Metabolism N6-methyladenosine